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1. 发明专利

JP2008190879A Analysis method of biomolecule 有权
标题翻译：生物分子分析方法
公开(公告)号：JP2008190879A
公开(公告)日：2008-08-21
申请号：JP2007022486
申请日：2007-01-31
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： SHIOZAWA MASATO , WATANABE OSAMU , HOSHINO FUMIHIKO , IGAWA YASUJI
IPC分类号： G01N33/566 , G01N33/533 , G01N33/543 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide an analysis method of a biomolecule capable of manifesting a function in the state where a bad influence on the function of the biomolecule immobilized on a solid phase carrier is suppressed. SOLUTION: A solid phase body formed by immobilizing the biomolecule on the solid phase carrier is prepared, and the function of the biomolecule on the solid phase carrier surface is analyzed, and thereafter an immobilization state of the biomolecule on the solid phase carrier is analyzed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够在固定在固相载体上的生物分子的功能受到不良影响的状态下表现出功能的生物分子的分析方法。解决方案：制备固相载体上固定生物分子形成的固相体，分析固相载体表面上的生物分子的功能，然后分析生物分子在固相载体上的固定状态进行了分析。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2012181070A Health degree detection method 审中-公开
标题翻译：健康度检测方法
公开(公告)号：JP2012181070A
公开(公告)日：2012-09-20
申请号：JP2011043318
申请日：2011-02-28
申请人： Toyota Central R&D Labs Inc , Healthcare Systems Co Ltd , 株式会社ヘルスケアシステムズ , 株式会社豊田中央研究所
发明人： HOSHINO FUMIHIKO , WATANABE OSAMU , TAKIMOTO YOSUKE , WU XIAO HONG , OSAWA TOSHIHIKO
IPC分类号： G01N33/493 , G01N33/53 , G01N33/92
摘要： PROBLEM TO BE SOLVED: To provide a detection method capable of detecting a change in a process from a health state to a disease state concerning a subject individual.SOLUTION: A method for detecting a health degree in a subject individual includes: measuring 8-OHdG and HEL in urine collected from the subject individual; acquiring change tendencies in the blood HDL cholesterol and BMI of the subject individual within a normal range with the measured 8-OHdG density in the urine as an index; and acquiring the intake tendency of an antioxidant compound in the subject individual within the normal range with the measured HEL density in the urine as an index.
摘要翻译：要解决的问题：提供一种能够检测从健康状态到关于受试者个体的疾病状态的过程的变化的检测方法。解决方案：用于检测个体健康程度的方法包括：测量从受试者个体收集的尿液中的8-OHdG和HEL; 以测定的尿中8-OHdG密度作为指标，在正常范围内获取受试者个体的血液HDL胆固醇和BMI的变化趋势; 并以所测定的尿中的HEL密度为指标，求出正常范围内的个体抗氧化剂的摄取趋势。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2010260032A Adsorptive carrier which has region of selective adsorption of target molecule, and production method of the same 有权
标题翻译：具有选择性吸收目标分子的吸附载体及其生产方法
公开(公告)号：JP2010260032A
公开(公告)日：2010-11-18
申请号：JP2009115007
申请日：2009-05-11
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： NARITA MAMIKO , HOSHINO FUMIHIKO , WATANABE OSAMU
IPC分类号： B01J20/30 , B01J19/00 , B01J20/26 , C07K1/14 , C08F20/34 , C12M1/00 , C12M3/00 , C12N1/02 , G01N30/00 , G01N30/88 , G01N33/547
摘要： PROBLEM TO BE SOLVED: To provide a target-molecule-adsorptive carrier which can realize good selectivity and good adsorptivity. SOLUTION: A target-molecule-adsorptive carrier having one or two or more regions of selective adsorption of one or two or more kinds of molecules is produced by feeding the target molecules into the surface of a solid-phase material to produce an interaction with the target molecules on the surface to allow them to be adsorbed by the surface and removing the target molecules from the surface of the solid-phase material. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够实现良好选择性和良好吸附性的靶分子吸附载体。解决方案：通过将目标分子进料到固相材料的表面中，产生具有一个或两个或更多个选择性吸附一个或两个或更多种分子的区域的靶分子吸附载体，以产生与表面上的目标分子的相互作用，以使它们被表面吸附并从固相材料的表面除去目标分子。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2009065853A Solid phase material and production method thereof 有权
标题翻译：固相材料及其生产方法
公开(公告)号：JP2009065853A
公开(公告)日：2009-04-02
申请号：JP2007235044
申请日：2007-09-11
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： MORI MAKOTO , NARITA MAMIKO , SHIOZAWA MASATO , IGAWA YASUJI , HOSHINO FUMIHIKO , WATANABE OSAMU
IPC分类号： C12N11/08 , B01J19/00
摘要： PROBLEM TO BE SOLVED: To provide a solid phase material 4 in which hydrophilicity is added to such an extent that the adsorption of biomolecules is controllable in optional regions. SOLUTION: A hydrophilized solid phase material 4 can be obtained by photoirradiating at least one part of the surface of a solid phase material 3 being photoplasticizable by photoirradiation under conditions contacting with a hydrophilic vehicle, wherein the solid phase material 3 comprises a matrix 5 including a light response component 6 causing a change in a molecular structure or a molecular sequence by light, and a hydrophilic component 8. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供其中加入亲水性的固相物质4，使得生物分子的吸附在任选区域是可控的。解决方案：通过光电照射固相材料3的表面的至少一部分，可以通过光亲水载体在接触条件下通过光照射可光塑化而获得亲水化的固相材料4，其中固相材料3包括基质 5包括引起光分子结构或分子序列变化的光反应组分6和亲水组分8.版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008232877A Material for biomolecule immobilization, solid phase to which biomolecule is immobilized, and its manufacturing method 审中-公开
标题翻译：用于生物分子固定的材料，生物分子固定的固相及其制造方法
公开(公告)号：JP2008232877A
公开(公告)日：2008-10-02
申请号：JP2007073984
申请日：2007-03-22
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： MORI HIROYUKI , HOSHINO FUMIHIKO , NAKANISHI KAZUYUKI , WATANABE OSAMU
IPC分类号： G01N33/551 , C07K17/14 , G01N33/53 , G01N33/543 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a material for biomolecules immobilization having stable immobilizing power. SOLUTION: Silicon is made contained in a carbonaceous film to develop immobilizing power to biomolecules. In other words, the immobilizing power of the material for immobilization is made derived not from chemical modification but from the structure of the carbonaceous film itself. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供具有稳定固定力的生物分子固定材料。解决方案：硅被包含在碳质膜中以产生对生物分子的固定能力。换句话说，用于固定的材料的固定力不是从化学改性而是从碳质膜本身的结构得到的。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2009109452A Orientation control material 审中-公开
标题翻译：定向控制材料
公开(公告)号：JP2009109452A
公开(公告)日：2009-05-21
申请号：JP2007284782
申请日：2007-11-01
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： HOSHINO FUMIHIKO , WATANABE OSAMU
IPC分类号： G01N33/53 , C07K7/00 , C07K17/02
摘要： PROBLEM TO BE SOLVED: To provide an orientation control material for immobilizing a target material on a solid phase material by avoiding or suppressing direct interaction with the solid phase material including an immobilization element for immobilizing the target material. SOLUTION: The target material is immobilized on the solid phase material by utilizing as the orientation control material, a material having following characteristics: (a) including organic molecules having a chain structure; (b) having the first element capable of interacting with the target material on at least one end of the chain structure; (c) and having the second element capable of interacting with the solid phase material on at least the other end of the chain structure. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过避免或抑制与包含用于固定靶材料的固定元件的固相材料的直接相互作用而将靶材固定在固相材料上的取向控制材料。解决方案：通过利用作为取向控制材料的目标材料固定在固相材料上，具有以下特征的材料：（a）包括具有链结构的有机分子; （b）使所述第一元件能够与所述链结构的至少一端上的目标材料相互作用; （c）并且具有能够在链结构的至少另一端上与固相材料相互作用的第二元件。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2012181068A Solid phase body suitable for holding liquid medium 审中-公开
标题翻译：固体液体适用于保存液体介质
公开(公告)号：JP2012181068A
公开(公告)日：2012-09-20
申请号：JP2011043307
申请日：2011-02-28
申请人： Toyota Central R&D Labs Inc , Healthcare Systems Co Ltd , 株式会社ヘルスケアシステムズ , 株式会社豊田中央研究所
发明人： HOSHINO FUMIHIKO , WATANABE OSAMU , TAKIMOTO YOSUKE , WU XIAO HONG , OSAWA TOSHIHIKO
IPC分类号： G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a solid phase body capable of holding a liquid medium uniformly on an intended surface.SOLUTION: A solid phase body has a surface comprising a first region which has a first liquid repellent property for a liquid medium and mainly holds the liquid medium, and a second region which is in contact at least with a part of the contour of the first region and has a second liquid repellent property for the liquid medium, which is lower than the first repellent property. As a result, at least a part of the surface tension of the liquid medium in the first region is cancelled by the second region, so that the liquid medium can be held uniformly in the first region.
摘要翻译：要解决的问题：提供能够将液体介质均匀地保持在预期表面上的固相体。解决方案：固相体具有包括第一区域的表面，所述第一区域具有用于液体介质的第一液体排斥性质并且主要保持液体介质，以及至少与轮廓的一部分接触的第二区域并且具有低于第一排斥性能的液体介质的第二液体排斥性质。结果，第一区域中的液体介质的表面张力的至少一部分被第二区域抵消，使得液体介质可以均匀地保持在第一区域中。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2009109453A Method of manufacturing solid phase object having fine object immobilized thereon, and its use 有权
标题翻译：制造固体物质的固体相对物体的方法及其使用方法
公开(公告)号：JP2009109453A
公开(公告)日：2009-05-21
申请号：JP2007284783
申请日：2007-11-01
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： HOSHINO FUMIHIKO , WATANABE OSAMU , IGAWA YASUJI , MORI MAKOTO , NARITA MAMIKO , SHIOZAWA MASATO
IPC分类号： G01N33/543 , C07K7/00 , C07K17/02 , G01N33/53 , G01N37/00
CPC分类号： C07K1/04 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , C40B80/00 , G01N33/54353
摘要： PROBLEM TO BE SOLVED: To provide a method of immobilizing a fine object on a solid phase material by avoiding or suppressing direct interaction with the solid phase material including an immobilization element for immobilizing the fine object. SOLUTION: When immobilizing the fine object 4 on the solid phase material 10, the fine object 4 is immobilized on the solid phase material 10 based on a characteristic immobilization principle in the state where a mediating material 20 having the first element capable of interacting at least with the fine object 4 is allowed to exist between the fine object 4 and the solid phase material 10 to such a degree that the immobilization principle which is characteristic to the fine object 4 and the solid phase material 10 is not disturbed. Since prescribed mediating molecules 20 are allowed to exist between the solid phase material 10 and the fine object 3, immobilization based on the characteristic immobilization principle is possible without direct contact between the solid phase material 10 and the fine object 4. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过避免或抑制与包含用于固定微细物体的固定元件的固相材料的直接相互作用而将微细物体固定在固相材料上的方法。解决方案：当将微细物体4固定在固相材料10上时，基于特征固定原理，将细微物体4固定在固相材料10上，其中具有第一元素的介质材料20能够至少与微细物体4相互作用允许在微细物体4和固相材料10之间存在微细物体4和固相材料10特有的固定原理不受干扰的程度。由于在固相材料10和微细物体3之间允许存在规定的介质分子20，所以在固相材料10和细小物体4之间不会直接接触的情况下，可以根据特性固定原理进行固定。版权所有：（C）2009，JPO＆INPIT

9. 发明专利

JP2008170241A Light-fixing solid-phase carrier and manufacturing method therefor 有权
标题翻译：轻固定固体载体及其制造方法
公开(公告)号：JP2008170241A
公开(公告)日：2008-07-24
申请号：JP2007002914
申请日：2007-01-10
申请人： Toyota Central R&D Labs Inc , 株式会社豊田中央研究所
发明人： WATANABE OSAMU , NARITA MAMIKO , IGAWA YASUJI , HOSHINO FUMIHIKO
IPC分类号： G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a light-fixing solid-phase carrier capable of obtaining proper detection characteristics, with respect to the interaction of the fine matters on the surface of a fixing solid-phase object with other components.
SOLUTION: As the light-fixing solid-phase carrier 2, a light responsive layer 4 of which the surface has an arithmetic average roughness Ra of 2 nm or smaller and which contains a light responsive component is provided. By providing the light responsive layer 4, of which the surface is very much smoothed, proper optical characteristics can be obtained, after the fine matter is fixed on the light responsive layer 4.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够获得适当的检测特性的光固定固相载体，涉及固定固相物体表面上的微细物质与其它成分的相互作用。解决方案：作为光固定固相载体2，提供其表面具有2nm或更小的算术平均粗糙度Ra并包含光响应分量的光响应层4。通过设置光响应层4，其表面非常平滑，在细微物质固定在光响应层4上之后，可以获得适当的光学特性。（C）2008，JPO＆INPIT

10. 发明专利

JP2005102612A Method for implanting cell and method for preparing cellular tissue 有权
标题翻译：用于植入细胞的方法和用于制备细胞组织的方法
公开(公告)号：JP2005102612A
公开(公告)日：2005-04-21
申请号：JP2003341369
申请日：2003-09-30
申请人： Toyota Central Res & Dev Lab Inc , 株式会社豊田中央研究所
发明人： HOSHINO FUMIHIKO , IGAWA YASUJI , WATANABE OSAMU , TAKAHASHI HARUO , KODA KATSUNORI , YOKOI NOBUKAZU
IPC分类号： C12N1/00 , C12N5/07 , C12N5/071 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a cell-implanting method which is suitable and simple for observation, research and screening of cells and researches of cellular interaction and a method for preparing a cellular tissue utilizing the method. SOLUTION: In the cell-implanting method, an implanting substrate using a light-fixing material capable of performing light deformation and exhibiting fixing ability to a minute article arranged on the surface when irradiated with light in at least surface layer part is constituted. The method for implanting cells comprises carrying out (A) a light fixing step for fixing a cell-implanting element exhibiting adhesive property or binding property to an unspecified or specific cell to the surface of the implanting substrate by irradiation with light and (B) an implanting step for implanting the cell by bringing the unspecified or the specific cell or cell group into contact with the light-fixed cell-implanting element. The method for preparing the cellular tissue comprises further carrying out a step for preparing a cellular sheet or tissue by proliferation or differentiation of the implanted cell or cell group and recovering the cellular sheet or tissue. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供适用于和细胞观察，研究和筛选以及细胞相互作用研究和使用该方法制备细胞组织的方法的细胞移植方法。解决方案：在细胞植入方法中，构成了使用能够对至少表面层部分中的光照射时布置在表面上的微小物体进行光变形并显示定影能力的光固定材料的植入基板。用于植入细胞的方法包括：（A）光固定步骤，用于通过光照射将表现出与未指定或特定细胞显示粘合性或结合性的细胞注入元件固定在植入基底的表面上，（B）通过使未指定的或特定的细胞或细胞组与光固定的细胞植入元件接触来植入细胞的植入步骤。制备细胞组织的方法还包括通过植入细胞或细胞群的增殖或分化来制备细胞片或组织的步骤，并回收细胞片或组织。版权所有（C）2005，JPO＆NCIPI

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