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1. 发明专利

JP2011158369A Biochip, kit for antigen-antibody reaction detection, and detection method for antigen-antibody reaction 有权
标题翻译： BIOCHIP，抗真菌反应检测试剂盒，抗原抗体检测方法
公开(公告)号：JP2011158369A
公开(公告)日：2011-08-18
申请号：JP2010020998
申请日：2010-02-02
申请人： National Institute Of Advanced Industrial Science & Technology , Tohoku Univ , 国立大学法人東北大学 , 独立行政法人産業技術総合研究所
发明人： TAWA KEIKO , UMETSU MITSUHISA , KUMAGAI IZUMI , HATTORI MINEMITSU , ASANO RYUTARO
IPC分类号： G01N21/64 , G01N21/78 , G01N33/543 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a biochip capable of performing highly sensitive detection, and arraying antibodies for recognizing a target specifically on the chip surface with high density, and to provide a kit for antigen-antibody reaction detection, and a detection method for an antigen-antibody reaction.
SOLUTION: This biochip (1) includes a base substrate (2) having a cyclic structure on the surface, a metal layer (4) formed on the cyclic structure, an extinction suppression layer (6) formed on the metal layer (4), and a bispecific antibodies (7) bonded on the extinction suppression layer (6). The metal layer (4) is formed of a metal capable of generating surface plasmon resonance light, and the extinction suppression layer (6) is formed of zinc oxide (ZnO), and the bispecific antibody (7) is an antibody whose one end recognizes zinc oxide, and whose other end recognizes a fluorescence labeled protein, and light is allowed to enter to generate an electric field enhanced by the surface plasmon resonance light, and enhanced fluorescence is detected by using the generated electric field as an excitation field of the fluorescence labeled protein.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够进行高灵敏度检测的生物芯片，并且排列抗体以高密度特异性地识别芯片表面上的靶，并提供用于抗原 - 抗体反应检测的试剂盒，以及检测抗原 - 抗体反应的方法。解决方案：该生物芯片（1）包括在表面上具有环状结构的基底（2），形成在环状结构上的金属层（4），形成在金属层上的消光抑制层（6） 4）和结合在消光抑制层（6）上的双特异性抗体（7）。金属层（4）由能够产生表面等离子体共振光的金属形成，消光抑制层（6）由氧化锌（ZnO）形成，双特异性抗体（7）是其一端识别的抗体氧化锌，其另一端识别荧光标记的蛋白质，并且允许光进入以产生由表面等离子体共振光增强的电场，并且通过使用所产生的电场作为荧光的激发场来检测增强的荧光标记蛋白。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011068625A Protein accumulation and utilization thereof 有权
标题翻译：蛋白质的积累和利用
公开(公告)号：JP2011068625A
公开(公告)日：2011-04-07
申请号：JP2009223331
申请日：2009-09-28
申请人： Tohoku Univ , Toyota Central R&D Labs Inc , 国立大学法人東北大学 , 株式会社豊田中央研究所
发明人： MATSUYAMA TAKASHI , IGAWA YASUJI , IKEUCHI AKINORI , TAKAHASHI HARUO , ISHIDA NOBUHIRO , KATAHIRA SATOSHI , JO SONJIN , UMETSU MITSUHISA , KUMAGAI IZUMI , ASANO RYUTARO
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , C07K19/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new protein accumulating agent to heighten the affinity and bondability to a target of a protein having a prescribed function. SOLUTION: As the protein-accumulating agent, a peptide is utilized which has one amino acid sequence selected from (a) a specific amino acid sequence and (b) an amino acid sequence having one or more kinds of substitution, deletion, addition and insertion of one or several amino acids in the specific amino acid sequence. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种新的蛋白质积聚剂，以提高具有规定功能的蛋白质的靶标的亲和力和结合能力。作为蛋白质积聚剂，使用具有一个选自（a）特定氨基酸序列和（b）具有一个或多个取代，缺失的氨基酸序列的氨基酸序列的肽，在特定氨基酸序列中添加和插入一个或几个氨基酸。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2012179051A Highly functional bispecific antibody 有权
标题翻译：高功能双歧杆菌抗体
公开(公告)号：JP2012179051A
公开(公告)日：2012-09-20
申请号：JP2012083565
申请日：2012-04-02
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： KUMAGAI IZUMI , ASANO RYUTARO
IPC分类号： C12N15/09 , A61K39/395 , C07K16/28 , C07K16/30 , C07K16/46 , C12N5/10 , C12P21/02 , C12P21/08
CPC分类号： C07K16/2809 , A61K35/12 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2317/64 , C07K2317/732
摘要： PROBLEM TO BE SOLVED: To provide a humanized bispecific antibody having excellent functions such as exhibition of sufficient effects independently without improvement in structural stability and co-administration of activated lymphocyte (T-LAK).SOLUTION: The humanized highly functional bispecific antibody includes: an antibody that contains a humanized variable region (5H) of an H chain and a humanized variable region (5L) of an L chain of antihuman epidermal cell growth factor receptor 1 antibody 528 and a humanized variable region (OH) of an H chain and a humanized variable region (OL) of an L chain of anti-CD3 antibody OKT3, and has the following structure: an antibody in which a humanized diabody type bispecific antibody constituted of two kinds of single-stranded polypeptides of (OH5L) and (5HOL) is bonded with any one of the single-stranded polypeptides through a hinge region to two Fc regions of a human antibody.
摘要翻译：要解决的问题：提供具有优异功能的人源化双特异性抗体，例如独立地展现足够的效果而不改进结构稳定性和共同给予活化淋巴细胞（T-LAK）。解决方案：人源化高功能双特异性抗体包括：包含H链的人源化可变区（5H）和抗人表皮细胞生长因子受体1抗体528的L链的人源化可变区（5L）的抗体和抗-CD3抗体OKT3的L链的H链和人源化可变区（OL）的人源化可变区（OH），具有以下结构：其中由人源化双抗体型双特异性抗体构成的抗体（OH5L）和（5HOL）的单链多肽的种类通过铰链区与任一种单链多肽键合到人抗体的两个Fc区。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2012161324A High functional bispecific antibody 有权
标题翻译：高功能双歧杆菌抗体
公开(公告)号：JP2012161324A
公开(公告)日：2012-08-30
申请号：JP2012083566
申请日：2012-04-02
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： KUMAGAI IZUMI , ASANO RYUTARO
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/46 , C12N5/10
CPC分类号： C07K16/2809 , A61K35/12 , A61K39/39558 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2317/64 , C07K2317/732
摘要： PROBLEM TO BE SOLVED: To provide a bispecific antibody that is structurally stable, and can show alone a sufficient effect without the co-administration of activated lymphocyte (T-LAK).SOLUTION: A humanized highly functional bispecific antibody includes humanized variable regions of the heavy chain (5H) and the light chain (5L) of an anti-human EGF receptor 1 antibody 528, and humanized variable regions (OH) of the heavy chain and humanized variable regions (OL) of the light chain of the anti CD antibody OKT3 and has one of the following structures: any one of the single-chain polypeptides of (OH5L)-(a peptide linker)-(5HOL), (OH5H)-(a peptide linker)-(5LOL), or (5L5H)-(a peptide linker)-(OHOL) is bonded to two Fc regions of a human antibody via each hinge region.
摘要翻译：要解决的问题：提供结构稳定的双特异性抗体，并且可以单独显示足够的效果而不共同给予活化淋巴细胞（T-LAK）。解决方案：人源化高功能双特异性抗体包括抗人EGF受体1抗体528的重链（5H）和轻链（5L）的人源化可变区和重的人类化可变区（OH）抗CD抗体OKT3的轻链的链和人源化可变区（OL），并且具有以下结构之一：（OH5L） - （肽接头） - （5HOL）的单链多肽中的任一种 OH5H） - （肽接头） - （5LOL）或（5L5H） - （肽接头） - （OHOL）经由每个铰链区键合到人抗体的两个Fc区。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2014001168A Peptide having saccharification residual component binding capacity and its use 有权
标题翻译：具有分离残留成分结合能力的肽及其使用
公开(公告)号：JP2014001168A
公开(公告)日：2014-01-09
申请号：JP2012137719
申请日：2012-06-19
申请人： Toyota Motor Corp , トヨタ自動車株式会社 , Toyota Central R&D Labs Inc , 株式会社豊田中央研究所 , Tohoku Univ , 国立大学法人東北大学
发明人： ASANO HIDEKI , IKEUCHI AKINORI , KODA KATSUNORI , UMETSU MITSUHISA , KUMAGAI IZUMI , ASANO RYUTARO , NAKAZAWA HIKARI
IPC分类号： C07K7/08 , B01J20/24 , B09B3/00 , C07K19/00 , C12N9/02 , C12P19/14
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive method to prevent the inhibitory action of saccharification residual components with respect to carbohydrase.SOLUTION: A peptide includes at least one amino acid sequence selected from specific sequences and has a saccharification residual component binding capacity, a saccharification residual component adsorbent includes the peptide and, preferably, includes lignin-degrading enzyme, or fluorescent material or luminescent material, and a saccharification method includes a step to saccharify a carbohydrate polymer by carbohydrase in the presence of the peptide and/or the saccharification residual component adsorbent.
摘要翻译：要解决的问题：提供一种廉价的方法来防止糖化残留组分相对于碳水解酶的抑制作用。解决方案：肽包括至少一个选自特定序列的氨基酸序列，并具有糖化残留组分结合能力，糖化残留成分吸附剂包括肽，优选包括木质素降解酶或荧光材料或发光材料，糖化方法包括在肽和/或糖化残留成分存在下通过糖酶将糖类聚合物糖化的步骤吸附剂。

6. 发明专利

JP2012034668A Fragment of humanized anti-egfr antibody substituted-lysine variable region, and use thereof 审中-公开
标题翻译：人类抗EGFR抗体替代赖氨酸可变区的片段及其用途
公开(公告)号：JP2012034668A
公开(公告)日：2012-02-23
申请号：JP2010180693
申请日：2010-08-12
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： KUMAGAI IZUMI , NAKANISHI TAKESHI , SANADA HIDEAKI , ASANO RYUTARO , UMETSU MITSUHISA
IPC分类号： C12N15/09 , A61K39/395 , A61P35/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/626
摘要： PROBLEM TO BE SOLVED: To provide fragments of humanized anti-EGFR antibody substituted-lysine light-chain or heavy-chain variable regions, or single-strand antibodies, etc., composed of these, sufficiently holding binding activity (affinity) with target cells, and site-specifically and uniformly achieving various chemical modifications.SOLUTION: In the fragments of humanized anti-EGFR antibody substituted-lysine light-chain variable regions, all of the lysine residues or all of the lysine residues except lysine residues of one specific part are substituted by other amino acid in light-chain or heavy-chain humanized variable regions of antihuman epidermal cell growth factor receptor 1 (Her 1) antibody 528 comprising specific amino acid sequence.
摘要翻译：待解决的问题：为了提供由这些构成的人源化抗EGFR抗体取代的赖氨酸轻链或重链可变区或单链抗体等的片段，具有充分保持的结合活性（亲和性）具有目标细胞，并且特异性地并且均匀地实现各种化学修饰。解决方案：在人源化抗EGFR抗体取代的赖氨酸轻链可变区的片段中，除了一个特定部分的赖氨酸残基之外的所有赖氨酸残基或所有赖氨酸残基被其它氨基酸取代，包含特定氨基酸序列的抗人表皮细胞生长因子受体1（Her1）抗体528的链或重链人源化可变区。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2010119303A Multimeric low molecular antibody 有权
标题翻译：多分子低分子抗体
公开(公告)号：JP2010119303A
公开(公告)日：2010-06-03
申请号：JP2008292894
申请日：2008-11-17
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： KUMAGAI IZUMI , ASANO RYUTARO , UMETSU MITSUHISA
IPC分类号： C12N15/09 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K16/28 , C12N1/21 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To modify the linker of a single strand antibody (scFv) to an anti-epidermal growth factor receptor (EGFR) to improve drug disposition with the increase of molecular weight and further reinforce affinity and antitumor effect due to a polyvalent effect, thus providing an inexpensive new medicinal molecule.
SOLUTION: A multimeric low molecular antibody comprises a single strand antibody (scFv) containing an H strand human type variable region (h5H) and an L strand human type variable region (h5L) of an anti-human-epithelial cell growth factor receptor 1 antibody 528. The h5H and the h5L are amino acid sequences in which one or several amino acids are substituted, deleted, inserted or added and have the substantially same antigen-binding properties as those of the variable regions.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：将单链抗体（scFv）的接头修饰为抗表皮生长因子受体（EGFR），以随着分子量的增加改善药物配置，并进一步增强亲和力和抗肿瘤作用，由于多价效应，从而提供廉价的新药物分子。解决方案：多聚体低分子抗体包含含有H链人类可变区（h5H）和抗人上皮细胞生长因子的L链人类可变区（h5L）的单链抗体（scFv）受体1抗体528.h5H和h5L是氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入或添加，并且具有与可变区的抗原结合性质基本相同的氨基酸序列。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009297022A Method for preparation of recombinant polypeptide 有权
标题翻译：制备重组多肽的方法
公开(公告)号：JP2009297022A
公开(公告)日：2009-12-24
申请号：JP2009117036
申请日：2009-05-13
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： KUMAGAI IZUMI , ASANO RYUTARO , NAKANISHI TAKESHI , UMETSU MITSUHISA
IPC分类号： C12P21/02 , A61K38/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a method for recovering biological activity at high efficiency in a recombinant polypeptide produced as an insoluble fraction in hosts such as E. coli or the like, and further imparting an excellent property not found in nature. SOLUTION: The method for preparation of recombinant polypeptide includes a chemical modification using a polyethylene glycol etc., of a polypeptide before rewinding, a soluble aggregate or an insoluble aggregate of the polypeptide formed after rewinding, or either of rewinding intermediates of the polypeptide in a stepwise dialysis process in preparation of the polypeptide produced by using a gene recombinant cell of the E. coli or the like. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种在诸如大肠杆菌等宿主中作为不溶性级分生产的重组多肽以高效率回收生物活性的方法，并进一步赋予自然界中没有发现的优异性质。解决方案：重组多肽的制备方法包括使用聚碳酸乙二醇等进行的化学修饰，在倒卷之前的多肽，可回收的聚集体或在倒卷后形成的多肽的不溶性聚集体，多肽在制备通过使用大肠杆菌等的基因重组细胞产生的多肽的逐步透析过程中。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2005213166A Functional polypeptide and method for forming multimer of protein therewith 审中-公开
标题翻译：功能多肽和形成多种蛋白质的方法
公开(公告)号：JP2005213166A
公开(公告)日：2005-08-11
申请号：JP2004019633
申请日：2004-01-28
申请人： Hokkaido Univ , Tohoku Univ , 国立大学法人北海道大学 , 国立大学法人東北大学
发明人： TSUMOTO KOHEI , KUMAGAI IZUMI , YO BIN , TANAKA ISAO
IPC分类号： C12N15/09 , C07K1/113 , C07K14/47 , C07K19/00
摘要： PROBLEM TO BE SOLVED: To provide a peptide capable of multimerizing an arbitrary protein, and to provide a method for multimerizing a protein therewith.
SOLUTION: This polypeptide comprises the following (a) or (b). (a) is a polypeptide comprising an amino acid sequence in the C-terminal portion of L-isoaspartate-O-methyltransferase originating from Suflolobus tokodaii. (b) is a polypeptide which comprises the amino acid sequence represented in (a) wherein one or more amino acids are substituted, deleted or added, forms an α-helix structure, and has a multimer-forming ability.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供能够使任意蛋白质多聚化的肽，并提供其蛋白质多聚化的方法。解决方案：该多肽包含以下（a）或（b）。（a）是包含源自Suflolobus tokodaii的L-异天冬氨酸-O-甲基转移酶的C末端部分中的氨基酸序列的多肽。（b）是包含（a）中表示的氨基酸序列的多肽，其中一个或多个氨基酸被取代，缺失或添加，形成α-螺旋结构，并具有多聚体形成能力。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2010252789A Protein complex for decomposing cellulose and use of the same 审中-公开
标题翻译：用于分解纤维素的蛋白复合物及其使用
公开(公告)号：JP2010252789A
公开(公告)日：2010-11-11
申请号：JP2010083962
申请日：2010-03-31
申请人： Tohoku Univ , Toyota Central R&D Labs Inc , 国立大学法人東北大学 , 株式会社豊田中央研究所
发明人： MATSUYAMA TAKASHI , IKEUCHI AKINORI , IGAWA YASUJI , ISHIDA NOBUHIRO , IMAMURA CHIE , TAKAHASHI HARUO , UMETSU MITSUHISA , KUMAGAI IZUMI
IPC分类号： C12N9/42 , C12N9/98 , C12N15/09 , C12P7/08 , C12P19/14
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a protein complex in which proteins contributing to cellulose decomposition are clustered and which is suitable for improving the functions of these proteins and synergistic effects between the proteins and other proteins.
SOLUTION: A complex is formed for cellulose decomposition, wherein the complex is provided with a carrier having a plurality of biotin binding sites and one or more of the multiple cellulose decomposition proteins which are biotinylated and retained on the carrier and contribute to the decomposition of cellulose.
COPYRIGHT: (C)2011,JPO&INPIT

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