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1. 发明专利

JP2008273959A Ophthalmic solution 有权
标题翻译： OPHTHALMIC解决方案
公开(公告)号：JP2008273959A
公开(公告)日：2008-11-13
申请号：JP2008097783
申请日：2008-04-04
申请人： Nof Corp , Taisho Pharmaceutical Co Ltd , 大正製薬株式会社 , 日油株式会社
发明人： KIMURA KAORI , MORITO AKIHISA , NAGAHAMA TORU
IPC分类号： A61K31/80 , A61K9/107 , A61K31/01 , A61K31/23 , A61K31/231 , A61P27/04
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic solution which can effectively treat dry eye syndromes or the like, is not limited on the concentration of compounded ingredients such as salts, is stable, and is easy to use.
SOLUTION: The ophthalmic solution contains, in the form of an emulsion, an oil selected from the group consisting of castor oil, liquid paraffin, lanolin, and vaseline and a water-soluble polymer being a copolymer of 2-methacryloyloxyethylphosphorylcholine with butyl (meth)acrylate.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了提供能够有效治疗干眼综合征等的眼用溶液，不限于盐等复合成分的浓度，稳定，易于使用。溶液：眼用溶液含有选自蓖麻油，液体石蜡，羊毛脂和凡士林的油以及2-甲基丙烯酰氧基乙基磷酰胆碱与丁基的共聚物的水溶性聚合物，其为乳液形式（甲基）丙烯酸酯。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2011148837A Lipase inhibitor 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：JP2011148837A
公开(公告)日：2011-08-04
申请号：JP2011103356
申请日：2011-05-06
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： ISHIBE MASUMI , ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： A61K36/73 , A61K36/00 , A61K36/18 , A61K36/28 , A61K36/70 , A61P3/04 , A61P3/06 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a safe and effective lipase inhibitor even by taking continuously for a long period, since the lipase is an enzyme catalyzing the decomposition of lipids in digestive tract, and on inhibiting its activity, the decomposition of the lipid is inhibited or delayed and the absorption of the lipid can be suppressed, the lipase inhibitor suppresses the elevation of serum lipid and accumulation of the lipids in a body and is useful for the prevention or improvement of hyperlipemia, obesity, etc. SOLUTION: The lipase inhibitor is obtained by blending one or two or more kinds selected from the group consisting of crude medicines derived from plants such as dried leaves of Rhododendron spp., dried Biota orientalis, dried fruits of Alpinia oxyphylla, dried Polygonum multiflorum roots, dried seeds of Prunus persica, dried roots of Sanguisorba officinalis, dried flowers of Inula britannica, dried roots of Bolboschoenus fluviatilis. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：即使长时间连续服用，也能提供安全有效的脂肪酶抑制剂，因为脂肪酶是催化消化道脂质分解的酶，抑制其活性，因此，脂质被抑制或延迟，并且可以抑制脂质的吸收，脂肪酶抑制剂抑制血清脂质的升高和脂质在体内的积累，并且可用于预防或改善高脂血症，肥胖症等。解决方案：脂肪酶抑制剂是通过混合选自植物中的一种或两种以上选自由杜鹃花干燥的叶子，干燥的生物芋，干果，枸杞干，杏仁干燥的种子，Sanguisorba officinalis的干燥根，Inula britannica的干花，紫花苜蓿干根。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2008266318A Retina protecting agent 有权
标题翻译： RETINA保护代理
公开(公告)号：JP2008266318A
公开(公告)日：2008-11-06
申请号：JP2008082436
申请日：2008-03-27
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA
IPC分类号： A61K31/085 , A61K31/11 , A61K31/201 , A61K31/231 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a prophylactic or therapeutic agent for visual functional disorders which inhibits the deterioration of visual functions caused by retinal functional disorders and is safe and effective even in long-term use since the resina takes on the center of eyesight and is an essential tissue for maintaining healthy visual functions and retinal functional disorders cause remarkable deterioration of the visual functions to reduce the quality of life.
SOLUTION: The preventing or therapeutic agent for visual functional disorders comprises a phenylpropanoid compound as an active ingredient.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于抑制由视网膜功能障碍引起的视觉功能恶化的视觉功能障碍的预防或治疗剂，并且即使在长期使用中也是安全和有效的，视力是维持健康视觉功能和视网膜功能障碍的重要组织，导致视觉功能的显着恶化，以降低生活质量。解决方案：用于视觉功能障碍的预防或治疗剂包括苯丙素类化合物作为活性成分。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2013144668A Oral body odor-improving composition 有权
标题翻译：口腔健康改善组合物
公开(公告)号：JP2013144668A
公开(公告)日：2013-07-25
申请号：JP2012266058
申请日：2012-12-05
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社 , Ogawa & Co Ltd , 小川香料株式会社
发明人： MORITO AKIHISA , NAKAMURA MASANORI , TAKEI TAKUTO , SUZUKI RYUICHIRO , MATSUMOTO KATSUYUKI
IPC分类号： A61K31/085 , A23L1/30 , A61K31/045 , A61P1/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition which can improve a body odor by being orally administered.SOLUTION: The oral body odor-improving composition includes guaiacol and benzyl alcohol, and further one or more compounds selected from linalool oxide, anethole and phenethyl alcohol.
摘要翻译：要解决的问题：提供可口服给药改善体臭的组合物。溶液：口腔改善气味组合物包括愈创木酚和苄醇，还有一种或多种选自芳樟醇，茴香脑和苯乙醇的化合物。

5. 发明专利

JP2013144667A Oral body odor-improving composition 有权
标题翻译：口腔健康改善组合物
公开(公告)号：JP2013144667A
公开(公告)日：2013-07-25
申请号：JP2012266056
申请日：2012-12-05
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社 , Ogawa & Co Ltd , 小川香料株式会社
发明人： MORITO AKIHISA , NAKAMURA MASANORI , TAKEI TAKUTO , SUZUKI RYUICHIRO , MATSUMOTO KATSUYUKI
IPC分类号： A61K31/125 , A23L1/30 , A61K31/045 , A61K31/085 , A61P1/02 , A61P17/00
摘要： PROBLEM TO BE SOLVED: To provide a composition which can improve a body odor by being orally administered.SOLUTION: The oral body odor-improving composition includes camphor and hexenol, and further includes one or more compounds selected from linalool oxide, anethole and phenethyl alcohol.
摘要翻译：要解决的问题：提供通过口服给药可以改善身体气味的组合物。解决方案：口腔体改善气味的组合物包括樟脑和己烯醇，还包括一种或多种选自芳樟醇，茴香脑和苯乙醇的化合物。

6. 发明专利

JP2013074886A Method of evaluating anti-fatigue substance 有权
标题翻译：评估抗疲劳物质的方法
公开(公告)号：JP2013074886A
公开(公告)日：2013-04-25
申请号：JP2012199227
申请日：2012-09-11
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA , NAKAYAMA YUKI
IPC分类号： C12Q1/25 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method of objectively determining efficacy of a test substance against fatigue.SOLUTION: In the method, the efficacy of a test substance against fatigue is determined using ribonuclease L (an interferon-induced antivirus enzyme) in a biological sample as an index.
摘要翻译：要解决的问题：提供客观地确定测试物质对疲劳的功效的方法。解决方案：在该方法中，使用生物样品中的核糖核酸酶L（干扰素诱导的抗病毒酶）作为指标来测定测试物质对疲劳的功效。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2013144669A Oral body odor-improving composition 有权
标题翻译：口腔健康改善组合物
公开(公告)号：JP2013144669A
公开(公告)日：2013-07-25
申请号：JP2012266060
申请日：2012-12-05
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社 , Ogawa & Co Ltd , 小川香料株式会社
发明人： MORITO AKIHISA , NAKAMURA MASANORI , TAKEI TAKUTO , SUZUKI RYUICHIRO , MATSUMOTO KATSUYUKI
IPC分类号： A61K31/085 , A61K31/045 , A61K31/341 , A61P17/00
摘要： PROBLEM TO BE SOLVED: To provide a composition which can improve a body odor by being orally administered.SOLUTION: The oral body odor-improving composition includes guaiacol and hexenol, and further one or more compounds selected from linalool oxide, anethole and phenethyl alcohol.
摘要翻译：要解决的问题：提供通过口服给药可以改善体臭的组合物。解决方案：口腔改善组合物包含愈创木酚和己烯醇，还有一种或多种选自芳樟醇，茴香脑和苯乙醇的化合物。

8. 发明专利

JP2013076691A Fatigue biomarker 审中-公开
标题翻译：疲劳生物标记
公开(公告)号：JP2013076691A
公开(公告)日：2013-04-25
申请号：JP2012199231
申请日：2012-09-11
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA , NAKAYAMA TAKEKI
IPC分类号： G01N33/68 , C12Q1/42 , C12Q1/68 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for determining fatigue level of a subject, a method for determining efficacy of a material (subject material) against fatigue which can relieve, alleviate or prevent fatigue, and a method for searching a material which can relieve, alleviate or prevent fatigue, with use of a biological specimen which can be easily prepared from a subject, and to provide a biomarker to be used for these methods.SOLUTION: A method for determining fatigue is based on an eosinophil-derived ribonuclease as an index in a biological specimen.
摘要翻译：要解决的问题：提供一种用于确定受试者的疲劳水平的方法，用于确定材料（主体材料）对减轻，减轻或预防疲劳的疲劳的功效的方法以及用于搜索材料的方法其可以使用可以容易地从受试者制备的生物标本来缓解，减轻或预防疲劳，并提供用于这些方法的生物标志物。解决方案：一种测定疲劳的方法是基于嗜酸性粒细胞衍生的核糖核酸酶作为生物标本中的指标。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012205590A Method for determining fatigue using gene expression 审中-公开
标题翻译：使用基因表达确定疲劳的方法
公开(公告)号：JP2012205590A
公开(公告)日：2012-10-25
申请号：JP2012055519
申请日：2012-03-13
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： OGAWA SHINICHI , MORITO AKIHISA , TOKUDA YASUSHI , KATO KEITA
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a method for determining a degree of fatigue of a subject using a biological sample easily obtainable from the subject, a method for determining effectiveness against fatigue of a test substrate, a method for searching a substrate capable of recovering, improving or preventing fatigue, and to provide a reagent for determining fatigue or a kit.SOLUTION: The method for determining the degree of fatigue in biological samples (blood, cells etc.) derived from a subject (a human etc.) includes analyzing and/or comparing the expression variation of one or more genes selected from a specific gene or a homologue gene thereof.
摘要翻译：要解决的问题：提供一种使用从受试者容易获得的生物样品来确定受试者的疲劳程度的方法，用于确定测试基底的疲劳的有效性的方法，用于检测基底的方法的恢复，改善或预防疲劳，并提供用于确定疲劳的试剂或试剂盒。解决方案：用于确定来自受试者（人等）的生物样品（血液，细胞等）的疲劳程度的方法包括分析和/或比较一种或多种选自以下的基因的表达变异：特异性基因或其同源基因。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2012006975A Lipase inhibitor 有权
标题翻译：脂肪酶抑制剂
公开(公告)号：JP2012006975A
公开(公告)日：2012-01-12
申请号：JP2011206870
申请日：2011-09-22
申请人： Taisho Pharmaceutical Co Ltd , 大正製薬株式会社
发明人： ISHIBE MASUMI , ASANO TOSHIKI , MORITO AKIHISA
IPC分类号： A61K36/73 , A61K36/00 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/48 , A61K36/53 , A61P3/04 , A61P3/06 , A61P9/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a lipase inhibitor which is safe and effective, even when continuously administered for a long period.SOLUTION: The lipase inhibitor is characterized by compounding one or more materials selected from the group consisting of Chaenomeles speciosa, Rubus chingii, R. crataegifolius, R.coreanus and R. parvifolius; an Epimedium plant such as Epimedium sagittatum or E.grandiflorum; Polygala tenuifolia, Desmodium styracifolium, Viola mandshurica or V. japonica; Elfvingia applanata or Phellinus igniarius; Magnolia biondi, M.liliflora or M.salicifolia; Artemisia capillaries or A.iwqayomogi; Notopterygium incisum, N.forbesli var. oviforme; Pogostemon cablin or Agastache rugosa; Artemisia argyi, A. princeps, A.lavandulaefolia, or A.Montana; Caesalpinia sappan; Psoralea corylifolia; and Perilla frutescens. Since this galenical has an excellent lipase-inhibiting action, the galenical can be used for medicines for treating or preventing lopase-originating diseases such as hyperlipemia or obesity, and for foods, and the like.
摘要翻译：要解决的问题：即使连续施用长时间，提供安全有效的脂肪酶抑制剂。脂肪酶抑制剂的特征在于，配合选自木瓜属（Cheenomeles speciosa），胡桃木（Rubus chingii），红树林（R. crataegifolius），R，属（R.crataegifolius）淫羊藿植物，例如淫羊藿（Epimedium sagittatum）或E藜（Egrandiflorum）; 茯苓，丝，，中华堇或粳稻; 小灵芝或桑黄; 玉兰ion di;;;;;;;;;;;;;; 艾蒿毛细血管或A.iwqayomogi; ium藜，N.forbesli var。 oviforme; Pogostemon cablin或Agastache rugosa; 艾蒿，A. ps，黄曲霉或A.Montana; Caesalpinia sappan; 茯苓和紫苏。由于该醋酸酯具有极好的脂肪酶抑制作用，所以可以用于治疗或预防诸如高脂血症或肥胖症之类的早发型疾病的药物，以及食品等。版权所有（C）2012，JPO＆INPIT

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