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1. 发明专利

JP2008089440A Electrophoresis apparatus 有权
标题翻译：电泳装置
公开(公告)号：JP2008089440A
公开(公告)日：2008-04-17
申请号：JP2006271397
申请日：2006-10-03
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： NAKAMURA SHIN , YAMAMOTO RINTARO , HARADA TORU , HAZAMA HAJIME , IKEGAMI TAKASHI , KACHI TORU , INAMI JIYUNJI , OHASHI TETSUO , UTSUNOMIYA SHINICHI , MIYAMOTO KEISUKE , ENDO NAOYA , KUMAGAI HIDESATO
IPC分类号： G01N27/447 , G01N35/10
CPC分类号： G01N27/44791 , G01N27/44721 , G01N27/44743 , G01N27/44782
摘要： PROBLEM TO BE SOLVED: To automate the operation of an electrophoresis apparatus and to improve the throughput. SOLUTION: This electrophoresis apparatus has two platens 2a and 2b capable of controlling temperature of electrophoresis plates placed thereon, a loading medium charging unit 8 for sending a loading medium under pressure, a loading medium charging nozzle mechanism 10 having a pair of nozzles 12a and 12b connected to the loading medium charging unit 8, a pipetter mechanism for dispensing samples to sample dispensing openings of the electrophoresis plates placed on the platens 2a and 2b, a stacker mechanism 16 for storing sample plates, a loading buffer solution supplying mechanism 20, a loading buffer solution dispensing mechanism having an injection nozzle connected to the loading buffer solution supplying mechanism, a power unit for allowing electrophoresis separation for each electrophoresis plate placed on the platens 2a and 2b, and a detector for optically detecting components migrating through each electrophoresis flow channel of the electrophoresis plates. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：使电泳装置的操作自动化并提高生产量。解决方案：该电泳装置具有能够控制放置在其上的电泳板的温度的两个压板2a和2b，用于在压力下发送装载介质的装载介质充电单元8，具有一对喷嘴的装载介质装料喷嘴机构10 12a和12b连接到装载介质充电单元8，用于分配样品以移送到放置在压板2a和2b上的电泳板的样品分配开口的移液器机构，用于存储样品板的堆积器机构16，装载缓冲溶液供应机构20 ，具有连接到装载缓冲溶液供给机构的注射喷嘴的装载缓冲溶液分配机构，用于对放置在台板2a和2b上的每个电泳板进行电泳分离的动力单元和用于光学检测通过每个电泳迁移的组分的检测器电泳板的流路。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2008241523A Electrophoresis apparatus and dna analysis method using the same 有权
标题翻译：电泳装置和使用该方法的DNA分析方法
公开(公告)号：JP2008241523A
公开(公告)日：2008-10-09
申请号：JP2007083926
申请日：2007-03-28
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： KACHI TORU
IPC分类号： G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To save manpower and reduce a cost by reducing the quantity of a required sample even if a plurality of separation analyses having different separation characteristics need to be implemented. SOLUTION: Two separating flow paths 15, 16 are provided in a substrate 11, and have one end connected to a common sample well 12, and the other end separated as separation medium filling ports 13, 14. Different separation mediums have the different separation characteristics. The flow paths 15, 16 are filled with the separation mediums. The sample is injected into the sample well 12 once, introduced into both flow paths 15, 16, and maintained. While the sample is electrophoresed, the separation analysis is implemented in parallel. A plurality of the separation analyses having the different separation characteristics can be concurrently or sequentially implemented in a single sample injection. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：即使需要实现具有不同分离特性的多个分离分析，也可通过减少所需样品的量来节省人力并降低成本。解决方案：两个分离流路15,16设置在基板11中，并且一端连接到公共样品阱12，另一端作为分离介质填充口13,14分离。不同的分离介质具有不同的分离特性。流路15,16填充有分离介质。将样品一次注入样品孔12中，引入两个流动路径15,16并保持。样品电泳时，分离分析是并行实现的。具有不同分离特性的多个分离分析可以在单个样品注入中同时或依次实施。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2010099053A Method of determining base sequence of dna 有权
标题翻译：确定DNA基因序列的方法
公开(公告)号：JP2010099053A
公开(公告)日：2010-05-06
申请号：JP2008275967
申请日：2008-10-27
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： KACHI TORU
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method of determining the base sequence of DNA using a cycle sequence reaction, which method exhibits a high signal strength.
SOLUTION: The method of determining the base sequence of DNA using a cycle sequence reaction includes a process of subjecting a solution comprising DNA wherein the base sequence is to be determined to a heat treatment, a process of subjecting the same to a cooling treatment, and a process of carrying out a cycle sequence reaction by adding heat-resistant DNA polymerase, deoxyribonucleotide triphosphates with respect to each of the four species of the bases, and dideoxyribonucleotide triphosphates with respect to each of the four species of the bases thereinto.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供使用循环序列反应来测定DNA的碱基序列的方法，该方法表现出高的信号强度。解决方案：使用循环序列反应测定DNA的碱基序列的方法包括使包含其中碱基序列的DNA的溶液进行热处理的方法，对其进行冷却的方法以及通过添加耐热DNA聚合酶，相对于四种碱基中的每一种的脱氧核糖核苷酸三磷酸酯和相对于四种碱基中的每一种的二脱氧核糖核苷酸三磷酸进行循环序列反应的方法。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009265032A Bidirectional electrophoresis device, microchip, and bidirectional electrophoresis method 有权
标题翻译：双向电泳装置，微电脑和双向电泳方法
公开(公告)号：JP2009265032A
公开(公告)日：2009-11-12
申请号：JP2008117692
申请日：2008-04-28
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： KACHI TORU , SHIBATA HIKARI
IPC分类号： G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a bidirectional electrophoresis device, which can be used from a reverse direction of a separation passage, when adsorption of protein, or the like, to the inner wall of the separation passage or an injection-side trouble occurs, and reduces analysis cost. SOLUTION: The device includes a holding substrate 21, having an optical window 22 extending from the upper surface to the lower surface thereof; transparent microchips 15, 17 mounted on the holding substrate 21 and including a separation passage 16 for electrophoresis and sample reservoirs 13a and 13b, connected to both ends of the separation passage 16; electrodes 11a and 11b for applying a high voltage necessary for electrophoresis to the separation passage 16; and an optical measuring system 5 for measuring electrophoresis in the separation passage 16 via the optical window 22. The direction of the microchips 15 and 17 is set to a reverse direction relative to the holding substrate 21 together with the electrodes 11a and 11b, thereby electrophoresis is made to be carried out in the reverse direction in the separation passage 16. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种可以从分离通道的相反方向使用的双向电泳装置，当将蛋白质等吸附到分离通道的内壁或注入侧时发生故障，降低分析成本。解决方案：该装置包括保持基板21，其具有从其上表面延伸到下表面的光学窗口22; 安装在保持基板21上的透明微芯片15,17，包括连接于分离通道16的两端的电泳用分离通道16和试样容器13a，13b; 用于向分离通道16施加电泳所需的高电压的电极11a和11b; 以及用于经由光学窗口22在分离通道16中测量电泳的光学测量系统5.微芯片15和17的方向与电极11a和11b一起相对于保持基板21设置为相反方向，从而进行电泳在分离通道16中沿相反方向进行。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2011053111A Electrophoretic system and electrophoretic method 有权
标题翻译：电泳系统和电泳方法
公开(公告)号：JP2011053111A
公开(公告)日：2011-03-17
申请号：JP2009202910
申请日：2009-09-02
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： KACHI TORU
IPC分类号： G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an electrophoretic system and an electrophoretic method which can freely change an effective electrophoretic length, automate measurement of a separation medium requiring various electrophoretic conditions, and reduce analysis cost. SOLUTION: The electrophoretic system includes: an electrophoretic device 2 loaded with microchips (15, 17) including a transparent material having a separation channel 16; an introduction reserver 12i for introducing the separation medium into the separation channel 16, and a microchip, and including a holding substrate 21 having a wider width than a width of the separation channel 16 and having on a part, an optical path formation means 22 extending in the longitudinal direction of the separation channel 16; and an optical measuring system 5 for measuring reflected light or transmitted light from the separation medium introduced into the separation channel 16 through the optical path formation means 22. A distance from a position of the introduction reserver 12 i to a detection position on the separation channel 16 of the optical measuring system 5 is continuously changed by moving the optical measuring system 5 relatively with respect to the electrophoretic device 2 along a longitudinal direction of the separation channel 16. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可以自由地改变有效电泳长度的电泳系统和电泳方法，自动测量需要各种电泳条件的分离介质，并降低分析成本。电泳系统包括：装载有包括具有分离通道16的透明材料的微芯片（15,17）的电泳装置2; 用于将分离介质引入分离通道16的介质储存器<12> 和微芯片，并且包括具有比分离通道16的宽度宽的宽度的保持基板21，沿分离通道16的纵向方向延伸的光路形成装置22; 以及用于测量从通过光路形成装置22引入分离通道16的分离介质的反射光或透射光的光学测量系统5.从介质储存器12的位置到从通过沿着分离通道16的长度方向相对于电泳装置2移动光学测量系统5，连续地改变光学测量系统5的分离通道16上的检测位置。（C） 2011年，JPO＆INPIT

6. 发明专利

JP2007298126A Valve mechanism and channel substrate 审中-公开
标题翻译：阀门机构和通道基板
公开(公告)号：JP2007298126A
公开(公告)日：2007-11-15
申请号：JP2006127318
申请日：2006-05-01
申请人： Shimadzu Corp , 株式会社島津製作所
发明人： KACHI TORU
IPC分类号： F16K31/06 , F16K7/18
CPC分类号： F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0026 , F16K99/0046 , Y10T137/86879
摘要： PROBLEM TO BE SOLVED: To assemble a valve mechanism without complicating the structure of a channel substrate. SOLUTION: A valve chamber 4 which is a rectangular space is formed in the channel substrate 1. Channels 2a, 2b, 2c are connected from different directions with each other in the valve chamber 4. The channels 2a and the channel 2b are connected to a first surface 5a and a second surface 5b, which are mutually opposite, of the valve chamber 4. The channel 2c is connected to a third surface 5c different from the first surface 5a and the second surface 5b. A valve body 8 sliding between the first surface 5a side and the second surface 5b side in the valve chamber 4 is stored in the valve chamber 4. Electromagnets 10a and 10b are mounted on the channel substrate 1 laterally to the first surface 5a and the second surface 5b outside the valve chamber 4 so as to hold the valve chamber 4 between the electromagnets. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：组装阀机构而不使通道基板的结构复杂化。解决方案：在通道基板1中形成有矩形空间的阀室4.通道2a，2b，2c在阀室4中彼此不同方向连接。通道2a和通道2b是连接到彼此相对的阀室4的第一表面5a和第二表面5b。通道2c连接到与第一表面5a和第二表面5b不同的第三表面5c。在阀室4中存储有在阀室4中的第一表面5a侧和第二表面5b侧之间滑动的阀体8.电磁体10a和10b横向于第一表面5a安装在通道基板1上，表面5b在阀室4之外，以将阀室4保持在电磁体之间。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2002310990A ELECTROPHORETIC EQUIPMENT 失效
公开(公告)号：JP2002310990A
公开(公告)日：2002-10-23
申请号：JP2001115014
申请日：2001-04-13
申请人： SHIMADZU CORP
发明人： KACHI TORU , YAMAMOTO RINTARO , NAKAMURA SHIN
IPC分类号： G01N27/447 , G01N35/04 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To realize the simultaneous analysis of many specimens using an electrophoretic member in flow channel constitution. SOLUTION: Eight sample reservoirs of a migration chip 1 for dispensing a sample at first are positioned at a sample dispensing position 9 by a table 3. A head 5 is driven by a sample dispensing mechanism to suck the specimens housed in eight different wells 7a of a sample plate 7 by eight nozzles 5a and, thereafter, the head 5 is moved to the sample dispensing position 9 and the specimens sucked in the nozzles 5a are dispensed in eight sample reservoirs at same time. The sample reservoirs are successively positioned at the sample dispensing position 9 by the table 3 and the dispensation of the specimens in the sample reservoirs is successively performed by the sample dispensing mechanism. Electrodes are arranged in the reservoirs pf the migration chip 1 and predetermined voltage is applied across the electrodes by a voltage applying part and the specimens housed in the sample reservoirs are separated and migated in separation flow channels to be detected by a detector.

8. 发明专利

JPH08285772A OPTICAL ANALYZER 失效
公开(公告)号：JPH08285772A
公开(公告)日：1996-11-01
申请号：JP8784995
申请日：1995-04-13
申请人： SHIMADZU CORP
发明人： KACHI TORU , NAKAMURA KENJI
IPC分类号： G01N21/64 , G01N21/27 , G01N21/59
摘要： PURPOSE: To obtain a portable optical analyzer suitable for convenient measurement at a measuring site in which a plurality of measurements can be carried out through optical analysis. CONSTITUTION: In the optical analyzer for analyzing a sample through an optical means comprising systems 1, 2 for irradiating a sample in a measuring cell 3 and measuring systems 4-8 for detecting the light from the sample, the measuring systems 4-8 comprise a first detection means 4 directed toward a converging point (a) within the position for arranging the measuring cell 3 on an optical path passing through the converging point (a), and a second detection means 6 directed toward the converging point (a) on the outside of the optical path. Using the output from the first or second detection means 4 or 6 selectively, the ratio of output from at least the first or second detection means 4 or 6 to the irradiation luminosity is determined and the sample is analyzed optically. When a common irradiation system is employed and the output from detection means is selected, a plurality of optical analyses can be carried out using a single optical analyzer.

9. 发明专利

JP2002336678A LIQUID TRANSFERRING CONTAINER 失效
公开(公告)号：JP2002336678A
公开(公告)日：2002-11-26
申请号：JP2001141450
申请日：2001-05-11
申请人： SHIMADZU CORP
发明人： KACHI TORU
IPC分类号： G01N1/00 , B01D57/02 , B01J4/00 , B03C5/00 , C12M1/00 , G01N1/10 , G01N27/447
摘要： PROBLEM TO BE SOLVED: To provide a liquid transferring container by which a very small amount of a solution can be handled. SOLUTION: The negatively charged objective substance contained in a liquid sample S is made to flow into a slender tube 1 by charging an electrode 2 in the tube 1 positively and an electrode 6 in a container A negatively in such a state that the tube 1 is soaked in the sample S since the objective substance has the negative polarity. The objective substance-sucked tube 1 is inserted in another container B, the polarity of the electrode 2 is reversed to charge the electrode 2 negatively and the electrode 6' in the container B is charged positively. As a result, the sample S in the tube 1 is discharged into the container B since the objective substance is charged negatively.

10. 发明专利

JPH10232191A SOIL-SOLUTION SAMPLING DEVICE 失效
公开(公告)号：JPH10232191A
公开(公告)日：1998-09-02
申请号：JP3642397
申请日：1997-02-20
申请人： SHIMADZU CORP , FUJIWARA MFG CO LTD
发明人： KACHI TORU , MIHARA MASAYUKI
IPC分类号： G01N1/14 , G01N33/24
摘要： PROBLEM TO BE SOLVED: To provide a soil-solution sampling device, which can sample the solution of soil under the specified conditions regardless of the moisture content of the soil without disturbing the soil. SOLUTION: This is the device, which performs the sampling without disturbing soil by sucking the soil solution that is the moisture contained in the soil. By supplying the moisture into the soil by a water injecting means 2, the state, under which the sucking of the soil solution can be sucked, is obtained. The sampling of the moisture content under the specified conditions, can be performed by the measuring of the moisture content of the soil by a moisture- content measuring device 4. In this way, even when the moisture content is different by the differences of the sampling position and time, the sampling of the soil solution can be performed under the specified moisture-content conditions.

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