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1. 发明专利

JPH09208594A METHYLPHOSHONIC ACID DERIVATIVE 失效
公开(公告)号：JPH09208594A
公开(公告)日：1997-08-12
申请号：JP2033696
申请日：1996-02-07
申请人： SANKYO CO
发明人： HOTODA HITOSHI , KANEKO MASAKATSU , TAKAHASHI MASAAKI , TANZAWA KAZUHIKO , TAKAHASHI HIDEJI
IPC分类号： C07H19/20 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P43/00 , C07F9/6561
摘要： PROBLEM TO BE SOLVED: To obtain the subject new compound capable of being massively produced, acting on an inositol 1,4,5-trisphosphate receptor, having an excellent enhancing action on the concentration of calcium ions in cells and useful as a vasopressor medicine, a bed sore medicine, a medicine for cerebral diseases such as geriatric dementia, etc. SOLUTION: A compound of formula I (R is a 1-4C alkyl) or its salt. For example, a compound of formula II. The compound of formula I is obtained from a 3,4,6-tri-O-acetyl-2-O-benzyl-α-D-glucopyranosyl bromide of formula III (Ac is acetyl; Bn is benzyl) and a 2'-O-(t-butyldimethylsilyl)-5'-O-(4- methoxyphenyldiphenylme thylmethyl)-N,N-dibenzoyladenosine of formula IV (TBS is t-butyldimethylsilyl; MMTr is 4-methoxytrityl) as starting substances.

2. 发明专利

JPH0499792A NEW COMPOUND A-70615 SUBSTANCE AND PRODUCTION THEREOF 失效
公开(公告)号：JPH0499792A
公开(公告)日：1992-03-31
申请号：JP21710490
申请日：1990-08-20
申请人： SANKYO CO
发明人： NAKAJIMA MUTSUO , ANDO OSAMU , TAKAHASHI HIDEJI , TORIGATA AKIO , HARUYAMA HIDEYUKI , KINOSHITA TAKESHI , OKAZAKI HISAO
IPC分类号： C12P19/28 , A01N43/76 , C07H17/00 , C12N1/20 , C12N9/99 , C12R1/29
摘要： NEW MATERIAL:The compound of formula having the following physical properties. Nature, basic white powder; solubility, soluble in water and methanol and insoluble in acetone and chloroform; color reaction, positive to sulfuric acid reaction; molecular formula, C13H22N2O10; molecular weight, 336 (FAB-mass spectrum); specific rotation, [alpha] =+99.5 deg. (c=0.41, water); etc. USE:A trehalose-inhibitor. Useful for mildew-proofing agent and insecticide (insect- controlling agent). PREPARATION:A microbial strain belonging to genus Micromonospora and capable of forming A-70615 compound [e.g. Micromonospora sp. SANK 62390 (FERM P-11631)] is aerobically cultured at 22-28 deg.C.

3. 发明专利

JPH0413358B2 失效
公开(公告)号：JPH0413358B2
公开(公告)日：1992-03-09
申请号：JP20878984
申请日：1984-10-04
申请人： SANKYO CO
发明人： INAOKA YOSHINORI , TAKAHASHI HIDEJI , TAMAOKI HIDETSUNE , ENOKIDA RYUZO
IPC分类号： C07G99/00 , A61K35/74 , A61K38/55 , A61P25/04 , A61P43/00 , C07K5/06 , C07K5/078 , C07K7/02 , C07K14/81 , C12P1/02 , C12P21/02 , C12R1/01 , C12R1/465 , C12R1/645

4. 发明专利

JPS62153291A ANTIBIOTIC DEOXYLAIDLOMYCIN AND PRODUCTION THEREOF 失效
公开(公告)号：JPS62153291A
公开(公告)日：1987-07-08
申请号：JP29766385
申请日：1985-12-26
申请人： SANKYO CO
发明人： HAISHI TATSUO , TAKAHASHI HIDEJI , TORIGATA AKIO , FUKAZAWA YUMI , ITO YASUHIRO , OKAZAKI HISAO , SATO SADAO , TOYAMA TOSHIMITSU
IPC分类号： C07D493/10 , A61K31/35 , A61P31/04 , C07D307/00 , C07D311/00 , C12P17/18 , C12R1/625
摘要： NEW MATERIAL:An antibiotic deoxylaidlomycin expressed by the formula and salt thereof having the following characteristic (as sodium salt); Property; acidic and fat-soluble colorless crystal. Specific rotatory power; [alpha] D+42 deg. (c, 0.2, chloroform). Molecular weight; 704 (M ). Molecular formula; C37H61O11Na. Solubility; hardly soluble in water and readily soluble in chloroform, ethyl acetate, ether, acetone and alcohol. Color reaction; positive to iodine and potassi um permanganate and negative to ninhydrin reaction. Thin layer chromatography; Rf value 0.54 (silica gel, benzene: acetone 2:1), etc. USE:An antimicrobial agent effective against Gram-positive bacteria, mycoplasmas, etc. PREPARATION:A deoxylaidlomycin-producing bacterium beloning to the genus Streptoverivillium [example; Streptoverticillium Sp. SANK 61484 (FERM P-No. 8003), etc. is cultivated and the aimed product is collected from the culture.

5. 发明专利

JPS6188884A Encephalinase b-inhibiting substance and its preparation 失效
标题翻译： ENCEPHALINASE B抑制物质及其制备
公开(公告)号：JPS6188884A
公开(公告)日：1986-05-07
申请号：JP20878984
申请日：1984-10-04
申请人： Sankyo Co Ltd
发明人： INAOKA YOSHINORI , TAKAHASHI HIDEJI , TAMAOKI HIDETSUNE , ENOKIDA RYUZO
IPC分类号： C07G99/00 , A61K35/74 , A61K38/55 , A61P25/04 , A61P43/00 , C07K5/06 , C07K5/078 , C07K7/02 , C07K14/81 , C12P1/02 , C12P21/02 , C12R1/01 , C12R1/465 , C12R1/645
CPC分类号： C07K5/06165
摘要： NEW MATERIAL:Propioxanthine A and B of formula (R is H or methyl) and their salt, having the following physical and chemical properties. Appearance, acidic white powder; color reaction; negative to ninhydrin reaction, positive to the reaction after hydrolysis; solubility, soluble in water, methanol, etc., and insoluble in ethyl acetate, etc.; molecular formula, C17H29N3O6 for A, and C18H31N3O6 for B. USE:Encephalinase B-inhibiting substance useful as an analgesic agent. PREPARATION:A microbial strain belonging to Kitasatosporia genus and capable of producing propioxanthine A or B [e.g. Kitasatosporia sp. SANK60684 (FERM- P No.7581)] is cultured preferably in a liquid medium at 5.5-8pH and about 28 deg.C under shaking, and the objective substance is separated from the culture product.
摘要翻译：新材料：式（R为H或甲基）的丙基黄嘌呤A和B及其盐具有以下物理和化学性质。外观，酸性白色粉末; 颜色反应; 反应为茚三酮反应，水解后反应呈阳性; 溶解性，溶于水，甲醇等，不溶于乙酸乙酯等; 分子式，A的C 17 H 29 N 3 O 6和B的C 18 H 31 N 3 O 6 .EEE：可用作止痛剂的脑苷酸酶B抑制物质。制备：属于北沙氏菌属的能够产生丙基黄嘌呤A或B [...]的微生物菌株。北海孢属 SANK60684（FERM-P No.7581）]优选在5.5-8pH和约28℃的液体培养基中振荡培养，并将目标物质与培养产物分离。

6. 发明专利

JPS6115694A Antibiotic nitracidomycins a and b and their preparation 失效
标题翻译：抗生素NITRACIDOMYCINS A和B及其制备
公开(公告)号：JPS6115694A
公开(公告)日：1986-01-23
申请号：JP13751784
申请日：1984-07-03
申请人： Sankyo Co Ltd
发明人： HAISHI TATSUO , TAKAHASHI HIDEJI , INUKAI MASATOSHI , TORIGATA AKIO , ITOU YASUHIRO , ENOKIDA RIYUUZOU , TAKATSU TOSHIO , IWATOU SEIGO
IPC分类号： C12P13/02 , C07C291/02 , C12R1/465
摘要： PURPOSE: In the titled novel antibiotic, to prepare an antibiotic effective against Gram-positive and Gram-negative bacteria, by cultivating a bacterium belonging to the genus Streptomyces, capable of producing nitracidomycins A and B.
CONSTITUTION: Sp. SANK60784(FERM-P 7582) belonging to the genus Streptomyces separated from soil is cultivated by a culture method used for well-known ray fungus. Nitracidomycins A and B which exist mainly in a liquid part of a cultrue are collected by a method such as filtration, adsorption, etc. A compound of nitracidomycin shown by the formula where R is methyl is nitracidomycin A, and one where R is ethyl group is nitracidomycin B. This novel antibiotics are used for various microbisms.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：在名称为抗生素的抗生素中，为了制备抗革兰氏阳性和革兰氏阴性菌的抗生素，通过培养属于链霉菌属的细菌，能够产生亚硝酸霉素A和B。通过用于众所周知的射线真菌的培养方法培养属于从土壤分离的链霉菌属的SANK60784（FERM-P 7582）。通过过滤，吸附等方法收集主要存在于培养液的液体部分中的Nitracidomycins A和B.由式中R为甲基的亚硝基霉素化合物为硝酸霉素A，R为乙基的化合物是硝酸霉素B.这种新型抗生素用于各种微生物。

7. 发明专利

JPH09316093A POLYPHOSPHORIC ACID DERIVATIVE 失效
公开(公告)号：JPH09316093A
公开(公告)日：1997-12-09
申请号：JP6568497
申请日：1997-03-19
申请人： SANKYO CO
发明人： HOTODA HITOSHI , MURAYAMA KAZUHIRO , KANEKO MASAKATSU , TAKAHASHI MASAAKI , TANZAWA KAZUHIKO , TAKAHASHI HIDEJI
IPC分类号： C07H19/167 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P3/08 , A61P3/10 , A61P3/14 , A61P9/02 , A61P17/00 , A61P25/00 , A61P25/28 , A61P37/04 , A61P43/00 , C07H19/20
摘要： PROBLEM TO BE SOLVED: To obtain the subject new derivative which is a specific polyphosphoric acid derivative, having activities for acting on an inositol triphosphate receptor and raising the intracellular Ca concentration and useful as a therapeutic agent for cerebropathy, an immunipotentiator, a therapeutic agent for an insulin- dependent type (I type) diabetes, etc. SOLUTION: This new phosphoric acid derivative is represented by formula I R to R are each H or a phosphoric acid residue [P(=O)(OH)2 ]; R is H, a 1-4C alkoxy or formula II (X is H or a halogen), etc., except a compound in which all the R to R are H, a compound in which R , R R are each a phoshoric acid residue and R , R and R are each H and a compound in which R and R are each a phosphoric acid residue and R to R and R are each H when R is adenyl}. The derivative has activities for acting on an inositol 1,4,5-trisphosphate receptor and raising the intracellular calcium ion concentration and is useful as a therapeutic agent for cerebropathy such as senile dementia, Alzheimer diseases or Huntingtone chorea, a vasopressor, an immunopotentiator, an agent for decubitus, a therapeutic agent for epitheial ulcer, a therapeutic agent for insulin-dependent type (I type) diabetes, etc.

8. 发明专利

JPH08127590A 3'-GLUCOSYLADENOSINE DERIVATIVE 失效
公开(公告)号：JPH08127590A
公开(公告)日：1996-05-21
申请号：JP22145995
申请日：1995-08-30
申请人： SANKYO CO
发明人： HOTODA HITOSHI , KANEKO MASAKATSU , TAKAHASHI MASAAKI , TANZAWA KAZUHIKO , TAKAHASHI HIDEJI
IPC分类号： C07H19/167 , C07H19/20
摘要： PURPOSE: To obtain the subject new derivative useful as a synthetic intermediate, etc., for substances raising Ca concentration by acting on inositol 1,4,5- triphosphate receptor, by condensing a specific adenosine derivative with a glucose derivative. CONSTITUTION: This new 3'-glucosyladenosine derivative is expressed by formula I [R and R are each an acyl; R and R are each a (substituted)benzyl, a trialkylsilyl, an alkoxyalkyl, etc.; R is a (substituted)trrphenylmethyl or trialkylsilyl; R to R are each an acyl] and is useful as an important intermediate, etc., in the synthesis of adenophostins having activity to increase an intracellular calcium ion concentration by acting on inositol 1,4,5-triphosphate (InsP3) receptor. The derivative is obtained by condensing an adenosine derivative expressed by formula II with a glucose derivative expressed by formula III (X is an eliminable group).

9. 发明专利

JPH07291992A NOVEL COMPOUND B4317 失效
公开(公告)号：JPH07291992A
公开(公告)日：1995-11-07
申请号：JP8938194
申请日：1994-04-27
申请人： SANKYO CO
发明人： TAKAHASHI HIDEJI , SHIOZAWA HIDEYUKI , KAGASAKI TAKESHI , KODAMA KENTARO
IPC分类号： C12P21/02 , A61K38/00 , A61P11/00 , A61P29/00 , A61P31/04 , C07K5/078 , C07K14/195 , C07K14/41 , C12N1/20 , C12R1/01
摘要： PURPOSE:To obtain the novel compound for antiasthmatics, anti-inflammatory agents, antimicrobial agents, etc., having antagonism and antimicrobial action of leukotriene by culturing B4317-producing bacterium belonging to the genus Alteromonas and collecting a product from the cultured mixture. CONSTITUTION:This compound B4317 expressed by the structural formula has the following properties. Appearance, colorless powder; molecular formula, C28H32N4O9; molecular weight, 568 (measured by MS method); specific rotation, [alpha] D=-50.2 deg. (C=1.3 in CHCl3); solubility, soluble in alcohols such as methanol, ethanol, propanol and butanol, dimethylsulfoxide, dimethylformamide, chloroform, ethyl acetate, acetone or ethyl ether and insoluble in n-hexane and water; color reaction, positive to sulfuric acid, iodine, potassium permanganase. The compound is obtained by culturing a B4317-producing bacterium belonging to the genus Alteromonas (e.g., Alteromonas rava SANK 70294 strain) and collecting a product from the cultured mixture.

10. 发明专利

JPH0561280B2 失效
公开(公告)号：JPH0561280B2
公开(公告)日：1993-09-06
申请号：JP15103083
申请日：1983-08-19
申请人： SANKYO CO
发明人： MATSUEDA REI , HIGASHIDA SUSUMU , FURUMOTO HIROSHI , HAISHI TATSUO , TAKAHASHI HIDEJI , KITAMI MINORU
IPC分类号： C07K11/00 , A61K38/00 , A61P31/04 , C07K11/02

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