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1. 发明专利

JP2008221208A Mixing device/method of fluid and mold configuration 有权
标题翻译：混合装置/流体和模具配置方法
公开(公告)号：JP2008221208A
公开(公告)日：2008-09-25
申请号：JP2008032495
申请日：2008-02-14
申请人： Nagoya Industrial Science Research Inst , Univ Nagoya , 国立大学法人名古屋大学 , 財団法人名古屋産業科学研究所
发明人： SHAMOTO EIJI , TOKESHI MANABU , KACHI NORIMASA , BABA YOSHINOBU , SAKAI YASUHIKO , SUZUKI NORIKAZU
IPC分类号： B01F5/00 , B01F3/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To realize a fluid mixing device which is compact and inexpensive on account of the use of a flow path of a single-layer structure which can be formed by a mold. SOLUTION: A flow path A through which a fluid A flows extends to the lower part of a flow path B through which a fluid B flows, from a position (b) to a position (c). Therefore, the fluid A flows into the lower flow layer of the fluid B. After that, the flow path is separated to the right and left sides in a position (d) and a position (e), and in each of the separate flow paths, the two fluids A and B are mixed in the form of two upper and lower layers. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：实现由于可以通过模具形成的单层结构的流动路径的使用而实现小型且便宜的流体混合装置。解决方案：流体A流过的流路A从流体B流过的流路B的下部延伸到从位置（b）到位置（c）的流路A. 因此，流体A流入流体B的下流层。之后，流动路径在位置（d）和位置（e）处分离成左右两侧，并且在每个分离流中两个流体A和B以两个上层和下层的形式混合。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2013139034A Mixing device/method of fluid and mold construction 审中-公开
标题翻译：混合装置/流体和模具结构的方法
公开(公告)号：JP2013139034A
公开(公告)日：2013-07-18
申请号：JP2013030408
申请日：2013-02-19
申请人： Nagoya Univ , 国立大学法人名古屋大学 , Nagoya Industrial Science Research Institute , 公益財団法人名古屋産業科学研究所
发明人： SHAMOTO EIJI , TOKESHI MANABU , KACHI NORIMASA , BABA YOSHINOBU , SAKAI YASUHIKO , SUZUKI NORIKAZU
IPC分类号： B01F5/00 , B01F3/08 , B01J19/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a fluid mixing device which is compact and inexpensive by use of a flow path of a single layer structure that can be molded by a mold.SOLUTION: In the fluid mixing device, two fluids are mixed by making at least two channels joined, at least two channels are formed from the same surface in the same direction in one microchip that composes the mixing device and is constituted of one channel accommodating one fluid and another channel accommodating another fluid. The mixing device is provided with a first channel part and a second channel part. In the first channel part, a position of a lowest part of one channel in a vertical direction perpendicular to a channel direction is lower than a position of a lowest part of another channel in a vertical direction. In the second channel part in a state after channel joining, a lowest part in a vertical direction of a part extended from one channel is located just under a lowest part of a part extended from another channel. The channel part immediately after joining and subsequent at lest one channel part respectively have different shapes of faces that are perpendicular to the channel direction.
摘要翻译：要解决的问题：提供一种通过使用可由模具成型的单层结构的流路而紧凑且便宜的流体混合装置。解决方案：在流体混合装置中，将两种流体混合在连接了至少两个通道，在构成混合装置的一个微芯片中，从相同方向上的相同表面形成至少两个通道，并且由一个容纳一个流体的通道和另一个容纳另一个流体的通道构成。混合装置设有第一通道部分和第二通道部分。在第一通道部分中，垂直于通道方向的垂直方向上的一个通道的最低部分的位置低于另一个通道在垂直方向上的最低部分的位置。在通道连接之后的第二通道部分中，从一个通道延伸的部分的垂直方向上的最低部分位于从另一个通道延伸的部分的最下部。刚刚接合后的通道部分和随后的一个通道部分分别具有垂直于通道方向的不同形状的面。

3. 发明专利

JP2009288201A Flow velocity determination method of analyte, analyte evaluation method using the method, and design method of analyte evaluation device 有权
标题翻译：分析仪的流速测定方法，使用方法的分析评估方法和分析仪评估装置的设计方法
公开(公告)号：JP2009288201A
公开(公告)日：2009-12-10
申请号：JP2008143849
申请日：2008-05-30
申请人： Fujitsu Ltd , Univ Nagoya , 国立大学法人名古屋大学 , 富士通株式会社
发明人： AKI MASAHIKO , ARINAGA KENJI , BABA YOSHINOBU , TOKESHI MANABU , KACHI NORIMASA
IPC分类号： G01N33/543 , G01N21/64 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To enable rational flow velocity determination, when evaluating an analyte by means of fluorescence emission. SOLUTION: The analyte or a material other than the analyte which is a material, capable of changing intensity of fluorescence emission from a fluorescence-labeled substance by being coupled with the fluorescence-labeled substance, is allowed to flow during light reception onto the fluorescence-labeled substance capable of changing intensity of fluorescence emission, by being coupled with the analyte during light reception, to be brought into contact with the fluorescence-labeled substance, and flow velocity to be used for evaluating the analyte is determined from the relation between a time constant and the flow velocity, determined by standardizing a gradient of the rises time or the fall time change of the fluorescence intensity from the fluorescence labeled substance. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：当通过荧光发射评估分析物时，能够确定合理的流速。解决方案：允许通过与荧光标记物质偶联，能够改变荧光标记物质的荧光发射强度的分析物或分析物以外的材料，该分析物是能够在光接收期间流过荧光标记物质的荧光发射强度，荧光标记的物质能够通过与受光时的分析物结合而与荧光标记的物质接触，并且可以从用于评价分析物的流速来改变荧光发射强度通过标准化来自荧光标记物质的荧光强度的上升时间或下降时间变化的梯度来确定时间常数和流速之间的关系。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2014039480A Method for detecting circulating tumor cell 审中-公开
标题翻译：检测循环肿瘤细胞的方法
公开(公告)号：JP2014039480A
公开(公告)日：2014-03-06
申请号：JP2012181987
申请日：2012-08-21
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： OKAMOTO YUKIHIRO , OTSUKA KOHEI , HASE TETSUNARI , TOKESHI MANABU , HASEGAWA YOSHINORI , BABA YOSHINOBU
IPC分类号： C12Q1/04 , C12Q1/37 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a circulating tumor cell (CTC) detection means that can detect even EpCAM negative CTC.SOLUTION: Provided is a detection method for a circulating tumor cell comprising the steps of: (1) preparing a culture plate composed of a gel material containing urokinase-specific substrate; (2) inoculating a blood sample to the culture plate and incubating it; and (3) detecting a signal derived from the urokinase-specific substrate.
摘要翻译：要解决的问题：提供可以检测EpCAM阴性CTC的循环肿瘤细胞（CTC）检测手段。解决方案：提供一种循环肿瘤细胞的检测方法，包括以下步骤：（1）制备由含有尿激酶特异性底物的凝胶材料; （2）将血液样品接种到培养板上并孵育; 和（3）检测从尿激酶特异性底物衍生的信号。

5. 发明专利

JP2011095193A Analytical device, method for manufacturing the same, and analyzer using the same 审中-公开
标题翻译：分析装置，其制造方法和使用该分析装置的分析仪
公开(公告)号：JP2011095193A
公开(公告)日：2011-05-12
申请号：JP2009251536
申请日：2009-10-30
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： ONOJIMA DAISUKE , KACHI NORIMASA , TOKESHI MANABU , BABA YOSHINOBU
IPC分类号： G01N35/08 , G01N21/27 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an analytical device using a versatile optical system and having high detection sensitivity, and to provide an analyzer, and an easy and inexpensive method for manufacturing the analytical device.
SOLUTION: The analyzer 1 includes: the analytical device 5 including a specimen liquid introduction port 10 for introducing specimen liquid, a measuring part 20 for measuring the specimen liquid introduced from the specimen liquid introduction port, and a specimen liquid discharge port 30 for receiving the specimen liquid discharged from the measuring part; a light irradiator 50 for irradiating the measuring part 20 of the analytical device 5 with inspection light; and a photodetector 60 for detecting measurement light from the measuring part 20 of the analytical device 5. The measuring part 20 comprises a channel whose aspect ratio d/w between a depth d and a width w is 3 or more, and whose width w is below 50 μm, and a depth direction of the channel agrees with an optical path direction of inspection light and the measurement light passing the channel.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用通用光学系统并具有高检测灵敏度的分析装置，并提供分析器，以及用于制造分析装置的简单且便宜的方法。解决方案：分析装置1包括：分析装置5，包括用于引入样本液体的标本液引入口10，用于测量从试样液导入口导入的检体液的测定部20和试样液排出口30 用于接收从测量部件排出的样品液体; 用于利用检查光照射分析装置5的测量部分20的光照射器50; 以及用于检测来自分析装置5的测量部分20的测量光的光电检测器60.测量部分20包括其深度d和宽度w之间的纵横比d / w为3或更大并且其宽度w为低于50μm，并且通道的深度方向与检查光的光路方向和通过通道的测量光一致。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2012078168A Detection method and detection system using nano structure 有权
标题翻译：使用纳米结构的检测方法和检测系统
公开(公告)号：JP2012078168A
公开(公告)日：2012-04-19
申请号：JP2010222528
申请日：2010-09-30
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： YASUI TAKAO , KACHI NORIMASA , OKAMOTO YUKIHIRO , TOKESHI MANABU , BABA YOSHINOBU
IPC分类号： G01N21/47
摘要： PROBLEM TO BE SOLVED: To provide a detection method and a detection system which are unnecessary for labeling a sample, have a simple system configuration and can continuously measure.SOLUTION: The detection method includes a step of flowing a sample into a flow channel having a periodic nano structure region, a step of irradiating the nano structure region with light having single wavelength to generate diffraction light, and a step of detecting the variation of the diffraction angle of primary diffraction light out of the generated diffraction light, and a detection system is used for the detection method.

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