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1. 发明专利

JPH025397B2 失效
公开(公告)号：JPH025397B2
公开(公告)日：1990-02-01
申请号：JP16827881
申请日：1981-10-20
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , NABE KOICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/12 , C12P13/04 , C12P41/00 , C12R1/18

2. 发明专利

JPS6261585B2 失效
公开(公告)号：JPS6261585B2
公开(公告)日：1987-12-22
申请号：JP15004881
申请日：1981-09-21
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , PPONGO CHIKARA , YOSHIOKA RYUZO
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C227/34 , C07C229/36 , C07C301/00 , C07C309/24

3. 发明专利

JPS59170059A Production of optically active sulfonic acid and method for optical resolution of amino acid 失效
标题翻译：光活性磺酸的生产及氨基酸光解的方法
公开(公告)号：JPS59170059A
公开(公告)日：1984-09-26
申请号：JP4358383
申请日：1983-03-16
申请人： Tanabe Seiyaku Co Ltd
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , HONGOU CHIKARA , YOSHIOKA RIYUUZOU
IPC分类号： C07C309/24 , C07B57/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/02 , C07C229/08 , C07C229/26 , C07C277/08 , C07C279/14 , C07C301/00 , C07C303/22 , C07C303/32
CPC分类号： C07B57/00
摘要： PURPOSE: To isolate the titled compound useful as an optical resolving agent for amino acids in high purity, by reacting a racemic modification of α-phenylethanesulfonic acid with an optically active α-amino acid, and utilizing the solubility difference of the resultant diastereomer salts.
CONSTITUTION: A racemic modification of α-phenylethanesulfonic acid is reacted with an optically active α-amino acid (except p-hydroxyphenylglycine), and the solubility difference of the resultant two diastereomer salts is utilized to separate a salt of the optically active α-phenylethanesulfonic acid with the optically active α-amino acid which is a slightly soluble diastereomer salt of one thereof. The resultant salt is then resolved to give the aimed optically active α-phenylethanesulfonic acid or an optically active amino acid salt thereof. The above- mentioned optically active sulfonic acid can be used to give the optically active α-amino acid by utilizing the solubility difference of the resultant two diastereomer salts.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使α-苯基乙烷磺酸的外消旋体与光学活性α-氨基酸反应，并利用得到的非对映异构体盐的溶解度差来分离用作高纯度氨基酸的光学拆分剂的标题化合物。构成：将α-苯基乙烷磺酸的外消旋体改性与光学活性α-氨基酸（对羟基苯基甘氨酸除外）反应，并将所得两种非对映体盐的溶解度差异用于分离光学活性α-苯基乙烷磺酸盐酸与光学活性α-氨基酸，其是其中一种的微溶非对映异构体盐。然后将所得盐解析得到目标光学活性的α-苯基乙烷磺酸或其光学活性氨基酸盐。上述光学活性磺酸可用于通过利用所得两种非对映异构体盐的溶解度差来得到光学活性的α-氨基酸。

4. 发明专利

JPS5923794B2 失效
公开(公告)号：JPS5923794B2
公开(公告)日：1984-06-05
申请号：JP9566077
申请日：1977-08-09
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , NABE KOICHI , IZUMIO NOBUHIKO
IPC分类号： C12P7/26 , C12R1/01 , C12R1/02

5. 发明专利

JPS5852254A PREPARATION OF OPTICALLY ACTIVE P-HYDROXYPHENYLGLYCINE 失效
公开(公告)号：JPS5852254A
公开(公告)日：1983-03-28
申请号：JP15004881
申请日：1981-09-21
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , HONGOU CHIKARA , YOSHIOKA RIYUUZOU
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C227/34 , C07C229/36 , C07C301/00 , C07C309/24
摘要： PURPOSE:To prepare the titled compound useful as a raw material of semisynthetic penicillin, etc., easily and economically, in an industrial scale, by epimerizing the easily soluble diastereomer in a mixture of two kinds of diastereomers, and collecting the crystallized hardly soluble diastereomer. CONSTITUTION:In the two kinds of diastereomers of (DL-p-hydroxyphenylglycine).-(optically active alpha-phenylethanesulfonic acid salt) (abbreviated as DL- HPG and optically active PES, respectively), the easily soluble diasteromer is epimerized and the crystallized hardly soluble diastereomer of said salt is separated. The reaction enables essentially complete conversion of DL-HPG to the desired optically active HPG, and consequently, it is not necessary to convert the DL-HPG to other derivative not or carry out the racemization of the unnecessary optically active isomer after the optical resolution.

6. 发明专利

JPS5686139A PPHYDROXYPHENYLGLYCINE OOTOLUENESULFONATE 失效
公开(公告)号：JPS5686139A
公开(公告)日：1981-07-13
申请号：JP14015180
申请日：1980-10-06
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , HONGOU CHIKARA
IPC分类号： C07C227/34 , C07C67/00 , C07C227/00 , C07C229/36
摘要： NEW MATERIAL:p-Hydroxyphenylglycine o-toluenesulfonate. USE:A salt undergoing preferential crystallization to give optical active p-hydroxyphenylglycine useful as a raw material for a semisynthetic penicillin derivative and a semisynthetic cephalosporin derivative. The salt has properties necessary for optical resolution, racemic modification being more soluble than the optical active compound, the super saturated state of the optical compound being stable, etc. PROCESS:Free-hydroxyphenylglycine is neutralized with o-toluenesulfonic acid in a solvent, and the neutralized compound is crystallized by conventional means, e.g., concentration, cooling, etc. to give DL-p-hydroxyphenylglycine o-toluenesulfonate.

7. 发明专利

JPS53103440A SEPARATION OF OPTICAL ACTVATOR AND DLLISOMER OF PPHYDROXYPHENYLGLYCINE 失效
公开(公告)号：JPS53103440A
公开(公告)日：1978-09-08
申请号：JP1751377
申请日：1977-02-18
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , HONGOU CHIKARA
IPC分类号： C07C309/30 , C07C67/00 , C07C227/00 , C07C227/34 , C07C229/36 , C07C301/00
摘要： PURPOSE:To separate optical active-p-hydroxyphenylglycine and its DL-isomer by taking advantage of the difference of the solubility of their salts of o-toluenesulfonic acid.

8. 发明专利

JPH0312051B2 失效
公开(公告)号：JPH0312051B2
公开(公告)日：1991-02-19
申请号：JP4358283
申请日：1983-03-16
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , PPONGO CHIKARA , YOSHIOKA RYUZO
IPC分类号： C07C309/24 , C07B57/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/02 , C07C229/22 , C07C229/26 , C07C229/36 , C07C301/00 , C07C303/22 , C07C303/32

9. 发明专利

JPH0158957B2 失效
公开(公告)号：JPH0158957B2
公开(公告)日：1989-12-14
申请号：JP18588582
申请日：1982-10-21
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , NABE KOICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/05 , C12R1/07

10. 发明专利

JPS6261584B2 失效
公开(公告)号：JPS6261584B2
公开(公告)日：1987-12-22
申请号：JP15004781
申请日：1981-09-21
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , PPONGO CHIKARA , YOSHIOKA RYUZO
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C227/34 , C07C229/36 , C07C301/00 , C07C309/24

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