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1. 发明专利

JP2001270829A SMOOTH MUSCLE CELL GROWTH PROMOTER 失效
公开(公告)号：JP2001270829A
公开(公告)日：2001-10-02
申请号：JP2000083637
申请日：2000-03-24
申请人： SEIKAGAKU KOGYO CO LTD , NAT INST OF ADVANCED IND SCIEN
发明人： MITSUI YOJI , TANAKA YASUO , SAKURAI KATSUKIYO , ONUKI YOJI
IPC分类号： A61K31/728 , A61P9/14 , A61P17/02 , A61P43/00 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To obtain an excellent smooth muscle cell growth promoter and a vascularization promoter containing the smooth muscle cell growth promoter. SOLUTION: This smooth muscle cell growth promoter is obtained by including a hyaluronic acid which contains a glycosamino-glycan bearing sulfate groups in an amount of less than 0.01% and has an average molecular weight of 1,000-8,000 or its pharmacologically permissible salt as an active ingredient. The smooth muscle growth promoter active ingredient can be utilized as a treatment agent (therapeutic, prophylactic or progress inhibitory agent) for circulatory organ diseases, e.g. diabetic peripheral vessel injury, and the like, or a medicine aiming at tissue repair, wound cure promoter, or the like.

2. 发明专利

JP2006104461A Method for removing impurity in glycosaminoglycan fraction 审中-公开
$Method for removing impurity in glycosaminoglycan fraction$
标题翻译：用于去除糖蛋白聚糖分子中的残留的方法
公开(公告)号：JP2006104461A
公开(公告)日：2006-04-20
申请号：JP2005261689
申请日：2005-09-09
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： KOYAMA HIROSHI , IMAMURA KIMIHIRO , KOSHINBO AKIRA , ONUKI YOJI
IPC分类号： C08B37/00 , C08B37/08 , C08B37/10
摘要： PROBLEM TO BE SOLVED: To provide a method for easily, quickly and efficiently removing impurities such as nucleic acids, iron and proteins in a glycosaminoglycan fraction and a method for producing a large amount of glycosaminoglycan fraction free from the impurities. SOLUTION: The method for removing one or more substances selected from nucleic acids, iron and proteins in a glycosaminoglycan fraction contains (1) a step to contact a solution of the glycosaminoglycan fraction with activated carbon and (2) a step to separate the activated carbon contacted with the solution of the glycosaminoglycan fraction and collect the glycosaminoglycan fraction. The invention further provides a method containing the steps (1) and (2) and producing a glycosaminoglycan fraction having the following properties (a) to (c). (a) The content of nucleic acid is COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容易，快速且有效地除去糖胺聚糖部分中的核酸，铁和蛋白质等杂质的方法以及不含杂质的大量糖胺聚糖部分的制造方法。解决方案：在糖胺聚糖部分中除去选自核酸，铁和蛋白质中的一种或多种物质的方法包含（1）使糖胺聚糖部分与活性炭接触的步骤和（2）分离步骤活性炭与糖胺聚糖部分的溶液接触并收集糖胺聚糖部分。本发明还提供了包含步骤（1）和（2）并产生具有以下性质（a）至（c）的糖胺聚糖部分的方法。（a）每1mg糖胺聚糖级分，核酸含量<0.08μg，（b）铁含量≤0.07ppm，（c）蛋白质含量≤0.4％。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2004051579A Synthetic promoter of hyaluronic acid 有权
公开(公告)号：JP2004051579A
公开(公告)日：2004-02-19
申请号：JP2002213044
申请日：2002-07-22
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： ONUKI YOJI , KIMATA HIROHARU , ITANO NAOKI , MINAMIZAWA TOSHIKAZU , SUZUKI KIYOSHI , KIYOUGASHIMA MAMORU
IPC分类号： C07H15/18 , A61K31/7028 , A61P15/06 , A61P19/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an agent for promoting biosynthesis of hyaluronic acid by promoting activity of synthetic promoter of hyaluronic acid.
SOLUTION: The synthetic promoter of hyaluronic acid comprises an N-acetyl-D-glucosamine-containing sugar benzyl derivative represented by formula (1) [wherein Ac is an acetyl group; R
1 is H, a monosaccharide residue or a polysaccharide residue; X is O, S, NH or CH
2 ; R
2 is H or a substituent group (a halogen atom, a hydroxy group, a nitro group, a sulfuric acid group, an alkyl group or an acyl group) of a benzene ring].
COPYRIGHT: (C)2004,JPO

4. 发明专利

JPH07157500A HUMAN SYNOVIAL FLUID-DERIVED PROTEIN AFFINITIVE TO HYALURONAN AND ANTIBODY 失效
公开(公告)号：JPH07157500A
公开(公告)日：1995-06-20
申请号：JP33960993
申请日：1993-12-03
申请人： SEIKAGAKU KOGYO CO LTD
发明人： ONUKI YOJI , KOU RAI , KIMATA HIROHARU
IPC分类号： G01N33/53 , A61K39/395 , C07K14/47 , C07K16/00 , C07K16/18 , C12P21/02 , C12P21/08 , G01N33/577
摘要： PURPOSE:To obtain the subject new protein existing in knee synovial fluid of a patient with deformed arthritis of knee, rheumatoid arthritis of knee, etc., in the form of a hyaluronan-bonded protein, separable from such knee synovial fluid and enabling diagnosis of arthritis by analyzing the concentration in knee synovial fluid. CONSTITUTION:Knee synovial fluid of a patient with deformed arthritis of knee or rheumatoid arthritis of knee is collected and a protein-denaturing agent is added thereto. The resultant mixture is subjected to ultracentrifugation under a protein non-dissociation condition to obtain a fraction of high-concentration hyaluronan. After addition of a protein-denaturing agent thereto, the obtained fraction is subjected to ultracentrifugation under a protein dissociation condition and the obtained hyaluronan-protein composite material is treated with a hyaluronan lyase, thus affording the objective new protein having a molecular weight shown by two main bands of about 85 kD (X band) and about 83 kD (Y band) in an unreduced state when measured by the SDS-PAGE method and about 6.0 to 7.0 isoelectric point. Protease V8-treated X and Y bands are respectively represented by formula I and formula II (Xaa is unidentified).

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