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    • 9. 发明公开
    • 포도 줄기 껍질로부터 분리된 레스베라트롤 유도체 화합물을 포함하는 항암제 조성물
    • 用于治疗包含来自葡萄膜干燥分离的抑制剂衍生物的癌症的药物组合物
    • KR1020120116115A
    • 2012-10-22
    • KR1020110033674
    • 2011-04-12
    • 한국화학연구원국민대학교산학협력단
    • 최상운유시용김영섭최춘환최연희차미란김영균
    • A61K31/045A61K31/05A61K36/87A23L33/10A23L33/105A23L2/52
    • A61K31/045A23L2/52A23L33/10A23L33/105A61K31/05A61K36/87A61K2300/00
    • PURPOSE: An anticancer drug composition including resveratrol derivative compound separated from grape stem shell is provided to prevent and treat all kinds of cancers including lung cancer, ovarian cancer, melanoma, central nervous system tumor, colon carcinoma, and leukemia. CONSTITUTION: An anticancer drug composition includes vitisinol C, vitisinol E, cis-vitisin A, vitisin B, vitisin C, a pharmaceutically acceptable salt and isomer or a mixture thererof, and grape stem shell extract including thereof as an active ingredient. The grape stem shell extract is obtained by extracting methanol, methanol aqueous solution, ethanol, ethanol aqueous solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma or colon carcinoma. A health enhancement food having cancer cell growth inhibition efficacy contains vitisinol C, vitisinol E, cis-viticin A, viticin B, viticin C, pharmaceutically acceptable salt, isomer or a mixture thereof, and grapes stem shell extract including the same. The food is in beverage form. The grape stem shell extract is obtained by the following steps: extracting the grape stem shell by methanol and suspending the obtained extract in distilled water; partitioning thereof by dichloromethane; and extracting the obtained water layer by ethyl acetate.
    • 目的:提供包括从葡萄茎壳分离的白藜芦醇衍生物化合物的抗癌药物组合物,用于预防和治疗各种癌症,包括肺癌,卵巢癌,黑素瘤,中枢神经系统肿瘤,结肠癌和白血病。 构成:抗癌药物组合物包括维生素C,维生素E,顺式维生素A,维生素B,维生素C,其药学上可接受的盐和异构体或其混合物,以及包含它们的葡萄茎壳提取物作为活性成分。 葡萄茎壳提取物是通过提取甲醇,甲醇水溶液,乙醇,乙醇水溶液,丁醇,二氯甲烷,乙酸乙酯或其混合物得到的。 癌症是肺癌,卵巢癌,黑素瘤或结肠癌。 具有癌细胞生长抑制作用的健康增强食品包含维生素C,维生素E,顺式维生素A,维生素B,维生素C,其药学上可接受的盐,异构体或其混合物,以及包含其的葡萄茎壳提取物。 食物是饮料形式。 通过以下步骤获得葡萄茎壳提取物:用甲醇萃取葡萄茎壳,将得到的提取物悬浮于蒸馏水中; 用二氯甲烷分配; 并用乙酸乙酯萃取得到的水层。