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1. 发明专利

JP2009053191A Medium for membrane ion exchange chromatography based on polymeric primary amine, sorption device containing the medium, and chromatography scheme and purification method using the same 有权
标题翻译：用于基于聚合主要胺的膜交换色谱的介质，含有介质的分离装置和色谱方案和使用其的纯化方法
公开(公告)号：JP2009053191A
公开(公告)日：2009-03-12
申请号：JP2008209029
申请日：2008-08-14
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： KOZLOV MIKHAIL , WILSON MOYA , PHILLIPS MICHAEL W , RAMASWAMY SENTHILKUMAR , GAGNON BRIAN
IPC分类号： G01N30/88
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： PROBLEM TO BE SOLVED: To provide a porous sorptive medium strongly binding protein impurities and excelling in removal of host cell proteins from biological samples. SOLUTION: A porous sorptive medium comprises a substrate having a first external side and a second external side, both sides being porous, and a porous thickness between them, wherein the substrate has a sorptive material substantially covering the solid matrix of the substrate and the first and second external surfaces, and the sorptive material comprises a crosslinked polymer having attached primary amine groups. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供多孔吸附介质强烈结合蛋白质杂质和优异的从生物样品中去除宿主细胞蛋白质。解决方案：多孔吸附介质包括具有第一外侧和第二外侧的基底，两侧是多孔的，并且在它们之间具有多孔厚度，其中基底具有基本上覆盖基底的固体基质的吸附材料和第一和第二外表面，并且吸附材料包含具有连接的伯胺基团的交联聚合物。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2008188595A Membrane adsorber device 有权
标题翻译：膜吸收器件
公开(公告)号：JP2008188595A
公开(公告)日：2008-08-21
申请号：JP2008100002
申请日：2008-04-08
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： PHILLIPS MICHAEL W
IPC分类号： B01D15/00 , B01D61/14 , B01D61/00 , B01D61/18 , B01D63/08 , C07K1/34 , G01N1/34 , G01N1/40 , G01N30/00 , G01N30/52
CPC分类号： G01N1/405 , B01D61/00 , B01D61/18 , B01D63/08 , B01D63/084 , B01D2313/08 , B01D2313/90 , C07K1/34 , G01N1/34 , G01N2030/527 , G01N30/38
摘要： PROBLEM TO BE SOLVED: To provide a membrane adsorber device having a high throughput using the capacity thereof, which is efficient and preferably disposable so as to eliminate the necessity of cleaning and reconfirmation of the device before reuse.
SOLUTION: A membrane and a device are designed for the removal of trace contaminants in protein containing streams such as exist in the biopharmaceutical industry. A preferred membrane has tight pore size distribution and high permeability that allow for high throughput separations. One of such devices is formed of a series of disks, each disk having eight layers of membranes sealed to each of the two large surfaces of the disk. These disks are placed within a sealed capsule having an inlet on one end and an outlet on the other. The disks are sealed so that all the fluid that exit from the outlet does so by having first passed through the membranes on one side of a disk.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种高效率且优选一次性的具有高生产能力的膜吸附装置，以便在重新使用之前不需要清洁和重新确认装置。解决方案：膜和器件被设计用于去除含有蛋白质的物流中的痕量污染物，例如存在于生物制药工业中。优选的膜具有紧密的孔径分布和高渗透性，允许高通量分离。这种装置中的一个由一系列盘形成，每个盘具有密封到盘的两个大表面中的每一个的八层膜。这些盘被放置在密封的胶囊中，该胶囊具有一端的入口和另一端的出口。盘被密封，使得从出口排出的所有流体通过首先通过盘的一侧上的膜而这样做。版权所有（C）2008，JPO＆INPIT

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