专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2007321147A Film surface modification by radiation polymerization 审中-公开
标题翻译：通过辐射聚合的膜表面改性
公开(公告)号：JP2007321147A
公开(公告)日：2007-12-13
申请号：JP2007137035
申请日：2007-05-23
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： KOZLOV MIKHAIL , WILSON MOYA
IPC分类号： C08J9/42 , C08J7/00 , C08K5/00 , C08L101/00
CPC分类号： B01D67/0093 , B01D71/36 , B01D71/82 , B01D2323/02
摘要： PROBLEM TO BE SOLVED: To provide a porous membrane not requiring preliminary wetting with an organic solvent, and simultaneously minimizing nonspecific interaction with a biomolecule such as a protein and a peptide while keeping the stability under a typical alkaline condition usable for cleaning the membrane.
SOLUTION: The method for modifying at least a part of the surface of a porous membrane includes contacting a monomer having a polymerizable group or a monomer mixture, and a cationic polymerization initiator with the porous membrane, and polymerizing the monomer to modify at least a part of the surface of the porous membrane. The porous membrane of which at least a part of the surface is modified thus, and the method for using the porous membrane are also provided.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种不需要用有机溶剂预先润湿的多孔膜，同时使与生物分子如蛋白质和肽的非特异性相互作用最小化，同时保持在用于清洁的典型碱性条件下的稳定性膜。解决方案：用于改性多孔膜表面的至少一部分的方法包括将具有可聚合基团的单体或单体混合物和阳离子聚合引发剂与多孔膜接触，并将单体聚合以在多孔膜表面的至少一部分。其表面的至少一部分的多孔膜因此被改变，并且还提供了使用多孔膜的方法。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2012018171A Medium for membrane ion exchange chromatography including polymeric primary amine as main component, adsorption device containing medium for membrane ion exchange chromatography including polymeric primary amine as main component, and chromatography method and purification method using the same 有权
标题翻译：用于膜离子交换色谱的介质包括聚合主要胺作为主要组分，包含用于膜离子交换色谱的介质的吸附装置，包括作为主要组分的聚合主要胺，以及使用其的色谱方法和纯化方法
公开(公告)号：JP2012018171A
公开(公告)日：2012-01-26
申请号：JP2011173342
申请日：2011-08-08
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： KOZLOV MIKHAIL , MOYA WILSON , MICHAEL W PHILLIPS , SENTHIKUMAR RAMASWAMY , BRIAN GAGNON
IPC分类号： G01N30/88 , B01D15/04 , B01D15/08 , B01J20/26 , B01J39/04 , B01J41/04
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： PROBLEM TO BE SOLVED: To provide a purification method of a biological sample containing an antibody and an impurity, which strongly binds a protein impurity and excellently removes a host cell protein from the biological sample.SOLUTION: A purification method of a biological sample containing an antibody and an impurity comprises purifying the biological sample by subjecting the biological sample to an affinity chromatography; and then further purifying the biological sample by filling the biological sample into an anion exchange medium equipped with a porous-coating medium having a porous substrate and a porous film on the surface of the porous substrate, where the film contains one or more kinds of crosslinking polymeric primary amine or a copolymer thereof; and collecting this further purified sample.
摘要翻译：要解决的问题：提供含有抗体和杂质的生物样品的纯化方法，其强烈地结合蛋白质杂质并从生物样品中优异地除去宿主细胞蛋白质。解决方案：含有抗体和杂质的生物样品的纯化方法包括通过对生物样品进行亲和层析纯化生物样品; 然后通过将生物样品填充到多孔基材表面上具有多孔基材和多孔膜的多孔涂层介质的阴离子交换介质中，进一步纯化生物样品，其中该膜含有一种或多种交联聚合伯胺或其共聚物; 并收集这种进一步纯化的样品。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2007136449A Ultrafiltration membrane, manufacturing method of the same, and using method of ultrafiltration membrane 有权
标题翻译：超滤膜及其制造方法及超滤膜的使用方法
公开(公告)号：JP2007136449A
公开(公告)日：2007-06-07
申请号：JP2006277182
申请日：2006-10-11
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： MOYA WILSON , KOZLOV MIKHAIL
IPC分类号： B01D61/14 , B01D69/00 , B01D69/12 , B01D71/12 , B01D71/68 , C07K1/34
CPC分类号： B01D71/68 , A61L2/0017 , B01D67/0083 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/10 , B01D2323/02 , B01D2325/20 , B01D2325/36
摘要： PROBLEM TO BE SOLVED: To provide an inherently hydrophobicity macromolecule membrane base material having a surface rendered hydrophilic with a hydroxyakyl cellulose and having a throughput greater than about 1,500 L/m 2 . SOLUTION: A process for manufacturing the membrane includes a step of autoclaving in boiling water and/or steam or submerging in boiling water. The membrane is used for removing virus from a protein solution. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有使羟基酰基纤维素亲水化的表面并且具有大于约1,500L / m 2 SP 2的通过量的固有的疏水性大分子膜基材。解决方案：制造膜的方法包括在沸水和/或蒸汽中高压灭菌或浸在沸水中的步骤。该膜用于从蛋白质溶液中除去病毒。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2009053191A Medium for membrane ion exchange chromatography based on polymeric primary amine, sorption device containing the medium, and chromatography scheme and purification method using the same 有权
标题翻译：用于基于聚合主要胺的膜交换色谱的介质，含有介质的分离装置和色谱方案和使用其的纯化方法
公开(公告)号：JP2009053191A
公开(公告)日：2009-03-12
申请号：JP2008209029
申请日：2008-08-14
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： KOZLOV MIKHAIL , WILSON MOYA , PHILLIPS MICHAEL W , RAMASWAMY SENTHILKUMAR , GAGNON BRIAN
IPC分类号： G01N30/88
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： PROBLEM TO BE SOLVED: To provide a porous sorptive medium strongly binding protein impurities and excelling in removal of host cell proteins from biological samples. SOLUTION: A porous sorptive medium comprises a substrate having a first external side and a second external side, both sides being porous, and a porous thickness between them, wherein the substrate has a sorptive material substantially covering the solid matrix of the substrate and the first and second external surfaces, and the sorptive material comprises a crosslinked polymer having attached primary amine groups. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供多孔吸附介质强烈结合蛋白质杂质和优异的从生物样品中去除宿主细胞蛋白质。解决方案：多孔吸附介质包括具有第一外侧和第二外侧的基底，两侧是多孔的，并且在它们之间具有多孔厚度，其中基底具有基本上覆盖基底的固体基质的吸附材料和第一和第二外表面，并且吸附材料包含具有连接的伯胺基团的交联聚合物。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009125071A MEDIUM FOR MEMBRANE ION-EXCHANGE CHROMATOGRAPHY 审中-公开
公开(公告)号：JP2009125071A
公开(公告)日：2009-06-11
申请号：JP2008295590
申请日：2008-11-19
申请人： MILLIPORE CORP
发明人： KOZLOV MIKHAIL
IPC分类号： C12N7/02 , B01J20/26 , C12M1/28
摘要： PROBLEM TO BE SOLVED: To provide a medium for purifying virus in a high yield and high purity. SOLUTION: Provided is the medium for chromatographic applications, wherein the medium is a membrane having the surface coated with a polymer such as polyethyleneimine, etc. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary ammonium functionality to the medium. The medium is well suited for chromatographic purification of virus. COPYRIGHT: (C)2009,JPO&INPIT

6. 发明专利

JP2013189427A Removal of protein aggregate from biopharmaceutical preparation in flow-through mode 有权
标题翻译：在流动模式中从生物制备中去除蛋白质聚集
公开(公告)号：JP2013189427A
公开(公告)日：2013-09-26
申请号：JP2013027361
申请日：2013-02-15
申请人： Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
发明人： KOZLOV MIKHAIL , CATALDO WILLIAM , POTTY AJISH , GALIPEAU KEVIN
IPC分类号： C07K1/16 , C08F261/06
CPC分类号： C07K1/22 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J39/20 , B01J39/26 , B01J41/20 , B01J47/026 , C07K1/165 , C07K1/18 , C07K16/00
摘要： PROBLEM TO BE SOLVED: To provide novel compositions and methods for removal of protein aggregates from a sample in a flow-through mode.SOLUTION: A flow-through chromatography method of separating a monomeric protein of interest from protein aggregates in a sample includes a step of contacting the sample with a solid support comprising one or more cation exchange binding groups attached thereto, at a density of about 1 to about 30 mM, wherein the solid support selectively binds protein aggregates, thereby separating the monomeric protein of interest from protein aggregates.
摘要翻译：要解决的问题：提供用于从流通模式中从样品中去除蛋白质聚集体的新型组合物和方法。溶液：将样品中的单体蛋白质与蛋白质聚集体分离的流通色谱法包括步骤使样品与包含一个或多个与其连接的阳离子交换结合基团的固体支持物以约1至约30mM的密度接触，其中所述固体支持物选择性地结合蛋白质聚集体，从而将目标单体蛋白质与蛋白质聚集体分离。

7. 发明专利

JP2013051970A Medium for membrane ion exchange chromatography 审中-公开
标题翻译：用于膜离子交换色谱的介质
公开(公告)号：JP2013051970A
公开(公告)日：2013-03-21
申请号：JP2012253694
申请日：2012-11-19
申请人： Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
发明人： KOZLOV MIKHAIL
IPC分类号： C12N7/02 , B01J20/26 , B01J20/28 , B01J20/281 , B01J20/34 , G01N30/88 , G01N30/96
CPC分类号： B01D15/363 , A61L2/0017 , B01D69/147 , B01D71/26 , B01D2311/2626 , B01D2325/12 , B01J41/13 , B01J47/12 , G01N2030/527
摘要： PROBLEM TO BE SOLVED: To provide a medium which can purify viruses with high yield and purity.SOLUTION: The medium for chromatographic applications is a membrane having a surface coated with a polymer such as a polyethyleneimine. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary amine to the media. The medium are well suited for chromatographic purification of virus.

8. 发明专利

JP2013044748A Methods of reducing level of one or more impurities in sample during protein purification 有权
标题翻译：在蛋白质纯化过程中降低样品中一种或多种含量的方法
公开(公告)号：JP2013044748A
公开(公告)日：2013-03-04
申请号：JP2012179197
申请日：2012-08-13
申请人： E M D Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
发明人： BIAN NANYING , CHRISTOPHER GILLESPIE , MATTHEW T STONE , KOZLOV MIKHAIL , CHEN JIE , MARTIN SIWAK
IPC分类号： G01N30/88 , G01N30/02 , G01N30/26 , G01N30/96
CPC分类号： C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
摘要： PROBLEM TO BE SOLVED: To provide novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of a desired protein product.SOLUTION: The method comprises: bringing a sample comprising a protein of interest and one or more impurities into contact in a flow-through mode with (i) a carbonaceous material, (ii) a combination of a carbonaceous material and CEX media, (iii) a combination of a carbonaceous material and AEX media, (iv) a combination of a carbonaceous material and mixed-mode media, (v) a combination of a carbonaceous material and HIC media, and (vi) a combination of a carbonaceous material and CEX, AEX, and mixed-mode media; and then bringing the sample into contact with one or more chromatography columns comprising affinity media, AEX media, CEX media, HIC media or mixed-mode media, thereby to reduce a burden on the one or more chromatography columns.
摘要翻译：要解决的问题：提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。解决方案：该方法包括：使包含感兴趣的蛋白质的样品和一种或多种杂质以流通模式接触（i）碳质材料，（ii）碳质材料和CEX介质的组合，（iii）碳质材料和AEX介质的组合，（iv）碳质材料和混合模式介质的组合，（v）碳质材料和HIC介质的组合，以及（vi）碳质材料和CEX，AEX和混合模式介质; 然后使样品与包含亲和介质，AEX培养基，CEX培养基，HIC培养基或混合培养基的一个或多个色谱柱接触，从而减少一个或多个色谱柱的负担。版权所有（C）2013，JPO＆INPIT

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式