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1. 发明专利

JPH06192086A THERAPEUTIC AGENT FOR DIABETES 失效
公开(公告)号：JPH06192086A
公开(公告)日：1994-07-12
申请号：JP35373092
申请日：1992-12-15
申请人： TSUMURA & CO
发明人： ARAI ICHIRO , TAKEDA SHIGEFUMI , IKETANI YUKINOBU , OYAMA TSUTOMU
IPC分类号： A61K31/335 , A61K36/18 , A61P3/08 , A61P3/10 , A61K35/78
摘要： PURPOSE:To obtain a low toxic therapeutic agent for diabetes, comprising a germacrone epoxide as an active ingredient and excellent in improving action on glucose tolerance and excellent in safety. CONSTITUTION:This therapeutic agent for diabetes comprises (4S,5S)-(+)- germacrone-4,5-epoxide of the formula as an active ingredient. Furthermore, the daily dose of this compound for an adult is preferably within the range of 5-500mg.

2. 发明专利

JPH06172212A MEDICINE COMPOSITION 失效
公开(公告)号：JPH06172212A
公开(公告)日：1994-06-21
申请号：JP33035192
申请日：1992-12-10
申请人： TSUMURA & CO
发明人： FUJIWARA TADAMI , AMETANI SAKAE , OYAMA TSUTOMU
IPC分类号： A61K38/55 , A61P9/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/81 , A61K37/64
摘要： PURPOSE:To provide a medicine composition useful as a protease-inhibiting medicine or anti-shock medicine. CONSTITUTION:The medicine composition contains a peptide compound of the following formula or its pharmaceutically acceptable salt as an active ingredient. Tn-A-B-Pro-C-D-Leu-Tc (Tn is N-acetyl; A is arginine residue or lysine residue; B is lysine residue, asparagine residue, glycine residue, isoleucine residue, histidine residue or arginine residue; Pro is proline residue; C is tryptophan residue or tyrosine residue; D is phenylalanine residue or isoleucine residue; Leu is leucine residue; Tc is hydroxyl group).

3. 发明专利

JPH06135847A GALLSTONE FORMATION INHIBITOR 失效
公开(公告)号：JPH06135847A
公开(公告)日：1994-05-17
申请号：JP20698892
申请日：1992-07-13
申请人： TSUMURA & CO , TAKESHIGE KOTONDO
发明人： TAKEDA SHIGEFUMI , OYAMA TSUTOMU , TAKESHIGE KOTONDO
IPC分类号： A61K36/00 , A61P1/16 , A61K35/78
摘要： PURPOSE:To provide a medicine low in side effects and useful as an excellent medicine for prevention or improvement of gallstone diseases. CONSTITUTION:This gallstone formation inhibitor contains SHOSAIKOTO (kind of Chinese medicine) exhibiting an anti-inflammatory effect, a cell membrane stabilization effect, an anti-allergic effect, an immunological enhancement effect, etc., and, therefore, used for improving various kinds of chronic hepatic diseases as the active component. SHOSAIKOTO contains Bupleuri radix, Pinelliae tuber, Scutellariae radix, Zizyphi fructus, ginseng, Glycyrrhizae radix and Zingiberis rhizoma respectively in a ratio within a range of 4.0 to 7.0, 4.0 to 5.0, 3.0, 2.0 to 3.0, 2.0 to 3.0, 4.0 and 1.0 to 4.0. SHOSAIKOTO is used for preparation without any modification or in the form of an extract, preferably an aqueous extract in combination with a known medical carrier. This inhibitor has a remarkable inhibition effect on biliary hypertrophy or gallstone formation in the liver or the bile duct. As the suitable dosage, 3 to 15g/day per adult is administrated in several times a day.

4. 发明专利

JPH0827116A YUNACONITINE DERIVATIVE AND ANALGESIC AND ANTIINFLAMMATORY CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH0827116A
公开(公告)日：1996-01-30
申请号：JP15903794
申请日：1994-07-11
申请人： TSUMURA & CO , CHUGOKU KAGAKUIN KONMEI SHOKUB
发明人： OYAMA TSUTOMU , TAKI MASANORI , SHU TAKASHI , CHIN SHIEI
IPC分类号： C07D221/22 , A61K31/435 , A61P25/04 , A61P29/00

5. 发明专利

JPH0725777A SYNTHESIS PROMOTER FOR NEUROTROPHY FACTOR 失效
公开(公告)号：JPH0725777A
公开(公告)日：1995-01-27
申请号：JP17450393
申请日：1993-07-14
申请人： TSUMURA & CO
发明人： SUGIMOTO AKIRA , GOTO KAZUHIRO , ISHIGE ATSUSHI , OYAMA TSUTOMU
IPC分类号： A61K36/00 , A61P25/00 , A61P25/28 , A61P43/00 , A61K35/78
摘要： PURPOSE:To provide a medicine promoting biosynthesis of neurotrophy factors such as NGF and BDNF, thus effective for nervedeteriorative diseases such as Arzheimer's dementia or Parkinson's disease. CONSTITUTION:The promoter containing, as active ingredient(s), stone of Prunus armeniaca, stalk of Ephedra sinica, bark of Cinnamomum cassia, carrot, root of Angelica acutiloba, rhizome of Cnidium officinale, rhizome of Zingiber officinale, root of Glycyrrhiza glabra and/or gypsum, or extract (s) thereof.

6. 发明专利

JPH0624968A THERAPEUTIC AGENT FOR DISTURBANCE OF CONSCIOUSNESS 失效
公开(公告)号：JPH0624968A
公开(公告)日：1994-02-01
申请号：JP8311492
申请日：1992-03-05
申请人： TSUMURA & CO
发明人： SEKIGUCHI KYOJI , OYAMA TSUTOMU , ISHIGE ATSUSHI
IPC分类号： A61K31/09 , A61P25/28 , C07C43/23
摘要： PURPOSE:To obtain a therapeutic agent for disturbance of consciousness containing a schisandrin compound as an active ingredient, having action of retaining awareness of brain cortex and reduced in side effects. CONSTITUTION:This therapeutic agent contains a compound of the formula as an active ingredient. The compound of the formula is useful as a medicine for normalizing lethargic pattern of brain wave exhibited when brain stem reticular formation is broken. The compound of the formula is prepared in the form of tablet, capsule, granule, suppository, injection, ointment, liquid for external use, etc. The agent is administered divided in several portions in a daily dose of 5-50mg/adult based on weight of the compound of the formula in the cases of oral agents and daily 0.5-100mg/adult in the cases of parenteral agents. The compound of the formula is obtained by extracting Schizandrae Fructus with petroleum ether, etc., under heating, removing the solvent, dissolving the resultant residue in water, subjecting the solution to steam distillation and then purifying the distillate.

7. 发明专利

JPH05331060A PHTHALIDE DERIVATIVE AND CYTOSTATIC AGENT CONTAINING THE PHTHALIDE DERIVATIVE AS ACTIVE COMPONENT 失效
公开(公告)号：JPH05331060A
公开(公告)日：1993-12-14
申请号：JP16351292
申请日：1992-05-29
申请人： TSUMURA & CO
发明人： OGAWA YOSHIMITSU , YUASA KAZUNORI , HOSAKA KUNIO , OYAMA TSUTOMU
IPC分类号： A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P9/10 , A61P43/00 , C07D209/44 , C07D209/46 , C07D307/87 , C07D307/88 , C07D333/72
摘要： PURPOSE:To provide a new compound having cytostatic action and useful for the treatment of arteriosclerosis, etc. CONSTITUTION:The compound of formula (R1 to R4 are H, hydroxyl or methoxy; R5 is O or S; R5 is O, S or nitrogen atom having H or 1-7C alkyl; R7 and R6 are H, 1-7C alkyl or together form 1-7C alkylidene), e.g. (Z)-3- butylidene-5,6-dimethoxyphthalimidine. The compound of formula can be produced e.g. by subjecting 3,4-dimethoxybenzoic acid to an arbitrary reaction selected from nitrogen-substitution reaction, reducing reaction, demethylation reaction, sulfur-substitution reaction, alkylation reaction, etc., and their combination.

8. 发明专利

JPH05194590A HEXAPEPTIDE 失效
公开(公告)号：JPH05194590A
公开(公告)日：1993-08-03
申请号：JP20381692
申请日：1992-07-30
申请人： TSUMURA & CO
发明人： AMETANI SAKAE , FUJIWARA TADAMI , YUDA MASAKI , NAGASAWA MICHIO , OYAMA TSUTOMU
IPC分类号： A61K38/00 , A61P3/00 , A61P7/02 , A61P9/10 , A61P9/12 , A61P29/00 , A61P37/08 , A61P43/00 , C07K5/10 , C07K7/06
摘要： PURPOSE:To obtain the subject hexapeptide having suppressing action on vascular hyperpermeability, antiedemic, antiinflammatory actions, improving action on endothelial disorder, hypotensive, antiprotease, antidisseminated intravascular coagulation syndrome (anti-DIC) and wound curing actions or its pharmaceutically permissible salt. CONSTITUTION:The objective hexapeptide expressed by the formula A-B-Pro-C- D-E [A denotes arginine or lysine having alkylated N-terminal amino group; B denotes arginine, lysine or histidine; Pro denotes proline; C denotes tyrosine, tryptophan or phenylalanine; D denotes valine, isoleucine or leucine; E denotes valine, isoleucine or leucine having C-terminal substituted with COOR*, CH2OR or CONHR (R* denotes 1-4C alkyl group; R denotes hydrogen atom or 1-4C alkyl group)].

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