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    • 9. 发明专利
    • PREPARATION OF 2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINE
    • JPS5711968A
    • 1982-01-21
    • JP8735380
    • 1980-06-26
    • SUMITOMO CHEMICAL CO
    • KOJIMA TAKASHIYAMAKA ETSUONAGASAKI HIDEO
    • C07D215/06
    • PURPOSE:To obtain the titled substance in high yield, by condensing aniline with an acetone in the presence of an acidic catalyst, distilling away the titled substance and substances having lower boiling points than the titled substance, and reusing the resultant distillation residue as the acidic catalyst for the reaction described above. CONSTITUTION:Aniline is condensed with an acetone in the presence of a nonvolatile acidic catalyst, e.g. a sulfonic acid, and the titled substance and substances, e.g. the unreacted aniline, having lower boiling points than the titled substance are distilled away. The resultant residue containing the active catalyst is directly used as the acidic catalyst in the next condensing reaction. The distillation residue is a brown to dark brown tarry substance obtained after distilling most of the substances described above from the reaction product at a temperature in the range of 100- 300 deg.C, and usable as the catalyst 4-5 times. However, the activity is lost gradually, and a small amount of the catalyst is preferably added to keep the reaction rate. EFFECT:Reduced residues formed as a by-product and simplified steps for removing the catalyst.