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    • 2. 发明专利
    • PLASTER
    • JPS62198613A
    • 1987-09-02
    • JP3899586
    • 1986-02-26
    • WATANABE YAKUHIN KOGYO KK
    • NAGAI TSUNEJIMACHIDA RYOJITAKAYASU TOSHIYUKISHIBATA SHIGEKO
    • A61K9/70
    • PURPOSE:To provide a plaster having a three-layer structure composed of a drug-storage layer, an assistant layer and a substrate layer and capable of surely and effectively administering a proper kind of drug at a sufficient amount according to the purpose of treatment. CONSTITUTION:The objective plaster is composed of (A) a drug-storage layer composed of a water-containing hydrophilic polymer matrix containing a drug (e.g. anti-inflammatory agent, a local anesthetic, a hypotensor, a hypotensive diuretic, etc.), its dissolving agent and transcutaneous absorbefacient, (B) an assistant layer laminated to said drug-storage layer and composed of a water- containing hydrophilic polymer matrix at least containing a transcutaneous absorbefacient and free from the dissolving agent of the above drug and (C) an air-permeable substrate layer (e.g. porous synthetic resin film, paper, nonwoven fabric, etc.) bonded to the assistant layer. If necessary, various components such as plasticizer, dispersing agent, stabilizer, etc., may be added to the matrix forming the above drug-storage layer and the assistant layer.
    • 3. 发明专利
    • Plaster for drug administration
    • 塑料药物管理
    • JPS5925320A
    • 1984-02-09
    • JP13499782
    • 1982-08-02
    • Watanabe Yakuhin Kogyo Kk
    • YOSHIKAWA TOORUICHIKAWA MINORUKUSUNOKI AKIHIKOINOUE KIYOAKIYOSHIE KAZUNARI
    • A61K9/70
    • PURPOSE: To prepare the titled plaster having surface-protecting property as well as adhesivity, and exhibiting excellent remedying effect, by applying a hydrogel containing sodium polyacrylate, aluminum hydroxide and a drug for transcutaneous absorption to a breathable substrate, and covering the surface of the hydrogel with a releasable film.
      CONSTITUTION: Sodium polyacrylate (2.0W10.0wt% concentration) is mixed with aluminum hydroxide (0.05W0.5wt%) and a desired drug for transcutaneous absorption, e.g. alprenolol (a β-blocking agent), pronidin (a hypotensor), methylephedrin (a bronchodilator), etc., and if necessary with additives such as moisture retainer, dispersing agent, shape retaining agent, etc. homogeneously, to obtain a hydrogen. The gel is applied to the surface of a gas-permeable substrate (e.g. flannel, nonwoven fabric, etc.), and covered with a releasable film. The film is peeled off before use, and the hydrogel layer is attached directly to the skin, etc.
      COPYRIGHT: (C)1984,JPO&Japio
    • 目的:通过将含有聚丙烯酸钠,氢氧化铝和用于经皮吸收的药物的水凝胶应用于透气性基材,制备具有表面保护性和粘合性的标题的石膏,并显示出优异的补救效果,并且覆盖 水凝胶与可剥离膜。 组成:将聚丙烯酸钠(2.0-10.0重量%浓度)与氢氧化铝(0.05-0.5重量%)和用于经皮吸收的所需药物混合。 (β阻滞剂),抑制素(低分度抗生素),甲基蝶呤(支气管扩张剂)等,并且如果需要,可以均匀地添加如保湿剂,分散剂,形状保持剂等,以获得氢。 将凝胶施加到透气性基材(例如法兰绒,无纺布等)的表面,并用可剥离膜覆盖。 使用前将膜剥离,水凝胶层直接附着于皮肤等。