专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2010266448A Method and kit for determining allergic disease 有权
标题翻译：用于确定过敏性疾病的方法和试剂盒
公开(公告)号：JP2010266448A
公开(公告)日：2010-11-25
申请号：JP2010129694
申请日：2010-06-07
申请人： Univ Of Tokushima , 国立大学法人徳島大学
发明人： KIDO HIROSHI , TADA HITOMI , SAWABUCHI TAKAKO
IPC分类号： G01N33/53 , G01N33/551 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of determining an allergic disease capable of determining an expansion/contraction pattern of an allergen and/or the expansion/contraction pattern of an allergen epitope, to provide a method of determining the allergic disease capable of detecting an allergen recognition antibody in a specimen by an immunoassay using a Cy3 labeled secondary antibody, and to provide a kit for determining the allergic disease, available for these methods for determining the allergic disease.
SOLUTION: The method includes the steps of activating a diamond/DLC (Diamond-like Carbon) chip by an activating reagent, performing a coupling reaction of the allergen epitope of allergen protein or peptide containing the allergen epitope, bringing the specimen into contact with an allergen epitope determination chip which has been operated to block an unreacted active group, and detecting the allergen recognition antibody in the specimen captured by the allergen epitope determination chip by the immunoassay.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种测定能够测定变应原的扩张/收缩模式和/或变应原表位的扩张/收缩模式的过敏性疾病的方法，以提供确定过敏性疾病的方法能够通过使用Cy3标记的二次抗体的免疫测定来检测标本中的变应原识别抗体，并提供用于确定过敏性疾病的这些方法的试剂盒，用于确定过敏性疾病。解决方案：该方法包括通过活化剂激活金刚石/ DLC（类金刚石碳）芯片，进行变应原蛋白的变应原表位或含有变应原表位的肽的偶联反应，使样品进入与已经操作以阻断未反应的活性基团的过敏原表位测定芯片接触，并通过免疫测定法检测由变应原表位测定芯片捕获的样品中的变应原识别抗体。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010204130A Immobilization method of protein/peptide to diamond chip 有权
标题翻译：蛋白/肽对金刚石芯片的固定方法
公开(公告)号：JP2010204130A
公开(公告)日：2010-09-16
申请号：JP2010145212
申请日：2010-06-25
申请人： Univ Of Tokushima , 国立大学法人徳島大学
发明人： KIDO HIROSHI , TADA HITOMI , SAWABUCHI TAKAKO , YAMAKAWA YUMIKO , MIZUGUCHI HIROSHI , KINOSHITA MORITOSHI
IPC分类号： G01N33/543 , G01N33/551 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method of immobilizing protein/peptide to a chip substrate without damaging the function of protein, or keeping the function on the substrate without damaging the function.
SOLUTION: This method of immobilizing protein/peptide to the chip includes activating a chemically-modified diamond/DLC (Diamond-like Carbon) chip with an activation reagent, spotting the protein/peptide on the chip and performing a coupling reaction, and then performing a blocking operation of an unreacted active group. As a spotting additive, 30% dimethylsulfoxide (DMSO) or 30% polyethylene glycol (PEG) is used, or activation is performed by the activation reagent, then drying after cleaning with MilliQ water is performed by decompression/drying processing for one hour.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供将蛋白质/肽固定在芯片基板上的方法，而不损害蛋白质的功能，或将功能保持在基板上而不损害功能。解决方案：将蛋白质/肽固定在芯片上的方法包括用活化剂激活化学修饰的金刚石/ DLC（类金刚石碳）芯片，将芯片上的蛋白质/肽点样并进行偶联反应，然后执行未反应的活动组的阻止操作。作为点样添加剂，使用30％二甲基亚砜（DMSO）或30％聚乙二醇（PEG），或者通过活化剂进行活化，然后用MilliQ水清洗干燥后，通过减压/干燥处理1小时进行。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2006267058A Immobilization method of protein/peptide to diamond chip 有权
标题翻译：蛋白/肽对金刚石芯片的固定方法
公开(公告)号：JP2006267058A
公开(公告)日：2006-10-05
申请号：JP2005089518
申请日：2005-03-25
申请人： Otsuka Pharmaceut Co Ltd , Univ Of Tokushima , 国立大学法人徳島大学 , 大塚製薬株式会社
发明人： KIDO HIROSHI , TADA HITOMI , SAWABUCHI TAKAKO , YAMAKAWA YUMIKO , MIZUGUCHI HIROSHI , KINOSHITA MORITOSHI
IPC分类号： G01N33/551 , C07K17/14 , G01N33/02 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an immobilization method which enables the immobilization of protein/peptide on a chip substrate without damaging the function of protein or holding of their function on the substrate without damaging it.
SOLUTION: After a chemically modified diamond/DLC (Diamond-like Carbon) chip is activated by an activating reagent, protein/peptide is spotted on the chip to perform coupling reaction and the blocking operation of an unreacted active group is subsequently performed to immobilize protein/peptide on the chip. In the immobilization method, 30% dimethyl sulfoxide (DMSO) or 30% polyethylene glycol (PEG) is used as a spotting additive or, after the chip is activated by the activating reagent, the drying of the chip after washed with MilliQ water is performed by one hour vacuum drying treatment.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供能够将蛋白质/肽固定在芯片基板上而不损害蛋白质功能或保持其功能而不损坏其的固定方法。解决方案：化学改性的金刚石/ DLC（类金刚石碳）芯片由活化剂激活后，蛋白质/肽被点在芯片上进行偶联反应，随后进行未反应的活性基团的阻断操作以将蛋白质/肽固定在芯片上。在固定方法中，使用30％二甲基亚砜（DMSO）或30％聚乙二醇（PEG）作为点样添加剂，或者在芯片被活化剂活化后，进行用MilliQ水洗涤后的芯片的干燥通过1小时真空干燥处理。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007053942A Method for judging onset risk of encephalopathy by targeting antipyretic-analgesic and method for screening remedy for the encephalopathy 审中-公开
标题翻译：通过靶向抗精神病药物评估心律失常的风险的方法和筛查治疗心律失常的方法
公开(公告)号：JP2007053942A
公开(公告)日：2007-03-08
申请号：JP2005241885
申请日：2005-08-23
申请人： Univ Of Tokushima , 国立大学法人徳島大学
发明人： KIDO HIROSHI , AZUMA YOICHIRO , KOSAKA AOI
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/70 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for judging an antipyretic-analgesic to be useful in case of a high fever caused by infection with various viruses, including an influenza virus, infection with bacteria, and infection with other pathogens, and to provide a method for screening the safe antipyretic-analgesic.
SOLUTION: This method comprises bringing vascular endothelial cells into contact with the antipyretic-analgesic or its candidate pharmaceutical before, after, or when the cells are infected with the viruses in vitro, or administering the antipyretic-analgesic or the candidate pharmaceutical to a nonhuman animal before, after, or when the animal is infected with the viruses, then (1) measuring an extent of proliferation of the viruses in the vascular endothelial cells, (2) measuring an extent of exaltation of permeability of a blood vessel in the vascular endothelial cells, or (3) measuring an expression level of a protein composing tight junction between the vascular endothelial cells in a blood-brain barrier, and further evaluating the antipyretic-analgesic or the candidate pharmaceutical by comparing a result of the measurement with a result measured by not adding the antipyretic-analgesic or the candidate pharmaceutical thereto.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于判断解热镇痛剂的方法，用于在由各种病毒（包括流感病毒，细菌感染和感染其他病原体）感染引起的高热的情况下，以及提供筛选安全解热止痛药的方法。解决方案：该方法包括使血管内皮细胞与解热镇痛剂或其候选药物在细胞在体外感染病毒之前，之后或之时接触，或将解热止痛剂或候选药物施用于在动物感染病毒之前，之后或之后的非人动物，然后（1）测量血管内皮细胞中病毒的增殖程度，（2）测量血管通透性的升高程度血管内皮细胞，或（3）测定构成血脑屏障内的血管内皮细胞之间紧密连接的蛋白质的表达水平，并进一步评价解热镇痛药或候选药物，将测定结果与通过不添加解热镇痛剂或其候选药物而测定的结果。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006267063A Judging method of allergic disease and judging kit of allergic disease 有权
标题翻译：过敏性疾病的判断方法和过敏性疾病的判定工具
公开(公告)号：JP2006267063A
公开(公告)日：2006-10-05
申请号：JP2005089660
申请日：2005-03-25
申请人： Univ Of Tokushima , 国立大学法人徳島大学
发明人： KIDO HIROSHI , TADA HITOMI , SAWABUCHI TAKAKO
IPC分类号： G01N33/53 , C07K7/06 , C07K7/08 , G01N33/531 , G01N33/543 , G01N33/547 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a judging method of an allergic disease capable of judging the expansion/contraction pattern of an allergen and/or the expansion/contraction pattern of an allergen epitope, the judging method of the allergic disease capable of detecting the allergen recognition antibody in a specimen by immunoassay using a Cy3 labelled secondary antibody and a judging kit of the allergic disease capable of using these judging methods of the allergic disease. SOLUTION: After a diamond/DLC (Diamond-like Carbon) chip is activated by an activating reagent, the coupling reaction of the allergen epitope of allergen protein or peptide containing the allergen epitope is performed and a specimen is subsequently brought into contact with an allergen epitope judging chip which undergoes the blocking operation of an unreacted active group to detect the allergen recognition antibody in the specimen captured by the allergen epitope judging chip by immunoassay. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供能够判断变应原的扩张/收缩模式和/或变应原表位的扩张/收缩模式的过敏性疾病的判断方法，能够通过使用Cy3标记的二次抗体的免疫测定法检测样品中的变应原识别抗体，以及能够使用这些过敏性疾病判断方法的过敏性疾病的判断试剂盒。解决方案：金刚石/ DLC（类金刚石）芯片被活化剂激活后，进行变应原蛋白或含有变应原表位的肽的变应原表位的偶联反应，随后使样品接触与过敏原表位判断芯片进行未反应的活性基团的阻断操作，以通过免疫测定检测由变应原表位判断芯片捕获的样品中的变应原识别抗体。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2015042156A 血液検体のＡＴＰ測定方法及びキット有权
标题翻译：血液样品及其试剂盒的ATP测量方法
公开(公告)号：JP2015042156A
公开(公告)日：2015-03-05
申请号：JP2013174874
申请日：2013-08-26
申请人：国立大学法人北海道大学 , Hokkaido Univ , 国立大学法人徳島大学 , Univ Of Tokushima
发明人： ISHIDA AKIHIKO , HANADA YUKI , TANI HIROFUMI , TOKESHI MANABU , KIDO HIROSHI , CHIDA JUNJI
IPC分类号： C12Q1/26 , C12Q1/42 , C12Q1/48 , G01N21/78 , G01N33/50
摘要：【課題】簡便かつ迅速に高精度に血液検体中のATP濃度を測定できる方法及びこの方法に使用できるキットを提供する。【解決手段】以下の工程1〜5を含む血液検体中に含まれるATP測定方法及びそれに用いるキット。工程1:ATP含有試料溶液を得る工程、工程2:ATP含有試料溶液とアデノシンモノリン酸、ホスホエノールピルビン酸、アデニル酸キナーゼおよびピルビン酸キナーゼとを含有する緩衝液(pH7.8)を混合して1〜5分保持する工程、(但し、工程1における希釈倍率と工程2における希釈倍率との積は50倍以上である。)工程3:工程2で得た混合物とピルビン酸オキシダーゼを含有する緩衝液(pH5.7)を混合して保持する工程、(但し、工程3における希釈倍率は20倍以上であり、かつ工程1における希釈倍率と工程2における希釈倍率、工程4:工程3で得た混合物に酸、鉄(II)、および発色試薬を加えて保持する工程、および工程5:ATPの濃度を判定する工程。【選択図】なし
摘要翻译：要解决的问题：提供能够简单，快速且准确地测量血液样品中ATP浓度的方法，并提供可用于该方法的试剂盒。解决方案：本发明提供了一种测量ATP的方法，包括在血液样品中，该方法包括以下步骤1-5和用于其的试剂盒。步骤1用于获得含ATP样品溶液。步骤2是将含有腺苷单磷酸，磷酸烯醇丙酮酸，腺苷酸激酶和丙酮酸激酶的缓冲溶液（pH 7.8）与含ATP样品溶液混合，并保持1〜5分钟（在步骤1，步骤2中的稀释倍率为50倍以上）。步骤3是将通过步骤2获得的混合物与含有丙酮酸氧化酶的缓冲溶液（pH5.7）混合并保持（步骤3中的稀释倍率为20倍以上，步骤1中的稀释倍率的乘积步骤2中的稀释倍率为1000倍以上）。步骤4是将酸，铁（II）和着色试剂加入到通过步骤3获得的混合物中并保持。步骤5是确定ATP的浓度。

7. 发明专利

JP2010060308A Method of predicting risk of acquiring influenza 有权
标题翻译：预测感染风险的方法
公开(公告)号：JP2010060308A
公开(公告)日：2010-03-18
申请号：JP2008223385
申请日：2008-09-01
申请人： Fujifilm Corp , Univ Of Tokushima , 国立大学法人徳島大学 , 富士フイルム株式会社
发明人： TERAJIMA KAORU , KIDO HIROSHI
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545 , G01N33/547
CPC分类号： G01N33/6854 , G01N33/56983 , G01N33/582 , G01N2333/11 , G01N2800/50
摘要： PROBLEM TO BE SOLVED: To provide a method of predicting a risk of acquiring influenza which is characterized by a low price, low invasiveness, and applicability to total automation. SOLUTION: The method of predicting a risk of acquiring influenza comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种预测获得流感风险的方法，其特点是价格低廉，侵入性低，适用于全自动化。
解决方案：预测获得流感风险的方法包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2011095132A Method of predicting onset of allergy in infant and determining aggravation and improvement in allergy 有权
标题翻译：预防婴儿过敏症的方法和确定过敏症的改良和改善
公开(公告)号：JP2011095132A
公开(公告)日：2011-05-12
申请号：JP2009250098
申请日：2009-10-30
申请人： Oriental Yeast Co Ltd , Univ Of Tokushima , オリエンタル酵母工業株式会社 , 国立大学法人徳島大学
发明人： KIDO HIROSHI , SUZUKI KOICHI
IPC分类号： G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method of predicting presence or absence of the onset of allergy to a specific allergen within six months after birth during breast-feed for a newborn baby born inheriting constitution from the mother who has shown an allergy symptom before the birth, to provide a method of avoiding allergy appearing via mother's milk, and to provide an inspection method of accurately determining the degree of improvement in allergy and the degree of a treatment effect, such as whether the allergy is in an aggravation process, is in a healing process, or has been healed completely for infants who have shown symptoms of allergy at an age of less than one year old to a specific allergen, such as egg and milk allergens and then have been undergoing an allergy treatment, such as a food removal treatment method and hyposensitization.
SOLUTION: According to the method, IgA in cord blood with respect to allergen is measured; possibility of the onset of allergy in infants to allergen within six months is predicted, based on a determination evaluation score created in advance and the risk of onset of allergy via the mother's milk is inspected. Also, an antigen-specifical secretion-type IgA of saliva with respect to the allergy of allergy infants who shows symptoms of allergy at an age of less than one year old to the specific allergen is measured; and degree of improvement in the allergen symptoms of infants is inspected, based on the determination evaluation score created in advance.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种预测在出生后六个月内对特定变应原发生过敏反应的方法，该方法在母乳喂养期间从出现过敏的母亲出生的新生儿继承性结构中出生前的症状，提供通过母乳避免过敏的方法，并提供准确确定过敏程度和治疗效果程度的检查方法，例如过敏是否处于恶化过程中正在治愈过程中，或已经对小于一岁的年龄患有过敏症状的婴儿，如特定的过敏原，如鸡蛋和牛奶过敏原，已经完全治愈，然后进行过敏治疗，如作为食物去除处理方法和低敏感性。解决方案：根据该方法，测定脐带血相对于变应原的IgA; 根据事先确定的评估评分，并检查通过母乳发生变态反应的风险，预测在6个月内婴幼儿过敏原发生变态反应的可能性。此外，测量了对特异性变应原的年龄小于一岁的过敏症过敏症的过敏反应的唾液的抗原特异性分泌型IgA; 根据事先确定的评价分数，检查婴儿过敏原症状的改善程度。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2008247864A Mosaic serine protease, msp and its use 审中-公开
标题翻译： MOSAIC丝氨酸蛋白酶，MSP及其用途
公开(公告)号：JP2008247864A
公开(公告)日：2008-10-16
申请号：JP2007094184
申请日：2007-03-30
申请人： Univ Of Tokushima , 国立大学法人徳島大学
发明人： KIDO HIROSHI , OKUMURA YUJI
IPC分类号： A61K38/48 , A61K39/12 , A61K39/145 , A61P5/00 , A61P31/12 , A61P31/16 , A61P31/18 , A61P43/00 , C12N7/00 , C12N9/99 , C12N15/09 , C12Q1/37 , G01N33/15 , G01N33/50
CPC分类号： Y02A50/60
摘要： PROBLEM TO BE SOLVED: To promote a safer and more effective antiviral agent, and basic and applied research on highly pathogenic avian influenza, HPAI, and to establish a method for diagnosing abnormal production of a peptide hormone related to MSP under a situation that no vaccine nor drug having specific effectiveness against HPAI are practically used and an existing drug causes a serious side effect.
SOLUTION: MSPL, MSPS and TMPRSS13 inhibitors belonging to mosaic serine protease, MSP; a screening method for the above inhibitor using the degree of decomposition or cleavage of a substrate caused by these enzymes as an index; an antivirus agent and a therapeutic agent for peptide hormone disorder having the inhibitor as an active ingredient; an activation agent for enhancing infection and propagation of an HPAI virus and enabling its mass production; a therapeutic agent for peptide hormone disorder having the above enzymes as an active ingredient; an agent for diagnosing a hormone disorder using the amount of genetic expression of the above enzymes as an index; and the like.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了促进更安全，更有效的抗病毒剂，以及高致病性禽流感，HPAI的基础和应用研究，并建立了一种诊断与MSP有关的肽激素异常生成的方法没有实际使用对HPAI具有特异效力的疫苗或药物，现有的药物会引起严重的副作用。解决方案：MSPL，MSPS和TMPRSS13抑制剂属于马赛克丝氨酸蛋白酶，MSP; 使用由这些酶引起的底物的分解或裂解程度作为指标的上述抑制剂的筛选方法; 抗病毒剂和具有抑制剂作为活性成分的肽激素病症治疗剂; 用于增强HPAI病毒的感染和繁殖并使其大量生产的活化剂; 具有上述酶作为活性成分的肽激素病症治疗剂; 使用上述酶的遗传表达量作为指标诊断激素障碍的药剂; 等等。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2007186457A Tryptase activity inhibitor and its utilization 审中-公开
标题翻译： TRYPTASE活性抑制剂及其应用
公开(公告)号：JP2007186457A
公开(公告)日：2007-07-26
申请号：JP2006006124
申请日：2006-01-13
申请人： Ichimaru Pharcos Co Ltd , Univ Of Tokushima , 一丸ファルコス株式会社 , 国立大学法人徳島大学
发明人： ITO KENICHI , ARUNASIRI IDDAMALGODA , KIDO HIROSHI
IPC分类号： A61K8/49 , A23L1/30 , A61K8/97 , A61K31/352 , A61K31/353 , A61K36/00 , A61K36/18 , A61K36/70 , A61K36/73 , A61P1/02 , A61P1/04 , A61P7/02 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/04 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q5/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To provide a safety tryptase activity inhibitor and external preparation, internal medicine or food and drink formulated with the same for treating or prophylaxis of diseases such as itch, wrinkle, chapped skin, generalized anaphylaxis, asthma, interstitial lung disease, interstitial bladder cystitis, atopy, pain, gingivitis, chronic rheumatoid arthritis, arthritis, pollinosis. SOLUTION: The invention relates to the tryptase activity inhibitor comprising plants or extracts of the plants as an active ingredient such as catechins, flavones, flavonols, flavanones, tannins, Polygonaceae, Artocarpus, Quercus myrsinaefolia, betel nut, Phyllanthus emblica L. White Willow Bark, turmeric, Phellodendron Bark, Potentilla tormentilla, kaoliang, Alpinia katsumadai Hayata, Rumex crispus, Punica granatum, Geranium Robertianum, Sanguisorba minor Scop, gayangae rhizoma, Uncariae Uncis Cum Ramulus, Betula platyphylla, billberry, Rubus palmatus Thunb, eucalyptus, green tea, Spiraea, Cassia nomame, Jugluans ailanthifolia, usnea, Achillea alpina L, pueraria root, Sophora japonica L, Paullinia cupana, Juglans nigra L, Tilia cordata, Flower Bud of Official Magnolia, Hypericum erectum. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供安全型类胰蛋白酶活性抑制剂和外用制剂，内用药或与其配制的食品和饮料，用于治疗或预防诸如瘙痒，皱纹，裂纹皮肤，广泛性过敏反应，哮喘，间质性疾病肺病，间质性膀胱炎，特应性，疼痛，牙龈炎，慢性类风湿性关节炎，关节炎，花粉症。解决方案：本发明涉及包含作为活性成分的植物或提取物的类胰蛋白酶活性抑制剂，如儿茶素类，黄酮类，黄酮醇类，黄烷酮类，单宁酸，gon科，car藜，栎属，枸杞子，竹a。白柳树皮，姜黄，黄柏树皮，红堇，高粱，山茱萸，山茱萸，天竺葵，山茱萸，山茱萸，芜菁，桦木，枸杞，桉树，绿茶，绣线菊，决明子，Jugluans ailanthifolia，usnea，Achillea alpina L，葛根，Sophora japonica L，Paillinia cupana，Juglans nigra L，Tilia cordata，Flower Bud of Official Magnolia，Hypericum erectum。版权所有（C）2007，JPO＆INPIT

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式