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1. 发明专利

JP2010209115A Isoxazoline compound and process for preparation thereof 有权
标题翻译： ISOXAZOLINE化合物及其制备方法
公开(公告)号：JP2010209115A
公开(公告)日：2010-09-24
申请号：JP2010137878
申请日：2010-06-17
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： YAGIHARA TOMIO , HATANO MASAMI , OGUCHI TETSUSHI
IPC分类号： C07D261/04
CPC分类号： C07D261/04
摘要： PROBLEM TO BE SOLVED: To provide new 2-isoxazoline compounds having a substituent on the 3-position and processes for producing the same.
SOLUTION: There are provided 3-halo-2-isoxazoline compounds and 3-sulfonyl-2-isoxazoline compounds, and processes for the preparation of both, and processes for preparing 3-alkenyl or alkynyl-2-isoxazolines from 3-sulfonyl-2-isoxazolines.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供在3-位上具有取代基的新的2-异恶唑啉化合物及其制备方法。提供3-卤代-2-异恶唑啉化合物和3-磺酰基-2-异恶唑啉化合物及其制备方法，以及3-烯基或炔基-2-异恶唑啉的制备方法，磺酰基-2-异唑啉。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2004075610A Method for producing aminoimidazole compound 有权
公开(公告)号：JP2004075610A
公开(公告)日：2004-03-11
申请号：JP2002238435
申请日：2002-08-19
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： KOMATSU FUMIYOSHI , OGUCHI TETSUSHI , YAMADA YUICHI
IPC分类号： C07D233/90 , B01D9/02 , B01D11/04 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an aminoimidazole compound by which a high-purity white crystal of the aminoimidazole compound represented by formula (1) (wherein, R
1 is hydrogen atom, or a 1-4C alkyl, 6-10C aryl, heterocyclic or a 7-11C aralkyl group which may have a substituent) is produced, and which is applicable to industrial production.
SOLUTION: This method for producing the aminoimidazole compound represented by formula (1) comprises an extraction step for extracting the aminoimidazole compound from an aqueous solution containing the aminoimidazole compound represented by formula (1) by using a first organic solvent to provide an extract, and a decoloration step for carrying out decoloration treatment by adding a decolorizer to the organic solvent solution of the aminoimidazole compound.
COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2000086638A PRODUCTION OF 3,6-BIS SUBSTITUTED AMINO-2,5- PYRAZINECARBONITRILE 失效
公开(公告)号：JP2000086638A
公开(公告)日：2000-03-28
申请号：JP25707498
申请日：1998-09-10
申请人： NIPPON SODA CO
发明人： SUZUKI TATSUMI , OGUCHI TETSUSHI
IPC分类号： C07D241/26 , B01J23/04 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing, in high yield, 3,6-bis substituted amino-2,5-pyrazinecarbonitriles stably on a commercial scale. SOLUTION: This method produces 3,6-bis substituted amino-2,5- pyrazinecarbonitriles, expressed by formula I (R is a 1-16C alkyl or benzyl which may have a substituent), by reacting 3,6diamino-2,5-pyrazinecarbonitrile with an alkylation agent in the presence of a base, comprising a step of uniformly dissolving 3,6-diamino-2,5-pyrazinecarbonitrile in an organic solvent and another step of adding the alkylation agent and base to the uniform solution of 3,6-diamino-2,5-pyrazinecarbonitrile.

4. 发明专利

JP2008266201A Method for producing 2,6-dichloropurine 有权
标题翻译： 2,6-二氯乙烯生产方法
公开(公告)号：JP2008266201A
公开(公告)日：2008-11-06
申请号：JP2007111040
申请日：2007-04-19
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： KOMATSU FUMIYOSHI , OGUCHI TETSUSHI , KAWACHI JUNICHI
IPC分类号： C07D473/40
摘要： PROBLEM TO BE SOLVED: To provide a method for producing 2,6-dichloropurine, by which the 2,6-dichloropurine can be obtained in a high yield, while inhibiting the by-production of explosible methyl hypochlorite and the like.
SOLUTION: This method for producing the 2,6-dichloropurine comprises mixing 2,6-dithiopurine with hydrochloric acid to obtain an alcohol-free suspension, blowing chlorine in the suspension to obtain 2,6-dichloropurine hydrochloride solution, cooling the solution to crystallize the 2,6-dichloropurine hydrochloride, suspending the crystals of the 2,6-dichloropurine hydrochloride in water, raising the pH of the suspension to ≥8 to dissolve the crystals of the 2,6-dichloropurine hydrochloride, and then adjusting the pH of the solution to 4 to 7 to purify the 2,6-dichloropurine.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种2,6-二氯嘌呤的制备方法，通过该方法可以高收率地获得2,6-二氯嘌呤，同时抑制可爆炸的甲基次氯酸盐等的副产物。解决方案：该2,6-二氯嘌呤的制造方法包括将2,6-二硫嘌呤与盐酸混合以获得无醇悬浮液，在悬浮液中吹入氯，得到2,6-二氯嘌呤盐酸盐溶液，冷却溶液使2,6-二氯嘌呤盐酸盐结晶，将2,6-二氯嘌呤盐酸盐的晶体悬浮于水中，将悬浮液的pH升高至≥8以溶解2,6-二氯嘌呤盐酸盐的晶体，然后调节将溶液的pH调至4至7以纯化2,6-二氯嘌呤。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2004321006A Method for producing optically active 2-piperazinecarboxylic acid 审中-公开
公开(公告)号：JP2004321006A
公开(公告)日：2004-11-18
申请号：JP2003115787
申请日：2003-04-21
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： TAKASE MITSURU , OGUCHI TETSUSHI , HATANO MASAMI , YAMAZAKI SATORU
IPC分类号： C12P41/00 , C12R1/72
摘要： PROBLEM TO BE SOLVED: To industrially provide optically active 2-piperazinecarboxylic acid of high optical purity in high yield by using a hydrolase.
SOLUTION: The method for producing the optically active 2-piperazinecarboxylic acid represented by formula (S)-(II) or (R)-(II) with which the optically active 2-piperazinecarboxylic acid can be obtained in high yield is carried out as follows. A piperazinecarboxylic acid ester represented by general formula (I) (wherein, R denotes a 1-3C alkyl group; and * denotes an asymmetric carbon atom) is hydrolyzed with a lipase derived from a Candida cylindracea strain, a Candida rugosa strain, a Pseudomonas aeruginosa strain, an Alcaligenes sp. strain, a Candida antarctica strain or a Mucor miehei strain.
COPYRIGHT: (C)2005,JPO&NCIPI

6. 发明专利

JP2006001892A Method for producing 3,7(9)-dihydro-1h-purine-2,6-dithione compound 有权
标题翻译：制备3,7（9） - 二氢-1H-嘌呤-2,6-二氧化物的方法
公开(公告)号：JP2006001892A
公开(公告)日：2006-01-05
申请号：JP2004180829
申请日：2004-06-18
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： KOMATSU FUMIYOSHI , HATANO MASAMI , OGUCHI TETSUSHI
IPC分类号： C07D473/20
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially advantageously producing a 3,7-dihydro-1H-purine-2,6-dithione compound or a 3,9-dihydro-1H-purine-2,6-dithione compound important as a production intermediate of various kinds of purine derivatives exemplified by adenine and guanine of constituent components of nucleic acids.
SOLUTION: The method for producing the compound represented by formulas (Ia) or (Ib) involves (1) reacting a compound represented by formulas (IIa) or (IIb) with a compound represented by formula (III), or (2) reacting a compound represented by formulas (IIa) or (IIb) with carbon disulfide and a compound represented by R
4 OH in the presence of an inorganic base, in a polar solvent. (In the formulas, R
1 and R
2 are each independently a hydrogen atom, an alkyl group which may have a substituent or an aryl group which may have a substituent; R
3 is a hydrogen atom, a 1-10C alkyl group or an alkali metal atom; R
4 is a hydrogen atom or a 1-10C alkyl group; and M is an alkali metal atom or the like).
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种工业上有利地制备3,7-二氢-1H-嘌呤-2,6-二硫代化合物或3,9-二氢-1H-嘌呤-2,6-二硫酮的方法作为核酸的构成成分的腺嘌呤和鸟嘌呤示例的各种嘌呤衍生物的生产中间体是重要的。解决方案：由式（Ia）或（Ib）表示的化合物的制备方法包括：（1）使由式（IIa）或（IIb）表示的化合物与式（III）表示的化合物或（ 2）在极性溶剂中，在无机碱的存在下，使由式（IIa）或（IIb）表示的化合物与二硫化碳和由R SPM 4表示的化合物反应。（式中，R SP 1和R SP 2各自独立地为氢原子，可以具有取代基的烷基或可具有取代基的芳基; R 3 是氢原子，1-10C烷基或碱金属原子; R SP 4是氢原子或1-10C烷基; M是碱金属原子等）。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2000247961A 3-HALO-2-ISOXAZOLINE AND ITS PRODUCTION 失效
公开(公告)号：JP2000247961A
公开(公告)日：2000-09-12
申请号：JP4768499
申请日：1999-02-25
申请人： NIPPON SODA CO
发明人： YAGIHARA TOMIO , HATANO MASAMI , OGUCHI TETSUSHI
IPC分类号： C07D261/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject new compound having no substituent and useful as a precursor, a physiologically active skeleton, a herbicide and an insecticide/ acaricide. SOLUTION: This compound is represented by the formula (X is chlorine, bromine or iodine) e.g. 3-chloro-2-isooxazoline. The compound of the formula is obtained by reacting a halonitrile of the formula: X-C≡N→O with ethylene wherein the halonitrile is obtained by reacting glyoxylic oxime with a halogenating agent such as N-chlorosuccinimide, t-butyl hypochlorite or N- bromosuccinimide in an ether solvent (e.g. tetrahydrofuran, dioxane or dimethoxyethane) in the presence of a base (e.g. potassium carbonate) and proper amount of water.

8. 发明专利

JP2004075611A Method for producing aminoimidazole carboxamide 有权
公开(公告)号：JP2004075611A
公开(公告)日：2004-03-11
申请号：JP2002238457
申请日：2002-08-19
申请人： Nippon Soda Co Ltd , 日本曹達株式会社
发明人： KOMATSU FUMIYOSHI , OGUCHI TETSUSHI , YAMADA YUICHI
IPC分类号： C07D233/90 , B01D9/02 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an aminoimidazole carboxamide by which a high-purity white crystal of the free aminoimidazole carboxamide represented by formula (1) (wherein, R
1 is hydrogen atom, a 1-4C alkyl group which may have a substituent, a 6-10C aryl group which may have a substituent, a heterocyclic group which may have a substituent, or a 7-11C aralkyl group which may have a substituent) is produced, and which is appliable to industrial production.
SOLUTION: The method for producing the aminoimidazole carboxamide represented by formula (1) comprises a step for carrying out a decoloration treatment of an organic solvent solution of the aminoimidazole carboxamide represented by formula (1) by using a decolorizer and a step for crystallizing the aminoimidazole carboxamide represented by formula (1) by adding poor solvent to the solution obtained by the decoloration treatment, and carrying out solid-liquid separation of the resultant mixture.
COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2002249486A 2-(THIAZOL-2-YL)CYANOACETIC ACID ESTER DERIVATIVE AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：JP2002249486A
公开(公告)日：2002-09-06
申请号：JP2001386628
申请日：2001-12-19
申请人： NIPPON SODA CO
发明人： YAGIHARA TOMIO , OGUCHI TETSUSHI , HATANO MASAMI
IPC分类号： C07D277/20 , C07D277/30 , C07D277/593
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a 2-(4-substituted thiazol-2-yl) cyano-acetic acid ester industrially advantageously which is useful as an intermediate of the agricultural and medical chemicals. SOLUTION: The method for producing a new 2-(4-substituted thiazol-2-yl) cyanoacetic acid ester represented by general formula (1) is characterized by reacting a compound represented by general formula (2) with a cyanoacetic acid ester represented by formula (3) in the presence of a base. (wherein R1 is a 1-6C alkyl, phenyl which may be substituted; R2 is a 1-6C alkyl or allyl; R3 is a 1-3C alkyl or aryl).

10. 发明专利

JP2000297080A PRODUCTION OF 2-ISOXAZOLINE COMPOUND HAVING UNSATURATED GROUP AT 3-POSITION 失效
公开(公告)号：JP2000297080A
公开(公告)日：2000-10-24
申请号：JP10563099
申请日：1999-04-13
申请人： NIPPON SODA CO
发明人： YAGIHARA TOMIO , HATANO MASAMI , OGUCHI TETSUSHI
IPC分类号： C07D261/04
摘要： PROBLEM TO BE SOLVED: To easily obtain, using easily available raw materials, the subject compound having no substitutents at the 4- and 5-positions of the isoxazoline and having an unsaturated group at the 3-position thereof, by reacting a specified compound with an unsaturated Grignard reagent. SOLUTION: This compound of formula II is obtained by reacting (A) a 3-sulfonyl-2-isoxazoline of formula I [R is a 1-6C alkyl or a (substituted) aryl] with (B) an unsaturated Grignard reagent of the formula R1MgX (R1 is a 2-6C alkenyl or a 2-6C alkynyl; X is a halogen) in (C) a solvent at room temperature or, as necessary, by heating to the boiling point of the solvent. The component A can be produced by the process described in the Japanese Patent Application No.11-105606. As a component C, an ether such as diethyl ether or tetrahydrofuran, and/or an aromatic hydrocarbon such as benzene, toluene or xylene, is used.

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