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1. 发明专利

JPH1132799A ASSAY OF NUCLEIC ACID AND REAGENT THEREFOR 失效
公开(公告)号：JPH1132799A
公开(公告)日：1999-02-09
申请号：JP19282497
申请日：1997-07-17
申请人： SHISEIDO CO LTD
发明人： SHIBATA MICHIO , INOUE KAORI , ITAGAKI HIROSHI , ICHIKAWA HIDEYUKI
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To assess skin irritancy by using each specific primer and probe to assay nucleic acid coding for interleukin-6 and TNF-α involved in allergy onset. SOLUTION: Using oligonucleotides hybridizable with the respective nucleotide regions 36-55, 208-226 and 166-190 of a nucleic acid coding for interleukin-6 as primer, primer and probe, respectively, mRNA or cDNA coding for interleukin-6 is assayed. Whereas, using oligonucleotides (composed of 15-35 nucleotides) hybridizable with the respective nucleotide regions 848-867, 1,055-1,075 and 1,027-1,052 of a nucleic acid coding for TNF-α as primer, primer and probe, respectively, mRNA or cDNA coding for TNF-αis assayed. In the above assays, a PCR is conducted using a DNA polymerase having 5'-3' exonuclease activity.

2. 发明专利

JP2012193172A Transparent or translucent oil-in-water emulsified cosmetic 有权
标题翻译：透明或透明的水包油化妆品
公开(公告)号：JP2012193172A
公开(公告)日：2012-10-11
申请号：JP2012040755
申请日：2012-02-27
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： UYAMA MAKOTO , MIYAHARA REIJI , INOUE KAORI , KINOSHITA KOICHI
IPC分类号： A61K8/06 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/86 , A61Q19/00
CPC分类号： A61K8/062 , A61K8/345 , A61K8/39 , A61K8/416 , A61K8/86 , A61K2800/21 , A61K2800/262 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an oil-in-water emulsified cosmetic in which transparency or translucency can be maintained by stabilizing a system in which a di-long-chain cationic surfactant is blended, and which can be simply manufactured by a means such as mixing and stirring, regardless of the method of high pressure emulsification or the like.SOLUTION: This transparent or translucent oil-in-water emulsified cosmetic contains (A) 0.1-2 mass% of the di-long-chain cationic surfactant, (B) 0.1-2 mass% of a nonionic surfactant having HLB of 10-18, (C) 0.01-2 mass% of an oil which is liquid at room temperature (25°C), (D) 1-20 mass% of glycols, and (E) water, wherein the blending amount of the (C) component is not more than 0.65 (mass ratio) to the total blending amount of the (A) component and the (B) component. Further, menthol and/or camphor may be contained.
摘要翻译：要解决的问题：提供一种水包油乳化化妆品，其中可以通过使其中混合二长链阳离子表面活性剂的系统稳定来维持透明性或半透明度，并且其可以简单地由无论高压乳化等的方法如何，均可混合搅拌。该透明或半透明的水包油乳化化妆品含有（A）0.1-2质量％的二长链阳离子表面活性剂，（B）0.1-2质量％的具有HLB的非离子表面活性剂 10-18，（C）0.01-2质量％的在室温（25℃）下为液体的油，（D）1-20质量％的二醇和（E）水，其中，（C）成分相对于（A）成分和（B）成分的总混合量不大于0.65（质量比）。此外，可以含有薄荷醇和/或樟脑。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2005263645A Method for inhibiting inflammation and composition for the same 审中-公开
标题翻译：抑制其相互影响的组合物的方法
公开(公告)号：JP2005263645A
公开(公告)日：2005-09-29
申请号：JP2004074638
申请日：2004-03-16
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： INOUE KAORI , DENDA MITSUHIRO , FUJIWARA SHIGEYOSHI
IPC分类号： C12N15/09 , A61K8/00 , A61K8/30 , A61K8/46 , A61K31/185 , A61K31/655 , A61K45/00 , A61P17/16 , A61P29/00 , A61Q19/00 , A61K7/00 , A61K7/48
CPC分类号： A61K31/655 , A61K8/466 , A61K2800/75 , A61Q17/00 , A61Q19/004
摘要： PROBLEM TO BE SOLVED: To provide a means for inhibiting/improving the onset of dermatitis by an outside irritation to begin with ultraviolet light irradiation and drying irritation. SOLUTION: The method and composition for improving inflammation and inhibiting the onset of the same is provided by blocking ATP receptors in cells by effecting an ATP receptor antagonist to inhibit the release of inflammatory cytokinin of the cells, especially interleukin-6 (IL-6) and/or interleukin-8 (IL-8). COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供通过外界刺激来抑制/改善皮炎的发作的手段，以开始紫外线照射和干燥刺激。解决方案：通过阻止ATP受体拮抗剂抑制细胞炎症细胞分裂素的释放，特别是白细胞介素-6（IL），阻断细胞中的ATP受体，提供改善炎症和抑制其发病的方法和组合物 -6）和/或白细胞介素-8（IL-8）。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2009298752A Skin care preparation composition for external use 审中-公开
标题翻译：用于外用的皮肤护理制剂组合物
公开(公告)号：JP2009298752A
公开(公告)日：2009-12-24
申请号：JP2008158042
申请日：2008-06-17
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： INOUE KAORI , KATSUTA YUJI , HIBINO TOSHIHIKO
IPC分类号： A61K8/55 , A61K8/49 , A61K31/522 , A61K31/7076 , A61P17/16 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin care preparation composition for external use that has extremely low skin irritation, excellent epidermal cell growth promotion action and is simply usable.
SOLUTION: The skin care preparation composition for external use comprises ADP and a xanthine derivative. The skin care preparation composition comprises 0.01-100 mM of ADP and 0.0005-5 mass% of the xanthine derivative. In the skin care preparation composition, preferably the xanthine derivative is caffeine and/or theophylline. In the skin care preparation composition for external use, preferably the composition is an epidermal cell growth promoter for external use. The leave-on type cosmetic comprises the skin care preparation composition for external use. The epidermal cell growth promotion method comprises applying an skin care preparation composition containing ADP and a xanthine derivative to the skin surface. In the method, the skin care preparation composition for external use contains 0.01-100 mM of ADP and 0.0005-5 mass% of a xanthine derivative.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有极低的皮肤刺激，优异的表皮细胞生长促进作用的外用皮肤护理制剂组合物，并且是简单可用的。
解决方案：用于外用的皮肤护理制剂组合物包括ADP和黄嘌呤衍生物。皮肤护理制剂组合物包含0.01-100mM的ADP和0.0005-5质量％的黄嘌呤衍生物。在护肤制剂组合物中，优选黄嘌呤衍生物是咖啡因和/或茶碱。在外用护肤制剂组合物中，优选组合物是用于外用的表皮细胞生长促进剂。休假型化妆品包括用于外用的护肤制剂组合物。表皮细胞生长促进方法包括将含有ADP和黄嘌呤衍生物的护肤制剂组合物施用于皮肤表面。在该方法中，外用护肤制剂组合物含有0.01-100mM的ADP和0.0005〜5质量％的黄嘌呤衍生物。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2004175687A Agent for promoting recovery of skin barrier function 审中-公开
公开(公告)号：JP2004175687A
公开(公告)日：2004-06-24
申请号：JP2002340804
申请日：2002-11-25
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： DENDA MITSUHIRO , FUJIWARA SHIGEYOSHI , INOUE KAORI
IPC分类号： G01N33/15 , A61K8/00 , A61K8/34 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/60 , A61K8/64 , A61K31/198 , A61K31/277 , A61K31/4045 , A61K31/48 , A61K31/55 , A61K31/7076 , A61K45/00 , A61P17/00 , A61P17/06 , A61P17/16 , A61P43/00 , A61Q19/00 , C07H19/213 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain an agent for promoting recovery of a skin barrier function, containing a compound for inhibiting the activity or the production of intracellular cAMP.
SOLUTION: This agent for promoting the recovery of the skin barrier function contains the compound for inhibiting the activity or the production of the intracellular cyclic AMP (adenosine monophosphate, cAMP). The method for screening the agent for promoting the recovery of the skin barrier function comprises reacting a compound as a candidate of the agent for promoting the recovery of the skin barrier function with a mammal cell, measuring the concentration of the intracellular cAMP after the reaction, and selecting the compound, by which the concentration of the intracellular cAMP is reduced, as the compound for promoting the recovery of the skin barrier function.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2002062294A METHOD AND DEVICE FOR MEASURING SKIN SURFACE CONDITION 失效
公开(公告)号：JP2002062294A
公开(公告)日：2002-02-28
申请号：JP2000252732
申请日：2000-08-23
申请人： SHISEIDO CO LTD
发明人： DENDA MITSUHIRO , ASHIDA YUTAKA , INOUE KAORI
IPC分类号： G01N33/50 , A61B5/00 , G01N27/28 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide a method and a device for measuring a skin surface condition so as to measure and digitize a human sense given by a stimulation to the skin surface and to provide a method and a device for measuring effect of a protective drug against the sense if the sense is mentally minus. SOLUTION: A skin section is floated on the surface of a culture solution stored in a vessel with the skin section surface side directed upward, and a potential difference between the skin section skin surface and the culture solution is measured. By giving stimulation to the skin surface or adding a stimulant to the culture solution, the potential difference is measured for measuring the degree of stimulation to the skin. By applying the drug to the skin section after giving the stimulation to the skin surface or adding the stimulant to the culture solution, the potential difference is measured for measuring the degree of reduction of skin stimulation due to the drug. By adding the drug to the culture solution after giving the stimulation to the skin surface or adding the stimulant to the culture solution, the potential difference is measured for measuring the degree of reduction of skin stimulation due to the drug.

7. 发明专利

JP2014080386A Skin-lightening method, and screening method for melanin synthesis inhibitor 有权
标题翻译：胶原蛋白合成抑制剂的护肤方法及筛选方法
公开(公告)号：JP2014080386A
公开(公告)日：2014-05-08
申请号：JP2012228730
申请日：2012-10-16
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HOSOI JUNICHI , YAMADA AKIKO , INOUE KAORI
IPC分类号： A61K45/00 , A61K8/73 , A61K31/716 , A61P43/00 , A61Q19/02 , C12N5/077 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide more effective skin-lightening methods or skin-lightening agents, and further provide more efficient and simpler methods of evaluating the skin-lightening effects of test substances.SOLUTION: More effective skin-lightening methods or skin-lightening agents are achieved by the activation of Langerhans cells of the skin. Methods of evaluating the skin-lightening effects of test substances use the activation of Langerhans cells of the skin as indices.
摘要翻译：要解决的问题：提供更有效的护肤方法或减轻皮肤亮白剂，并进一步提供更有效和更简单的评估测试物质的减轻皮肤的效果的方法。解决方案：更有效的减轻皮肤护理或减轻皮肤刺激药物通过激活皮肤的朗格汉斯细胞来实现。评估测试物质的减轻皮肤效果的方法使用皮肤的朗格汉斯细胞的活化作为指标。

8. 发明专利

JP2013227248A Membrane-softening agent for biomembrane 审中-公开
标题翻译：生物膜的膜结合剂
公开(公告)号：JP2013227248A
公开(公告)日：2013-11-07
申请号：JP2012099985
申请日：2012-04-25
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： UYAMA MAKOTO , MIYAHARA REIJI , INOUE KAORI , KINOSHITA KOICHI
IPC分类号： A61K8/40 , A61K8/34 , A61K31/045 , A61K31/14 , A61P17/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a softening agent for biomembrane, an activity-regulating agent for a protein that is present in a Raft region, and a cool feeling effect-enhancing agent.SOLUTION: A tetraalkylammonium salt is found to be able to soften a biomembrane. The tetraalkylammonium salt can soften a Raft region and regulate activation of a receptor present in the Raft region and thereby can enhance a cool feeing effect.
摘要翻译：要解决的问题：提供生物膜软化剂，存在于筏区域的蛋白质的活性调节剂和凉爽感觉效果增强剂。解决方案：发现四烷基铵盐能够软化一种生物膜。四烷基铵盐可以软化Raft区域并调节存在于Raft区域中的受体的活化，从而可以提高凉爽的效果。

9. 发明专利

JP2002372530A Detection method of skin irritation 审中-公开
标题翻译：皮肤刺激检测方法
公开(公告)号：JP2002372530A
公开(公告)日：2002-12-26
申请号：JP2001180366
申请日：2001-06-14
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： INOUE KAORI , FUJIWARA SHIGEYOSHI , DENDA MITSUHIRO , DENDA SUMIKO
IPC分类号： A61K49/00 , A61P17/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/68 , G01N33/84
CPC分类号： G01N33/5044 , A61K49/0006 , G01N33/5008 , G01N33/502 , G01N33/6872 , G01N33/84
摘要： PROBLEM TO BE SOLVED: To find out new knowledge by researching on mechanism of human sense of pain, and to find out a means for contributing to development of industry by utilizing the knowledge. SOLUTION: As the result of study on a nociceptive irritation acceptor, it is found out that the stimulus acceptor exists also in epidermal cells or the like, and that fluctuation of the calcium ion concentration in the cells corresponding to the state of the stimulus acceptor is recognized. In this detection method of skin irritation, the skin irritation of a test material is detected by correlating the skin irritation of the test material in contact with epithelial cells such as the epidermal cells with increase and decrease of the calcium ion concentration in the epithelial cells.
摘要翻译：要解决的问题：通过研究人的痛苦机制，找出新知识，并通过利用知识找出促进行业发展的手段。解决方案：作为伤害感受刺激受体的研究结果，发现刺激受体也存在于表皮细胞等中，并且与刺激受体状态对应的细胞中钙离子浓度的波动为认可在这种皮肤刺激的检测方法中，通过与上皮细胞等上皮细胞接触的皮肤刺激与上皮细胞中钙离子浓度的增加和减少相关联来检测测试材料的皮肤刺激。

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