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1. 发明专利

JP2007008871A Percutaneous absorption promoting composition 有权
标题翻译： PERCUTANEOUS吸收促进组合物
公开(公告)号：JP2007008871A
公开(公告)日：2007-01-18
申请号：JP2005192231
申请日：2005-06-30
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： IHARA KATSUMI , WATANABE TETSUYA , OKADA KAZUTO
IPC分类号： A61K31/485 , A61K47/12 , A61K47/14 , A61K47/22 , A61P25/04
摘要： PROBLEM TO BE SOLVED: To obtain a percutaneous absorption promoting composition mitigating expressing side effects, good in morphine's percutaneous absorption, and slight in skin irritancy when administered.
SOLUTION: The percutaneous absorption promoting composition is obtained by including morphine in a composition that is prepared by incorporating, as necessary, an organic acid, a fatty acid ester, an aromatic ester and/or the like in a pyrrolidone derivative and a 10-18C higher fatty acid as the essential two components. This composition is such that the morphine's percutaneous absorption from the skin's keratin, via corium layer's capillary vessels and the blood vessels at the depth thereof, into the systemic circulatory system is easily improved.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了获得减轻表现副作用的经皮吸收促进组合物，施用吗啡的经皮吸收良好，皮肤刺激性轻微。解决方案：经皮吸收促进组合物是通过将吗啡包含在通过将必要的将有机酸，脂肪酸酯，芳香酯等引入到吡咯烷酮衍生物中制备的组合物中获得的， 10-18C高脂肪酸作为必需的两个成分。这种组合物使得吗啡容易地改善吗啡从皮肤角蛋白经由corium层的毛细血管及其深度的血管经皮吸收进入系统循环系统。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2005002009A Fentanyl-containing patch for mucous membrane in oral cavity 有权
标题翻译：含有口腔粘膜的口腔粘膜
公开(公告)号：JP2005002009A
公开(公告)日：2005-01-06
申请号：JP2003164943
申请日：2003-06-10
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： IHARA KATSUMI , NAGATA MITSUHIRO , INATSUKI SAYOKO
IPC分类号： A61K9/70 , A61K9/00 , A61K31/4468 , A61K47/32 , A61K47/38 , A61P25/04
CPC分类号： A61K31/4468 , A61K9/006
摘要： PROBLEM TO BE SOLVED: To provide an easily handleable and highly safe fentanyl-containing patch for the mucous membrane in the oral cavity rapidly raising blood level of a fentanyl drug and reducing migration to an alimentary canal.
SOLUTION: This fentanyl-containing patch for the mucous membrane in the oral cavity is obtained by successively laminating a water-insoluble or sparingly water-soluble support layer and a support to one surface of a drug layer containing fentanyl or its salt as a medicinal effective ingredient, a methyl vinyl ether-maleic anhydride copolymer as a pressure-sensitive adhesive and one or more kinds of substances selected from hydroxypropyl cellulose, hydroxypropyl methyl cellulose and hydroxyethyl cellulose as a thickener.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供容易处理和高度安全的含有芬太尼的口腔粘膜的贴剂，快速提高芬太尼药物的血液水平并减少向消化道的迁移。解决方案：通过将含有芬太尼或其盐的药物层的一个表面依次层压水不溶性或微水溶性支持层和支持体，来获得口腔内用于粘膜的含芬太尼的贴剂，作为药用有效成分，作为压敏粘合剂的甲基乙烯基醚 - 马来酸酐共聚物和选自羟丙基纤维素，羟丙基甲基纤维素和羟乙基纤维素作为增稠剂的一种或多种物质。版权所有（C）2005，JPO＆NCIPI

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