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1. 发明专利

JP2005154367A Analgesic agent for neuropathic pain containing propafenone 有权
标题翻译：含有丙酮的神经性疼痛药物
公开(公告)号：JP2005154367A
公开(公告)日：2005-06-16
申请号：JP2003397665
申请日：2003-11-27
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： WATANABE TETSUYA , SHIBATA DAIKI , NAGATA MITSUHIRO
IPC分类号： A61P25/04 , A61K31/138
摘要： PROBLEM TO BE SOLVED: To obtain an analgesic agent extremely effective for suppressing neuropathic pain and having little side action.
SOLUTION: This analgesic agent for the neuropathic pain contains propafenone or its pharmaceutically permissible salt as an active component. This invention further discloses an analgesic agent for neuropathic pain containing propafenone hydrochloride as an active component.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得极度有效抑制神经性疼痛并且具有很小副作用的止痛剂。解决方案：用于神经性疼痛的镇痛剂包含普罗帕酮或其药学上允许的盐作为活性成分。本发明还公开了含有盐酸普罗帕酮作为活性成分的神经性疼痛镇痛剂。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2007008871A Percutaneous absorption promoting composition 有权
标题翻译： PERCUTANEOUS吸收促进组合物
公开(公告)号：JP2007008871A
公开(公告)日：2007-01-18
申请号：JP2005192231
申请日：2005-06-30
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： IHARA KATSUMI , WATANABE TETSUYA , OKADA KAZUTO
IPC分类号： A61K31/485 , A61K47/12 , A61K47/14 , A61K47/22 , A61P25/04
摘要： PROBLEM TO BE SOLVED: To obtain a percutaneous absorption promoting composition mitigating expressing side effects, good in morphine's percutaneous absorption, and slight in skin irritancy when administered.
SOLUTION: The percutaneous absorption promoting composition is obtained by including morphine in a composition that is prepared by incorporating, as necessary, an organic acid, a fatty acid ester, an aromatic ester and/or the like in a pyrrolidone derivative and a 10-18C higher fatty acid as the essential two components. This composition is such that the morphine's percutaneous absorption from the skin's keratin, via corium layer's capillary vessels and the blood vessels at the depth thereof, into the systemic circulatory system is easily improved.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了获得减轻表现副作用的经皮吸收促进组合物，施用吗啡的经皮吸收良好，皮肤刺激性轻微。解决方案：经皮吸收促进组合物是通过将吗啡包含在通过将必要的将有机酸，脂肪酸酯，芳香酯等引入到吡咯烷酮衍生物中制备的组合物中获得的， 10-18C高脂肪酸作为必需的两个成分。这种组合物使得吗啡容易地改善吗啡从皮肤角蛋白经由corium层的毛细血管及其深度的血管经皮吸收进入系统循环系统。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2005154368A Analgesic agent for neuropathic pain containing disopyramide 审中-公开
标题翻译：含有二恶英的神经性疼痛的化学药剂
公开(公告)号：JP2005154368A
公开(公告)日：2005-06-16
申请号：JP2003397668
申请日：2003-11-27
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： WATANABE TETSUYA , SHIBATA DAIKI , NAGATA MITSUHIRO
IPC分类号： C07D213/56 , A61K31/4402 , A61P25/00
摘要： PROBLEM TO BE SOLVED: To obtain an analgesic agent extremely effective for suppressing neuropathic pain and having little side action.
SOLUTION: This analgesic agent for the neuropathic pain contains disopyramide or its salt as an active component. This invention further discloses an analgesic agent for neuropathic pain containing disopyramide phosphate as an active component.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得极度有效抑制神经性疼痛并且具有很小副作用的止痛剂。解决方案：用于神经性疼痛的止痛剂含有丙吡胺或其盐作为活性成分。本发明还公开了一种含有磷酸丙吡胺作为活性成分的神经性疼痛止痛剂。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004202086A Medicator for electroporation, and system and method of medication for electroporation 审中-公开
标题翻译：用于电气的药物，以及用于电气的药物的系统和方法
公开(公告)号：JP2004202086A
公开(公告)日：2004-07-22
申请号：JP2002377275
申请日：2002-12-26
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO , OKAMOTO KENSEI , INATSUKI SAYOKO , WATANABE TETSUYA
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide a medicator for electroporation capable of further reducing the adverse reaction to an organism than a conventional one, with excellent efficiency in feeding and sending a medicament, to be easily handled, and a system and a method of medication for electroporation.
SOLUTION: Electrodes 112 are mounted on a plurality of recesses 114 formed in an electrode support body 113, and a medicine 131 comprising the medicament and electrolyte is stored in the recesses. As the electrode is not directly in contact with a subject of dosing 135, the adverse reaction to the organism can be further reduced than a conventional one. In addition, as the electricity can be fed from the electrode via the medicine, the dosing part functions as a microelectrode and the intensity of the electric field can be enhanced, so that the electroporation can be efficiently performed.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够进一步减少对常规的生物体的不良反应的电穿孔药剂，其具有优异的给药和送药效率，容易处理的效果，以及系统和方法用于电穿孔。解决方案：电极112安装在形成在电极支撑体113中的多个凹部114上，并且包含药物和电解质的药物131储存在凹部中。由于电极不直接与给药物135接触，对生物体的不良反应可以比常规方法进一步降低。此外，由于能够通过药物从电极供给电力，所以配量部件作为微电极起作用，能够提高电场强度，能够有效地进行电穿孔。版权所有（C）2004，JPO＆NCIPI

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