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1. 发明专利

JPS62257901A PRODUCTION OF HYALURONIC ACID 失效
公开(公告)号：JPS62257901A
公开(公告)日：1987-11-10
申请号：JP10110886
申请日：1986-05-02
申请人： SEIKAGAKU KOGYO CO LTD
发明人： MORIKAWA KIYOSHI , HAMAI AKIO , HORIE KATSUYUKI
IPC分类号： C08B37/08 , C12P19/26 , C12R1/46
摘要： PURPOSE:To obtain in high yield hyaluronic acid having outstanding therapeutic effect in such fields as ophthalmology and dermatology, by incorporating a culture medium with glucosamine, pyruvic acid and/or acetoin when hyaluronic acid-producing bacteria are cultured in a carbohydrate-contg. medium. CONSTITUTION:The objective hyaluronic acid can be obtained by culturing, in a carbohydrate-contg. medium (e.g. with a pH 7.5 containing 0.50% of yeast extract, 0.75% of peptone, 0.02% of sodium sulfite, and 1-3% of glucose), hyaluronic acid-producing bacteria [e.g. Streptococcus zooepidemicus strain No.60001 (Fermentation Research Institute No.8673), Streptococcus zooepidemicus strain No.60019 (Fermentation Research Institute No.8674)] in such a manner that, for example, in case 1-3% glucose-added medium is used, said medium is incorporated with normally 0.5-2.0%, 0.5-2.0% and/or 0.125-0.5% of glucosamine or its salt, pyruvic acid or its salt, and/or acetoin, respectively.

2. 发明专利

JP2005338064A Joint information determining method and method for discriminating normal joint from pathologic joint 有权
标题翻译：联合信息确定方法和方法从病理学联合中分离正常关节
公开(公告)号：JP2005338064A
公开(公告)日：2005-12-08
申请号：JP2005118281
申请日：2005-04-15
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , HORIE KATSUYUKI
IPC分类号： G01N33/53 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a method and a kit for determining joint information.
SOLUTION: In the joint information determining method, information on the amount of normal aglycan and the amount of whole proteoglycan in a specimen is compared with these amounts in synovial fluid derived from a normal joint, to determine whether the information belongs to pathologic joints or to normal joints, on the basis of the presence or absence of a significant difference. The kit for determining joint information includes reagents A-C of the following constitution. A is a reagent for dissolving or removing hyaluronic acid, combined with normal aglycan in the specimen or free hyaluronic acid. B is a solid phase for specifically combining or adsorbing normal aglycan. C is a reagent for detecting normal aglycan, combined with or adsorbed by the solid phase B.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于确定联合信息的方法和工具包。解决方案：在联合信息确定方法中，将来自标准关节的滑液中正常糖苷配基的量和整个蛋白多糖的量的信息与这些量进行比较，以确定信息是否属于病理学关节或正常关节，基于存在或不存在显着性差异。用于确定联合信息的试剂盒包括以下构成的试剂A-C。 A是用于溶解或除去透明质酸的试剂，与样品中的正常糖苷配基或游离透明质酸结合。 B是用于特异性结合或吸附正常糖苷配基的固相。 C是用于检测与固相B结合或吸附的正常糖苷配基的试剂。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JPH01290631A AGENT FOR SUPPRESSING PROLIFERATION OF VASCULAR ENDOTHELIAL CELL 失效
公开(公告)号：JPH01290631A
公开(公告)日：1989-11-22
申请号：JP11927488
申请日：1988-05-18
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HORIE KATSUYUKI , MATSUBARA TSUKASA , TOKUYASU KIYOCHIKA
IPC分类号： A61K31/715 , A61P29/00 , A61P35/00 , A61P43/00
摘要： PURPOSE:To obtain an agent for suppressing the proliferation of vascular endothelial cell, having suppressing action to the proliferation of vascular endothelial cell and useful for the treatment of malignant tumor, etc., by using hyaluronic acid or its salt having a specific molecular weight as an active component. CONSTITUTION:Hyaluronic acid or its salt (e.g. sodium salt or potassium salt) having a molecular weight of 50,000-3,000,000 is used as an active component. The molecular weight of the hyaluronic acid or its salt is preferably 500,000-1,800,000. The dose is preferably 0.2-5mg daily for adult in the case of using as an instillation. In the case of using the agent as an injection, it is preferably administered at a rate of 25-250mg of the active component per dose by single injection or by dripping. The hyaluronic acid having a molecular weight of 50,000-3,000,000 can be produced by subjecting a chicken comb to digestion with protease, precipitation with cetylpyridinium chloride and fractionation with ethanol.

4. 发明专利

JPS6344883A NOVEL HYALURONIDASE SD-678 AND PRODUCTION THEREOF 失效
公开(公告)号：JPS6344883A
公开(公告)日：1988-02-25
申请号：JP18861286
申请日：1986-08-13
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HAMAI AKIO , MORIKAWA KIYOSHI , HORIE KATSUYUKI
IPC分类号： C12N9/26 , C12R1/46
摘要： PURPOSE:To separate and collect novel hyaluronidase SD-678 from a culture mixture, by cultivating Streptococcus dysgalactiae or a variant thereof to give the culture mixture. CONSTITUTION:Streptococcus dysgalactia or a variant thereof is subjected to spinner culture in a liquid medium. A carbon source, nitrogen source, inorganic salt, etc., which Streptococcus dysgalactiae, etc., can use may be utilized as the nutrient source and addition of hyaluronic acid, chondroitin, etc., as hyaluronidase SD-678 inducer to the medium can raise productivity. Addition of a reducing agent is not preferable. The mold is removed from the culture mixture and hyaluronidase SD-678 is obtained by ordinary purification of enzyme. The substance has 5.8-6.6 optimum pH and 37 deg.C optimum temperature, decomposes hyaluronic acid but not chondroitin sulfuric acid, etc., and is inhibited with Fe , Cu , etc.

5. 发明专利

JPS6121241B2 JPS6121241B2 - 失效
公开(公告)号：JPS6121241B2
公开(公告)日：1986-05-26
申请号：JP14650878
申请日：1978-11-29
申请人： Seikagaku Kogyo Co Ltd
发明人： HAMAI AKIO , HORIE KATSUYUKI , YAMAGUCHI TOSHIJIRO
IPC分类号： C08B37/08 , C12P19/04

6. 发明专利

JPS5574796A SEPARATION OF ACIDIC POLYSACCHARIDES 失效
公开(公告)号：JPS5574796A
公开(公告)日：1980-06-05
申请号：JP14650878
申请日：1978-11-29
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HAMAI AKIO , HORIE KATSUYUKI , YAMAGUCHI TOSHIJIROU
IPC分类号： C08B37/08 , C12P19/04
摘要： PURPOSE:To separate hyaluronic acid and chondroitin sulfate from animal tissue, easily, in high yield, by heating the animal tissue in a solution of a quaternary ammonium salt, and treating with protease to separate hyaluronic acid, and then treating the residue with a salt solution to obtain chondroitin sulfate. CONSTITUTION:Animal tissue such as cockscombs, naval cords, skin, etc. is heated in an aqueous solution of a quaternary ammonium slat, cut to pieces, added with water, and treated with protease. The treated solution is filtered to concentrate hyaluronic acid in the filtrate (solution A). The residue is treated with a solution of a salt such as NaCl or of an alkali such as NaOH, to collect chondroitin sulfate in the filtrate (solution B). The hyaluronic acid and the chondroitin sulfate are precipitated by adding an alcohol to the solutions A and B.

7. 发明专利

JPH10324633A BLOOD COAGULATION ACCELERANT 失效
公开(公告)号：JPH10324633A
公开(公告)日：1998-12-08
申请号：JP13192797
申请日：1997-05-22
申请人： SEIKAGAKU KOGYO CO LTD
发明人： KIYOUGASHIMA MAMORU , MEYA JUNICHI , HORIE KATSUYUKI
IPC分类号： A61K31/715 , A61K38/00 , A61P7/00 , A61P7/04
摘要： PROBLEM TO BE SOLVED: To obtain a blood coagulation accelerant that contains sulfated lipid, as an active ingredient, promotes blood coagulation at the traumatic or subcutaneous bleeding sites or at an arbitrary site desirably to be clotted. SOLUTION: A sulfated lipid (preferably sulfated glycolipid because of its strength of blood coagulation and low antigenicity, for example, sulfated sphingoglycolipid as sulfated galactosylceramide monosulfate, sulfated glyceroglycolipid as galactosylalkylacylgrlycerol monosulfate) is used as an active ingredient to prepare a topical blood coagulation accelerant for topical application. When it is used as a hemostatic agent, it is given in the form of powder or liquid and directly sprinkled to the bleeding-halting site. In the case that it is used as a vascular occlusion, it is administered to the site to be clotted by using a vascular injector in an amount of 5-20 ml for 10-120 minutes. When it is used in the form of a liquid, the sulfated lipid or its salt is dissolved or dispersed in a solvent as physiological salt solution or glycerol in an amount of 0.01-50 mg/ml.

8. 发明专利

JPH0630603B2 失效
公开(公告)号：JPH0630603B2
公开(公告)日：1994-04-27
申请号：JP10110886
申请日：1986-05-02
申请人： SEIKAGAKU KOGYO CO LTD
发明人： MORIKAWA KYOSHI , HAMAI AKIO , HORIE KATSUYUKI
IPC分类号： C08B37/08 , C12P19/26 , C12R1/46

9. 发明专利

JPH04330280A STABILIZED CHONDROITINASE ABC, ITS PRESERVATION AND TREATING AGENT 失效
公开(公告)号：JPH04330280A
公开(公告)日：1992-11-18
申请号：JP12538591
申请日：1991-04-26
申请人： SEIKAGAKU KOGYO CO LTD
发明人： HAMAI AKIO , SEKIGUCHI KAZUHIRO , HORIE KATSUYUKI
IPC分类号： A61K38/46 , A61K38/51 , A61P43/00 , C12N9/96
摘要： PURPOSE:To provide a dried and stabilized chondroitinase ABC added with a specific additive component, effective for preventing the lowering of the activity in lyophilizing process, having improved storage stability and useful as an active component for an agent for the treatment of disk herniation. CONSTITUTION:The objective enzyme contains an additive component selected from dextrans, saccharose, lactose, maltose, mannitol, xylitol, sorbitol and serum albumin. It can be prepared by mixing the above additive components with chondroitinase ABC and lyophilizing an aqueous medium solution of the obtained mixture.

10. 发明专利

JPH0456805B2 失效
公开(公告)号：JPH0456805B2
公开(公告)日：1992-09-09
申请号：JP11828384
申请日：1984-06-11
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SAKURAI KATSUKYO , HORIE KATSUYUKI , SAKAMOTO TAKASHI , OKUYAMA TAKASHI
IPC分类号： C08B37/08 , A61K31/715 , A61P35/00 , C08B37/00

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