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1. 发明专利

JPH0789857A AQUEOUS SUPENSION SOLUTION 失效
公开(公告)号：JPH0789857A
公开(公告)日：1995-04-04
申请号：JP17642094
申请日：1994-07-28
申请人： SENJU PHARMA CO , TAKEDA CHEMICAL INDUSTRIES LTD
发明人： NAKAYAMA HISAYUKI , USHIO KAZUMICHI , INADA KATSUHIRO
IPC分类号： C07D277/20 , A61K9/107 , A61K31/425 , A61K31/426 , A61K47/10 , A61K47/14 , A61P27/02 , A61P27/12 , C07D277/34
摘要： PURPOSE:To obtain a stable aqueous suspension solution containing 5-(3-ethoxy-4- n-pentyloxyphenyl) thiazolidine-2,4-dione useful as a therapeutic agent for corneal disorder as an active ingredient. CONSTITUTION:This aqueous suspension solution of fine crystal of 5-(3-ethoxy-4- n-pentyloxyphenyl)thiazolidine-2,4-dione contains a water-soluble polymer, chlorobutanol and benzalkonium chloride and/or p-oxybenzoic ester.

2. 发明专利

JPH05186348A PREPARATION OF AQUEOUS SUSPENSION AGENT 失效
公开(公告)号：JPH05186348A
公开(公告)日：1993-07-27
申请号：JP6757492
申请日：1992-03-25
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , USHIO KAZUMICHI , INADA KATSUHIRO
IPC分类号： A61K9/107 , A61K31/425 , A61K47/34 , A61K47/38 , A61P27/02 , A61P27/12
摘要： PURPOSE:To provide a process for producing a stable aqueous suspension agent containing 5-(3-ethoxy-4-n-pentyloxyphenyl)thiazolidine-2,4-dione useful as an agent for the treatment of corneal disorder, etc. CONSTITUTION:A fine aqueous suspension agent of 5-(3-ethoxy-4-n- pentyloxyphenyl thiazolidine-2,4-dione is produced by dissolving 5-(-ethoxy-4-n- pentyloxyphenyl) thiazolidine-2, 4-dione and one or more kinds of polymers selected from polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropylmethy cellulose, methyl ellulose and hydroxyethyl cellulose in water to obtain an aqueous solution having pH of >=8 and adjusting the pH of the solution to

3. 发明专利

JPH1160505A ANTISEPTIC COMPOSITION 失效
公开(公告)号：JPH1160505A
公开(公告)日：1999-03-02
申请号：JP13343898
申请日：1998-05-15
申请人： SENJU PHARMA CO , SHISEIDO CO LTD
发明人： NISHIHATA SHUICHI , YAMAGUCHI MASAYO , INADA KATSUHIRO
IPC分类号： A61K9/08 , A61K9/00 , A61K31/35 , A61K31/70 , A61K31/715 , A61K47/26 , A61P27/02 , A61P27/12 , A61P27/16 , A61K31/725
摘要： PROBLEM TO BE SOLVED: To obtain a composition having stable and sufficient antiseptic effect by formulating a specified amount of chlorhexidine gluconate in an aqueous composition containing a specific medicinal agent. SOLUTION: This antiseptic composition is obtained by including (A) pref. 0.001-5 wt.% of at least one compound selected from hyaluronic acid, cromoglycic acid, flavinadeninedinucleotide and salts thereof and (B) pref. 0.001-0.05 wt.% of chlorhexidine gluconate so as not to form any insoluble conjugate. This composition is useful, in particular, as a local liquid agent for external use, furthermore, as an eye drop, ear drop, or nasal drop.

4. 发明专利

JPH1129483A COMPOSITION CONTAINING DIFLUPREDNATE 失效
公开(公告)号：JPH1129483A
公开(公告)日：1999-02-02
申请号：JP12990898
申请日：1998-05-13
申请人： SENJU PHARMA CO , MITSUBISHI CHEM CORP
发明人： KIMURA KIYOKO , YASUEDA SHINICHI , YAMAGUCHI MASAZUMI , INADA KATSUHIRO
IPC分类号： A61K9/107 , A61K31/575 , A61P11/02 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition good in transferability to a diseased part, homogeneous in drug distribution, hardly causing a sense of incompatibility and foreign body sensation, and capable of preventing and treating inflammatory disease and allergic disease by including difluprednate, an oil, water and an emulsifier. SOLUTION: This composition contains difluprednate, an oil containing a fatty acid ester of glycerol, water and an emulsifier containing a surfactant. The formulation amounts of the components are 10-100,000 pts.wt. oil, 100-100,000 pts.wt. water and 10-100,000 pts.wt. emulsifier based on 1 pt.wt. difluprednate. Especially, the weight ratio of the oil to the water, which is a medium, is preferably (1:4) to (1:99). The composition is prepared to form an aqueous preparation such as oil-in-water type emulsion. The administration in low doses sufficiently manifests drug action, and thereby the side effect is reduced and the composition is readily administered to a topical portion such as an eye, a nose and an ear.

5. 发明专利

JP2000247887A AQUEOUS SUSPENSION AGENT AND ITS PRODUCTION 失效
公开(公告)号：JP2000247887A
公开(公告)日：2000-09-12
申请号：JP5277899
申请日：1999-03-01
申请人： SENJU PHARMA CO
发明人： SAWA SHIRO , INADA KATSUHIRO
IPC分类号： A61K47/30 , A61K9/107 , A61K31/00 , A61K31/52 , A61K31/522 , A61P27/00 , A61P27/02 , A61P31/00 , A61P31/12
摘要： PROBLEM TO BE SOLVED: To obtain an aqueous suspension agent of 9-[(2-hydroxyethoxy) methyl]guanine having a uniform particle diameter and a good dispersion state. SOLUTION: This aqueous suspension agent is produced by preparing an aqueous solution showing pH

6. 发明专利

JP2000273061A TERPENOID EMULSION 失效
公开(公告)号：JP2000273061A
公开(公告)日：2000-10-03
申请号：JP7558599
申请日：1999-03-19
申请人： SENJU PHARMA CO
发明人： INADA KATSUHIRO , YAMAGUCHI MASAZUMI , YAMAZAKI FUKIKO , NAKAYAMA HISAYUKI
IPC分类号： A61K9/107 , A61K47/32 , C07C29/94 , C07C35/12
摘要： PROBLEM TO BE SOLVED: To obtain an oil-in-water type terpenoid emulsion which does not lowering the content of the terpenoid, even when stored in a plastic container, by mixing the terpenoid with an oil and a surfactant. SOLUTION: This oil-in-water type terpenoid emulsion comprises (A) a terpenoid (for example, menthol, borneol or camphor), (B) an oil (preferably an animal or vegetable oil containing fatty acid glycerides as main components, especially preferably castor oil), and (C) a surfactant (preferably a nonionic surfactant, especially preferably a polyoxyethylene sorbitan fatty acid ester). The emulsion preferably comprises the component A in an amount of preferably 0.0005-1 W/V %, more preferably 0.001-0.1 W/V %, the component B in an amount of preferably 0.01-20 W/V %, more preferably 0.1-10 W/V %, and the component C in an amount of preferably 0.05-20 W/V %, more preferably 0.5-10 W/V %. The emulsion is preferably charged in a plastic container.

7. 发明专利

JP2001106626A LIQUID FOR PERFUSION AND WASHING OF EYE AND METHOD FOR PREVENTING PRECIPITATION IN THE LIQUID 失效
公开(公告)号：JP2001106626A
公开(公告)日：2001-04-17
申请号：JP28682299
申请日：1999-10-07
申请人： SENJU PHARMA CO , OTSUKA PHARMA FACTORY INC
发明人： INADA KATSUHIRO , FUJII HIRONORI , SHOJI HIDEKATSU , KAGA JUNJI , SUMIYOSHI NOBUAKI
IPC分类号： A61J1/10 , A61J1/14 , A61K9/08 , A61K33/06 , A61K33/10 , A61K47/12 , A61K47/16 , A61P27/04 , C11D7/10 , C11D7/12 , C11D7/26 , C11D7/32 , C11D17/04 , C11D17/08
摘要： PROBLEM TO BE SOLVED: To provide a liquid for the perfusion and washing of eye having suppressed precipitation tendency, especially provide the liquid in packaged form. SOLUTION: A liquid for the perfusion and washing of eye containing bicarbonate ion and calcium ion and/or magnesium ion is further incorporated with at least one kind of organic acid or its salt selected from edetic acid, tartaric acid, L-glutamic acid, L-pyroglutamic acid, D-aspartic acid, sorbic acid, lactic acid, malic acid, gluconic acid, maleic acid, malonic acid and ethylenediaminetetraacetic acid.

8. 发明专利

JPH11197215A EYE PERFUSION/CLEARING SOLVENT BAG PACKAGE 失效
公开(公告)号：JPH11197215A
公开(公告)日：1999-07-27
申请号：JP30257898
申请日：1998-10-23
申请人： SENJU PHARMA CO , OTSUKA PHARMA FACTORY INC
发明人： INADA KATSUHIRO , NISHIO MITSUHIRA , KIMURA YOSHIYUKI , KAGA JUNJI , MURAOKA KOICHI , SUMIYOSHI NOBUAKI , IGUCHI SEIICHIRO , YAMAMOTO HIROAKI
IPC分类号： A61J1/05 , A61J1/14
摘要： PROBLEM TO BE SOLVED: To provide an eye perfusion/clearing solvent bag package capable of preventing breaking of a glass container or glass flakes, housing eye perfusion/clearing solvent in a stable manner and visually determine the pH change of this liquid accurately. SOLUTION: In a package made by packing a gas permeable plastic plurilocular bag by a gas impermeable plastic packing material, the plurilocular bag includes an A room wherein medicinal liquid or solid formulation containing at least one selected from oxyglutathione and dextrose is sealed and a B room wherein medicinal liquid containing bicarbonate ion is sealed, a space part between the plurilocular bag and the packing material is filled with carbon dioxide gas and, in this space part, a pH indicator made by injecting and sealing liquid containing bicarbonate ion and a pH indication chemical for causing a color change according to the pH change of this liquid in a gas permeable plastic small container is arranged.

9. 发明专利

JPH1143446A VISCOSITY-INCREASING AGENT FOR AQUEOUS PREPARATION 失效
公开(公告)号：JPH1143446A
公开(公告)日：1999-02-16
申请号：JP12865898
申请日：1998-05-12
申请人： SENJU PHARMA CO , SHISEIDO CO LTD
发明人： NAKAYAMA HISAYUKI , INADA KATSUHIRO , YAMAGUCHI MASAYO
IPC分类号： A61K9/08 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To obtain a viscosity-increasing agent useful as an infusing agent which is used for therapy of contract or glaucoma and treatment of ocular operation such as keratoplasty and the like an injection, a preparation for external use and an eye wash using for treating injury and the like on the surface of ocular tissues by formulating boric acid with hyaluronic acid. SOLUTION: The objective viscosity-increasing agent is obtained by dissolving (A) hyaluronic acid with a molecular weight of 100,000-3,000,000 and (B) boric acid in the form of free acid or salt into water in amounts of 0.001-0.5 wt.% and 0.1-5 wt.% calculated as the free acid, respectively. The viscosity-increasing agent is adjusted at pH 5-7.5. As long as the objective is achieved, other pharmaceutically active ingredients (e.g. antimicrobials, chelating agents, etc.), tonicity agents (e.g. sodium chloride and the like), buffers (e.g. sodium acetate and the like) and pH regulators can be added to the viscosity-increasing agent. The viscosity of the aqueous solution of the component A tends to gradually decrease as days pass, but when the component B is added into the solution, the viscosity at the beginning when the solution is prepared is not only increased but the viscosity after days passed can also be maintained in remarkably high viscosity.

10. 发明专利

JPH10298109A PRESERVATIVE FOR EMULSION AND EMULSION 失效
公开(公告)号：JPH10298109A
公开(公告)日：1998-11-10
申请号：JP4047198
申请日：1998-02-23
申请人： SENJU PHARMA CO
发明人： YAMAGUCHI MASAZUMI , YAMAGUCHI MASAYO , INADA KATSUHIRO
IPC分类号： A61K9/107 , A61K47/12 , A61P27/02 , A61P27/16 , C07C57/10
摘要： PROBLEM TO BE SOLVED: To obtain an emulsion having excellent storage stability and less adverse effects, since the subjective preservative imparts its excellent preservative efficacy even to 0/W type emulsion at its low concentration. SOLUTION: This preservative for emulsion comprises sorbic acid or a pharmaceutically acceptable salt thereof, and as needed, disodium edetate and boric acid. The other objective emulsion comprises sorbic acid or a pharmaceutically acceptable salt thereof, and as needed, disodium edetate and boric acid as well as the major drug. The storage method for the emulsion comprises compounding the emulsion with sorbic acid or a pharmaceutically acceptable salt thereof, and as needed, disodium edetate and boric acid at their respective pharmaceutically acceptable concentrations effective for storage of the emulsion.

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