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1. 发明专利

JPH09176198A ANTIOBESTIC PROTEIN MONOCLONAL ANTIBODY AND HYBRIDOMA 失效
公开(公告)号：JPH09176198A
公开(公告)日：1997-07-08
申请号：JP34325695
申请日：1995-12-28
申请人： KIKKOMAN CORP , NODA SANGYO KAGAKU KENKYUSHO
发明人： SAITO MINORU , MORI YASUMICHI , TOBE KAZUYUKI , KADOWAKI TAKASHI , FUKUDA MASARU , KIKUCHI MAMORU
IPC分类号： C12N15/02 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/09 , C12P21/08 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain a new antibody produced from a fused cell of mammal antibody-producing cell immunized using antiobestic proteins as antigens with a myeloma cell and capable of specifically reacting with an antiobestic protein. SOLUTION: This new antiobestic protein monoclonal antibody is produced from a hybridoma obtained by fusion of mammal antibody-producing cell immunized by using antiobestic protein or its part as an antigen with myeloma cell and capable of specifically reacting with antiobestic protein and useful for determining the antiobestic protein in high accuracy and reproducibility. The monoclonal antibody is obtained by administering an antiobestic protein to BALB/C-based mouse together with an adjuvant, immunizing mouse, collecting the spleen cell after final immunization, fusing the cell with myeloma cell strains, selecting an antibody-producing cell by screening to afford a hybridoma, cloning the hybridoma, carrying out cell culture of cloned hybridoma and separating a produced antibody from the culture solution.

2. 发明专利

JPH0959166A EPITHELIAL CELL PROLIFERATION PROMOTER 失效
公开(公告)号：JPH0959166A
公开(公告)日：1997-03-04
申请号：JP23068295
申请日：1995-08-17
申请人： KIKKOMAN CORP , NODA SANGYO KAGAKU KENKYUSHO
发明人： MATSUURA MASARU , SAITO MINORU , OBATA AKIO , YAMATSUGU NOBUYUKI , TOBE KOUICHIROU
IPC分类号： A61K31/70 , A61K8/96 , A61K8/97 , A61K36/48 , A61P17/00 , A61P43/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an epithelial cell proliferation promoter, a skin cosmetic, a hair tonic, a skin preparation for external use, etc., having multiplying effect on epithelial cell, comprising malonylisoflavone glycoside as an active ingredient. SOLUTION: This epithelial cell proliferation promoter comprises malonylisoflavone glycoside as an active ingredient. The glycoside is obtained from soybeans or an extracted solution of soybeans with water and, for example, malonyldaizin etc., are preferably used. The glycoside, for example, is obtained by immersing peeled soybeans in water adjusted to pH7.5 to pH9.0 with caustic soda, etc., at 45-65 deg.C for 2-4 hours, removing the soybeans to give the immersion water as an extracted solution with water, removing protein from the extracted solution by an ultrafilter membrane to give a filtrate, bringing the filtrate into contact with an adsorbent and eluting the glycoside from the adsorbed material by using an aqueous solution of an alcohol or an alkali aqueous solution of an alcohol.

3. 发明专利

JPH08217674A INHIBITOR OF HISTIDINE DECARBOXYLASE 失效
公开(公告)号：JPH08217674A
公开(公告)日：1996-08-27
申请号：JP2817695
申请日：1995-02-16
申请人： NODA SANGYO KAGAKU KENKYUSHO , KIKKOMAN CORP
发明人： SAITO MINORU , KITAO SATORU , ICHIKAWA ATSUSHI
IPC分类号： C07H15/26 , A61K31/35 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7048 , A61P1/04 , A61P9/00 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D315/00 , C07H17/06
摘要： PURPOSE: To obtain the subject chemically stable inhibitor, containing a glycoside of an aglycone having a specific skeleton as an active ingredient, mild in actions, excellent in persistence of the actions and useful as an antiinflammatory, an antiallergic and antiulcer agents. CONSTITUTION: This inhibitor contains a glycoside of an aglycone having a flavan-3-ol skeleton as an active ingredient. Furthermore, the glycoside preferably contains any one of the group consisting of O-α-glycosides, O-β-glycosides and C-glycosides and further a glycoside comprising a sugar component which is glucose and an aglycone component that is (-)-catechin (e.g. 3,3'-4',5,7- pentahydroxyflavan represented by formula I), (+)-catechin (e.g. 3,3',4,5,7- pentahydroxyflavan represented by formula II), (-)-epicatechin, (+)-epicatechin, (-)-(epi)gallocatechin or a gallate derivative thereof. For example, the aglycone component is preferably obtained by extraction or separation thereof from a plant, especially a leaf of green tea.

4. 发明专利

JPH05238939A 失效
公开(公告)号：JPH05238939A
公开(公告)日：1993-09-17
申请号：JP7565092
申请日：1992-02-27
申请人： NODA SANGYO KAGAKU KENKYUSHO , KIKKOMAN CORP
发明人： SAITO MINORU , KATAOKA SHIGEHIRO , YAMATSUGU NOBUYUKI , ICHIKAWA ATSUSHI
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P1/16 , C07H19/213
摘要： PURPOSE:To provide a hepatitis-treating agent containing an N -substituted-, 8-substituted- or N -substituted-8-substituted-adenosine-3',5'-cyclic phosphoric acid or its physiologically permissible salt as an active ingredient, having low toxicity and not accompanied by adverse actions. CONSTITUTION:This hepatitis-treating agent contains an N -substituted- adenosine-3'5'-cyclic phosphoric acid, 8-substituted-adenosine-3',5'-cyclic phosphoric acid, N -substituted-8-substituted-adenosine-3',5'-cyclic phosphoric acid, are represented by the formula (R1, R2 are H, alkyl, aralkyl; R3 is halogen, benzyl, thiobenzyl, amino, alkylamino, OH, alkoxy) or physiologically permissible salt thereof (e.g. N -butyl-adenosine-3'5'-cyclic phosphoric acid) as an active ingredient. This treating agent can remarkably improve acute or chronic hepatitis.

5. 发明专利

JP2006087328A Low-salt soy sauce 审中-公开
标题翻译：低盐大豆
公开(公告)号：JP2006087328A
公开(公告)日：2006-04-06
申请号：JP2004275040
申请日：2004-09-22
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , MATSUMOTO HIROSUKE , SAITO MINORU , AOTA HITOMI , NAKAHARA TAKEHARU , FUKUDA MASARU , OGUMA TETSUYA , FUJII NORIKAZU
IPC分类号： A23L1/238 , A23L1/305
CPC分类号： A23L33/185 , A23L27/50 , A23V2002/00 , A23V2200/326 , A23V2250/5488
摘要： PROBLEM TO BE SOLVED: To provide low-salt soy sauce having good flavor, remarkably suppressing the blood pressure elevation, preventing cardiac hypertrophy, and usable as special nutritious food. SOLUTION: The low-salt soy sauce is obtained through adding 1.0-10.0 wt.% of potassium chloride, and 0.1-5.0 wt.% of γ-aminobutyric acid to low-salt soy sauce. Alternatively, KCl-containing low-salt soy sauce is obtained by (1) a method using mixed solution of KCl and salt as mother water in an ordinary soy sauce production process, (2) a method where soy sauce obtained by using salt water as mother water is added to soy sauce obtained by desalinating salt via electrodialysis, membrane treatment or the like, or some other method, and the γ-aminobutyric acid is added to the KCl-containing low-salt soy sauce to obtain the low-salt soy sauce having a salt concentration of 0-10 wt.%, and containing 1.0-10.0 wt.% of potassium chloride and 0.1-5.0 wt.% of the γ-aminobutyric acid. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有良好风味的低盐酱油，显着抑制血压升高，预防心脏肥大，并可用作特殊营养食品。
解决方案：通过向低盐酱油中加入1.0-10.0重量％的氯化钾和0.1-5.0重量％的γ-氨基丁酸，可以得到低盐酱油。或者，通过（1）在普通酱油生产方法中使用KCl和盐的混合溶液作为母水的方法获得含KCl的低盐酱油，（2）通过使用盐水获得的酱油将母水加入到通过电渗析，膜处理等进行盐水脱盐获得的酱油中，或者其他方法，将γ-氨基丁酸加入到含有KCl的低盐酱油中以获得低盐大豆盐浓度为0〜10重量％的酱油，含有1.0-10.0重量％的氯化钾和0.1-5.0重量％的γ-氨基丁酸。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005124517A Antithrombotic food and beverage 审中-公开
标题翻译：抗生素食品和饮料
公开(公告)号：JP2005124517A
公开(公告)日：2005-05-19
申请号：JP2003365414
申请日：2003-10-27
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： YAMAKOSHI JUN , SATO TAKUYA , UCHIDA RIICHIRO , TOKUTAKE SHOICHI , SAITO MINORU , KIKUCHI MAMORU , YODA TAKASHI , ABE KATSUSATO
IPC分类号： C12G3/12 , A23L1/30 , A61K36/899 , A61P7/02 , A61P9/10 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide foods and beverages exhibiting antithrombotic effect in antithrombotic foods and beverages effectively utilizing distillation residue which is a waste product for production of Shochu (Japanese distilled spirit). SOLUTION: The antithrombotic food and beverage comprise a distillation residue, obtained as a by-product of Shochu produced by a conventional method by using barley, rye, naked barley, adlay, etc., as a raw material, in which the majority of the residue is treated as an industrial waste, particularly a distillation residue of Shochu using barley as a raw material as an active ingredient. The antithrombotic food and beverage are obtained by adding the distillation residue to various kinds of foods and beverages. The distillation residue is formed in powder, tablet, capsule, etc., to provide a health food or the distillation residue is added to various kinds of beverages, e.g. an alcoholic beverage such as Shochu or a fruit-containing beverage, isotonic beverage, etc. to provide the antithrombotic food and beverage. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供在抗血栓形成食品和饮料中显示抗血栓形成作用的食品和饮料，有效地利用作为生产烧酒（日本蒸馏酒）的废弃产物的蒸馏残渣。解决方案：抗血栓形成的食品和饮料包含蒸馏残渣，作为通过使用大麦，黑麦，裸大麦，adlay等作为原料以常规方法生产的Shochu的副产物获得，其中大部分残留物作为工业废物处理，特别是使用大麦作为原料作为活性成分的Shochu的蒸馏残渣。通过将蒸馏残渣加入到各种食品和饮料中来获得抗血栓形成的食物和饮料。蒸馏残留物以粉末，片剂，胶囊等形成，以提供保健食品，或将蒸馏残余物加入到各种饮料中。诸如烧酒或含果实饮料的酒精饮料，等渗饮料等，以提供抗血栓形式的食物和饮料。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2003073293A Macrophage activator 审中-公开
标题翻译：大理石激活机
公开(公告)号：JP2003073293A
公开(公告)日：2003-03-12
申请号：JP2001267478
申请日：2001-09-04
申请人： Kikkoman Corp , キッコーマン株式会社
发明人： OBATA AKIO , TSUJI RYOHEI , SAITO MINORU , IZUMI TORU , TOBE KOUICHIROU
IPC分类号： A61K31/716 , A61K36/07 , A61K36/48 , A61P37/04 , A61K35/78 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To provide a new macrophage activator and a method of producing the same. SOLUTION: (1) Soybeans are fermented by using a microorganism, the fermentation mixture is extraction-treated with an organic solvent and the extract is used as an active ingredient for the macrophage activator. (2) the extract from fermented soybean is combined with β-glucan to give the macrophage activator.
摘要翻译：要解决的问题：提供一种新的巨噬细胞活化剂及其制备方法。解决方案：（1）通过使用微生物发酵大豆，发酵混合物用有机溶剂萃取处理，提取物用作巨噬细胞活化剂的活性成分。（2）将发酵大豆的提取物与β-葡聚糖结合，得到巨噬细胞活化剂。

8. 发明专利

JP2002080387A ANTIALLERGIC AGENT AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：JP2002080387A
公开(公告)日：2002-03-19
申请号：JP2001192200
申请日：2001-06-26
申请人： KIKKOMAN CORP
发明人： YAMAMOTO DAICHI , KANAMORI TOMOKO , YAMAGUCHI NORIO , SAITO MINORU , TSUJI RYOHEI , OBATA AKIO
IPC分类号： A23L1/30 , A61K8/00 , A61K8/96 , A61K8/97 , A61K36/81 , A61P37/08 , A61P43/00 , A61Q11/00 , A61K35/78 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a new antiallergic agent and to provide a method for producing the same. SOLUTION: (1) This antiallergic agent comprises a tomato extract as an active ingredient. (2) A histamine liberation inhibitor or leukotriene liberation inhibitor comprises a tomato extract as an active ingredient. (3) The antiallergic agent comprises a tomato pericarp as an active ingredient. (4) This medicine, food, beverage or cosmetic is characterized by comprising the antiallergic agent described in (1) or (3). (5) The medicine, food, beverage or cosmetic is characterized by comprising the histamine liberation inhibitor or leukotriene liberation inhibitor described in (2). (6) The method for producing the antiallergic agent is characterized by extracting a raw material tomato with a solvent.

9. 发明专利

JP2002000230A POWDER COMPOSITION FOR BEVERAGE 失效
公开(公告)号：JP2002000230A
公开(公告)日：2002-01-08
申请号：JP2000194824
申请日：2000-06-28
申请人： KIKKOMAN CORP
发明人： SAITO MINORU , YAMAZAKI EMIKO , OBATA AKIO
IPC分类号： A23L2/02 , A23J3/16 , A23L1/30 , A23L1/305 , A23L2/38 , A23L2/39 , A23L2/52 , A23L2/58 , A23L5/41 , A23L1/272
摘要： PROBLEM TO BE SOLVED: To provide a powder composition for beverage consisting of a powdered separated soybean protein and anthocyanin, exhibiting a color tone of reddish violet of the anthocyanin-based fresh color on dissolving or suspending it in water, milk, a sports beverage, etc., for beverage, also keeping the anthocyanin stably and maintaining various functions of the anthocyanin. SOLUTION: This edible and drinkable powdered composition is obtained by incorporating the powdered separated soybean protein, a powdered material containing the anthocyanin and an organic acid.

10. 发明专利

JPH1129465A ANTITUMOR AGENT 失效
公开(公告)号：JPH1129465A
公开(公告)日：1999-02-02
申请号：JP19912097
申请日：1997-07-10
申请人： KIKKOMAN CORP
发明人： SAITO MINORU , ISHIKAWA HIROHARU , YAMAGUCHI NORIO , ARIGA TOSHIAKI , KATAOKA SHIGEHIRO
IPC分类号： C07H15/203 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K36/18 , A61P1/04 , C07C49/835 , C07D311/78
摘要： PROBLEM TO BE SOLVED: To obtain a new antitumor agent useful for preventing and treating tumor of digestive system, especially stomach, etc., and having strong antitumor activity by using a specific polyisoprenylated benzophenone derivative as an active ingredient. SOLUTION: This antitumor agent contains a polyisoprenylated benzophenone derivative of formula I or formula II (R1 to R4 are each H, an alkali metal atom or a hydrophilic substituent group) as an active ingredient. The polyisoprenylated benzophenone derivative includes preferably garcinol, especially preferably 14-sulfoxy-garcinol, 14-O-β-D-glicopyranosyl garcinol or isogarcinol. The daily dose of the antitumor agent is suitably 50-5,000 mg/adult as the polyisoprenylated benzophenone derivative.

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