基本信息:
- 专利标题： Method for producing optically active 2-piperazinecarboxylic acid
- 申请号：JP2003115787 申请日：2003-04-21
- 公开(公告)号：JP2004321006A 公开(公告)日：2004-11-18
- 发明人： TAKASE MITSURU , OGUCHI TETSUSHI , HATANO MASAMI , YAMAZAKI SATORU
- 申请人： Nippon Soda Co Ltd , 日本曹達株式会社
- 专利权人： Nippon Soda Co Ltd,日本曹達株式会社
- 当前专利权人： Nippon Soda Co Ltd,日本曹達株式会社
- 优先权： JP2003115787 2003-04-21
- 主分类号： C12P41/00
- IPC分类号： C12P41/00 ; C12R1/72
摘要：
PROBLEM TO BE SOLVED: To industrially provide optically active 2-piperazinecarboxylic acid of high optical purity in high yield by using a hydrolase.
SOLUTION: The method for producing the optically active 2-piperazinecarboxylic acid represented by formula (S)-(II) or (R)-(II) with which the optically active 2-piperazinecarboxylic acid can be obtained in high yield is carried out as follows. A piperazinecarboxylic acid ester represented by general formula (I) (wherein, R denotes a 1-3C alkyl group; and * denotes an asymmetric carbon atom) is hydrolyzed with a lipase derived from a Candida cylindracea strain, a Candida rugosa strain, a Pseudomonas aeruginosa strain, an Alcaligenes sp. strain, a Candida antarctica strain or a Mucor miehei strain.
COPYRIGHT: (C)2005,JPO&NCIPI
SOLUTION: The method for producing the optically active 2-piperazinecarboxylic acid represented by formula (S)-(II) or (R)-(II) with which the optically active 2-piperazinecarboxylic acid can be obtained in high yield is carried out as follows. A piperazinecarboxylic acid ester represented by general formula (I) (wherein, R denotes a 1-3C alkyl group; and * denotes an asymmetric carbon atom) is hydrolyzed with a lipase derived from a Candida cylindracea strain, a Candida rugosa strain, a Pseudomonas aeruginosa strain, an Alcaligenes sp. strain, a Candida antarctica strain or a Mucor miehei strain.
COPYRIGHT: (C)2005,JPO&NCIPI