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    • 2. 发明专利
    • Microchip for capturing floating cancer cell in blood
    • 用于捕获血液中浮游癌细胞的MICROCHIP
    • JP2013029391A
    • 2013-02-07
    • JP2011164897
    • 2011-07-28
    • Toyama Prefecture富山県Toyama Univ国立大学法人富山大学
    • ONAGA TAKASHIOBATA TSUTOMUTAKADA KOJIMURAGUCHI ATSUSHIKISHI HIROYUKISHIMADA YUTAKATSUKADA KAZUHIRO
    • G01N33/543C12M1/00C12M1/34G01N33/545G01N33/574G01N37/00
    • PROBLEM TO BE SOLVED: To provide a resin microchip which is excellent in isolation or detection of floating cancer cells in blood at a low cost and whose productivity is high, and to provide the resin microchip which is especially effective for isolating and detecting the floating cancer cells in blood.SOLUTION: A microchip consists of a polymer compound obtained by polymerizing and solidifying a mixture consisting of: a monomer Z which has one polymerizable double bond and a carboxyl group and/or an epoxy group; a monomer X except the monomer Z, which has one polymerizable double bond; a monomer Y by which a crosslinking reaction is possible and which has two or more polymerizable double bonds; a polymer composition B, has a flow channel which has micro structure for passing through fluid on the surface or the inside of the polymer composition. In at least a part of the surface of the flow channel, an antibody which is coupled to an antigen existing on the surface of the cancer cells is fixed.
    • 要解决的问题:提供一种在低成本且高生产率下分离或检测血液中浮游癌细胞的优异树脂微片,并提供对隔离和检测特别有效的树脂微芯片 血液中的浮肿细胞。 解决方案:微芯片由通过聚合和固化由以下组成的混合物获得的高分子化合物组成:具有一个可聚合双键的单体Z和/或环氧基团; 除单体Z外的单体X,其具有一个可聚合双键; 可以进行交联反应的单体Y,其具有两个以上的可聚合双键; 聚合物组合物B具有流动通道,其具有用于通过聚合物组合物的表面或内部的流体的微结构。 在流动通道的表面的至少一部分中,与存在于癌细胞表面上的抗原偶联的抗体是固定的。 版权所有(C)2013,JPO&INPIT
    • 3. 发明专利
    • Microwell array chip and method of collecting cell
    • MICROWELL阵列芯片和收集细胞的方法
    • JP2012165738A
    • 2012-09-06
    • JP2011219147
    • 2011-10-03
    • Toyama PrefectureToyama Univ国立大学法人富山大学富山県
    • OBATA TSUTOMUKISHI HIROYUKITAKAMI SACHIKO
    • C12M1/00C12N5/07
    • C12M23/12
    • PROBLEM TO BE SOLVED: To provide a cell chip suitable for use in cell screening by fluorescent observation of a fluorescence-labeled antibody, and a method for specifically and efficiently specifying and collecting a target cell.SOLUTION: The microwell array chip has a microwell layer having a plurality of microwells on the surface of a substrate, one microwell has a shape and size for storing only one biological cell, the bottom surface of the microwell has a magnetic membrane and does not have a magnetic member other than the magnetic membrane, and the surfaces of the magnetic membrane and microwell layer have a multilayered membrane made of a light shielding membrane and silica or parylene membrane. The method stores specimen cells in the microwells of the microwell array and collects the target cell.
    • 要解决的问题:提供适用于通过荧光观察荧光标记的抗体进行细胞筛选的细胞芯片,以及用于特异性且有效地指定和收集靶细胞的方法。 解决方案:微孔阵列芯片具有在基底表面上具有多个微孔的微孔层,一个微孔具有仅存储一个生物细胞的形状和尺寸,微孔的底表面具有磁膜和 不具有磁性膜以外的磁性构件,并且磁性膜和微孔层的表面具有由遮光膜和二氧化硅或聚对二甲苯膜制成的多层膜。 该方法将样本细胞存储在微孔阵列的微孔中并收集目标细胞。 版权所有(C)2012,JPO&INPIT
    • 4. 发明专利
    • Method for screening cell
    • 筛选细胞的方法
    • JP2009034047A
    • 2009-02-19
    • JP2007201493
    • 2007-08-02
    • Sc World IncToyama PrefectureToyamaken Shinseiki Sangyo Kikoエスシーワールド株式会社富山県財団法人富山県新世紀産業機構
    • JIN AISHUNKISHI HIROYUKIMURAGUCHI ATSUSHIOBATA TSUTOMU
    • C12M1/34C12M1/18C12Q1/02G01N33/53
    • G01N33/54366G01N33/5047G01N33/566G01N33/6863G01N2333/52G01N2333/715
    • PROBLEM TO BE SOLVED: To provide a method capable of measuring the responses of lymphocytes held on a chip, against the antigen stimulations of more than 10,000 simultaneously and grasping the state of each of the cells individually, and a means used for the method. SOLUTION: This method for screening an objective cell is provided by using a micro well array having a plurality of wells on one of the major surfaces of a substrate material wherein, the well has a size of holding only one cell, and a coated layer of a substance having a bonding property with a material produced by the cell housed in the well on a major surface surrounding the wells, housing test cells in the wells of the micro well array together with the culturing liquid of the cell, immersing the coated layer and wells in the culturing liquid, culturing the cells in a state capable of diffusing the material contained in the culturing liquid from the well to the coated layer, supplying a labelling substance specifically bonding with the material produced by the objective cell contained in the test cells, to the coated layer, detecting the substance produced by the objective cell and bonded with the material of the coated layer by using the labelling substance to identify the objective cell. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:提供一种能够测量保持在芯片上的淋巴细胞的反应的方法,针对多于10,000次的抗原刺激同时并且单独地掌握每个细胞的状态,以及用于 方法。 解决方案:用于筛选目标细胞的方法是通过使用在衬底材料的一个主表面上具有多个孔的微孔阵列来提供的,其中阱具有仅保持一个电池的尺寸,并且 将与容纳在孔周围的孔中的细胞产生的材料具有结合性的物质的涂层与容器的培养液一起容纳在微孔阵列的孔中的测试电池, 涂布层和培养液中的孔,以能够将培养液中所含的材料从孔扩散到涂层的状态培养细胞,供给与由包含在所述培养液中的目标细胞产生的材料特异性结合的标记物质 测试细胞到涂层,检测由目标细胞产生的物质并通过使用标记物质与涂层的材料结合来识别对象 活细胞。 版权所有(C)2009,JPO&INPIT
    • 8. 发明专利
    • Hybrid sensor component
    • 混合传感器组件
    • JP2006329840A
    • 2006-12-07
    • JP2005154754
    • 2005-05-27
    • Toyama Prefecture富山県
    • OBATA TSUTOMUMATSUDA TOSHIHIRO
    • G01D21/00G01P15/08
    • PROBLEM TO BE SOLVED: To provide a compact sensor module having high functions and high performance that is laminated with a sensor and an integrated circuit, without influencing the sensor performance.
      SOLUTION: The sensor and the integrated circuit are laminated or combined via an interposer. This provides functions related to the reliability to the integrated circuit or the interposer, which is represented by a regulation plate in an acceleration sensor, and then the very compact sensor module having high performance and high reliability can be obtained.
      COPYRIGHT: (C)2007,JPO&INPIT
    • 要解决的问题:提供具有高功能和高性能的紧凑型传感器模块,其与传感器和集成电路层压,而不影响传感器性能。

      解决方案:传感器和集成电路通过插入器层压或组合。 这提供了与由加速度传感器中的调节板表示的集成电路或插入器的可靠性相关的功能,然后可以获得具有高性能和高可靠性的非常紧凑的传感器模块。 版权所有(C)2007,JPO&INPIT

    • 10. 发明专利
    • Hollow package
    • 中空包装
    • JP2013026486A
    • 2013-02-04
    • JP2011160553
    • 2011-07-22
    • Yamaha Corpヤマハ株式会社Toyama Prefecture富山県
    • OKUMIYA YASUOOBATA TSUTOMU
    • H01L23/02H01L23/08H01L29/84
    • PROBLEM TO BE SOLVED: To realize a hollow package having high airtightness.SOLUTION: A hollow package (1) includes: a first substrate (10); a second substrate (18); spacers (12), each of which is formed between the first substrate and the second substrate and formed by a resin having both end surfaces closely contacting with the first substrate and the second substrate; and metal films (14, 16) continuing into and closely contacting with a side wall surface of each spacer, the first substrate, and the second substrate. Parts of the metal films get into an area between the second substrate and each spacer.
    • 要解决的问题:实现具有高气密性的中空包装。 解决方案:中空包装(1)包括:第一基底(10); 第二基板(18); 间隔物(12),其各自形成在第一基板和第二基板之间,并且由具有与第一基板和第二基板紧密接触的两个端面的树脂形成; 以及与每个间隔件,第一基板和第二基板的侧壁表面连续并紧密接触的金属膜(14,16)。 金属膜的一部分进入第二基板和每个间隔件之间的区域。 版权所有(C)2013,JPO&INPIT