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    • 1. 发明专利
    • PLASTER
    • JPS62198613A
    • 1987-09-02
    • JP3899586
    • 1986-02-26
    • WATANABE YAKUHIN KOGYO KK
    • NAGAI TSUNEJIMACHIDA RYOJITAKAYASU TOSHIYUKISHIBATA SHIGEKO
    • A61K9/70
    • PURPOSE:To provide a plaster having a three-layer structure composed of a drug-storage layer, an assistant layer and a substrate layer and capable of surely and effectively administering a proper kind of drug at a sufficient amount according to the purpose of treatment. CONSTITUTION:The objective plaster is composed of (A) a drug-storage layer composed of a water-containing hydrophilic polymer matrix containing a drug (e.g. anti-inflammatory agent, a local anesthetic, a hypotensor, a hypotensive diuretic, etc.), its dissolving agent and transcutaneous absorbefacient, (B) an assistant layer laminated to said drug-storage layer and composed of a water- containing hydrophilic polymer matrix at least containing a transcutaneous absorbefacient and free from the dissolving agent of the above drug and (C) an air-permeable substrate layer (e.g. porous synthetic resin film, paper, nonwoven fabric, etc.) bonded to the assistant layer. If necessary, various components such as plasticizer, dispersing agent, stabilizer, etc., may be added to the matrix forming the above drug-storage layer and the assistant layer.