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1. 发明专利

JP2012206959A Composition for inhibiting glucosidase activity and method for screening the same 有权
标题翻译：用于抑制葡糖苷酶活性的组合物及其筛选方法
公开(公告)号：JP2012206959A
公开(公告)日：2012-10-25
申请号：JP2011072427
申请日：2011-03-29
申请人： Nihon Univ , Japan Health Science Foundation , 学校法人日本大学 , 財団法人ヒューマンサイエンス振興財団
发明人： HAKAMATA KO , NISHIO TOSHIYUKI , KURIHARA MASAAKI , TAKEBE YUTAKA
IPC分类号： A61K31/4045 , A61P31/18 , A61P43/00 , C07D209/14 , C07D409/12 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a composition for inhibiting glucosidase activity, a method for screening the same, a composition for inhibiting glucosidase activity, having anti-HIV activity and a method for screening the same.SOLUTION: The new composition for inhibiting glucosidase activity, having excellent glucosidase inhibition activity, high safety in ingestion by humans, etc., and anti-HIV activity is obtained by extracting an active site using the steric structure of an α-glucosidase as a target and virtually screening a compound compatible with the site from a well-known compound data base using a computer.
摘要翻译：待解决的问题：提供抑制葡糖苷酶活性的组合物，其筛选方法，抑制具有抗HIV活性的葡糖苷酶活性的组合物及其筛选方法。解决方案：通过使用α-葡萄糖苷酶的空间结构提取活性位点，获得了具有优异的葡糖苷酶抑制活性，人类摄取的高安全性以及抗HIV活性的抑制葡糖苷酶活性的新组合物作为目标，并使用计算机从众所周知的复合数据库中虚拟筛选与该位点相容的化合物。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2014030399A Purification method of n-acetylsucrosamine 审中-公开
标题翻译： N-乙酰氨基酚的纯化方法
公开(公告)号：JP2014030399A
公开(公告)日：2014-02-20
申请号：JP2012173599
申请日：2012-08-06
申请人： Nihon Univ , 学校法人日本大学
发明人： NISHIO TOSHIYUKI , HAKAMATA KO , HIRANO TAKAKO
IPC分类号： C12P19/00
摘要： PROBLEM TO BE SOLVED: To provide simple, efficient, low cost and safe purification of N-acetylsucrosamine from a glucide-mixed solution exemplified by a synthetic reaction solution of N-acetylsucrosamine by transglycosylation reaction of β-fructofuranosidase with sucrose and N-acetylglucosamine as a substrate.SOLUTION: A purification method of N-acetylsucrosamine from a glucide-mixed solution, comprises at least the following steps A to C. Step A: cultivating yeast in a glucide-mixed solution comprising N-acetylsucrosamine; step B: separating the yeast from the solution after cultivation; and step C: obtaining an N-acetylglucosamine purification fraction by column chromatography.
摘要翻译：要解决的问题：从由N-乙酰基异丙基苯胺的合成反应溶液所示的糖溶液混合溶液中提供简单，有效，低成本和安全的N-乙酰基异丙基苯胺的纯化，其通过葡萄糖醛糖苷酶与蔗糖和N-乙酰葡糖胺的反式糖基化反应作为底物。溶液：来自糖溶液混合溶液的N-乙酰基异丙基胺的纯化方法至少包括以下步骤A至C.步骤A：在包含N-乙酰基异丙基胺的糖溶液混合溶液中培养酵母; 步骤B：培养后将酵母与溶液分离; 和步骤C：通过柱色谱法获得N-乙酰葡糖胺纯化级分。

3. 发明专利

JP2005068109A Nitrogen monoxide-trapping agent 审中-公开
标题翻译：硝基一氧化碳捕捉剂
公开(公告)号：JP2005068109A
公开(公告)日：2005-03-17
申请号：JP2003303389
申请日：2003-08-27
申请人： Univ Nihon , 学校法人日本大学
发明人： OKU TADATAKE , NISHIO TOSHIYUKI , KAWACHI TAKASHI , SURUGA KOHEI
IPC分类号： G01N33/53 , A61K38/44 , A61P43/00 , C07K1/12 , C07K7/06 , C07K14/80 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To obtain a molecule that has excellent binding activity against to nitrogen monoxide with such a low level of toxicity that can be used as a medicine and provide a method for producing such a molecule.
SOLUTION: The subject nitrogen monoxide-trapping agent comprises a partial peptide of cytochrome c bearing a hem nucleus or its salt. The nitrogen monoxide-trapping agent contains a polypeptide or its salt having an amino acid sequences represented by the sequence numbers 1 through 3. Further, the nitrogen monoxide-trapping agent contains cytochrome c radiated with radioactive rays or its salt.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得具有优异的与一氧化氮的结合活性的分子，其毒性低，可以用作药物，并提供这种分子的制备方法。解决方案：本发明的一氧化氮捕获剂包含带有下缘核或其盐的细胞色素c的部分肽。一氧化氮捕获剂含有具有由序列号1〜3表示的氨基酸序列的多肽或其盐。此外，一氧化氮捕获剂含有用放射线照射的细胞色素c或其盐。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2006061085A NEW β-N-ACETYLHEXOSAMINIDASE 审中-公开
标题翻译：新的β-N-ACETYLHEXOSAMINIDASE
公开(公告)号：JP2006061085A
公开(公告)日：2006-03-09
申请号：JP2004248183
申请日：2004-08-27
申请人： Univ Nihon , 学校法人日本大学
发明人： NISHIO TOSHIYUKI , BEPPU TERUHIKO , UEDA KENJI , OKU TADATAKE , KAWACHI TAKASHI , OGAWA SHINKO
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/24 , C12P19/26
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To obtain an enzyme useful for producing N-acetylglucosamine from a chitin oligosaccharide. SOLUTION: A protein (enzyme) having the following physicochemical properties. (a) Action: the protein catalyzes an enzymatic reaction for hydrolyzing an oligosaccharide to produce N-acetylglucosamine. (b) Molecular weight: 55,800±500. (c) Optimal pH and stable pH range: the optimal pH is 5.5, when pNP N-acetyl-β-D-glucosaminide is used as a substrate, and the stable pH range is 5.3 to 10. (d) The range of a proper action temperature: a range of 55 to 75°C. (e) Thermal stability: when the protein is treated at pH 5.5 for 30 minutes, the protein holds the activity of ≥90% at 55°C, and the activity of 60% at 60°C. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：获得可用于从几丁质寡糖生产N-乙酰葡糖胺的酶。解决方案：具有以下物理化学性质的蛋白质（酶）。（a）作用：蛋白质催化水解寡糖以产生N-乙酰葡糖胺的酶反应。（b）分子量：55,800±500。（c）最佳pH值和稳定的pH范围：当pNP N-乙酰基-β-D-葡糖苷作为底物时，最适pH为5.5，稳定的pH范围为5.3〜10。（d）适当的动作温度：55至75°C的范围。（e）热稳定性：当蛋白质在pH 5.5处理30分钟时，蛋白质在55℃下保持≥90％的活性，60℃下的活性为60％。版权所有（C）2006，JPO＆NCIPI

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