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JP2010043110A Composition and method for reducing ocular hypertension 审中-公开
标题翻译：用于减少眼压高的组合物和方法
公开(公告)号：JP2010043110A
公开(公告)日：2010-02-25
申请号：JP2009235214
申请日：2009-10-09
申请人： Novartis Ag , ノバルティスアーゲー
发明人： REED KENNETH WARREN , YEN SHAU-FONG , SOU MARY , PEACOCK REGINA FLINN
IPC分类号： A61K9/08 , A61K31/557 , A61B5/103 , A61B5/11 , A61K9/00 , A61K31/5575 , A61K47/00 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/34 , A61P27/02 , A61P27/06
CPC分类号： A61K9/0048 , A61K31/5575
摘要： PROBLEM TO BE SOLVED: To provide an improved ocular composition including a prostaglandin active substance which is particularly useful to lower glaucoma related intraocular pressure.
SOLUTION: The composition includes a prostaglandin active substance (for example, a metabolite of F series prostaglandins, isopropyl unoprostone) together with a selected nonionic surfactant, a preservative and a nonionic tension modulator, and the composition includes (1) the prostaglandin active substance, (2) a first nonionic surfactant (for example, polysorbate 80), (3) a second nonionic surfactant (for example, a BRIJ surfactant), (4) a nonionic tension potentiating agent and (5) a chelator (for example, sodium edetate) in a preferred embodiment. Application of the disclosed composition effectuates improvements in a lowering effect of IOP (intraocular pressure), a preserving effect and lowered concentration of an additive.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种改善的眼部组合物，其包括前列腺素活性物质，其特别可用于降低青光眼相关的眼内压。组合物包括前列腺素活性物质（例如，F系列前列腺素的代谢物，异丙基异佛石）以及选择的非离子表面活性剂，防腐剂和非离子型张力调节剂，该组合物包括（1）前列腺素活性物质，（2）第一非离子表面活性剂（例如聚山梨醇酯80），（3）第二非离子表面活性剂（例如BRIJ表面活性剂），（4）非离子型增效剂和（5）螯合剂例如，依地酸钠）。所公开的组合物的应用可以改善IOP（眼内压）的降低作用，保存效果和降低添加剂浓度。版权所有（C）2010，JPO＆INPIT

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