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1. 发明专利

JP2015024976A 光学活性２級アルコールの製造方法审中-公开
标题翻译：用于生产光活性二级醇的方法
公开(公告)号：JP2015024976A
公开(公告)日：2015-02-05
申请号：JP2013156036
申请日：2013-07-26
申请人：関東化学株式会社 , Kanto Chem Co Inc , 国立大学法人北海道大学 , Hokkaido Univ
发明人： KATAYAMA TAKEAKI , TSUTSUMI KUNIHIKO , MURATA KUNIHIKO , OKUMA TAKESHI , ARAI NORIYOSHI
IPC分类号： C07C29/145 , B01J31/22 , C07C33/20 , C07C41/18 , C07C43/178
CPC分类号： C07C41/26 , B01J31/1815 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C2531/28 , C07C33/22 , C07C33/46 , C07C43/23
摘要：【課題】基質カルボニル化合物を高い効率で水素化し、高い光学純度の光学活性2級アルコールを製造する方法の提供。【解決手段】一般式:RuXYAB[X及びYは互いに同一又は異なり、H又はアニオン性基を示し、Aは式(2)で表される光学活性ジホスフィンを示し、Bは、式(3)で表されるアミン化合物を示す。]で表されるルテニウム錯体の存在下、基質カルボニル化合物を水素及び/又はHを供与する化合物と反応させる。(R1〜R8は炭化水素基等であり、*は不斉炭素原子を表す。)(各Dは、独立して同一又は異なり、C又はNを示し、R9〜R12は炭化水素基等であり、nは、0〜(4−(窒素原子であるDの数))の整数である。)【選択図】なし
摘要翻译：要解决的问题：提供一种通过以高效率氢化底物羰基化合物制备具有高光学纯度的光学活性仲醇的方法。解决方案：制备光学活性仲醇的方法包括使底物羰基化合物与氢和 /或由以下通式表示的钌络合物存在下的化合物：RuXYAB [X和Y彼此相同或不同，表示H或阴离子基团; A表示由式（2）表示的光学活性二膦; B表示式（3）表示的胺化合物]。（式（2）中，Rto Rare为烃基等，*表示不对称碳原子。）（式（3）中，D各自独立地相同或不同，表示C或N; R〜基团等; n为0〜（4-（D为氮原子的数）的整数）。

3. 发明专利

JPWO2012121301A1 含フッ素置換化合物の製造方法及び含フッ素置換化合物有权
公开(公告)号：JPWO2012121301A1
公开(公告)日：2014-07-17
申请号：JP2013503584
申请日：2012-03-07
申请人：国立大学法人京都大学 , 大陽日酸株式会社
发明人：吉田　潤一 , 潤一吉田 , 愛一郎永木 , 愛一郎永木
IPC分类号： C07C33/46 , C07C29/38 , C07C45/00 , C07C49/167 , C07C231/10 , C07C233/05 , C07C233/07 , C07F7/12 , C07F7/22 , C07F9/52
CPC分类号： C07F7/2212 , C07C29/40 , C07C29/62 , C07C33/20 , C07C33/46 , C07C33/483 , C07C45/00 , C07C45/455 , C07C49/80 , C07C231/00 , C07C231/10 , C07C233/13 , C07C233/15 , C07F7/0809 , C07F7/12 , C07F7/122 , C07F9/28 , C07F9/5022 , C07F9/5068 , C07C233/07 , C07C233/05 , C07C49/233
摘要：【課題】工業的に実施可能な温度条件下で、簡易な装置で、かつ、簡便な操作で、含フッ素置換化合物を製造可能な含フッ素置換化合物の製造方法の提供。【解決手段】本発明は、複数の液体を混合可能な流路を備えるマイクロリアクターに有機フッ素化合物と有機リチウム化合物とを導入して反応生成物を得る工程、及び前記マイクロリアクターに前記反応生成物と、前記反応生成物に対し求電子作用を示す求電子剤とを導入して含フッ素置換化合物を得る工程を含む含フッ素置換化合物の製造方法である。【選択図】図6

5. 发明专利

JP5447883B2 Method of manufacturing a phenyl alkane-1-ol 有权
公开(公告)号：JP5447883B2
公开(公告)日：2014-03-19
申请号：JP2011520447
申请日：2009-07-27
申请人：ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人：ヴァイスマルティネ , ブロイニンガーダニエル , エーベルクラウス , ヴィンゼルハラルト
IPC分类号： C07C29/154 , C07C33/46
CPC分类号： C07C67/317 , C07C29/149 , C07C67/343 , C07C69/65 , C07C69/738 , C07C33/46

6. 发明专利

JP2014040457A Method of manufacturing phosphoroamide compound and optically active alcohol 审中-公开
标题翻译：制备磷酰胺化合物和光活性醇的方法
公开(公告)号：JP2014040457A
公开(公告)日：2014-03-06
申请号：JP2013209580
申请日：2013-10-04
申请人： Nagoya Univ , 国立大学法人名古屋大学 , Sekisui Medical Co Ltd , 積水メディカル株式会社
发明人： ISHIHARA KAZUAKI , HATANO MANABU , MIYAMOTO TAKASHI
IPC分类号： C07F9/572 , B01J31/24 , C07B53/00 , C07B61/00 , C07C29/143 , C07C29/38 , C07C33/14 , C07C33/18 , C07C33/20 , C07C33/24 , C07C33/34 , C07C41/30 , C07C43/23 , C07D333/16 , C07F3/06 , C07F9/36 , C07F9/553 , C07F9/59 , C07F9/6533
CPC分类号： C07F19/00 , B01J31/1815 , B01J2231/643 , B01J2531/26 , C07B53/00 , C07B2200/07 , C07C29/40 , C07C41/30 , C07C2601/08 , C07C2601/10 , C07C2601/12 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D333/16 , C07F9/28 , C07F9/36 , C07F9/5532 , C07F9/5721 , C07F9/591 , C07F9/6533 , C07C33/20 , C07C33/46 , C07C33/34 , C07C33/16 , C07C43/23
摘要： PROBLEM TO BE SOLVED: To provide a method of high efficiency and high enantioselectivity for manufacturing an optically active alcohol from a carbonyl compound, and to provide a ligand used therefor.SOLUTION: An optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a phosphoroamide compound represented by a ligand (L) as a catalyst, where Ris a monovalent hydrocarbon group having 3 or more carbon atoms, Ris a different monovalent hydrocarbon group to R, Rand Rmay bond to each other to form a ring, R is an alkyl group, an aryl group or the like, Rto Rare each independently a monovalent hydrocarbon group, Rand R3, and Rand Rmay bond to each other to form a ring.
摘要翻译：要解决的问题：提供一种从羰基化合物制造光学活性醇的高效率和高对映选择性的方法，并提供用于其的配体。解决方案：通过羰基化合物和有机锌通过使用由配体（L）表示的磷酰胺化合物作为催化剂，其中R是具有3个或更多个碳原子的一价烃基，R是与R相连的不同的一价烃基，Rand R may彼此结合形成环， R是烷基，芳基等，Rto Rare各自独立地是一价烃基，Rand R3和Rand Rmay彼此结合形成环。

7. 发明专利

JP5379873B2 Optically active ammonium salt compound, and its manufacturing intermediates 有权
公开(公告)号：JP5379873B2
公开(公告)日：2013-12-25
申请号：JP2012036862
申请日：2012-02-22
申请人：日本曹達株式会社
发明人：啓二丸岡 , 靖久保田
IPC分类号： C07D487/10 , C07C25/18 , C07C43/225
CPC分类号： B01J31/0271 , C07B53/00 , C07B2200/07 , C07C22/04 , C07C25/18 , C07C33/46 , C07C43/225 , C07D223/18 , C07D487/10
摘要： An optically active quaternary ammonium salt compound represented by formula (1), wherein R 1 represents a halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, a C 2-8 alkynyl which is optionally substituted, a C 6-14 aryl which is optionally substituted, a C 3-8 heteroaryl which is optionally substituted, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, or a C 7-16 aralkyl which is optionally substituted; R 2 and R 21 each independently represents hydrogen, halogen, nitro, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, a C 2-8 alkynyl which is optionally substituted, a C 6-14 aryl which is optionally substituted, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, or a C 7-16 aralkyl which is optionally substituted; one of combinations of R 1 and R 21 , and R 2 and R 21 , may bond to form a C 1-6 alkylene which is optionally substituted, a C 1-6 alkylenemonooxy which is optionally substituted, or a C 1-6 alkylenedioxy which is optionally substituted; R 3 and R 4 each independently represents hydrogen, a C 6-14 aryl which is optionally substituted, a C 3-8 heteroaryl which is optionally substituted, or a C 7-16 aralkyl which is optionally substituted, with a proviso that R 3 and R 4 are not hydrogen at the same time; R 5 represents hydrogen, halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, or a C 2-8 alkynyl which is optionally substituted; R 6 represents halogen, a C 1-8 alkyl which is optionally substituted and which is linear, branched, or cyclic, a C 1-8 alkoxy which is optionally substituted and which is linear, branched, or cyclic, a C 2-8 alkenyl which is optionally substituted, or a C 2-8 alkynyl which is optionally substituted, and R 5 and R 6 may bond to form an aromatic ring which is optionally substituted; ring A and ring B do not have a same substituent at the same time; symbols * and ** represent an optical activity having an axial chirality; and X - represents an anion.

8. 发明专利

JP2013043888A Asymmetric hydrogenation method for ketone compound 有权
标题翻译：酮类化合物的不对称加氢方法
公开(公告)号：JP2013043888A
公开(公告)日：2013-03-04
申请号：JP2012164529
申请日：2012-07-25
申请人： Nippon Chem Ind Co Ltd , 日本化学工業株式会社
发明人： WANBIN ZHANG , LIU DELONG , GUO HUI , LIU YANGANG
IPC分类号： C07C29/145 , B01J31/24 , C07B53/00 , C07B61/00 , C07C33/18 , C07C33/22 , C07C33/24 , C07C33/46 , C07C35/32 , C07C35/36 , C07C37/00 , C07C39/11 , C07C41/26 , C07C43/23 , C07C213/00 , C07C215/68 , C07D213/30 , C07D307/42
CPC分类号： C07C29/145 , C07B53/00 , C07B2200/07 , C07C37/002 , C07C41/26 , C07C213/00 , C07C2102/08 , C07C2102/10 , C07C2602/08 , C07C2602/10 , C07C33/22 , C07C33/20 , C07C33/46 , C07C43/23 , C07C39/11 , C07C33/24 , C07C33/18 , C07C35/36 , C07C35/32 , C07C215/68
摘要： PROBLEM TO BE SOLVED: To provide an asymmetric hydrogenation method for ketone compounds, the method which is simple in operation, gives high selectivity and productivity, and has high atom economy and a bright prospect of industrial application.SOLUTION: The asymmetric hydrogenation method for ketone compounds includes a step of adding a ketone compound and an alkali into a second solvent to carry out the reaction of asymmetric hydrogenation of the ketone compound in a hydrogen atmosphere and in the presence of an in-situ catalyst obtained from a chiral ligand and a metal ruthenium salt. The in-situ catalyst is preferably obtained by reacting the chiral ligand with the metal ruthenium salt in a first solvent.
摘要翻译：要解决的问题：为了提供酮化合物的不对称氢化方法，操作简单的方法具有高选择性和高生产率，原子经济性高，工业应用前景广阔。解决方案：酮化合物的不对称氢化方法包括将酮化合物和碱加入到第二溶剂中以在氢气氛中进行酮化合物的不对称氢化反应和在 - 由手性配体和金属钌盐获得的催化剂。原位催化剂优选通过在第一溶剂中使手性配体与金属钌盐反应而获得。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012153691A Optically active ammonium salt compound and production intermediate thereof 有权
标题翻译：光学活性铵盐化合物及其生产中间体
公开(公告)号：JP2012153691A
公开(公告)日：2012-08-16
申请号：JP2012036862
申请日：2012-02-22
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： MARUOKA KEIJI , KUBOTA YASUSHI
IPC分类号： C07D487/10 , C07C25/18 , C07C43/225
CPC分类号： B01J31/0271 , C07B53/00 , C07B2200/07 , C07C22/04 , C07C25/18 , C07C33/46 , C07C43/225 , C07D223/18 , C07D487/10
摘要： PROBLEM TO BE SOLVED: To provide an optically active quaternary ammonium salt compound useful as a chiral phase-transfer catalyst, and a production intermediate of the optically active quaternary ammonium salt compound.SOLUTION: The optically active quaternary ammonium salt compound is represented by formula (1). In the formula: Ris an alkyl or alkoxy; Rand Rare hydrogen; Ris hydrogen, alkyl or alkoxy; Ris aryl or aralkyl; Rand Rare alkenyl and connects together to form an aromatic ring; * and ** show optical activity having shaft asymmetry; and Xshows an anion.
摘要翻译：要解决的问题：提供可用作手性相转移催化剂的光学活性季铵盐化合物和光学活性季铵盐化合物的制备中间体。解决方案：光学活性季铵盐化合物由式（1）表示。在式中：R 1 是烷基或烷氧基; R 2 和R 4 是氢; R 21是氢，烷基或烷氧基; R 3是芳基或芳烷基; R 5 和R 6 是烯基并连接在一起形成芳环; *和**表示具有轴不对称性的光学活动; 而X - 显示阴离子。版权所有（C）2012，JPO＆INPIT

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