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3. 发明专利

JP2002528382A 失效
公开(公告)号：JP2002528382A
公开(公告)日：2002-09-03
申请号：JP2000533451
申请日：1999-02-12
IPC分类号： C12P21/02 , A61K38/00 , A61K38/12 , A61P31/04 , C07K7/56 , C07K7/60 , C12R1/045
摘要： The invention relates to a calcium salt of the compound of formula (II),where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.

4. 发明专利

JP3140228B2 失效
公开(公告)号：JP3140228B2
公开(公告)日：2001-03-05
申请号：JP32340792
申请日：1992-12-02
IPC分类号： A61K31/435 , A61K31/445 , A61P31/04 , A61P35/00 , A61P37/06 , C07D498/18 , C12N1/20 , C12P17/18 , C12R1/045 , C12R1/465
摘要： This invention provides the novel culture, Streptomyces hygroscopicus FERM BP-3688 and the macrocyclic lactones which were produced by the culture Streptomyces hygroscopicus (FERM BP-3688), Actinoplanes sp. (FERM BP-3832) or Streptomyces toyocaensis subsp.humicola (ATCC 39471) and an immunosuppressive agent, an antimycotic agent and an antitumor agent which comprises the said macrocyclic lactones. The macrocyclic lactones have formula (I) wherein R is oxygen, two hydrogens or one hydrogen and one hydroxy; R , R and R are each independently hydrogen, hydroxy or methoxy; and R is hydroxy or hydrogen; provided that when R is oxygen, R is hydroxy and R and R are methoxy, R is neither hydrogen nor methoxy.

5. 发明专利

JP3107564B2 失效
公开(公告)号：JP3107564B2
公开(公告)日：2000-11-13
申请号：JP30003590
申请日：1990-11-07
IPC分类号： C12P21/00 , C07K1/14 , C07K1/36 , C07K11/00 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/045

6. 发明专利

JPH08309327A GARBAGE TREATMENT APPARATUS 失效
公开(公告)号：JPH08309327A
公开(公告)日：1996-11-26
申请号：JP14675395
申请日：1995-05-22
申请人： MITSUI KUSHIKINO KOZAN KK
发明人： YAMANOGUCHI YOSHINARI , INOUE KEIJI , NAKAMURA TADASHI
IPC分类号： C12N1/20 , B09B3/00 , C05F9/02 , C12R1/01 , C12R1/045
摘要： PURPOSE: To attain an inexpensive cost, a large treatment capacity, the elimination of troubles and offensive odors, easy and inexpensive maintenance, and the smooth descent of treatment powder by circulating a treatment member which was dropped by swaying a scraper by rotating a circulating helix which raises the treatment powder. CONSTITUTION: A lid 10 is opened, treatment powder (a) is supplied from a supply port 7 in the upper part of a porous cylinder 5, and a handle 22 is reciprocated with garbage fed on the powder (a). A scraping blade 21 on a scraper 20 is rotated to scrape the lower surface side of the powder (a) to drop and accumulate the powder (a) on a funnel part 26. When a circulating helix 12 is rotated by operating a manual handle 35, the powder (a) is turned by a scraping rotary blade 30 and a stirring rod 36 to be induced to the middle of the funnel 26. Since a fixed scraping blade 29 is fixed at the lower end of a circulating cylinder 14, the powder (a) is taken into the lower end 28 of the cylinder 14 to be raised by a circulating helix 12. The powder (a) overflows from an opening 15 and flows on a frame 16 to be sprinkled on the upper part of the garbage 6 by a diffusion blade 17.

7. 发明专利

JPH07106144B2 失效
公开(公告)号：JPH07106144B2
公开(公告)日：1995-11-15
申请号：JP27883590
申请日：1990-10-17
IPC分类号： C12N1/19 , A61K35/14 , A61K35/23 , A61K38/00 , A61K38/16 , A61K38/21 , A61P31/12 , A61P35/00 , A61P43/00 , C07H21/04 , C07K1/00 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/555 , C07K14/57 , C12N1/00 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/20 , C12N15/23 , C12N15/70 , C12N15/71 , C12N15/81 , C12N15/85 , C12P21/02 , C12R1/045 , C12R1/19 , C12R1/865 , C12R1/91

8. 发明专利

JPH075638B2 失效
公开(公告)号：JPH075638B2
公开(公告)日：1995-01-25
申请号：JP8991783
申请日：1983-05-20
IPC分类号： C12P21/04 , A61K35/74 , A61K38/00 , A61P31/04 , C07K1/02 , C07K1/06 , C07K1/113 , C07K7/08 , C12P21/02 , C12R1/045 , C12R1/62
摘要： A-21978C cyclic peptides of the formula wherein R is selected from the group consisting of hydrogen, an amino-protecting group, 8-methyldecanoyl, 10-methylundecanoyl, 10-methyldodecanoyl, the specific C10-alkanoyl group of A-21978C factor C0 and the specific C12-alkanoyl groups of A-21978C factors C4 and C5; R and R are, independently, hydrogen or an amino-protecting group, and salts thereof, are prepared by enzymatic deacylation of an antibiotic selected from A-21978C complex, A-21978C factors C0, C1, C2, C3, C4 and C5 and blocked A-21978C complex and factors C0, C1, C2, C3, C4 and C5, using an enzyme produced by the Actinoplanaceae, preferably by Actinoplanes utahensis. These A-21978C cyclic peptides or a pharmaceutically-acceptable salt thereof are useful intermediates for preparing new alkanoyl, alkenoyl, benzoyl, acylamino, N-alkanoylaminoacyl, and alkyl cyclic peptide antibiotics.

9. 发明专利

JPH06298781A ANTIBIOTIC SUBSTANCE RECTIPLANIN 失效
公开(公告)号：JPH06298781A
公开(公告)日：1994-10-25
申请号：JP8590093
申请日：1993-04-13
申请人： SANKYO CO
发明人： INUKAI MASATOSHI , TAKEUCHI MICHIKO , OTANI HIROKO , SAKAIDA YOSHIAKI , OKAZAKI HISAO , ENOKIDA RYUZO , HARUYAMA HIDEYUKI
IPC分类号： A61K35/74 , A61P31/04 , C07G11/00 , C12P1/06 , C12R1/045
摘要： PURPOSE:To obtain rectiplanin having antibacterial activity effective on both Gram-positive bacteria and Gram-negative bacteria. CONSTITUTION:The antibacterial substance rectiplanin or its salt having the following physical and chemical properties. 1) Nature of the substance, ampholytic water-soluble white powder; 2) molecular formula, C70H113N4O35P (determined by high-resolution mass spectrometry); 3) infrared absorption spectrum, numaxcm , the infrared absorption spectrum measured in KBr tablet is shown in figure; 4) high-performance liquid chromatography (column, Senshu pack; 20mM triethylamine-phosphoric acid buffer solution containing 55% acetonitrile; flow rate, 1mL/min; detection wavelength, UV 200nm), retention time, 10.9min.

10. 发明专利

JPH04221387A PREPARATION OF MANNOSYLTEICHOPLANINE DERIVATIVE AND MANNOSYLTEICHOPLANINE AGLYCONE 失效
公开(公告)号：JPH04221387A
公开(公告)日：1992-08-11
申请号：JP8036391
申请日：1991-03-20
申请人： LEPETIT SPA
发明人： ANJIERO BORUGI , JIYANKARURO RANCHIINI
IPC分类号： A61K31/395 , A23K20/195 , A61K38/00 , A61K38/12 , A61K38/14 , A61P3/00 , A61P31/04 , C07D20060101 , C07D498/22 , C07K9/00 , C12P17/18 , C12P19/44 , C12P19/60 , C12P21/02 , C12R1/045

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