专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2011182823A Artificial skin 有权
标题翻译：人造皮肤
公开(公告)号：JP2011182823A
公开(公告)日：2011-09-22
申请号：JP2010048159
申请日：2010-03-04
申请人： Kitasato Institute , Shiseido Co Ltd , 学校法人北里研究所 , 株式会社資生堂
发明人： IRIYAMA SHUNSUKE , UMISHIO KENICHI , TSUNENAGA MAKOTO , INOMATA SHINJI , ADACHI EIJIRO
IPC分类号： A61L27/00
CPC分类号： A61K31/4406 , A61F2/105 , A61K8/4926 , A61K8/4946 , A61K8/64 , A61K31/4184 , A61K38/005 , A61K38/07 , A61K2800/782 , A61L27/362 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide an artificial skin which achieves sufficient communication between epidermis and dermis via epidermal basement membranes and is extremely similar to a structure of a natural skin. SOLUTION: A method of producing the artificial skin is characterized by adding a matrix metalloproteinase inhibitor and a heparanase inhibitor in a culture medium for formation of the artificial skin containing human epidermis derived keratinocytes and human dermis derived fibroblast cells and by culturing the cells in the culture medium for formation of the artificial skin to form the artificial skin. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供通过表皮基底膜实现表皮和真皮之间充分交流的人造皮肤，并且与天然皮肤的结构非常相似。解决方案：制备人造皮肤的方法的特征在于在培养基中加入基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂，以形成含有人表皮衍生的角质形成细胞和人真皮来源的成纤维细胞的人造皮肤，并通过培养细胞在用于形成人造皮肤的培养基中形成人造皮肤。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2007077104A Vascular endothelial growth factor inhibitor 审中-公开
标题翻译：血管内皮生长因子抑制剂
公开(公告)号：JP2007077104A
公开(公告)日：2007-03-29
申请号：JP2005269646
申请日：2005-09-16
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HASEGAWA KIYOTAKA , INOMATA SHINJI , UMISHIO KENICHI
IPC分类号： A61K36/00 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/96 , A61K36/18 , A61K36/73 , A61K36/899 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , A61Q1/12
摘要： PROBLEM TO BE SOLVED: To provide a VEGF (vascular endothelial growth factor) expression inhibitor characterized as comprising one or a plurality of kinds of crude drug extracts selected from the group consisting of crude drugs Coix extract, Chlorella Extract and Tormentilla Extract as an active ingredient. SOLUTION: The VEGF expression inhibitor is characterized as comprising the one or plurality of kinds of crude drug extracts selected from the group consisting of the Coix extract, the Chlorella Extract and the Tormentilla Extract as the active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供VEGF（血管内皮生长因子）表达抑制剂，其特征在于包含一种或多种选自以下的生药药物提取物：生药物ix ix提取物，小球藻提取物和Tormentilla提取物作为活性成分。解决方案：VEGF表达抑制剂的特征在于包含一种或多种选自由ix ix提取物，小球藻提取物和Tormentilla提取物组成的组的生药提取物作为活性成分。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2005281197A Parakeratosis inhibitor, pore reducing agent, and skin external preparation 审中-公开
标题翻译：防腐剂抑制剂，减水剂和皮肤外用制剂
公开(公告)号：JP2005281197A
公开(公告)日：2005-10-13
申请号：JP2004097799
申请日：2004-03-30
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： IIDA TOSHIMOCHI , INOMATA SHINJI , KAMINUMA MIKIKO , HINENO TERUHIKO
IPC分类号： C07D233/64 , A61K8/00 , A61K8/30 , A61K8/49 , A61K31/4172 , A61P17/16 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a novel parakeratosis inhibitor having excellent parakeratosis inhibition effects, a pore reducing agent having pore reducing effects, and a skin external preparation having the above excellent effects.
SOLUTION: Each of the parakeratosis inhibitor and the pore reducing agent is composed of β-alanyl-L-histidine and/or its salt; otherwise, each of the parakeratosis inhibitor and the pore reducing agent contains β-alanyl-L-histidine and/or its salt as the effective component. A skin external preparation for inhibiting parakeratosis is provided which contains the parakeratosis inhibitor; and a skin external preparation for reducing pores is provided which contains the pore reducing agent.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供具有优异的角化不全抑制作用的新型角化不全抑制剂，具有减孔效果的减孔剂和具有上述优异效果的皮肤外用剂。解决方案：角化不全抑制剂和减孔剂各自由β-丙氨酰-L-组氨酸和/或其盐组成; 否则，角化不全抑制剂和减孔剂均含有β-丙氨酰-L-组氨酸和/或其盐作为有效成分。提供了用于抑制角化不全的皮肤外用制剂，其含有角化不全抑制剂; 并提供含有孔还原剂的用于还原孔的外用皮肤外用剂。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005263689A Collagen formation promoter 审中-公开
标题翻译：胶原蛋白形成促进剂
公开(公告)号：JP2005263689A
公开(公告)日：2005-09-29
申请号：JP2004078478
申请日：2004-03-18
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： SUZUKI RIKAKO , HINENO TERUHIKO , INOMATA SHINJI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/02 , A61K8/04 , A61K8/06 , A61K8/97 , A61K36/00 , A61K36/81 , A61K38/00 , A61P17/16 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a collagen formation promoter having excellent effects on promotion of collagen formation and effective for prophylaxis/amelioration of wrinkles/slackness according to aging. SOLUTION: The collagen formation promoter comprises a hydrolyzed potato protein as an active ingredient. A method for promoting the collagen formation comprises promoting the formation of the collagen using the hydrolyzed potato protein. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供对促进胶原形成具有优异效果的胶原蛋白形成促进剂，并且能够根据老化有效地预防/改善皱纹/松弛。胶原蛋白形成促进剂包含水解马铃薯蛋白作为活性成分。用于促进胶原蛋白形成的方法包括使用水解的马铃薯蛋白促进胶原的形成。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2004337165A New enzyme for esterification of cholesterol and its use 审中-公开
公开(公告)号：JP2004337165A
公开(公告)日：2004-12-02
申请号：JP2004127437
申请日：2004-04-22
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： IIDA TOSHIMOCHI , YOSHIDA SEIICHI , TOJO YOSUKE , AOKI HIROFUMI , TSUNENAGA MAKOTO , INOMATA SHINJI , DENDA MITSUHIRO
IPC分类号： G01N33/15 , A61K8/00 , A61K8/66 , A61K8/96 , A61K38/43 , A61P3/06 , A61P17/16 , A61Q19/00 , C12N9/10 , C12P33/00 , A61K7/00 , A61K7/48
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a technology applicable for amelioration of state of the skin (prevention and amelioration of dry rough skin, prophylaxis, prevention, of melasma, wrinkle, etc.) or treatment of hyperlipidemia, etc., by developing a technology controlling amount of free fatty acids and cholesterol in the body. SOLUTION: The new cholesterol esterifying enzymes catalyze cholesterol producing reaction (transfer of an acyl group), without mediating action of coenzyme, by acting free fatty acids and cholesterol or its derivatives as substrates, not acting on fatty acid-CoA complex. The enzyme has 40-45 kDa of molecular weight (gel filtration technique), 3.0-7.0 of acting pH, 4.0-5.0 of optimal pH, acting at 4-60°C, 20-50°C of optimal temperature. COPYRIGHT: (C)2005,JPO&NCIPI

6. 发明专利

JP2000256122A MATRIX METALLOPROTEINASES INHIBITOR 失效
公开(公告)号：JP2000256122A
公开(公告)日：2000-09-19
申请号：JP5494999
申请日：1999-03-03
申请人： SHISEIDO CO LTD
发明人： INOMATA SHINJI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K31/00 , A61K36/53 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K7/00 , A61K7/02 , A61K7/06 , A61K7/48 , A61K7/50 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain the subject inhibitor against matrix metalloproteinases belonging to a gelatinase group which excels in cutaneous senility preventive or improving action and is highly safe and is useful in basic cosmetics or makeup cosmetics by including an extract from Thymus serpyllum L. SOLUTION: This inhibitor is obtained by including preferably 0.0001-20.0 wt.%, more preferably 0.001-10.0 wt.% of an extract from Thymus serpyllum subsp.quinquecostatus (botanical name: Thymus serpyllum L.) as a dry matter. The above extract is obtained by immersing or heating under reflux the whole grass of the above plant in or with an extraction solvent such as ethanol followed by filtration and then concentrating the filtrate. This inhibitor is useful in hair cosmetics, bath preparations, etc.

7. 发明专利

JPH11246388A ANTIAGING AGENT 失效
公开(公告)号：JPH11246388A
公开(公告)日：1999-09-14
申请号：JP6779698
申请日：1998-03-03
申请人： SHISEIDO CO LTD
发明人： INOMATA SHINJI , OTA MASAHIRO
IPC分类号： C12N9/99 , A61K8/00 , A61K8/02 , A61K8/96 , A61K8/97 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/48 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject agent having an elastase inhibiting activity, keeping the skin taut and elastic of, holding a state of a young skin and useful for e.g. foundation cosmetics, makeup cosmetics, hair cosmetics or bath liquids, by including a solvent extract of Thea sinensis L. SOLUTION: This antiaging agent comprising a solvent extract of Thea sinensis L is obtained by subjecting an extract from the leaves and springs of the above plant to soaking or heat reflux process together with the extract solvent (e.g. methanol, ethanol or 1,3-buthylene glycol), and subjecting it to filtration and concentration. The blending ratio of the extract to the whole agent for external use is 0.001 to 10.0 wt.% based on the dried extract. The antiaging agent may be blended with e.g. a beautifully whitening agent, moisture-retaining agent, antioxidant or oil component. There may be blended e.g. disodium edetate or sodium citrate. The antiaging agent is pref. applied to cosmetics.

8. 发明专利

JPH11246338A ANTIAGING AGENT 失效
公开(公告)号：JPH11246338A
公开(公告)日：1999-09-14
申请号：JP6779298
申请日：1998-03-03
申请人： SHISEIDO CO LTD
发明人： OTA MASAHIRO , INOMATA SHINJI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/18 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q19/08 , A61Q19/10 , A61K7/00 , A61K7/06 , A61K7/50 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an antiaging agent which keeps the skin taut and elastic and can maintain the skin in a fresh state. SOLUTION: This antiaging agent contains a solvent extract from a gromwell (botanical name: Lithospermum erythrorhizon Siebold et Zuccarini). The extract from the gromwell possesses elastase inhibitory effect and prevents skin from aging. The extract from the gromwell on this invention is blended in an amount of 0.0005-20.0 wt.%, preferably 0.001-10.0 wt.%, based on the whole weight of the preparation for external use in the dry basis. When it is less than 0.0005 wt.%, the effect on this invention is not efficiently exerted and when it is more than 20.0 wt.%, it is not favorable due to the difficulty of pharmaceutical manufacturing. Further, even when the amount of more than 10.0 wt.% is blended, the very great improvement of the effect is not observed.

9. 发明专利

JPH1017461A PREPARATION FOR EXTERNAL USE FOR IMPROVING SKIN ROUGHNESS 失效
公开(公告)号：JPH1017461A
公开(公告)日：1998-01-20
申请号：JP18823596
申请日：1996-06-28
申请人： SHISEIDO CO LTD
发明人： INOMATA SHINJI , INABA TOMOYUKI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/48 , A61P17/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a highly safe skin roughness-improving preparation for external use, having excellent effects for improving and preventing various kinds of skin diseases, skin roughness, rough skins, etc., by compounding the extract of Sophora flavescens Aiton. SOLUTION: This preparation for external use for improving skin roughness contains the solvent extract of a perennial plant, Sophora flavescens Aiton, as an active ingredient in an amount of 0.0005-20wt.%, preferably 0.001-10wt.%, based on the whole amount of the preparation for external use as a dry product. The extract is especially obtained by immersing or thermally refluxing the roots of the Sophora flavescens Aiton in a solvent (e.g. 1,3-butyleneglycol), filtering and subsequently concentrating the filtrate. Ointments, creams, milky lotions, lotions, packs, bath articles, etc., can be prepared by conventional methods. The skin roughness-improving preparation for external use especially exhibits an inhibiting activity against serine protease as a protease-inhibiting agent. The preparation is effective for skin roughness caused by various kinds of skin diseases such as contact dermatitis and psoriasis, the skin roughness of healthy person, rough skins, etc.

10. 发明专利

JPH08242878A PRODUCTION OF SAIKO SAPONIN 失效
公开(公告)号：JPH08242878A
公开(公告)日：1996-09-24
申请号：JP7830895
申请日：1995-03-08
申请人： SHISEIDO CO LTD
发明人： KATAGIRI CHIKA , INOMATA SHINJI , YOKOYAMA MINEYUKI , WACHI YOJI
IPC分类号： C12P19/44 , A61K31/70 , A61K36/00 , A61K36/23 , A61P1/16 , C12N5/00 , C12N5/04 , C12R1/91
摘要： PURPOSE: To obtain saiko saponin having a hepatic damage-improving action, etc., useful as a galenical ingredient, etc., in a short time in a largely increased yield by culturing the tissue-cultured root of a plant belonging to the genus Bupleurum in a culture medium containing an organic acid salt. CONSTITUTION: A method for producing siaiko saponin comprises wrapping the seed of a Bupleurum plant (e.g. Bupleurum falcatum) with a gauze, immersing the wrapped seed in 70% ethanol for 10sec. rinsing the wrapped seed with water, treating the rinsed seed with a 2% antiformin solution for 10min, immersing the treated seed in sterilized water at room temperature over a night, planting the treated seed in a culture medium, culturing and germinating the seed at 22 deg.C periodically alternately in a dark place and in a lighted place, subculturing the germinated seedling at 26 deg.C in a medium containing 3% sucrose at 26 deg.C for 12hr, cutting the roots, etc., of the aseptically grown plant, culturing the cut roots in a culture medium containing indolebutyric acid, culturing the generated callus and roots in a medium containing an organic acid salt (e.g. sodium acetate), lyophilizing the cultured product, grinding the lyophilized product with a mixer, and finally extracting the ground product with 75% ethanol containing 0.5% KOH. Thus, the objective saiko saponin is obtained in a high yield.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式