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1. 发明专利

JP2008221208A Mixing device/method of fluid and mold configuration 有权
标题翻译：混合装置/流体和模具配置方法
公开(公告)号：JP2008221208A
公开(公告)日：2008-09-25
申请号：JP2008032495
申请日：2008-02-14
申请人： Nagoya Industrial Science Research Inst , Univ Nagoya , 国立大学法人名古屋大学 , 財団法人名古屋産業科学研究所
发明人： SHAMOTO EIJI , TOKESHI MANABU , KACHI NORIMASA , BABA YOSHINOBU , SAKAI YASUHIKO , SUZUKI NORIKAZU
IPC分类号： B01F5/00 , B01F3/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To realize a fluid mixing device which is compact and inexpensive on account of the use of a flow path of a single-layer structure which can be formed by a mold. SOLUTION: A flow path A through which a fluid A flows extends to the lower part of a flow path B through which a fluid B flows, from a position (b) to a position (c). Therefore, the fluid A flows into the lower flow layer of the fluid B. After that, the flow path is separated to the right and left sides in a position (d) and a position (e), and in each of the separate flow paths, the two fluids A and B are mixed in the form of two upper and lower layers. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：实现由于可以通过模具形成的单层结构的流动路径的使用而实现小型且便宜的流体混合装置。解决方案：流体A流过的流路A从流体B流过的流路B的下部延伸到从位置（b）到位置（c）的流路A. 因此，流体A流入流体B的下流层。之后，流动路径在位置（d）和位置（e）处分离成左右两侧，并且在每个分离流中两个流体A和B以两个上层和下层的形式混合。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2013139034A Mixing device/method of fluid and mold construction 审中-公开
标题翻译：混合装置/流体和模具结构的方法
公开(公告)号：JP2013139034A
公开(公告)日：2013-07-18
申请号：JP2013030408
申请日：2013-02-19
申请人： Nagoya Univ , 国立大学法人名古屋大学 , Nagoya Industrial Science Research Institute , 公益財団法人名古屋産業科学研究所
发明人： SHAMOTO EIJI , TOKESHI MANABU , KACHI NORIMASA , BABA YOSHINOBU , SAKAI YASUHIKO , SUZUKI NORIKAZU
IPC分类号： B01F5/00 , B01F3/08 , B01J19/00 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a fluid mixing device which is compact and inexpensive by use of a flow path of a single layer structure that can be molded by a mold.SOLUTION: In the fluid mixing device, two fluids are mixed by making at least two channels joined, at least two channels are formed from the same surface in the same direction in one microchip that composes the mixing device and is constituted of one channel accommodating one fluid and another channel accommodating another fluid. The mixing device is provided with a first channel part and a second channel part. In the first channel part, a position of a lowest part of one channel in a vertical direction perpendicular to a channel direction is lower than a position of a lowest part of another channel in a vertical direction. In the second channel part in a state after channel joining, a lowest part in a vertical direction of a part extended from one channel is located just under a lowest part of a part extended from another channel. The channel part immediately after joining and subsequent at lest one channel part respectively have different shapes of faces that are perpendicular to the channel direction.
摘要翻译：要解决的问题：提供一种通过使用可由模具成型的单层结构的流路而紧凑且便宜的流体混合装置。解决方案：在流体混合装置中，将两种流体混合在连接了至少两个通道，在构成混合装置的一个微芯片中，从相同方向上的相同表面形成至少两个通道，并且由一个容纳一个流体的通道和另一个容纳另一个流体的通道构成。混合装置设有第一通道部分和第二通道部分。在第一通道部分中，垂直于通道方向的垂直方向上的一个通道的最低部分的位置低于另一个通道在垂直方向上的最低部分的位置。在通道连接之后的第二通道部分中，从一个通道延伸的部分的垂直方向上的最低部分位于从另一个通道延伸的部分的最下部。刚刚接合后的通道部分和随后的一个通道部分分别具有垂直于通道方向的不同形状的面。

3. 发明专利

JP2008228646A Diagnostic for type ii diabetes 审中-公开
标题翻译： DI型糖尿病诊断
公开(公告)号：JP2008228646A
公开(公告)日：2008-10-02
申请号：JP2007072563
申请日：2007-03-20
申请人： Hokkaido Univ , Univ Nagoya , 国立大学法人北海道大学 , 国立大学法人名古屋大学
发明人： HARASHIMA HIDEYOSHI , IIDA SHINYA , KAMIYA HIROYUKI , HAYASHI YASUHIRO , BABA YOSHINOBU
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a diagnostic for type II diabetes, to provide a diagnostic kit for type II diabetes, to provide a method for screening a substance consisting of a prophylactic and/or curative agent for type II diabetes, and to provide a kit for use in the screening. SOLUTION: The diagnostic for type II diabetes comprises a specific antibody (or its fragment) bindable to a nucleic acid hybridizable, under stringent conditions, with the base sequence(s) of at least one or more genes selected from 38 kinds of genes and/or bindable to a protein encoded by either one of the genes. This diagnostic is to confirm, in leukocyte, the expression of a gene associated with type II diabetes development, and by analyzing type II diabetes alternatively to conventional genes usable for diagnosing type II diabetes or additionally thereto, the above gene can further improve the accuracy of determination that the patient in question has type II diabetes or is possible to have the disease. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供II型糖尿病的诊断，提供II型糖尿病的诊断试剂盒，以提供筛选由II型糖尿病的预防和/或治愈剂组成的物质的方法，以及提供用于筛选的试剂盒。解决方案：II型糖尿病的诊断包括可在严格条件下与核酸可杂交的特异性抗体（或其片段），其中至少一种或多种基因的碱基序列选自38种基因和/或可与任何一个基因编码的蛋白质结合。这种诊断是在白细胞中确认与II型糖尿病发展相关的基因的表达，并且通过分析II型糖尿病可替代地可用于诊断II型糖尿病的常规基因或另外，可以进一步提高上述基因的准确性确定所述患者具有II型糖尿病或可能患有该疾病。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2009288201A Flow velocity determination method of analyte, analyte evaluation method using the method, and design method of analyte evaluation device 有权
标题翻译：分析仪的流速测定方法，使用方法的分析评估方法和分析仪评估装置的设计方法
公开(公告)号：JP2009288201A
公开(公告)日：2009-12-10
申请号：JP2008143849
申请日：2008-05-30
申请人： Fujitsu Ltd , Univ Nagoya , 国立大学法人名古屋大学 , 富士通株式会社
发明人： AKI MASAHIKO , ARINAGA KENJI , BABA YOSHINOBU , TOKESHI MANABU , KACHI NORIMASA
IPC分类号： G01N33/543 , G01N21/64 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To enable rational flow velocity determination, when evaluating an analyte by means of fluorescence emission. SOLUTION: The analyte or a material other than the analyte which is a material, capable of changing intensity of fluorescence emission from a fluorescence-labeled substance by being coupled with the fluorescence-labeled substance, is allowed to flow during light reception onto the fluorescence-labeled substance capable of changing intensity of fluorescence emission, by being coupled with the analyte during light reception, to be brought into contact with the fluorescence-labeled substance, and flow velocity to be used for evaluating the analyte is determined from the relation between a time constant and the flow velocity, determined by standardizing a gradient of the rises time or the fall time change of the fluorescence intensity from the fluorescence labeled substance. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：当通过荧光发射评估分析物时，能够确定合理的流速。解决方案：允许通过与荧光标记物质偶联，能够改变荧光标记物质的荧光发射强度的分析物或分析物以外的材料，该分析物是能够在光接收期间流过荧光标记物质的荧光发射强度，荧光标记的物质能够通过与受光时的分析物结合而与荧光标记的物质接触，并且可以从用于评价分析物的流速来改变荧光发射强度通过标准化来自荧光标记物质的荧光强度的上升时间或下降时间变化的梯度来确定时间常数和流速之间的关系。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2007082458A Method for diagnosing type 2 diabetes 审中-公开
标题翻译：诊断2型糖尿病的方法
公开(公告)号：JP2007082458A
公开(公告)日：2007-04-05
申请号：JP2005274751
申请日：2005-09-21
申请人： Hokkaido Univ , Univ Nagoya , 国立大学法人北海道大学 , 国立大学法人名古屋大学
发明人： IIDA SHINYA , BABA YOSHINOBU , KAMIYA HIROYUKI , HARASHIMA HIDEYOSHI
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a method for diagnosing type 2 diabetes by an expression analysis of genes in a tissue easily carrying out sampling (whether or not there is the possibility of onset of the type 2 diabetes in future especially before the onset of the type 2 diabetes can be diagnosed and the type 2 diabetes can be detected in an early stage). SOLUTION: The one or two or more kinds of genes selected from prescribed genes are utilized when the type 2 diabetes is diagnosed by using the expression level of the prescribed genes in leukocytes collected from blood of a subject in an insulin-tolerance state or a fast state as an index. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过对容易进行抽样的组织中的基因的表达分析来提供用于诊断2型糖尿病的方法（将来是否存在2型糖尿病发病的可能性，特别是在 2型糖尿病的发病可以诊断，2型糖尿病可以在早期发现）。解决方案：当通过使用从胰岛素耐受状态的受试者的血液中收集的白细胞中规定的基因的表达水平诊断为2型糖尿病时，选择选自规定的基因的一种或两种以上的基因或作为索引的快速状态。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2014185224A Semiconductor nanoparticle and fluorescent probe for labeling biological samples 有权
标题翻译：用于标记生物样品的半导体纳米材料和荧光探针
公开(公告)号：JP2014185224A
公开(公告)日：2014-10-02
申请号：JP2013060365
申请日：2013-03-22
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： YUKAWA HIROSHI , NISHI HIROYASU , TORIMOTO TSUKASA , BABA YOSHINOBU
IPC分类号： C09K11/56 , C09K11/08
CPC分类号： G01N21/643 , B82Y15/00 , C09K11/54 , G01N33/582 , H01B1/10
摘要： PROBLEM TO BE SOLVED: To provide a semiconductor nanoparticle low in toxicity and high in emission quantum yield.SOLUTION: The semiconductor nanoparticle is a particle of a core shell structure having a core and a shell surrounding the core. The core is (AgIn)ZnS, where x satisfies 0.4≤x≤0.95. The shell is ZnS or ZnO and has hydrophilic functional groups on its surface. The hydrophilic functional groups include a carboxyl group or a sulfo group. The semiconductor nanoparticle can be used for a fluorescent probe for labeling biological samples as its toxicity is low and an emission quantum yield is high.
摘要翻译：要解决的问题：提供低毒性和高发射量子产率的半导体纳米颗粒。解决方案：半导体纳米颗粒是具有芯和围绕芯的壳的核心壳结构的颗粒。核心是（AgIn）ZnS，其中x满足0.4≤x≤0.95。壳体为ZnS或ZnO，表面具有亲水性官能团。亲水性官能团包括羧基或磺基。半导体纳米颗粒可用于标记生物样品的荧光探针，因为其毒性低，发射量子产率高。

7. 发明专利

JP2014168449A Stretching/immobilizing device of nucleic acid, stretching/immobilizing method of nucleic acid using the device, nucleic acid immobilizing member, and nucleic acid specimen fabricated by using stretching/immobilizing device of nucleic acid 有权
标题翻译：使用装置的核酸的拉伸/固定装置，使用装置的核酸的固化/固化方法，核酸固定成员和通过使用拉伸/固定的核酸装置制备的核酸样本
公开(公告)号：JP2014168449A
公开(公告)日：2014-09-18
申请号：JP2013043361
申请日：2013-03-05
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： ONOJIMA DAISUKE , YAZAKI KEIJU , YASUI TAKAO , KACHI NORIMASA , BABA YOSHINOBU
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a stretching/immobilizing device of nucleic acid which does not require modification treatment and a drying process, and is capable of stretching/immobilizing nucleic acid efficiently and with high reproducibility, a stretching/immobilizing method of nucleic acid using the device, a nucleic acid immobilizing member, and a nucleic acid specimen fabricated by the stretching/immobilizing device of nucleic acid.SOLUTION: A stretching/immobilizing device of nucleic acid includes: a nucleic acid immobilizing member including an immobilizing part which immobilizes nucleic acid; an injection port for injecting solution containing nucleic acid; a flow channel of the solution; and a flow channel member including a suction port which sucks the solution. In a stretching/immobilizing method of nucleic acid, nucleic acid is stretched/immobilized to the immobilizing part of the nucleic acid immobilizing member equipped with groove parts which make a pair by sucking solution containing the nucleic acid injected from the injection port of the stretching/immobilizing device of nucleic acid from the suction port at a predetermined speed.
摘要翻译：要解决的问题：为了提供不需要改性处理和干燥过程的核酸的拉伸/固定装置，并能够有效和高重现性地拉伸/固定核酸，使用核酸的拉伸/固定方法，使用该装置，一种核酸固定构件和一种通过核酸的拉伸/固定装置制备的核酸试剂。解决方案：核酸的拉伸/固定装置包括：核酸固定构件，其包含固定核酸的固定部分 ; 用于注射含有核酸的溶液的注射口; 溶液的流动通道; 以及流路构件，其包括抽吸溶液的吸入口。在核酸的拉伸/固定化方法中，将核酸拉伸/固定于配备有槽部的核酸固定部件的固定部，所述槽部通过将含有从注射口注射的核酸的拉伸/ 以预定的速度从吸入口固定核酸的装置。

8. 发明专利

JP2010261920A Diagnostic agent for type-two diabetes 审中-公开
标题翻译：两型糖尿病诊断剂
公开(公告)号：JP2010261920A
公开(公告)日：2010-11-18
申请号：JP2009125826
申请日：2009-04-28
申请人： Hokkaido Univ , Nagoya Univ , 国立大学法人北海道大学 , 国立大学法人名古屋大学
发明人： HARASHIMA HIDEYOSHI , HAYASHI YASUHIRO , KAMIYA HIROYUKI , KAJIMOTO KAZUAKI , BABA YOSHINOBU , KACHI NORIMASA
IPC分类号： G01N33/53 , A61K45/00 , A61P3/10 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a diagnostic agent and diagnostic kit for diagnosing type-two diabetes, and a method and kit for screening a substance having a prophylactic agent and a therapeutic agent for type-two diabetes. SOLUTION: The diagnostic agent for type-two diabetes uses as an index an expression level, of at least one or more kinds of genes to be chosen from among predetermined genes. This diagnostic agent confirms a diagnosis of type-two diabetes, by using as the index the expression level of the predetermined genes in leukocytes collected from blood of a subject in a fasting state. The predetermined genes provided, further, improve the diagnostic accuracy of type-two diabetes of the subject by substituting for genes available for a conventional diagnosis of type-two diabetes or adding thereto as an analysis object. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于诊断二型糖尿病的诊断试剂和诊断试剂盒，以及用于筛选具有预防剂和二型糖尿病治疗剂的物质的方法和试剂盒。解决方案：二型糖尿病诊断剂用作从预定基因中选择的至少一种或多种基因的表达水平的指标。该诊断试剂通过以空白状态使用从受试者血液中收集的白细胞中的预定基因的表达水平作为指标，证实了二型糖尿病的诊断。此外，通过将可用于二型糖尿病的常规诊断的基因替代或作为分析对象添加，预先确定的基因进一步提高了受试者的二型糖尿病的诊断准确性。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2012078168A Detection method and detection system using nano structure 有权
标题翻译：使用纳米结构的检测方法和检测系统
公开(公告)号：JP2012078168A
公开(公告)日：2012-04-19
申请号：JP2010222528
申请日：2010-09-30
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： YASUI TAKAO , KACHI NORIMASA , OKAMOTO YUKIHIRO , TOKESHI MANABU , BABA YOSHINOBU
IPC分类号： G01N21/47
摘要： PROBLEM TO BE SOLVED: To provide a detection method and a detection system which are unnecessary for labeling a sample, have a simple system configuration and can continuously measure.SOLUTION: The detection method includes a step of flowing a sample into a flow channel having a periodic nano structure region, a step of irradiating the nano structure region with light having single wavelength to generate diffraction light, and a step of detecting the variation of the diffraction angle of primary diffraction light out of the generated diffraction light, and a detection system is used for the detection method.

10. 发明专利

JP2014039480A Method for detecting circulating tumor cell 审中-公开
标题翻译：检测循环肿瘤细胞的方法
公开(公告)号：JP2014039480A
公开(公告)日：2014-03-06
申请号：JP2012181987
申请日：2012-08-21
申请人： Nagoya Univ , 国立大学法人名古屋大学
发明人： OKAMOTO YUKIHIRO , OTSUKA KOHEI , HASE TETSUNARI , TOKESHI MANABU , HASEGAWA YOSHINORI , BABA YOSHINOBU
IPC分类号： C12Q1/04 , C12Q1/37 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a circulating tumor cell (CTC) detection means that can detect even EpCAM negative CTC.SOLUTION: Provided is a detection method for a circulating tumor cell comprising the steps of: (1) preparing a culture plate composed of a gel material containing urokinase-specific substrate; (2) inoculating a blood sample to the culture plate and incubating it; and (3) detecting a signal derived from the urokinase-specific substrate.
摘要翻译：要解决的问题：提供可以检测EpCAM阴性CTC的循环肿瘤细胞（CTC）检测手段。解决方案：提供一种循环肿瘤细胞的检测方法，包括以下步骤：（1）制备由含有尿激酶特异性底物的凝胶材料; （2）将血液样品接种到培养板上并孵育; 和（3）检测从尿激酶特异性底物衍生的信号。

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