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1. 发明专利

JP2005290383A 6-o-sulfated n-acetylheparosan and auxiliary of hematopoietic cell proliferation 审中-公开
标题翻译： 6-O-硫代氨基乙酸和辅助细胞增殖
公开(公告)号：JP2005290383A
公开(公告)日：2005-10-20
申请号：JP2005107760
申请日：2005-04-04
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KARIYA YUTAKA , KIYOUGASHIMA MAMORU , SUZUKI KIYOSHI , YASUDA YOSUKE
IPC分类号： A61K35/12 , A61K35/28 , A61P7/00 , A61P35/02 , C08B37/00 , C08B37/10 , C12N5/07 , C12N5/074 , C12N5/0775 , C12N5/0789 , C12N5/06
CPC分类号： C08B37/0063 , A61K2035/124 , C08B37/0075 , C12N5/0647 , C12N2501/21 , C12N2501/23 , C12N2501/91
摘要： PROBLEM TO BE SOLVED: To provide a material having excellent ability for proliferating a hematopoietic cell, being an analogue of heparan sulfate hardly providing a risk of pollution by a pathogenic virus or a prion protein, and capable of substituting an N-desulfated N-reacetylated heparin known to have such activities. SOLUTION: The 6-O-sulfated N-acetylheparosan is obtained by sulfating a primary hydroxy group of N-acetylglucosamine constituting N-acetylheparosan. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种具有优异的造血细胞增殖能力的材料，作为几乎不具有病原体病毒或朊病毒蛋白污染风险的硫酸乙酰肝素类似物，并能够代替N-脱硫酸已知具有这种活性的N-再乙酰化肝素。解决方案：通过硫化构成N-乙酰基鸟嘌呤的N-乙酰氨基葡萄糖的伯羟基来获得6-O-硫酸化的N-乙酰基鸟嘌呤。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005172440A Detection method of purkinje cell and detection kit 审中-公开
标题翻译：胰腺细胞和检测试剂盒的检测方法
公开(公告)号：JP2005172440A
公开(公告)日：2005-06-30
申请号：JP2003408435
申请日：2003-12-08
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KIYOUGASHIMA MAMORU , TAKAHASHI HIBIKI , AKIYOSHI JUNKO
IPC分类号： G01N33/53 , C12Q1/04
摘要： PROBLEM TO BE SOLVED: To provide a method for specifically detecting a Purkinje cell simply, rapidly and inexpensively, and a detection kit using it. SOLUTION: This detection method of the Purkinje cell includes at least a step for immunologically dyeing animal tissue using an anti-prion antibody and the detection kit of the Purkinje cell includes the anti-prion antibody as a constituent. The anti-prion antibody is preferably IgG and one refined as IgG is preferable and one bonded to prion originating from a chicken is preferable. Further, it is preferable to further include a step for treating animal tissue becoming an immunological dyeing object in an autoclave before immunological dyeing. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供简单，快速和廉价地特异性检测浦肯野细胞的方法和使用它的检测试剂盒。解决方案：浦肯野细胞的这种检测方法至少包括使用抗朊病毒抗体免疫染色动物组织的步骤，浦肯野细胞的检测试剂盒包括抗朊病毒抗体作为组分。抗朊病毒抗体优选为IgG，优选为IgG的精制，优选与来自鸡的朊病毒结合的抗体。此外，优选进一步包括在免疫染色之前在高压釜中治疗成为免疫染色对象的动物组织的步骤。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004002236A Method for producing partially desulfurized n-acetyllactosamine oligosaccharide 有权
公开(公告)号：JP2004002236A
公开(公告)日：2004-01-08
申请号：JP2002160419
申请日：2002-05-31
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KARIYA YUTAKA , KIYOUGASHIMA MAMORU , MOCHIZUKI HIDEO
IPC分类号： C07H11/00
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing a partially desulfurized N-acetyllactosamine oligosaccharide at a low cost.
SOLUTION: This method for producing the partially desulfurized N-acetyllactosamine oligosaccharide is characterized by treating an N-acetyllactosamine oligosaccharide containing at least one sulfurized N-acetyllactosamine unit obtained by sulfurizing all of the primary hydroxy groups of galactose residues and N-acetylglucosamine residues with an inorganic acid and an alcohol, thereby selectively eliminating the sulfate groups bound to the galactose residues without eliminating the sulfate groups bound to the N-acetylglucosamine.
COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2005255678A Allergic disease treating agent 有权
标题翻译：过敏性疾病治疗剂
公开(公告)号：JP2005255678A
公开(公告)日：2005-09-22
申请号：JP2005035232
申请日：2005-02-10
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： TSUKASA TAKAHIRO , MAEDA HIROSHI , GOTO YUKIO , MASUDA HIROYUKI , KIYOUGASHIMA MAMORU
IPC分类号： A61K31/737 , A61P17/00 , A61P37/08 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To obtain an allergic disease treating agent applicable even to patients sensitive to external irritations, slight in irritancy and good in feeling in use.
SOLUTION: This allergic disease treating agent comprises, as active ingredient, a galactosaminoglycan containing 20-100 mol% of 2-acetamido-2-deoxy-3-O-(4-deoxy-α-L-threo-hexy-pyranosyluronic acid)-4,6-bis-O-sulfo-D-galactose units or a pharmacologically acceptable salt of the galactosaminoglycan.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了获得适用于对外部刺激敏感的患者的过敏性疾病治疗剂，轻微的刺激性和使用感觉良好。解决方案：该过敏性疾病治疗剂包含含有20-100摩尔％的2-乙酰氨基-2-脱氧-3-O-（4-脱氧-α-L-苏式 - 羟基 - 吡喃糖醛酸）-4,6-双-O-磺基-D-半乳糖单元或半乳糖聚糖的药理学上可接受的盐。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2004051579A Synthetic promoter of hyaluronic acid 有权
公开(公告)号：JP2004051579A
公开(公告)日：2004-02-19
申请号：JP2002213044
申请日：2002-07-22
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： ONUKI YOJI , KIMATA HIROHARU , ITANO NAOKI , MINAMIZAWA TOSHIKAZU , SUZUKI KIYOSHI , KIYOUGASHIMA MAMORU
IPC分类号： C07H15/18 , A61K31/7028 , A61P15/06 , A61P19/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an agent for promoting biosynthesis of hyaluronic acid by promoting activity of synthetic promoter of hyaluronic acid.
SOLUTION: The synthetic promoter of hyaluronic acid comprises an N-acetyl-D-glucosamine-containing sugar benzyl derivative represented by formula (1) [wherein Ac is an acetyl group; R
1 is H, a monosaccharide residue or a polysaccharide residue; X is O, S, NH or CH
2 ; R
2 is H or a substituent group (a halogen atom, a hydroxy group, a nitro group, a sulfuric acid group, an alkyl group or an acyl group) of a benzene ring].
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2004018390A Granulocyte-macrophage colony-stimulating factor secretagogue 有权
公开(公告)号：JP2004018390A
公开(公告)日：2004-01-22
申请号：JP2002171373
申请日：2002-06-12
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： SAKAI TOKIKO , NAITO YUKIHISA , KIYOUGASHIMA MAMORU
IPC分类号： A61K31/737 , A61P7/00 , A61P7/06 , A61P35/00 , A61P35/02 , A61P43/00 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To provide a new granulocyte-macrophage colony-stimulating factor secretagogue promoting secretion of the granulocyte-macrophage colony-stimulating factor for a cell or a tissue and highly safe even when contaminated in vivo.
SOLUTION: The granulocyte-macrophage colony-stimulating factor comprises chondroitin sulfate satisfying the relationship of n/N≥0.3 between the total number N of disaccharide units in the basic skeleton and the total number n of the disaccharide units represented by formula (1) in the basic skeleton or its pharmacologically acceptable salt.
COPYRIGHT: (C)2004,JPO

7. 发明专利

JPH09169664A AGENT HAVING DIFFERENTIATION INDUCING ACTION 失效
公开(公告)号：JPH09169664A
公开(公告)日：1997-06-30
申请号：JP35457595
申请日：1995-12-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： INOKUCHI JINICHI , NOJIRI HISAO , KIYOUGASHIMA MAMORU
IPC分类号： C07D295/12 , A61K31/5375 , A61K35/12 , A61K35/14 , A61K45/00 , A61P35/00 , A61P43/00 , C07D295/125
摘要： PROBLEM TO BE SOLVED: To provide the subject agent containing glycosphingolipid biosynthesis inhibitor as an active component and capable of restoring a cell to normal state in various diseases caused by the abnormal proliferation of undifferentiated cell. SOLUTION: This agent contains a glycosphingolipid biosynthesis inhibitor, preferably a 2-acylaminopropanol derivative of the formula [R is a (substituted) phenyl; (n) is 1-16] or its pharmacologically allowable salt, e.g. 1-phenyl-2- decanoylamino-3-morpholino-1-propanol as an active component. The agent is administered in the form of e.g. oral drug, injection, rectal infusion or skin agent for external use at a daily dose of 0.5-100mg/kg in one or several divided doses.

8. 发明专利

JP2001187740A VULNERARY AGENT 失效
公开(公告)号：JP2001187740A
公开(公告)日：2001-07-10
申请号：JP2000005305
申请日：2000-01-05
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KIYOUGASHIMA MAMORU , HORI YUSUKE , SAKAI TOKIKO
IPC分类号： A61K31/726 , A61P17/02 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To provide a vulnerary agent that can effectively heal the damages on the skin and surface tissues, particularly burning, skin ulcers, wounds that have not been sufficiently recovered with conventional therapy or therapeutic agents without serious side effects. SOLUTION: The objective vulnerary agent comprises, as active ingredients, a specific uronic acid composition, chondroitinase B of about 40-100 wt.% digestibility, a disaccharide type galactosaminoglycan or the pharmaceutically acceptable salt thereof.

9. 发明专利

JPH10324633A BLOOD COAGULATION ACCELERANT 失效
公开(公告)号：JPH10324633A
公开(公告)日：1998-12-08
申请号：JP13192797
申请日：1997-05-22
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KIYOUGASHIMA MAMORU , MEYA JUNICHI , HORIE KATSUYUKI
IPC分类号： A61K31/715 , A61K38/00 , A61P7/00 , A61P7/04
摘要： PROBLEM TO BE SOLVED: To obtain a blood coagulation accelerant that contains sulfated lipid, as an active ingredient, promotes blood coagulation at the traumatic or subcutaneous bleeding sites or at an arbitrary site desirably to be clotted. SOLUTION: A sulfated lipid (preferably sulfated glycolipid because of its strength of blood coagulation and low antigenicity, for example, sulfated sphingoglycolipid as sulfated galactosylceramide monosulfate, sulfated glyceroglycolipid as galactosylalkylacylgrlycerol monosulfate) is used as an active ingredient to prepare a topical blood coagulation accelerant for topical application. When it is used as a hemostatic agent, it is given in the form of powder or liquid and directly sprinkled to the bleeding-halting site. In the case that it is used as a vascular occlusion, it is administered to the site to be clotted by using a vascular injector in an amount of 5-20 ml for 10-120 minutes. When it is used in the form of a liquid, the sulfated lipid or its salt is dissolved or dispersed in a solvent as physiological salt solution or glycerol in an amount of 0.01-50 mg/ml.

10. 发明专利

JP2003252906A SULFATED FUCOBIOSYLCHONDROITIN SULFATE DERIVATIVE 审中-公开
公开(公告)号：JP2003252906A
公开(公告)日：2003-09-10
申请号：JP2002055053
申请日：2002-02-28
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KARIYA YUTAKA , SAKAI TOKIKO , KANEKO TAKATSUGU , KIYOUGASHIMA MAMORU
IPC分类号： A61K31/737 , A61P7/02 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To provide a new chondroitin sulfate derivative having a hyperfibrinolysis effect. SOLUTION: The provided chondroitin sulfate derivative is a sulfated fucobiosylchondroitin sulfate having a sulfated fucobiosyl group side chain in a part of its molecule to properly show the hyperfibrinolysis effect. COPYRIGHT: (C)2003,JPO

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