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1. 发明专利

JPH0158957B2 失效
公开(公告)号：JPH0158957B2
公开(公告)日：1989-12-14
申请号：JP18588582
申请日：1982-10-21
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIRO , YAMADA SHIGEKI , NABE KOICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/05 , C12R1/07

2. 发明专利

JPS60156394A PREPARATION OF L-2-AMINO-4-PHENYLBUTYRIC ACID 失效
公开(公告)号：JPS60156394A
公开(公告)日：1985-08-16
申请号：JP1291584
申请日：1984-01-26
申请人： TANABE SEIYAKU CO
发明人： TOSA TETSUYA , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO , YONEDA NAOTO , HAYASHI MASAAKI , NUMANAMI KENICHI
IPC分类号： C12P7/40 , C12P7/54 , C12P13/04 , C12R1/01 , C12R1/025 , C12R1/07 , C12R1/085
摘要： PURPOSE:To obtain L-2-amino-4-phenylbutyric acid by the use of an enzyme industrially advantageously, by treating 2-oxo-4-phenylbutyric acid with a mold obtained from a culture solution of a specific bacterium. CONSTITUTION:2-oxo-4-Phenylbutyric acid is treated with a culture solution of a bacterium belonging to the genus Achromobacter, Acinetobacter, Bacillus, or Paracoccus, capable of producing 2-oxo-4-phenylbutyric acid from L-2-amino-4- phenylbutyric acid, a mold obtained from the culture solution, or a treated material of the mold. Formed L-2-amino-4-phenylbutyric acid is collected. In order to shorten the reaction time or increase an accumulation amount of L-2-amino- 4-phenylbutyric acid, the reaction is preferably carried out in the presence of L-amino acid, surface active agent and/or enzyme, etc.

3. 发明专利

JPS63273486A PRODUCTION OF 1-(4-METHOXYPHENYL)-2-AMINOPROPANE 失效
公开(公告)号：JPS63273486A
公开(公告)日：1988-11-10
申请号：JP10838187
申请日：1987-04-30
申请人： TANABE SEIYAKU CO
发明人： NABE KOICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO , CHIKADA MIKIHIKO
IPC分类号： C12P13/00 , C12R1/01 , C12R1/13
摘要： PURPOSE:To produce the titled compound important as a raw material for drugs, by treating 1-(4-methoxyphenyl)-2-propanone with a culture solution of a specific bacterium belonging to the genus Sarcina or Brevibacterium, a cell or a treated material of the cell. CONSTITUTION:Sarcina lutea IAM1099, Brevibacterium linens IFO12141 or Brevibacterium protophormiae IFO12128 is aerobically cultivated in a medium containing 0.1-10% carbon source, 0.1-10% nitrogen source, 0.001-1% in organic salt and 0.1-1% 1-(4-methoxyphenyl)-2-aminopropane at 30-37 deg.C at pH6-7 and the prepared culture solution, a cell or a treated material of the cell is reacted with an aqueous solution containing 0.1-1% 1-(4-methoxyphe nyl)-2-propanone in the presence of preferably an amino group donor, a surface active agent or a coenzyme to give the aimed compound.

4. 发明专利

JPS5944354A Racemization of optically active n-acetyl-methioninamide 失效
标题翻译：光活性N-乙酰甲氨喋呤的研究
公开(公告)号：JPS5944354A
公开(公告)日：1984-03-12
申请号：JP15435682
申请日：1982-09-03
申请人： Tanabe Seiyaku Co Ltd
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , HONGOU CHIKARA , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C07B55/00 , C07B31/00 , C07C67/00 , C07C313/00 , C07C323/60
摘要： PURPOSE: To prepare the titled compound useful as a preparation raw material of N-acetyl-L-methionine, by heating optically active N-acetyl-methioninamide in an alkanol in the presence of an alkali metal hydroxide, etc.
CONSTITUTION: The objective compound is prepared by reacting an optically active N-acetyl-methioninamide in an alkanol in the presence of an alkali metal hydroxide, alkaline earth metal hydroxide or alkali metal alcoholate under atmospheric or positive pressure at 30W100°C. The amount of the alkali metal hydroxide, etc. is preferably 0.01W0.5mol per 1mol of the optically active N- acetyl-methionineamide.
EFFECT: The racemization can be carried out completely without decomposition of N-acetyl-D-methioninamide.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：制备用作N-乙酰基-L-甲硫氨酸的制备原料的标题化合物，通过在碱金属氢氧化物等存在下，在链烷醇中加热光学活性N-乙酰基 - 甲硫氨酰胺等。构成：目标化合物通过使光学活性的N-乙酰基 - 甲硫氨酰胺在碱金属氢氧化物，碱土金属氢氧化物或碱金属醇化物的存在下在烷基醇中在大气压或正压下在30-100℃下反应来制备。碱金属氢氧化物等的量优选为每摩尔光学活性N-乙酰基 - 甲硫氨酰胺0.01-0.5mol。效果：外消旋可以完全进行，不会分解N-乙酰基-D-甲硫氨酰胺。

5. 发明专利

JPS5886082A PREPARATION OF L-PHENYLALANINE AMMONIA-LYASE 失效
公开(公告)号：JPS5886082A
公开(公告)日：1983-05-23
申请号：JP18195281
申请日：1981-11-12
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12N9/88
摘要： PURPOSE:To prepare L-phenylalanine ammonia-lyase, by contacting micro- organisms belonging to Rhodotorula genus or Sporobolomyces genus with a specific amino acid. CONSTITUTION:Cells of microorganisms obtained by culturing microorganisms belonging to Rhodotorula genus or Sporobolomyces genus, e.g. Rhodotorula glutinis IFO 0559, Sporobolomyces roseus 221 (FERM P-3853), etc. are made to contact with one or more amino acids selected from the group of isoleucine, valine and leucine at 20-40 deg.C and 6-8pH, or said amino acids are added to the cultivation liquid of said microorganisms, and the produced L-phenylalanine ammonia-lyase is separated from the medium.

6. 发明专利

JPS5871892A PREPARATION OF N-ACETYL-L-METHIONINE 失效
公开(公告)号：JPS5871892A
公开(公告)日：1983-04-28
申请号：JP16827881
申请日：1981-10-20
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/12 , C12P13/04 , C12P41/00 , C12R1/18
摘要： PURPOSE:To prepare N-acetyl-L-methionine from N-acetyl-DL-methioninamide using an enzyme produced by microorganisms belonging to Erwinia genus. CONSTITUTION:Microorganisms belonging to Erwinia genus and capable of producing N-acetyl-L-methionine from N-acetyl-DL-methioninamide, e.g. Erwinia carotovora 3057 (FERM-P No.6176), are cultured under aerobic conditions, and the cultured liquid, the cells separated from the liquid, or treated product of the cells, is made to contact with N-acetyl-DL-methioninamide, and the produced N-acetyl-L-methionine is separated from the system.

7. 发明专利

JPS5799198A PREPARATION OF L-PHENYLALANINE 失效
公开(公告)号：JPS5799198A
公开(公告)日：1982-06-19
申请号：JP17224580
申请日：1980-12-05
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/01 , C12R1/025 , C12R1/06 , C12R1/15 , C12R1/20 , C12R1/265 , C12R1/38
摘要： PURPOSE:To prepare the titled substance industrially advantageously, by treating acetamidocinnamic acid, etc. with a culture solution of a bacterium capable of producing the titled substance from acetamidocinnamic acid. CONSTITUTION:A bacterium, e.g., Achromobacter luquidum, Achromobacter aerogenes, Pseudomonas fluorescens, Flavobacterium flavescens, etc., capable of producing L-phenylalanine from acetamidosuccinic acid, is cultivated in a common nutrient medium. The prepared culture solution, mold, treated mold, etc. is treated with acetamidocinnamic acid or its salt. In the reaction, acetamidocinnamic acid may be added to the culture solution containing the mold after culture or the mold, etc. may be added to an aqueous solvent containing acetamidocinnamic acid, followed by the reaction. The formed L-phenylalanine is separated and purified by a common ion exchange resin method, etc.

8. 发明专利

JPH0362397B2 失效
公开(公告)号：JPH0362397B2
公开(公告)日：1991-09-25
申请号：JP13280184
申请日：1984-06-26
申请人： TANABE SEIYAKU CO
发明人： TOSA TETSUYA , NABE KOICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/20

9. 发明专利

JPS59156293A Preparation of l-tryptophan 失效
标题翻译： L-酪氨酸的制备
公开(公告)号：JPS59156293A
公开(公告)日：1984-09-05
申请号：JP3151483
申请日：1983-02-25
申请人： Tanabe Seiyaku Co Ltd
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/20
摘要： PURPOSE: To obtain the titled substance efficiently, by reacting a culture solution of a specific new bacterium, a mold collected from it, or a treated mold with D-, L-, or DL-5-(indol-3-yl-methyl)hydantoin.
CONSTITUTION: A culture solution of Flavobacterium sp. I-3 strain (FERM-P 6901) of a novel bacterium, crude enzymatic product, purified enzymatic product, a mold collected from the culture solution, or a treated mold as an enzyme source is reacted with D-, L-, or DL-hydantoin. The reaction is carried out at 20W60°C, preferably at 30W45°C, at 6W10pH, preferably at 8W9pH, and the concentration of substrate is about 0.1W30wt%.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使特定新细菌的培养液，从其收集的霉菌或经处理的模具与D-，L-或DL-5-（吲哚-3-基 - 甲基）乙内酰脲。构成：黄杆菌属的培养液将新的细菌，粗酶产物，纯化的酶产物，从培养溶液收集的霉菌或作为酶源的处理的霉菌的I-3菌株（FERM-P 6901）与D-，L-或DL 海因。反应在20-60℃，优选30-45℃，6-10pH，优选8-9pH进行，底物浓度为约0.1-30重量％。

10. 发明专利

JPS5974994A Preparation of l-phenylalanine 失效
标题翻译： L-苯乙胺的制备
公开(公告)号：JPS5974994A
公开(公告)日：1984-04-27
申请号：JP18588582
申请日：1982-10-21
申请人： Tanabe Seiyaku Co Ltd
发明人： SENHATA ICHIROU , YAMADA SHIGEKI , NABE KOUICHI , NISHIDA YUTAKA , NAKAMICHI KATSUHIKO
IPC分类号： C12P13/22 , C12R1/05 , C12R1/07
摘要： PURPOSE: To prepare L-phenylalanine from α-acetamidocinnamic acid, by using a microorganism belonging to the genus Bacillus or Alcaligenes.
CONSTITUTION: A culture fluid, cultivated microbial cell or treated microbial cell of a microorganism, e.g. Bacillus sphaericus N-7 strain (FERM-P No.6746) or Alcaligenes faecalis S-7 strain (FERM-P No.6745), belonging to the genus Bacillus or Alcaligenes, and having the ability to produce L-phenylalanie from α-acetamidocinnamic acid is reacted with the α-acetamidocinnamic acid or a salt thereof in the presence of an L-amino acid, e.g. L-glutamic acid or L-aspartic acid, and L-phenylalanine transaminase to collect the aimed resultant L-phenylalanine.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使用属于芽孢杆菌属或产碱杆菌属的微生物从α-乙酰氨基肉桂酸制备L-苯丙氨酸。构成：培养液，培养的微生物细胞或微生物处理的微生物细胞，例如微生物。属于芽孢杆菌属或产碱杆菌属的芽孢球芽孢杆菌N-7菌株（FERM-P No.6746）或粪产碱杆菌S-7菌株（FERM-P No.6745），并具有从α- 乙酰氨基肉豆蔻酸在α-氨基酸存在下与α-乙酰氨基肉桂酸或其盐反应，例如 L-谷氨酸或L-天冬氨酸和L-苯丙氨酸转氨酶收集目的产生的L-苯丙氨酸。

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