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1. 发明专利

JPH1143446A VISCOSITY-INCREASING AGENT FOR AQUEOUS PREPARATION 失效
公开(公告)号：JPH1143446A
公开(公告)日：1999-02-16
申请号：JP12865898
申请日：1998-05-12
申请人： SENJU PHARMA CO , SHISEIDO CO LTD
发明人： NAKAYAMA HISAYUKI , INADA KATSUHIRO , YAMAGUCHI MASAYO
IPC分类号： A61K9/08 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To obtain a viscosity-increasing agent useful as an infusing agent which is used for therapy of contract or glaucoma and treatment of ocular operation such as keratoplasty and the like an injection, a preparation for external use and an eye wash using for treating injury and the like on the surface of ocular tissues by formulating boric acid with hyaluronic acid. SOLUTION: The objective viscosity-increasing agent is obtained by dissolving (A) hyaluronic acid with a molecular weight of 100,000-3,000,000 and (B) boric acid in the form of free acid or salt into water in amounts of 0.001-0.5 wt.% and 0.1-5 wt.% calculated as the free acid, respectively. The viscosity-increasing agent is adjusted at pH 5-7.5. As long as the objective is achieved, other pharmaceutically active ingredients (e.g. antimicrobials, chelating agents, etc.), tonicity agents (e.g. sodium chloride and the like), buffers (e.g. sodium acetate and the like) and pH regulators can be added to the viscosity-increasing agent. The viscosity of the aqueous solution of the component A tends to gradually decrease as days pass, but when the component B is added into the solution, the viscosity at the beginning when the solution is prepared is not only increased but the viscosity after days passed can also be maintained in remarkably high viscosity.

2. 发明专利

JP2002029954A COMPOSITION FOR SUPPRESSING BODY SMELL 失效
公开(公告)号：JP2002029954A
公开(公告)日：2002-01-29
申请号：JP2000216138
申请日：2000-07-17
申请人： NIPPON FINE CHEMICAL CO , SENJU PHARMA CO
发明人： YANO MAYUMI , HORIE KIYOSHI , NAKAYAMA HISAYUKI
IPC分类号： A61K8/00 , A61K8/97 , A61Q15/00 , A61K7/32
摘要： PROBLEM TO BE SOLVED: To obtain a composition for suppressing body smell capable of suppressing the emission of the body smell and having deodorant effects even on the emitted body smell. SOLUTION: This composition for suppressing the body smell comprises (a) a compound represented by general formula (I) (wherein, R1 and R2 denote each the same or different hydrogen atom or methyl group) or its salt and (b) a plant extracted ingredient.

3. 发明专利

JP2002219162A UNHEATED DISINFECTANT FOR SOFT CONTACT LENS 审中-公开
公开(公告)号：JP2002219162A
公开(公告)日：2002-08-06
申请号：JP2001348164
申请日：2001-11-14
申请人： SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , YAMAZAKI FUKIKO
IPC分类号： G02C13/00 , A01N25/00 , A01N47/44 , A01N59/00 , A61L2/16 , A61L2/18
摘要： PROBLEM TO BE SOLVED: To provide a chemical agent for a soft contact lens, capable of eliminating a feeling of dryness and a foreign-body sensation by imparting a continuous refreshing feeling to a wearer's eyes when he/she wears the soft contact lenses. SOLUTION: An unheated disinfectant for the soft contact lens is characterized by containing a monoterpenoid with a concentration of 0.0005-0.02 (W/V)%.

4. 发明专利

JPH08194192A PRODUCTION OF FREEZE-DRIED MATERIAL CONTAINING PROTEOLYTIC ENZYME 失效
公开(公告)号：JPH08194192A
公开(公告)日：1996-07-30
申请号：JP440095
申请日：1995-01-13
申请人： SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , KIMOTO AKIHIRO , TSUCHINO NORIKO
IPC分类号： G02C7/04 , C11D3/386 , C11D7/42 , C11D17/00 , C12N9/50
摘要： PURPOSE: To obtain a method for producing a freeze-dried material contg. proteolytic enzyme with the deactivation suppressed in freeze drying by freeze- drying an aq. composition contg. the enzyme in the presence of a surfactant. CONSTITUTION: An aq. composition contg. proteolytic enzyme is freeze-dried in the presence of a surfactant, especially at least one kind selected from anionic surfactant, amphoteric surfactant and nonionic surfactant. In this case, the deactivation of the enzyme is suppressed by conducting the freeze drying at -3 to -40 deg.C, and the meltability when in use is improved since the grain of the freeze-dried material is refined. Further, as the drying after freeze drying is conducted at

5. 发明专利

JPH07146454A STABILIZING METHOD FOR CONTACT LENS USE AGENT 失效
公开(公告)号：JPH07146454A
公开(公告)日：1995-06-06
申请号：JP21183494
申请日：1994-08-11
申请人： SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , KIMOTO AKIHIRO , TSUCHINO NORIKO
IPC分类号： G02C7/04 , C11D3/00 , C11D3/386 , C11D7/32 , C11D7/42 , C12N9/76 , C12R1/07 , G02C13/00
摘要： PURPOSE:To prevent decomposition in an aqueous solution condition of the enzyme in a contact lens use agent containing a protein decomposing enzyme. CONSTITUTION:A stabilizing method for a contact lens use agent containing a protein decomposing enzyme characterized by blending a pyrolidone compound, a contact lens use agent manufacturing method and the contact lens use agent, are provided. This contact lens use agent can be formed as a liquid-shaped or solid-shaped medicine. A liquid agent can be formed as a monoagent type which does not need to be dissolved when it is used. When the liquid-shaped medicine and the solid-shaped medicine are dissolved into water, activity of the protein decomposing enzyme is maintained long, and it can be effectively used for cleaning, preservation or the like of a contact lens.

6. 发明专利

JPH0789857A AQUEOUS SUPENSION SOLUTION 失效
公开(公告)号：JPH0789857A
公开(公告)日：1995-04-04
申请号：JP17642094
申请日：1994-07-28
申请人： SENJU PHARMA CO , TAKEDA CHEMICAL INDUSTRIES LTD
发明人： NAKAYAMA HISAYUKI , USHIO KAZUMICHI , INADA KATSUHIRO
IPC分类号： C07D277/20 , A61K9/107 , A61K31/425 , A61K31/426 , A61K47/10 , A61K47/14 , A61P27/02 , A61P27/12 , C07D277/34
摘要： PURPOSE:To obtain a stable aqueous suspension solution containing 5-(3-ethoxy-4- n-pentyloxyphenyl) thiazolidine-2,4-dione useful as a therapeutic agent for corneal disorder as an active ingredient. CONSTITUTION:This aqueous suspension solution of fine crystal of 5-(3-ethoxy-4- n-pentyloxyphenyl)thiazolidine-2,4-dione contains a water-soluble polymer, chlorobutanol and benzalkonium chloride and/or p-oxybenzoic ester.

7. 发明专利

JPH05186348A PREPARATION OF AQUEOUS SUSPENSION AGENT 失效
公开(公告)号：JPH05186348A
公开(公告)日：1993-07-27
申请号：JP6757492
申请日：1992-03-25
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , USHIO KAZUMICHI , INADA KATSUHIRO
IPC分类号： A61K9/107 , A61K31/425 , A61K47/34 , A61K47/38 , A61P27/02 , A61P27/12
摘要： PURPOSE:To provide a process for producing a stable aqueous suspension agent containing 5-(3-ethoxy-4-n-pentyloxyphenyl)thiazolidine-2,4-dione useful as an agent for the treatment of corneal disorder, etc. CONSTITUTION:A fine aqueous suspension agent of 5-(3-ethoxy-4-n- pentyloxyphenyl thiazolidine-2,4-dione is produced by dissolving 5-(-ethoxy-4-n- pentyloxyphenyl) thiazolidine-2, 4-dione and one or more kinds of polymers selected from polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropylmethy cellulose, methyl ellulose and hydroxyethyl cellulose in water to obtain an aqueous solution having pH of >=8 and adjusting the pH of the solution to

8. 发明专利

JPH11171762A COLLUNARIUM 失效
公开(公告)号：JPH11171762A
公开(公告)日：1999-06-29
申请号：JP36219197
申请日：1997-12-10
申请人： SENJU PHARMA CO
发明人： DOI KOJI , NAKAYAMA HISAYUKI
IPC分类号： A61K9/12 , A61K31/045 , A61K31/125 , A61K36/18 , A61P27/16 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To prevent the decrease in the content of a terpenoid contained in a terpenoid-containing collunarium charged in a spray container. SOLUTION: A terpenoid-containing collunarium charged in a spray container whose inner wall surface brought into contact with the nasal drop on its charging is formed from a material comprising an epoxy resin, a polyamideimide resin or a fluororesin. The terpenoid-containing collunarium charged in the container can be preserved without accompanying the remarkable decrease in the content of the terpenoid.

9. 发明专利

JPH11130667A OPHTHALMIC COMPOSITION FOR SOFT CONTACT LENS, WETTING ENHANCEMENT OF SOFT CONTACT LENS AND ADSORPTION SUPPRESSION OF TERPENOID 失效
公开(公告)号：JPH11130667A
公开(公告)日：1999-05-18
申请号：JP19580098
申请日：1998-07-10
申请人： SENJU PHARMA CO
发明人： DOI KOJI , NAKAYAMA HISAYUKI , NAKAJIMA TAKUYA , SAKAI NORIKO
IPC分类号： G02C7/04 , A61K9/00 , A61K9/08 , A61K31/045 , A61K31/12 , A61K31/125 , A61P27/02 , A61P27/04 , A61P31/04 , G02C13/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition by using terpenoid(s) as active ingredient to enhance the wettability of a soft contact lens, in its turn suppress the decrease in the water content of the lens and suppress development of dryness and foreign body sensations. SOLUTION: This ophthalmic composition contains, as active ingredient, terpenoid(s), pref. at least one kind selected from menthol, borneol and camphor; wherein it is preferable that this composition is in the form of an eye drop, or in the form of a liquid containing a polyoxyethylene sorbitan ester when to be used, and also adjusted to >=pH 5.5 when to be used.

10. 发明专利

JPH0776700A STABILIZATION OF AGENT FOR CONTACT LENS 失效
公开(公告)号：JPH0776700A
公开(公告)日：1995-03-20
申请号：JP829094
申请日：1994-01-28
申请人： SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , KIMOTO AKIHIRO , TSUCHINO NORIKO
IPC分类号： C11D7/42 , C11D1/10 , C11D1/66 , C11D1/72 , C11D1/90 , C11D1/94 , C11D3/00 , C11D3/386 , C11D17/00 , G02C13/00
摘要： PURPOSE:To efficiently stabilize a contact lens treating agent containing a proteinase and having excellent solubility in use by compounding a surfactant to the agent. CONSTITUTION:An agent for the treatment of contact lens and containing a proteinase such as bioprase originated from a microorganism belonging to the genus Bacillus (the concentration of the enzyme is preferably 10-5,000unit/ml) is stabilized by compounding preferably 0.01-10 (W/V)% of one or more kinds of surfactants selected from anionic surfactant, ampholytic surfactant and nonionic surfactant. The contact lens treating agent is produced preferably by freeze-drying an aqueous composition containing the proteinase in the presence of the surfactant at -10 to -40 deg.C.

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