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1. 发明专利

JP2012162582A Method of manufacturing mandelic acids and mandelic acids crystal 有权
标题翻译：制备柔性酸和水溶性水晶的方法
公开(公告)号：JP2012162582A
公开(公告)日：2012-08-30
申请号：JP2012129240
申请日：2012-06-06
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： MORI HIROYUKI , SATO EIJI , NOGAMI HIROYUKI , SAITO TAKAYUKI , KOKUBU NOBUTAKA , NINOMIYA YASUHIRO , OGURA KUNIYOSHI
IPC分类号： C07C51/08 , C07B53/00 , C07C59/50
摘要： PROBLEM TO BE SOLVED: To provide a method of manufacturing high-purity mandelic acids useful as pesticide raw material, a liquid crystal material, and an optical resolving agent, and to provide high-purity mandelic acids crystal.SOLUTION: In the method of manufacturing mandelic acids by hydrolyzing mandelonitriles with mineral acid, reaction and aging is performed in the condition where the unreacting mandelonitriles exist and a portion of the generated mandelic acids is deposited. In the method of manufacturing mandelic acids by hydrolyzing mandelonitriles with mineral acid, reaction and aging is performed in the condition where the unreacting mandelonitriles exist and 50-99.9 wt.% of the generated mandelic acids is deposited.
摘要翻译：要解决的问题：提供一种制造用作农药原料的高纯度扁桃酸的方法，液晶材料和光学拆分剂，并提供高纯度扁桃酸晶体。解决方案：在通过用无机酸水解扁桃酸的方法制造扁桃酸的方法中，在存在未反应的扁桃腈并且产生的扁桃酸的一部分沉积的条件下进行反应和老化。在用无机酸水解扁桃酸制造扁桃酸的方法中，在存在未反应的扁桃腈的条件下进行反应和老化，并沉积50-99.9重量％的生成的扁桃酸。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2012092036A Method for producing salt of carnitine 审中-公开
标题翻译：生产盐酸盐的方法
公开(公告)号：JP2012092036A
公开(公告)日：2012-05-17
申请号：JP2010240040
申请日：2010-10-26
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OAIRA KAZUYA , SATO EIJI , MORI HIROYUKI , YOSHIOKA AKIRA , INABA HIDEYUKI
IPC分类号： C07C227/40 , C07C51/15 , C07C51/42 , C07C229/22
摘要： PROBLEM TO BE SOLVED: To provide a salt of carnitine which does not produce agglomeration even when preserved for a long period of time.SOLUTION: This method for producing a salt of carnitine includes: a step (1) of preparing wet crystals of the salt of carnitine having a size to pass through a sieve with a mesh size of 5.6 mm; and a step (2) of drying the wet crystals of the salt of carnitine obtained in the step (1).
摘要翻译：待解决的问题：提供即使长时间保存也不产生团聚的肉碱盐。解决方案：用于生产肉碱盐的方法包括：制备具有通过筛孔尺寸为5.6mm的筛子的肉碱盐的湿结晶的步骤（1）以及干燥步骤（1）中获得的肉碱盐的湿结晶的步骤（2）。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2011088871A Method for purifying carnitine 审中-公开
标题翻译：净化CARNITINE的方法
公开(公告)号：JP2011088871A
公开(公告)日：2011-05-06
申请号：JP2009245236
申请日：2009-10-26
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： TAKIGAWA YUYA , SATO EIJI , MORI HIROYUKI
IPC分类号： C07C227/40 , A61K31/205 , A61P3/06 , A61P9/00 , C07C229/22
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining carnitine having reduced impurities and a high purity since L-carnitine is noticed as a therapeutic agent for heart disease, therapeutic agent for hyperlipemia, therapeutic agent for venous disease, etc., is also referred to as vitamin BT and is an important compound related to metabolism of fatty acid in an organism.
SOLUTION: The method for purifying carnitine includes a step for removing (i) a compound represented by formula: R
1 -CH
2 -CH(OH)-CH
2 -R
2 (wherein R
1 and R
2 are each the same or different and primary to quaternary amino or carboxy) and (ii) a compound represented by formula (2) (wherein R
3 is amide or carboxy) and/or crotonobetaine present in an alcohol solvent by filtration.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种获得肉碱含量低的肉碱的方法，因为L-心碱被认为是心脏病的治疗剂，高脂血症的治疗剂，静脉疾病的治疗剂等，也称为维生素BT，是与生物体中脂肪酸代谢相关的重要化合物。解决方案：用于纯化肉毒碱的方法包括除去（i）由下式表示的化合物的步骤：R -CH 2 -CH（OH）-CH （其中R SB 1和R SB 2各自相同或不同，并且伯至季氨基或羧基）和（ii）通过过滤存在于醇溶剂中的式（2）表示的化合物（其中R SB 3是酰胺或羧基）和/或巴豆甜菜碱。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2011084529A Method for preservation of aqueous solution of carnitinamide 审中-公开
标题翻译：氯化碳水溶液保存方法
公开(公告)号：JP2011084529A
公开(公告)日：2011-04-28
申请号：JP2009239790
申请日：2009-10-16
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OISHI KOSUKE , TAKIGAWA YUYA , SATO EIJI
IPC分类号： C07C231/22 , A61K31/221 , A61P3/06 , A61P9/00 , C07C227/18 , C07C229/22 , C07C237/06
摘要： PROBLEM TO BE SOLVED: To provide a method for preserving an aqueous solution of carnitinamide without forming flocculate and clouding.
SOLUTION: The method for preserving the carnitinamide aqueous solution comprises the preservation of the solution by adjusting pH to ≥9.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种保持肉毒碱水溶液而不形成絮凝和混浊的方法。解决方案：用于保存肉毒碱水溶液的方法包括通过将pH调节至≥9来保存溶液。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2011032243A Process for producing carnitine 审中-公开
标题翻译：生产CARNITINE的方法
公开(公告)号：JP2011032243A
公开(公告)日：2011-02-17
申请号：JP2009182058
申请日：2009-08-05
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OISHI KOSUKE , SATO EIJI , MORI HIROYUKI , YOSHIOKA AKIRA , HASHIMOTO CHIE
IPC分类号： C07C227/18 , A61K31/205 , A61P3/06 , A61P9/00 , C07B61/00 , C07C51/06 , C07C59/01 , C07C229/22 , C07C231/12 , C07C237/06
摘要： PROBLEM TO BE SOLVED: To provide a process which efficiently produces high purity carnitine having reduced impurities difficult to identify.
SOLUTION: The process for producing carnitine comprises hydrolyzing carnitineamide by a basic catalyst with the use of a carnitineamide solution containing not more than 1 mass% compound represented by the formula (I): R-CH=CH-CH
2 OH [wherein R is -CN, -CONH
2 , -COOX (wherein X is hydrogen, an alkali metal or an alkaline earth metal) or -COOR' (wherein R' is a 1C-20C hydrocarbon group)].
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效地生产具有难以鉴别的杂质减少的高纯度肉碱的方法。解决方案：生产肉毒碱的方法包括使用含有不多于1质量％的由式（I）表示的化合物的肉碱酰胺溶液通过碱性催化剂水解肉碱酰胺：R-CH = CH-CH 2 OH [其中R是-CN，-CONH 2 SB，-COOX（其中X是氢，碱金属或碱土金属）或-COOR'（其中R'是 1C-20C烃基）]。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2009000097A Method for producing 4-halo-3-hydroxybutyramide and its derivative 审中-公开
标题翻译：生产4-羟基-3-羟基吡啶及其衍生物的方法
公开(公告)号：JP2009000097A
公开(公告)日：2009-01-08
申请号：JP2007322180
申请日：2007-12-13
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： WATANABE TAKESHI , NINOMIYA YASUHIRO , OISHI KOSUKE , SATO EIJI
IPC分类号： C12P13/02 , C07B53/00 , C07C231/12 , C07C235/06 , C07C237/06
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a 4-halo-3-hydroxybutyramide, completing reaction in a short time and not requiring a lot of nitrile hydratase. SOLUTION: The method for producing the 4-halo-3-hydroxybutyramide comprises a step I of subjecting an epihalohydrin and/or a 1,3-dihalo-2-propanol and a cyanide donor to enzymatic reaction to synthesize a 4-halo-3-hydroxybutyronitrile and a step II of bringing the 4-halo-3-hydroxybutyronitrile into contact with nitrile hydratase so that the product of the concentration (mass%) of the nitrile with salt concentration (total of a salt of an alkali metal salt with a buffer agent salt and salts of metals composed of nickel, zinc and cobalt) (mass%) becomes ≤160. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供4-卤代-3-羟基丁酰胺的制备方法，在短时间内完成反应，不需要大量的腈水合酶。解决方案：4-卤代-3-羟基丁酰胺的制备方法包括使表卤代醇和/或1,3-二卤代-2-丙醇和氰化物供体进行酶反应的步骤I，合成4- 卤代-3-羟基丁腈，以及使4-卤-3-羟基丁腈与腈水合酶接触的步骤II，使得腈的浓度（质量％）与盐浓度（碱金属的盐的总量）的乘积盐与缓冲剂盐和由镍，锌和钴组成的金属盐）（质量％）变为≤160。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2008131861A Method for industrially producing 4-halo-3-hydroxybutyronitrile 有权
标题翻译：用于工业生产4-羟基-3-羟基吡啶的方法
公开(公告)号：JP2008131861A
公开(公告)日：2008-06-12
申请号：JP2006318380
申请日：2006-11-27
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： NINOMIYA YASUHIRO , SATO EIJI
IPC分类号： C12P13/00 , C07C253/34 , C07C255/12
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a 4-halo-3-hydroxybutyronitrile, by which an un-reacted 1,3-dihalo-2-propanol and an un-reacted cyanide donor can be reused to profitably produce the 4-halo-3-hydroxybutyronitrile.
SOLUTION: This method for producing the 4-halo-3-hydroxybutyronitrile from the 1,3-dihalo-2-propanol and the cyanide donor by an enzymatic reaction in an aqueous system is characterized by comprising (1) the process of distilling the aqueous reaction solution after the finish of the enzymatic reaction to recover the un-reacted 1,3-dihalo-2-propanol and the un-reacted cyanide donor, and (2) the process of repeatedly using the recovered cyanide donor and the recovered 1,3-dihalo-2-propanol for the enzymatic reaction once or more.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种4-卤代-3-羟基丁腈的制备方法，其中未反应的1,3-二卤代-2-丙醇和未反应的氰化物供体可以重复利用产生4-卤代-3-羟基丁腈。解决方案：在水性体系中通过酶反应从1,3-二卤代-2-丙醇和氰化物供体生产4-卤代-3-羟基丁腈的方法的特征在于包括（1）在酶反应完成后蒸馏水反应溶液以回收未反应的1,3-二卤代-2-丙醇和未反应的氰化物供体，和（2）重复使用回收的氰化物供体和回收1,3-二卤代-2-丙醇进行酶促反应一次或多次。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2007217440A Purification method for optically active alpha-trifluoromethyl lactate 审中-公开
标题翻译：光学活性阿尔法三氟甲磺酸的净化方法
公开(公告)号：JP2007217440A
公开(公告)日：2007-08-30
申请号：JP2007150595
申请日：2007-06-06
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： SATO EIJI , ENOMOTO KANEHIKO , URAGAKI TOSHITAKA
IPC分类号： C07C51/43 , C07B57/00 , C07C59/115
摘要： PROBLEM TO BE SOLVED: To provide a simple purification method for optically active α-trifluoromethyl lactate that is useful as an effective intermediate for optically active medicine or optically active agrochemical.
SOLUTION: The optically active α-trifluoromethyl lactate that is represented by formula (I) (wherein * indicates an asymmetric carbon) is recrystallized by using one kind of solvent or a mixed solvent including plural kinds of solvents selected from the group consisting of aromatic hydrocarbon solvent, aliphatic hydrocarbon solvent, ether solvent, ester solvent, ketone solvent, acetonitrile, and N,N-dimethylformamide, then the optical purity-improved portion is collected, namely the precipitated crystal or the mother liquor residue.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供用作光学活性药物或光学活性农药的有效中间体的光学活性α-三氟甲基乳酸盐的简单纯化方法。解决方案：通过使用一种溶剂或包含多种溶剂的混合溶剂将由式（I）表示的光学活性α-三氟甲基乳酸盐（其中*表示不对称碳）重结晶，所述溶剂或多种溶剂选自的芳族烃溶剂，脂族烃溶剂，醚溶剂，酯溶剂，酮溶剂，乙腈和N，N-二甲基甲酰胺，然后收集光学纯度改进部分，即沉淀的晶体或母液残余物。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2011250720A Method for manufacturing 4-halo-3-hydroxy butyl amide 审中-公开
标题翻译：制备4-羟基-3-羟基丁酸酰胺的方法
公开(公告)号：JP2011250720A
公开(公告)日：2011-12-15
申请号：JP2010125492
申请日：2010-06-01
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： WATANABE TAKESHI , IIZUKA AYA , OISHI KOSUKE , NINOMIYA YASUHIRO , SATO EIJI
IPC分类号： C12P13/02
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently manufacturing 4-halo-3-hydroxy butyl amide.SOLUTION: The method for manufacturing 4-halo-3-hydroxy butyl amide includes following processes: (1) a process of supplying gas to a solution containing 4-halo-3-hydroxy butyronitrile, and (2) a process of amidating the nitrile by putting it in contact with nitrile hydratase in the presence of a metallic salt.

10. 发明专利

JP2011246370A Method for preserving 4-halo-3-hydroxybutyronitrile 审中-公开
标题翻译：用于保存4-羟基-3-羟基丁基的方法
公开(公告)号：JP2011246370A
公开(公告)日：2011-12-08
申请号：JP2010119700
申请日：2010-05-25
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： WATANABE TAKESHI , NINOMIYA YASUHIRO , SATO EIJI
IPC分类号： C07C253/32 , C07C255/12 , C12P13/00
摘要： PROBLEM TO BE SOLVED: To provide a method for stably preserving a solution containing 4-halo-3-hydroxybutyronitrile.SOLUTION: The method for preserving the 4-halo-3-hydroxybutyronitrile includes regulating the pH of the solution containing the 4-halo-3-hydroxybutyronitrile so as to be ≤7.

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