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1. 发明专利

JP2013255505A Production method for optically active amino acid and n-alkoxycarbonylamino acid 审中-公开
标题翻译：光活性氨基酸和N-烷氧羰基氨基酸的生产方法
公开(公告)号：JP2013255505A
公开(公告)日：2013-12-26
申请号：JP2013162935
申请日：2013-08-06
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： KATO OSAMU , MORI HIROYUKI
IPC分类号： C12P41/00 , C07C227/32 , C07C229/08
摘要： PROBLEM TO BE SOLVED: To produce an optically active amino acid and an optically active N-alkoxycarbonylamino acid which can obtain an optically active amino acid and an optically active N-alkoxycarbonylamino acid with good yield.SOLUTION: After a pH of an aqueous solution including racemic amino acid amide is adjusted by an acid in the vicinity of neutral, enantioselective hydrolysis reaction by amidase of amino acid amide is carried out. Afterwards, in a production method for an optically active amino acid, an inorganic base compound of an amount of mol with which the acid is almost neutralized is added in the aqueous solution, and furthermore, an optically active amino acid is crystalized and recovered by substituting the solvent of the aqueous solution from water by the solvent of an alcohol with three or more carbons. A production method for an optically active N-alkoxycarbonylamino acid uses a raw material of optically active N-alkoxycarbonylamino acid production without purification operation of optically active amino acid which is recovered from a hydrolysis reaction solution.
摘要翻译：要解决的问题：制备光学活性氨基酸和光学活性N-烷氧基羰基氨基酸，其可以以良好的产率获得光学活性氨基酸和光学活性N-烷氧基羰基氨基酸。溶液：在包括外消旋氨基酸酰胺由中性附近的酸调节，进行酰氨基酰胺酰胺酶的对映选择性水解反应。然后，在光学活性氨基酸的制造方法中，在该水溶液中添加摩尔量几乎中和的无机碱化合物，此外，光学活性氨基酸通过置换通过具有三个或更多个碳的醇的溶剂将水溶液从水中溶解。光学活性N-烷氧基羰基氨基酸的制备方法使用旋光活性N-烷氧基羰基氨基酸的原料，而不需要从水解反应溶液中回收的光学活性氨基酸的纯化操作。

2. 发明专利

JP2011102282A Optically active cyanohydrin compounds and process for producing the same 有权
标题翻译：光学活性氰胺化合物及其制备方法
公开(公告)号：JP2011102282A
公开(公告)日：2011-05-26
申请号：JP2009258736
申请日：2009-11-12
申请人： Hokkaido Univ , Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社 , 国立大学法人北海道大学
发明人： OKUMA TAKESHI , KURONO NOBUHITO , UEMURA MASATO , MORI HIROYUKI
IPC分类号： C07F7/18 , B01J31/24
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an optically active cyanohydrin compound and a process for producing the same.
SOLUTION: The optically active cyanohydrin compound is represented by formula (1) (wherein R
1 is a linear alkyl group which may have a branch; a cyclic alkyl group which may have a substituent, a linear alkenyl group which may have a branch, a cyclic alkenyl group which may have a substituent, an aryl group which may have a substituent or a heterocycle which may have a substituent; R
2 is hydrogen, an alkali metal, a hydrocarbon group which may have a substituent or a silyl group which may have a substituent; R
3 is an alkyl group, an alkenyl group, allyl group or an aryl group; and R
1 and R
3 may be linked to form a lactone).
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供光学活性羟腈化合物及其制备方法。解决方案：光学活性羟腈化合物由式（1）表示（其中R SB 1是可以具有支链的直链烷基;可以具有取代基的环状烷基，可以具有取代基的环状烷基，可以具有支链的直链烯基，可以具有取代基的环状链烯基，可以具有取代基的芳基或可以具有取代基的杂环; R SB 2是氢，碱金属，可以具有取代基的烃基或可以具有取代基的甲硅烷基; R SB 3是烷基，烯基，烯丙基或芳基; R SB“ 1 和R 3 可以连接形成内酯）。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2009102263A Method for isolating and purifying l-carnitine 有权
标题翻译：用于分离和纯化L-卡尼汀的方法
公开(公告)号：JP2009102263A
公开(公告)日：2009-05-14
申请号：JP2007275858
申请日：2007-10-24
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： TAKIGAWA YUYA , SATO EIJI , MORI HIROYUKI , INABA HIDEYUKI
IPC分类号： C07C227/42 , B01D9/02 , C07C229/22
摘要： PROBLEM TO BE SOLVED: To provide a method for isolating and purifying L-carnitine, by which the isolation and purification can simply and efficiently be carried out in an industrial scale.
SOLUTION: This method for isolating and purifying the L-carnitine comprises the processes of: (1) preparing an L-carnitine aqueous solution; (2) crystallizing the L-carnitine from the solution prepared in the process (1); (3) recycling a mother liquid prepared in the process (2) or the L-carnitine contained in the mother liquid to the process (1) and/or the process (2); and recrystallizing the L-carnitine crystals, after the process (2) is finished.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供分离和纯化左旋肉碱的方法，通过该方法可以以工业规模简单有效地进行分离和纯化。解决方案：这种分离和纯化L-肉碱的方法包括以下过程：（1）制备L-肉碱水溶液; （2）从方法（1）中制备的溶液中结晶L-肉碱; （3）将方法（2）中制备的母液或母液中所含的左旋肉碱再循环至方法（1）和/或方法（2）; （2）结束后重结晶左旋肉碱晶体。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2008273920A Method for producing alkanediol 审中-公开
标题翻译：生产阿尔卡尼醇的方法
公开(公告)号：JP2008273920A
公开(公告)日：2008-11-13
申请号：JP2007211793
申请日：2007-08-15
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： SAITO TAKAYUKI , MORI HIROYUKI
IPC分类号： C07C29/147 , C07B53/00 , C07C31/20
摘要： PROBLEM TO BE SOLVED: To easily produce an alkanediol of high purity at a high yield useful as a raw material for a medicine, an agricultural chemical, a liquid crystal and a polymer, and to produce an alkanediol of high optical purity, without decreasing its optical purity in the case of using an optically active substance as a raw material.
SOLUTION: Disclosed is a method for producing an alkanediol by reducing an alkanediester by virtue of a metal hydride such as a hydrogenated bis(2-methoxyethoxy)aluminum-sodium and further post-treating the resulting product with an aqueous solution of sodium-potassium tartrate.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：为了容易地以高产率生产用作药物，农药，液晶和聚合物的原料的高纯度链烷二醇，并且制备高光学纯度的链烷二醇，在使用光学活性物质作为原料的情况下不降低其光学纯度。解决方案：公开了通过金属氢化物如氢化双（2-甲氧基乙氧基）铝钠还原烷基二醇制备链烷二醇的方法，并进一步用钠水溶液对所得产物进行后处理酒石酸钾。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2008231046A Method of purifying optically active carnitinamide halide 审中-公开
标题翻译：净化光学活性炭黑的方法
公开(公告)号：JP2008231046A
公开(公告)日：2008-10-02
申请号：JP2007074531
申请日：2007-03-22
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OISHI KOSUKE , SATO EIJI , MORI HIROYUKI
IPC分类号： C07C231/20 , C07C237/06
摘要： PROBLEM TO BE SOLVED: To provide a method of controlling the optical purity of an optically active carnitinamide halide such as an L-carnitinamide halide which is useful as a precursor of L-carnitine relating to the fatty acid metabolism in the living body by a simple method.
SOLUTION: The optical purity of a carnitinamide halide can be changed by crystallization from that of an optically active carnitinamide halide which is subjected to crystallization.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种控制光活性的肉碱胺卤化物如L-肉碱酰胺卤化物的光学纯度的方法，其可用作与活体中的脂肪酸代谢有关的左旋肉碱的前体通过一个简单的方法。解决方案：可以通过结晶从结晶化的光学活性肉碱酰胺卤化物的光学纯度来改变肉毒碱酰卤的光学纯度。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2007223993A Method for producing optically active mandelic acid or its derivative 有权
标题翻译：用于生产光学活性的苹果酸或其衍生物的方法
公开(公告)号：JP2007223993A
公开(公告)日：2007-09-06
申请号：JP2006049994
申请日：2006-02-27
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： SAITO TAKAYUKI , MORI HIROYUKI , OGURA KUNIYOSHI
IPC分类号： C07C51/08 , C07B53/00 , C07C59/50
摘要： PROBLEM TO BE SOLVED: To provide a method for producing, in high yield, a high-purity mandelic acid or its derivative in which its dimer which is an impurity is efficiently reduced. SOLUTION: The method for producing mandelic acid or its derivative comprises carrying out of hydrolytic reaction of mandelic nitrile or its derivative with a mineral acid so that production ratio of mandelic acid or its derivative to mandelic acid or its derivative and mandelic amide or its derivative becomes ≤50%. In the production method, hydrolytic reaction temperature required until mandelic nitrile or its derivative is substantially lost is preferably COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了提供高纯度扁桃酸或其衍生物的制备方法，其中其二聚体作为杂质被有效降低。解决方案：生产扁桃酸或其衍生物的方法包括用无机酸进行扁桃腈或其衍生物的水解反应，使得扁桃酸或其衍生物与扁桃酸或其衍生物和扁桃酸酰胺的生产比例其衍生物变为≤50％。在制造方法中，直至扁桃腈或其衍生物所需的水解反应温度基本上损失为优选<50℃。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006347886A METHOD FOR PRODUCING CONCENTRATE OF CYANOHYDRINS AND alpha-HYDROXYCARBOXYLIC ACID CRYSTAL 审中-公开
公开(公告)号：JP2006347886A
公开(公告)日：2006-12-28
申请号：JP2005171906
申请日：2005-06-13
申请人： MITSUBISHI RAYON CO
发明人： OGURA KUNIYOSHI , SATO EIJI , MORI HIROYUKI , NOGAMI HIROYUKI , KATO OSAMU , SAITO TAKAYUKI , KOKUBU NOBUTAKA , NINOMIYA YASUHIRO
IPC分类号： C07C253/34 , C07B53/00 , C07C51/08 , C07C51/47 , C07C59/50 , C07C59/56 , C07C253/00 , C07C255/33 , C07C255/35 , C12N15/09 , C12P13/00
摘要： PROBLEM TO BE SOLVED: To obtain a concentrate of cyanohydrins or crystals of α-hydroxycarboxylic acids having good safety and handling property. SOLUTION: The method for producing the concentrate of cyanohydrins comprises concentrating cyanohydrins by distilling water and/or an organic solvent away without separating an enzyme from enzyme reaction solution containing cyanhydrins, the enzyme and water and/or the organic solvent. The method for producing crystals of α-hydroxycarboxylic acids comprises hydrolyzing the concentrate of cyanohydrins obtained by the method and recovering the resultant crystals of hydroxycarboxylic acids. In the method for producing crystals of α-hydroxycarboxylic acids, the crystals are preferably subjected to contact treatment with activated carbon before recovering the crystals. COPYRIGHT: (C)2007,JPO&INPIT

8. 发明专利

JP2003192681A METHOD FOR PRODUCING (S)-3-CHLORO-1-(2-THIENYL)-1-PROPANOL AND (S)-3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL 审中-公开
公开(公告)号：JP2003192681A
公开(公告)日：2003-07-09
申请号：JP2001397944
申请日：2001-12-27
申请人： MITSUBISHI RAYON CO
发明人： OGURA KUNIYOSHI , MORI HIROYUKI , INOUE YOSHIKI
IPC分类号： C07D333/02 , C07B61/00
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially producing 1-(2-thienyl)-3- chloropropane-1-one and (S)-3-N-methylamino-1-(2-thienyl)-1-propanol. SOLUTION: This method for producing the (S)-3-chloro-1-(2-thienyl)-1- propanol comprises reacting 1-(2-thienyl)-3-chloropropane-1-one with hydrogen in the presence of an asymmetric hydrogenation catalyst containing a transition metal, a base and an optically active nitrogen-containing compound. This method for producing the (S)-3-N-methylamino-1-(2-thienyl)-1-propanol comprises steps for reacting thiophene with 3-chloropropionic acid chloride in the presence of a Friedel-Crafts catalyst to provide 1-(2-thienyl)-3-chloropropane-1-one, reacting the resultant compound with hydrogen in the presence of an asymmetric hydrogenation catalyst containing a transition metal, the base and the optically active nitrogen-containing compound to carry out asymmetric hydrogenation and then reacting the resultant compound with methylamine. COPYRIGHT: (C)2003,JPO

9. 发明专利

JP2000044557A PRODUCTION OF ISOCHROMANONE DERIVATIVE 失效
公开(公告)号：JP2000044557A
公开(公告)日：2000-02-15
申请号：JP22857498
申请日：1998-07-30
申请人： MITSUBISHI RAYON CO
发明人： MORITA HIKARI , MORI HIROYUKI , TAMURA KIMIO , FURUBAYASHI YOSHIMASA
IPC分类号： C07D311/76
摘要： PROBLEM TO BE SOLVED: To readily control a reaction and produce the subject compound useful as a raw material for medicines, agrochemicals, etc., in high yield at a low cost in a short time by oxidizing a specific indanone derivative with an alkali persulfate in an aprotic polar solvent. SOLUTION: An indanone derivative represented by formula I (R1 and R2 are each H, a halogen, a 1-3C alkyl or the like) (e.g. 2-indanone or 4,7- dimethyl-2-indanone) is oxidized with an alkali persulfate (preferably ammonium persulfate) as an oxidizing agent in an aprotic polar solvent (e.g. N,N- dimethylformamide or acetonitrile) at 0-50 deg.C reactional temperature for 1-10 h reactional time to produce an isochromanone derivative represented by formula II. The resultant derivative can be separated and purified from the reactional system by distillation, recrystallization, extraction, etc.

10. 发明专利

JP2015044746A グリシジル（メタ）アクリレートの連続製造方法审中-公开
标题翻译：连续生产甘氨酸（甲基）丙烯酸酯的方法
公开(公告)号：JP2015044746A
公开(公告)日：2015-03-12
申请号：JP2013175196
申请日：2013-08-27
申请人：三菱レイヨン株式会社 , Mitsubishi Rayon Co Ltd
发明人： MURATA NAOSHI , MORI HIROYUKI , INOUE KAZUTAKA
IPC分类号： C07D303/16 , C07D301/30
摘要：【課題】高収率で生産性の良い、安定合成可能なグリシジル(メタ)アクリレートの製造方法を提供すること。【解決手段】触媒及び重合防止剤の存在下に、(メタ)アクリル酸アルカリ金属塩とエピクロロヒドリンとを反応させることによりグリシジル(メタ)アクリレートを製造する方法において、(メタ)アクリル酸アルカリ金属塩基準の転化率を50%以上に維持して連続的にグリシジル(メタ)アクリレート製造することを特徴とする方法。【選択図】なし
摘要翻译：要解决的问题：提供一种以高产率和高生产率稳定合成（甲基）丙烯酸缩水甘油酯的方法。提供一种连续制备（甲基）丙烯酸缩水甘油酯的方法，该方法是使（甲基）丙烯酸缩水甘油酯甲基）丙烯酸和表氯醇在催化剂和聚合抑制剂的存在下反应。基于（甲基）丙烯酸的碱金属盐的转化率保持在50％以上。

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