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1. 发明专利

JP2013056837A Apoptosis inhibitory protein ligand-estrogen receptor ligand hybrid compound, estrogen receptor decomposition inducing agent utilizing the same, and prophylactic and therapeutic agent for breast cancer, cervical cancer or ovarian cancer 有权
标题翻译：杀虫剂抑制蛋白配体 - 雌激素受体配体混合化合物，雌激素受体分解诱导其使用的药剂，以及用于乳腺癌，癌症或卵巢癌的预防和治疗药物
公开(公告)号：JP2013056837A
公开(公告)日：2013-03-28
申请号：JP2011195081
申请日：2011-09-07
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： NAITO MIKIHIKO , OKUHIRA KEIICHIRO , IZUMI YASUSUKE , KURIHARA MASAAKI
IPC分类号： A61K47/48 , A61K31/138 , A61K31/16 , A61K31/4535 , A61K31/565 , A61K47/16 , A61P15/00 , A61P35/00 , C07C237/22
摘要： PROBLEM TO BE SOLVED: To provide an apoptosis inhibitory protein ligand-estrogen receptor ligand hybrid compound, which specifically decomposes an estrogen receptor expressing in the cancer cells of a breast cancer or the like to induce a cell death by a new mechanism of action.SOLUTION: The apoptosis inhibitory protein ligand-estrogen receptor ligand hybrid compound is represented by general formula (I) (wherein, X represents an apoptosis inhibitory protein ligand specifically bonded to an apoptosis inhibitory protein; Y represents an estrogen receptor ligand specifically bonded to an estrogen receptor; and Z represents a low molecular chain linker bonding both the apoptosis inhibitory protein ligand and estrogen receptor ligand without inhibiting the specific bondability of the apoptosis inhibitory protein ligand and estrogen receptor ligand).
摘要翻译：待解决的问题：提供一种凋亡抑制蛋白配体 - 雌激素受体配体杂化化合物，其特异性分解乳腺癌等的癌细胞中表达的雌激素受体，以通过新的机制诱导细胞死亡行动。凋亡抑制蛋白配体 - 雌激素受体配体杂化化合物由通式（I）表示（其中，X表示与细胞凋亡抑制蛋白特异性结合的凋亡抑制蛋白配体; Y表示特异性键合的雌激素受体配体到雌激素受体; Z代表结合凋亡抑制蛋白配体和雌激素受体配体的低分子链接，而不抑制凋亡抑制蛋白配体和雌激素受体配体的特异性结合能力）。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012217379A Method for screening therapeutic agent for dementia, transgenic non-human animal and expression vector 有权
标题翻译：用于筛选治疗药物的方法，转基因非人动物和表达载体
公开(公告)号：JP2012217379A
公开(公告)日：2012-11-12
申请号：JP2011085642
申请日：2011-04-07
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： TSUDA REO , HAYASHI EMI
IPC分类号： C12N15/09 , A01K67/027 , G01N33/15 , G01N33/48 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a method for screening an unerring therapeutic agent for dementia at an individual level.SOLUTION: A transgenic non-human animal in which a dementia-related gene is expressed is created by introducing an expression vector carrying the dementia-related gene into the inner ear hair cells of a non-human animal being a test subject. A candidate compound is administered to a transgenic non-human animal in which the dementia-related gene is expressed. Sense of hearing of the transgenic non-human animal in which the candidate compound is administered is detected. In such a case where the degree of hearing disorder in a transgenic non-human animal in which a candidate compound is administered is more dissolved than the degree of hearing disorder in a transgenic non-human animal in which a candidate compound is not administered, the candidate compound is determined to be effective as a therapeutic agent for dementia.
摘要翻译：待解决的问题：提供一种用于在个体水平上筛选痴呆治疗剂的方法。解决方案：通过将携带痴呆相关基因的表达载体导入作为受检对象的非人动物的内耳毛细胞来产生其中表达痴呆相关基因的转基因非人动物。将候选化合物施用于其中表达痴呆相关基因的转基因非人动物。检测其中施用候选化合物的转基因非人动物的听觉。在其中施用候选化合物的转基因非人动物中的听觉障碍程度比没有施用候选化合物的转基因非人动物中的听力障碍程度更多的情况下，候选化合物被确定为有效作为痴呆症的治疗剂。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2012205927A Cell sheet containing mesenchymal stem cell 有权
标题翻译：含细胞干细胞的细胞表
公开(公告)号：JP2012205927A
公开(公告)日：2012-10-25
申请号：JP2012164205
申请日：2012-07-24
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： NAGATANI NORITOSHI , MORI EIZO , MIYAHARA YOSHINORI
IPC分类号： A61L27/00 , A61K35/28 , A61P9/04 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/12 , A61L27/3834 , A61L27/3873 , C12N5/0667 , C12N2539/10
摘要： PROBLEM TO BE SOLVED: To demonstrate that a mesenchymal stem cell sheet has therapeutic potential for a severely damaged heart due to its pluripotency and in situ self-renewal capability, while mesenchymal stem cells are pluripotent cells capable of differentiating into myocardial and vascular endothelial cells.SOLUTION: The mesenchymal stem cells derived from adipose tissue are cultured to prepare the mesenchymal stem cell sheet. Four weeks after induction of myocardial infarction in rats, the mesenchymal stem cell sheet is transplanted to the heart. The mesenchymal stem cell sheet is readily engrafted to the surface of the scarred myocardium, grew gradually in situ, and formed a thick layer (approximately 600 μm) in the four weeks. The grown transplanted mesenchymal tissue contains newly formed blood vessels, myocardial cells, and undifferentiated mesenchymal cells. The engrafted mesenchymal stem cells inhibits thinning of the myocardial wall in the scar area, and improves cardiac function and survival rate in the rats with myocardial infarcts.
摘要翻译：待解决的问题：为了证明间充质干细胞片由于其多能性和原位自我更新能力而对严重损伤的心脏具有治疗潜力，而间充质干细胞是能够分化为心肌和血管的多能细胞内皮细胞。解决方案：培养源于脂肪组织的间充质干细胞以制备间充质干细胞片。诱导大鼠心肌梗塞后4周，将间充质干细胞片移植至心脏。间充质干细胞片容易移植到瘢痕性心肌的表面，在原位逐渐生长，并在四周内形成厚层（约600μm）。生长的移植间质组织包含新形成的血管，心肌细胞和未分化的间充质细胞。移植的间充质干细胞抑制瘢痕区域心肌壁变薄，改善心肌梗死大鼠的心脏功能和存活率。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2012039946A Establishment of immortalized endometriotic epithelial cell keeping characteristic of endometriotic epithelial cell 审中-公开
标题翻译：内皮细胞上皮细胞的内质网上皮细胞保持特征的建立
公开(公告)号：JP2012039946A
公开(公告)日：2012-03-01
申请号：JP2010184161
申请日：2010-08-19
申请人： Japan Health Science Foundation , Kanazawa Univ , 国立大学法人金沢大学 , 財団法人ヒューマンサイエンス振興財団
发明人： KYO SATORU , TAKAKURA MASAHIRO , YASUNO YUKIKO , INOUE MASAKI , KIYONO TORU
IPC分类号： C12N15/09 , C12N5/10 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide an immortalized endometriotic epithelial cell keeping the characters of an endometriotic epithelial cell.SOLUTION: The immortalized endometriotic epithelial cell keeping the characters of an unimmortalized endometriotic epithelial cell is provided, which is obtained by isolating an endometriotic epithelial cell from an endometriotic tissue so as not to contaminate it with interstitial cells and then transferring an extrinsic immortalizing gene into the isolated endometriotic epithelial cell to immortalize the endometriotic epithelial cell.
摘要翻译：待解决的问题：提供保持子宫内膜异位上皮细胞特征的永生化子宫内膜异位上皮细胞。提供了保持异质性子宫内膜异位上皮细胞特征的永生化子宫内膜异位上皮细胞，其通过从子宫内膜异位组织中分离子宫内膜异位上皮细胞而获得，以便不与间质细胞污染，然后转移外源性永生化基因进入孤立的子宫内膜异位上皮细胞以永生化子宫内膜异位上皮细胞。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2012034725A Mononuclear cell separation tube, mononuclear cell separation system, and method of separating mononuclear cell, mononuclear cell, and intracorporally-administered medicine 有权
标题翻译：单核细胞分离管，单核细胞分离系统和分离单核细胞，单核细胞和静脉内给药的方法
公开(公告)号：JP2012034725A
公开(公告)日：2012-02-23
申请号：JP2010175056
申请日：2010-08-04
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： TAGUCHI AKIHIKO , YAMAHARA KENICHI
IPC分类号： A61M1/02 , A61K35/14 , A61L27/00 , A61P9/00 , A61P9/04 , A61P13/12 , A61P25/00 , A61P25/28 , B03B5/32 , B04B5/02
CPC分类号： A61K35/14 , A61M1/3693 , A61M2202/10
摘要： PROBLEM TO BE SOLVED: To provide a mononuclear cell separation tube which permits mononuclear cells to be easily separated.SOLUTION: The mononuclear cell separation tube has an upper chamber 110 which stores a sample solution before centrifugal separation and in which mononuclear cells as a low specific gravity component located after centrifugal separation, a lower chamber 120 which stores a centrifugal separation medium before centrifugal separation and in which a high specific gravity component as an unnecessary component is located after centrifugal separation, a three-way stopper 130 openably connecting the lower-side opening of the upper chamber 110 and the upper-side opening of the lower chamber 120, and a lid 140 airtightly stopping the upper-side opening of the upper chamber 110.
摘要翻译：待解决的问题：提供允许单核细胞容易分离的单核细胞分离管。解决方案：单核细胞分离管具有上室110，其在离心分离前存储样品溶液，其中作为离心分离后的低比重组分的单核细胞，存在离心分离介质的下室120 离心分离后，作为不必要成分的高比重成分位于离心分离后，可开闭地连接上室110的下侧开口和下室120的上侧开口的三通阀130，和盖子140气密地停止上室110的上侧开口。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2012012344A Wound healing agent 审中-公开
标题翻译：创伤治疗代理
公开(公告)号：JP2012012344A
公开(公告)日：2012-01-19
申请号：JP2010151139
申请日：2010-07-01
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： KOTOBUKI YORIHISA , SERADA SATOSHI , NAKA TETSUJI
IPC分类号： A61K38/00 , A61K45/00 , A61P17/02
摘要： PROBLEM TO BE SOLVED: To provide a wound healing agent containing a component showing a healing effect to a wound, and having high safety and high stability.SOLUTION: A fibroblast proliferation promoter contains periostin as an effective component, and a wound healing agent contains the fibroblast proliferation promoter. It is found that periostin works as a proliferation promoting factor to fibroblast, and further shows an excellent wound healing effect.
摘要翻译：待解决的问题：提供含有对伤口显示愈合作用的成分的伤口愈合剂，并且具有高安全性和高稳定性。解决方案：成纤维细胞增殖启动子含有骨膜素作为有效成分，伤口愈合剂含有成纤维细胞增殖启动子。发现骨膜素作为成纤维细胞的增殖促进因子，进一步显示出良好的伤口愈合效果。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2011188835A Tissue microarray and tissue analysis method 审中-公开
标题翻译：组织微阵列和组织分析方法
公开(公告)号：JP2011188835A
公开(公告)日：2011-09-29
申请号：JP2010059800
申请日：2010-03-16
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： HASEGAWA MASANORI , KANEDA TSUGUHIRO , ICHIHARA SHU , MORIYA SUZUKO
IPC分类号： C12M1/40 , C12Q1/00 , G01N1/28
摘要： PROBLEM TO BE SOLVED: To provide a tissue microarray which can easily obtain a comprehensive protein expression profile of an individual patient to enable individualized medicine in a clinical site. SOLUTION: In the tissue microarray, a plurality of small sliced tissue pieces 100 obtained by cutting an identical tissue of an identical case of an identical person are arranged on a slide plate 200. A positive control 110, a negative control 120, and a normal tissue 130 can be arranged on the slide plate 200 in addition to a plurality of the cut small sliced tissue pieces 100. The cut small sliced tissue pieces 100 of the tissue microarray 900 are each dyed with a plurality of dye markers. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种组织微阵列，其可以容易地获得个体患者的综合蛋白质表达谱，以使临床部位中的个体化药物成为可能。解决方案：在组织微阵列中，通过切割相同人的相同病例的相同组织而获得的多个小切片组织块100布置在滑板200上。阳性对照110，阴性对照120，并且除了多个切割的小切片组织片100之外，还可以在滑板200上布置正常组织130.组织微阵列900的切割的小切片组织片100每个染色有多个染色标记。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2011153106A Anti-trpv2 antibody 有权
标题翻译：抗TRPV2抗体
公开(公告)号：JP2011153106A
公开(公告)日：2011-08-11
申请号：JP2010016760
申请日：2010-01-28
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： IWATA HIROKO , WAKABAYASHI SHIGEO
IPC分类号： C07K16/28 , A61K39/395 , A61P9/00 , A61P21/00 , A61P43/00 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide an anti-TRPV2 (transient receptor potential cation channel, subfamily V, member 2) antibody having a function of specifically inhibiting TRPV2 activity and a TRPV2 inhibitor containing the anti-TRPV2 antibody as an active ingredient. SOLUTION: The anti-TRPV2 antibody is prepared by using an extracellular domain of TRPV2 or a cell expressing TRPV2 as an antigen and has a function of recognizing an extracellular domain of TRPV2 and specifically inhibiting TRPV2 activity. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有特异性抑制TRPV2活性的功能的抗TRPV2（瞬时受体潜在阳离子通道，亚族V，成员2）抗体和含有抗TRPV2抗体的TRPV2抑制剂作为活性成分。解决方案：通过使用TRPV2的细胞外结构域或表达TRPV2的细胞作为抗原并具有识别TRPV2的细胞外结构域并特异性抑制TRPV2活性的功能来制备抗TRPV2抗体。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2011130728A Hybridoma, monoclonal antibody, and cell fusion method 有权
标题翻译： HYBRIDOMA，单克隆抗体和细胞融合方法
公开(公告)号：JP2011130728A
公开(公告)日：2011-07-07
申请号：JP2009294814
申请日：2009-12-25
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： SUGIMOTO MASATAKA , NAKAMURA HIDEAKI
IPC分类号： C12N15/09 , C07K16/28 , C12N5/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide an antibody capable of detecting Hzf protein, to provide a hybridoma capable of producing the antibody, and to provide a cell fusion method for producing the hybridoma. SOLUTION: The hybridoma is obtained by cell-fusing the antibody-producing cell of a mammal immunized by LHPAPGPIRTAHGPILFSPY with the myeloma cell of a mammal. The hybridoma is deposited as receipt number NITE AP-853 to Independent administrative agency, Product evaluation technical substrate mechanism, International Patent Organism Depositary, or as receipt number NITE AP-854 to Independent administrative agency, Product evaluation technical substrate mechanism, International Patent Organism Depositary. The antibodies produced from the hybridomas can be detected by immunoblotting Hzf protein, immunoprecipitation method, and cellular immune dyeing method. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供能够检测Hzf蛋白的抗体，以提供能够产生抗体的杂交瘤，并提供用于产生杂交瘤的细胞融合方法。解决方案：通过将由LHPAPGPIRTAHGPILFSPY免疫的哺乳动物的抗体产生细胞与哺乳动物的骨髓瘤细胞融合来获得杂交瘤。杂交瘤作为收据编号NITE AP-853以独立行政机构，产品评估技术底物机制，国际专利生物保藏单位或作为收据编号NITE AP-854存入独立行政机构，产品评价技术底物机制，国际专利生物保藏中心。由杂交瘤产生的抗体可以通过免疫印迹的Hzf蛋白，免疫沉淀法和细胞免疫染色法检测。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2011106818A Wet sensor, wet measuring system, wet measuring method, and wet measuring program 审中-公开
标题翻译：湿度传感器，湿度测量系统，湿度测量方法和湿度测量程序
公开(公告)号：JP2011106818A
公开(公告)日：2011-06-02
申请号：JP2009258824
申请日：2009-11-12
申请人： Japan Health Science Foundation , 財団法人ヒューマンサイエンス振興財団
发明人： HIROSE HIDEYUKI , TOYAMA SHIGERU , EVAN W CALL
IPC分类号： G01N27/04 , G01N27/00
摘要： PROBLEM TO BE SOLVED: To provide a wet sensor etc. capable of measuring wetting of a measured object in contact with a dummy member. SOLUTION: The wet sensor 110 includes a dummy member 111 which imitates at least a part of a shape of an organism, contacts a measuring object 99, and discharges a liquid to the contacted measuring object 99; and a pair of electrodes 113 formed on the dummy member 111, in contact with the measuring object 99, and measuring wetting of the measuring object 99 to which the liquid is discharged by the dummy member 111. COPYRIGHT: (C)2011,JPO&INPIT

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