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1. 发明专利

JP2557241B2 失效
公开(公告)号：JP2557241B2
公开(公告)日：1996-11-27
申请号：JP32356987
申请日：1987-12-21
申请人： SNOW BRAND MILK PROD CO LTD
发明人： MORIKAWA YOSHIHIRO , NAKAMURA TETSUJI , TAKASU EMIKO , SOGO YUKIO , AHIKO KENKICHI , SHUTSUKE SAKANORI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/49 , A61K8/60 , A61K8/64 , A61K8/73 , A61K31/70 , A61P17/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48

2. 发明专利

JPH0566397B2 失效
公开(公告)号：JPH0566397B2
公开(公告)日：1993-09-21
申请号：JP26640184
申请日：1984-12-19
申请人： SNOW BRAND MILK PROD CO LTD
发明人： KAWAKAMI HIROSHI , NIIMOTO YOJI , DOSEMARI SHUNICHI , AHIKO KENKICHI
IPC分类号： C12N15/02 , A61K38/00 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/79 , C07K16/18 , C12P21/08 , C07K15/06 , C07K3/18 , C07K15/22

3. 发明专利

JPH0212467B2 失效
公开(公告)号：JPH0212467B2
公开(公告)日：1990-03-20
申请号：JP18434082
申请日：1982-10-20
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YOSHIDA HARUHIKO , AHIKO KENKICHI
IPC分类号： C07C309/14 , C07C67/00 , C07C301/00 , C07C303/44 , C07C309/45

4. 发明专利

JPH01163114A HAIR TONIC 失效
公开(公告)号：JPH01163114A
公开(公告)日：1989-06-27
申请号：JP32357087
申请日：1987-12-21
申请人： SHISEIDO CO LTD , SNOW BRAND MILK PROD CO LTD
发明人： MORIKAWA YOSHIHIRO , NAKAMURA TETSUJI , TAKASU EMIKO , SOGO YUKIO , AHIKO KENKICHI , SHUKKE SAKANORI
IPC分类号： A61K8/00 , A61K8/11 , A61K8/60 , A61K8/64 , A61K8/73 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To provide a safe hair tonic exhibiting excellent effect in promoting hair growth, preventing falling-off of hair and suppressing dandruff and itchiness and containing one or more compounds selected from sialic acid and its derivative having excellent hair-tonic effect. CONSTITUTION:The objective hair tonic contains one or more compounds selected from sialic acid (preferably N-acetylneuraminic acid) and sialic acid derivative (preferably oligosaccharide bonded with sialic acid, protein bonded with sialic acid, lipid bonded with sialic acid or sialic acid salt). The sialic acid and its derivative are produced by extracting a milk raw material from the viewpoint of economy.

5. 发明专利

JPS61172823A PRODUCTION OF HUMAN IGA SECRETION CELL 失效
公开(公告)号：JPS61172823A
公开(公告)日：1986-08-04
申请号：JP1507985
申请日：1985-01-29
申请人： SNOW BRAND MILK PROD CO LTD
发明人： NIIMOTO YOJI , KAWAKAMI HIROSHI , DOUSEMARI SHIYUNICHI , AHIKO KENKICHI
IPC分类号： A61K38/16 , A61K35/12 , A61K35/17 , A61K35/20 , A61K35/26 , A61K38/17
摘要： PURPOSE:To produce human IgA secretion cell in high efficiency, by culturing human lymphocyte B in human milk or a medium containing a human milk component. CONSTITUTION:A human lymphocyte B, preferably prepared by removing T cell and macrophage from the lymphocyte separated from peripheral blood, tonsil, spleen, etc., and stimulating and activating the lymphocyte with Staphylococcus aureus Cowan Istrain, is cultured in human milk or a medium containing 1-10% human milk component (fraction precipitated by saturated ammonium sulfate or fraction having a molecular weight of 60,000-90,000 and obtained by the fractionation with a gel-filtration carrier or with an ultra-fitlration membrane) at about 37 deg.C for about 3 days to effect the differentiation and induction of the lymphocyte to the objective IgA secretion cell.

6. 发明专利

JPS60243038A PREPARATION OF CONCENTRATED NATURAL VITAMIN K 失效
公开(公告)号：JPS60243038A
公开(公告)日：1985-12-03
申请号：JP9825084
申请日：1984-05-16
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YAHIRO MASATOSHI , MURAKAMI YUUJI , AHIKO KENKICHI , SATOU TAKAYOSHI , ASAI YOSHITERU , MATSUURA NORIO
IPC分类号： C07C46/10 , A61K36/00 , A61K36/48 , C07C45/00 , C07C50/14 , C07C67/00
摘要： PURPOSE:To obtain the titled concentrate suitable for enriching a food with vitamin K, by using deodorized scum of vegetable oil as the natural material rich in vitamin K, subjecting the material to molecular distillation, and purifying the obtained fraction by column chromatography. CONSTITUTION:A vegetable oil containing vitamin K, especially the deodorized distillate produced as a by-product of the purification process of a vegetable oil or soybean oil, is subjected to molecular distillation to remove the neutral fat, free fatty acid, pigment, and odor component existing in the scum. The obtained fraction is purified by column chromatography to obtain concentrated natural vitamin K. The yield can be further improved by carrying out the molecular distillation in two stages. As an alternative method, the concentrated vitamin K can be produced by removing sterol from the fraction obtained by the molecular distillation of the deodorized scum. USE:Processed powdery milk, special milk for medical use, and natural vitamin K enriching agent to be administered to a nursing woman.

7. 发明专利

JPS602163A COPPER-ENRICHING AGENT BONDED WITH PEPTIDE AND ITS PREPARATION 失效
公开(公告)号：JPS602163A
公开(公告)日：1985-01-08
申请号：JP10898983
申请日：1983-06-17
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YAHIRO MASATOSHI , MURAKAMI YUUJI , AHIKO KENKICHI
IPC分类号： A23L1/304 , A23L1/305
摘要： PURPOSE:To prepare the titled nutrient agent suitable as an additive of artificial milk, special milk for the remedy of hypocupremia nutrient agent for transintestinal administration, etc., by adding a copper salt to an aqueous solution of whey protein, and hydrolyzing the resultant adduct of whey protein and copper with a proteinase. CONSTITUTION:A 5-20% aqueous solution of concentrated whey protein (having a protein content of 35-80wt%) is added with an aqueous solution of a copper salt (e.g. cupric sulfate) containing 10-100mg of copper per 1 gram of the protein, and the obtained aqueous mixture is stirred keeping its pH at preferably 8-9 with sodium hydroxide, etc. to bond the whey protein with copper. The reaction mixture is subjected to the ultrafiltration or dialysis to remove the unreacted salts and ions, and then the filtrate, etc. is pulverized optionally after drying. A copper-enriching agent bonded with peptide can be obtained by this process.

8. 发明专利

JPS5991848A FRACTIONATION OF CASEIN 失效
公开(公告)号：JPS5991848A
公开(公告)日：1984-05-26
申请号：JP20237082
申请日：1982-11-18
申请人： SNOW BRAND MILK PROD CO LTD
发明人： DOUSAKO SHIYUNICHI , AHIKO KENKICHI
IPC分类号： A23C11/00 , A23C20/00 , A23J1/20 , C07K1/16 , C07K1/34 , C07K14/00
摘要： PURPOSE:To separate a whole casein into a fraction composed of kappa-casein and a faction composed of alphas-and beta-caseins, easily by dissolving the whole casein in a deionized water or in a specific buffer solution, and subjecting the solution to gel-filtration or ultrafiltration. CONSTITUTION:Whole casein obtained by adjusting an acidic casein to about 7 pH and dissolving again, is dissolved in deionized water or a buffer solution having a univalent salt concentration of =100,000 to obtain a fraction composed mainly of kappa-casein and a fraction composed mainly of alphas-and beta-caseins.

9. 发明专利

JPS5973561A Preparation of natural taurine 失效
标题翻译：天然陶瓷的制备
公开(公告)号：JPS5973561A
公开(公告)日：1984-04-25
申请号：JP18434082
申请日：1982-10-20
申请人： Snow Brand Milk Prod Co Ltd
发明人： YOSHIDA HARUHIKO , AHIKO KENKICHI
IPC分类号： C07C309/14 , C07C67/00 , C07C301/00 , C07C303/44 , C07C309/45
摘要： PURPOSE: To obtain high-purity taurine relatively inexpensively, by subjecting a water-soluble division of a taurine-containing aquatic animal, wherein highly cencentrated salt coexists, to electrophoresis so that it is desalted, passing it through an anion exchange resin so that taurine is adsorbed on it.
CONSTITUTION: A water-soluble division of taurine-containing aquatic animal (e.g., octopus, cuttlefish, oyster, scallop, etc.), wherein highly concentrated salt exists, is subjected to electrophoresis in order to remve chlorine ion mainly, so that it is desalted, it is then passed through an anion exchange resin of OH type, hydrogencarbonate type, or F type, so that taurine is adsorbed on the resin. Adsorbed taurine is washed with water, eluted with an alkali solution, acidic solution, or a neutral salt solution, and cooled. A water-soluble organic solvent is added to the eluted solution, to give the desired substance.
USE: Promoting secretion of bile, improving absorption of fats, having perspiration suppressing action, anticonvulsive action, antihypertensive action, etc. Being added to various kinds of drinks and foods and used.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：为了更廉价地获得高纯度牛磺酸，通过使其中高度浓度的盐共存的含有牛磺酸的水生动物的水溶性部分进行电泳，使其脱盐，使其通过阴离子交换树脂，使得牛磺酸被吸附在其上。构成：主要对氯离子主要进行电泳，对含有高浓度盐的牛磺酸水生动物（如章鱼，墨鱼，牡蛎，扇贝等）进行电泳，脱盐，然后通过OH型，碳酸氢盐型或F型的阴离子交换树脂，使得牛磺酸被吸附在树脂上。用水洗涤吸附的牛磺酸，用碱溶液，酸性溶液或中性盐溶液洗脱，并冷却。向洗脱的溶液中加入水溶性有机溶剂，得到所需物质。用途：促进胆汁分泌，改善脂肪吸收，排汗抑制作用，抗惊厥作用，抗高血压作用等。加入各种饮料和食品中使用。

10. 发明专利

JPS58174232A POLYPEPTIDE EMULSIFIER 失效
公开(公告)号：JPS58174232A
公开(公告)日：1983-10-13
申请号：JP2859482
申请日：1982-02-24
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YAMAUCHI KUNIO , KAMINOGAWA SHIYUUICHI , SHIMIZU MAKOTO , TAKAHASHI TAKESHI , AHIKO KENKICHI , KAKO MASATOSHI , KIMURA TOSHIAKI , DOUSAKO SHIYUNICHI
IPC分类号： A23L1/00 , A23L29/10 , B01F17/30
摘要： PURPOSE:To obtain an emulsifier having emulsification stability without spoling the waste of the emulsion product and without any drawback in nutrition by constituting the same of 5-50 pieces of amino acids obtd. by acting proteolytic enzyme on total casein. CONSTITUTION:A polypeptide emulsifier is constituted of 5-50 pieces of amino acids obtd. by acting proteolytic enzyme (e.g.; chymosin) on alphaS-casein and/or beta- casein. THe conditions for acting the proteolytic enzyme on the starting raw material vary largely with the kinds of the enzyme used; in general, in the case of the alphaS-casein, the enzyme is acted on the casein of 0.1-20wt% concn. for one minute- one week at 1/2-1/50,000 enzyme concn. based on the concn. of the casein, 2-12pH and 3-60 deg.C reaction temp. Techniques such as gel filtration, ion exchange chromatography, electrophoresis for sepn., or the like are applied for separating the intended polypeptide from the reaction mixture obtd. by the above-mentioned enzyme decomposition.

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