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1. 发明专利

JPH0214059B2 失效
公开(公告)号：JPH0214059B2
公开(公告)日：1990-04-06
申请号：JP30960086
申请日：1986-12-24
申请人： TERUMO CORP
发明人： WATANABE EIJI , YANAGAWA CHUJI , HAGIWARA MASARU , SUZUKI SHIGEKI , TAGUCHI SHIGERU
IPC分类号： A61K9/06 , A61K47/00 , A61K47/30 , A61L15/16

2. 发明专利

JPS63159317A ALLANTOIN-CONTAINING AQUEOUS PREPARATION 失效
公开(公告)号：JPS63159317A
公开(公告)日：1988-07-02
申请号：JP30959986
申请日：1986-12-24
申请人： TERUMO CORP
发明人： SUZUKI SHIGEKI , WATANABE EIJI , YANAGAWA CHUJI , HAGIWARA MASARU , TAGUCHI SHIGERU
IPC分类号： A61K31/415 , A61K47/00
摘要： PURPOSE:To obtain the titled aqueous preparation stably maintaining allantoin for a long period, showing high treating effects, by blending an allantoin- containing aqueous preparation with an organic acid, inorganic acid, amino acid or an alkali metallic salt thereof as a stabilizer. CONSTITUTION:An allantoin-containing aqueous preparation is blended with 0.01-20wt% organic acid (e.g. citric acid, tartaric acid or succinic acid), inorganic acid (e.g. phosphoric acid, polyphosphoric acid or hydrochloric acid), amino acid (e.g. glutamic acid, aspartic acid or glycine) or alkaline metallic salt thereof as a stabilizer. In the preparation, allantoin partially exists in a dissolved state and the preparation exhibits higher treating effects on ulcer, wound, decubitus, congelation and burn than an ointment or powder using an existing oily base.

3. 发明专利

JPH0227330B2 失效
公开(公告)号：JPH0227330B2
公开(公告)日：1990-06-15
申请号：JP13035286
申请日：1986-06-06
申请人： TERUMO CORP
发明人： WATANABE EIJI , YANAGAWA CHUJI , HAGIWARA MASARU , TAGUCHI SHIGERU
IPC分类号： A61K9/107 , A61K33/06 , A61K33/08 , A61K47/38 , A61P17/00

4. 发明专利

JPS63160661A SURGICAL COMPOSITION 失效
公开(公告)号：JPS63160661A
公开(公告)日：1988-07-04
申请号：JP30960086
申请日：1986-12-24
申请人： TERUMO CORP
发明人： WATANABE EIJI , YANAGAWA CHUJI , HAGIWARA MASARU , SUZUKI SHIGEKI , TAGUCHI SHIGERU
IPC分类号： A61K9/06 , A61K47/00 , A61K47/30 , A61L15/16

5. 发明专利

JPS62286925A ALUMINUM HYDROXIDE GEL COMPOSITION 失效
公开(公告)号：JPS62286925A
公开(公告)日：1987-12-12
申请号：JP13035286
申请日：1986-06-06
申请人： TERUMO CORP
发明人： WATANABE EIJI , YANAGAWA CHUJI , HAGIWARA MASARU , TAGUCHI SHIGERU
IPC分类号： A61K9/107 , A61K33/06 , A61K33/08 , A61K47/38 , A61P17/00
摘要： PURPOSE:To produce the titled composition having high physical stability, by uniformly dispersing aluminum hydroxide gel and a specific cellulose derivative in water at specific ratios. CONSTITUTION:The objective aluminum hydroxide gel composition can be produced by uniformly dispersing 0.5-8.0wt% aluminum hydroxide gel (in terms of aluminum oxide) and 0.3-8.0wt% cellulose derivative having hydroxyalkoxy group (e.g. hydroxypropyl methyl cellulose) as a stabilizer in water. The aluminum hydroxide gel is e.g. an aqueous suspension or its dried powder produced by dissolving a proper amount of an aluminum salt such as aluminum sulfate in purified water, dripping excess sodium carbonate or other carbonate solution thereto to form a precipitate, vigorously shaking the product to obtain a mixture and dialyzing the mixture. The composition can be used as a drug for external or internal use and may contain other drug-active component.

6. 发明专利

JPH037359B2 失效
公开(公告)号：JPH037359B2
公开(公告)日：1991-02-01
申请号：JP23292584
申请日：1984-11-05
申请人： TERUMO CORP
发明人： TAGUCHI SHIGERU , MARUYAMA TETSUPEI , NAKAGAME FUJIO , PPONDA HARUO
IPC分类号： A61K38/00 , A61K38/48 , A61P7/02 , C12N9/72 , C12N9/96 , C12N11/02

7. 发明专利

JPS62205052A NITRIC ACID ESTER DERIVATIVE AND VASODILATOR CONTAINING SAME 失效
公开(公告)号：JPS62205052A
公开(公告)日：1987-09-09
申请号：JP4815886
申请日：1986-03-05
申请人： TERUMO CORP
发明人： KUMONAKA YASUHIRO , SUWABE YASUSHI , TAGUCHI SHIGERU , WAKABAYASHI TOSHIO
IPC分类号： C07C233/57 , A61K31/21 , A61P9/08 , A61P9/10 , C07C67/00 , C07C231/00 , C07C233/12 , C07C235/28
摘要： NEW MATERIAL:The compound of formula I (R is H or 1-5C alkyl; m is 1 or 2; n is 2-5). EXAMPLE:N-(beta-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoic acid amide nitric acid ester. USE:A vasodilator for the remedy of coronary vessel disorder, cerebral vessel disorder and peripheral vessel disorder, etc., to which increase of blood flow rate is effective. PREPARATION:The compound of formula I can be produced by reacting 5-(3,4,5- trimethoxyphenyl)-2,4-pentadienoic acid thiazolidinethionamide with the compound of formula II.

8. 发明专利

JPS61111684A Preparation of purified urokinase complex 失效
标题翻译：纯化尿素复合物的制备
公开(公告)号：JPS61111684A
公开(公告)日：1986-05-29
申请号：JP23292584
申请日：1984-11-05
申请人： Terumo Corp
发明人： TAGUCHI SHIGERU , MARUYAMA TEPPEI , NAKAGAME FUJIO , HONDA HARUO
IPC分类号： A61K38/00 , A61K38/48 , A61P7/02 , C12N9/72 , C12N9/96 , C12N11/02
CPC分类号： C12N9/6462 , A61K38/00 , C12N11/02 , C12Y304/21073
摘要： PURPOSE: To prepare the titled substance having long duration of fibrolytic activity and strong affinity to fibrin, by mixing urokinase with blood components other than blood cells to effect the reaction, and separating and purifying a substance having a specific molecular weight from the reaction mixture.
CONSTITUTION: Urokinase is mixed to a collected blood component other than at least blood cells, e.g. blood serum or plasma protein, and is reacted by incubation. A substance having a molecular weight of 80,000W120,000 is separated and purified from the reaction mixture e.g. by gel-filtration, affinity chromatography, electrophoresis, etc. The obtained substance is a novel polymer complex which can be used as a thrombolytic agent.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过将尿激酶与血细胞以外的血液成分混合来制备纤维素活性长的纤维蛋白活性和对纤维蛋白的亲和力强的标题物质，从反应混合物中分离纯化具有特定分子量的物质。构成：将尿激酶混合至至少血细胞以外的收集血液成分，例如血清或血浆蛋白，并通过孵育反应。将分子量为80,000-120,000的物质从反应混合物中分离和纯化，如反应混合物。通过凝胶过滤，亲和层析，电泳等。所得物质是可用作血栓溶解剂的新型聚合物复合物。

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