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1. 发明专利

JP2012106999A Ophthalmic composition for soft contact lens 有权
标题翻译：柔性接触透镜的透明组合物
公开(公告)号：JP2012106999A
公开(公告)日：2012-06-07
申请号：JP2011230514
申请日：2011-10-20
申请人： Lion Corp , ライオン株式会社
发明人： SASAKI HIDENORI , OKUMURA TAKASHI , SUGAFUJI HISAHIRO , HATTORI MANABU
IPC分类号： A61K31/4402 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/36 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a means which suppresses adsorption of chlorpheniramine or its salt to a soft contact lens, and an ophthalmic composition for a soft contact lens wearer using the means and comprising chlorpheniramine or its salt.SOLUTION: The ophthalmic composition for a soft contact lens wearer contains: (A) chlorpheniramine maleate by 0.006 to 0.1 g/100 mL; (B) dipotassium glycyrrhizinate by 0.05 to 1.0 g/100 mL; (C) sodium chondroitin sulfate ester by 0.05 to 1.0 g/100 mL; (D) one or two kinds selected from sodium chloride and potassium chloride by 0.2 to 1.5 g/100 mL; and (E) one or two kinds selected from boric acid and borax by 1.2 to 1.8 g/100 mL, does not contain quaternary cation type antiseptic agent, paraben, chlorobutanol and sorbic acid, and has a pH of 6.6 to 7.3.
摘要翻译：要解决的问题：提供抑制氯苯那敏或其盐对软性隐形眼镜的吸附的方法，以及使用该方法并包含氯苯那敏或其盐的软性隐形眼镜佩戴者的眼用组合物。解决方案：用于软性隐形眼镜佩戴者的眼用组合物包含：（A）马来酸氯苯那敏剂0.006至0.1g / 100mL; （B）甘草酸二钾0.05〜1.0g / 100mL; （C）硫酸软骨素钠0.05〜1.0g / 100mL; （D）选自氯化钠和氯化钾中的一种或两种，0.2至1.5g / 100mL; 和（E）选自硼酸和硼砂中的一种或两种1.2至1.8g / 100mL，不含季阳离子型防腐剂，对羟基苯甲酸酯，氯丁醇和山梨酸，并且具有6.6至7.3的pH。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2014129330A Composition for mucosa 有权
标题翻译： MUCOSA的组合物
公开(公告)号：JP2014129330A
公开(公告)日：2014-07-10
申请号：JP2013120975
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： SASAKI KANA , OKUMURA TAKASHI , HATTORI MANABU , ARITA ATSUYA , ISHII REIKO , SASAKI HIDENORI , MIYAKE MIYUKI , KIKUCHI MAIKO
IPC分类号： A61K47/34 , A61K9/107 , A61K31/07 , A61K31/22 , A61K47/10 , A61K47/22
摘要： PROBLEM TO BE SOLVED: To provide a composition for mucosa where stability of the lipid-soluble active ingredient is maintained and also the appearance of the composition for mucosa is uniformed, adsorption of a lipid-soluble active ingredient into a mucosa such as cornea, conjunctiva, nasal mucous and oral cavity throat is enhanced and the effect is more exerted, as the lipid-soluble active ingredient is compounded with the composition for mucosa.SOLUTION: A composition for mucosa contains (A) 0.001 to 1.0 W/V% of a lipid-soluble active ingredient and (B) a nonionic surfactant selected from polyoxyethylene polyoxypropylene copolymers where the mass ratio presented by (A):(B) is 1:0.4 to 24.0; and comprises lipid-soluble active ingredient-containing nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B) to an aqueous phase at 75 to 90°C followed by stirring and have the components (A) and (B) as constitutional components.
摘要翻译：要解决的问题：为了提供保持脂溶性活性成分的稳定性并且粘膜组合物的外观均匀的粘膜组合物，将脂溶性活性成分吸附到粘膜如角膜，结膜中增加了鼻粘膜和口腔喉部的作用，因为脂溶性活性成分与粘膜组合物配合使用。溶液：粘膜组合物含有（A）0.001〜1.0W / V％脂质可溶性活性成分和（B）选自聚氧乙烯聚氧丙烯共聚物的非离子表面活性剂，其中（A）:( B）所示的质量比为1:0.4〜24.0; 并且包含含有脂溶性活性成分的纳米乳剂颗粒，其通过在75-90℃下将包含组分（A）和（B）的油相加入到水相中，然后搅拌并将组分（A）和（B）作为宪法组成部分。

3. 发明专利

JP2014129329A Composition for mucosa and production method thereof 有权
标题翻译： MUCOSA的组合物及其生产方法
公开(公告)号：JP2014129329A
公开(公告)日：2014-07-10
申请号：JP2013120659
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： ISHII REIKO , SASAKI HIDENORI , OKUMURA TAKASHI , SASAKI KANA , HATTORI MANABU , ARITA ATSUYA , MIYAKE MIYUKI , KIKUCHI MAIKO
IPC分类号： A61K31/07 , A61K9/107 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/34 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a composition for mucosa where the appearance of the composition is made transparent and stability in vitamin A is more excellent; and a production method thereof.SOLUTION: A composition for mucosa contains (A) 0.0005 to 0.12 W/V% of vitamin A, (B) 0.007 to 0.5 W/V%, as a nonionic surfactant total amount, of a nonionic surfactant having polyoxyethylene cured castor oil or polyoxyethylene sorbitan fatty acid ester as an essential component, where the mass ratio presented by (A):(B) is 1:0.4 to 14, and (C) one or more kinds selected from lower alcohol, sugar alcohol, sugar, chlorpheniramine maleate, diphenhydramine hydrochloride and flavin-adenine dinucleotide sodium; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B) to an aqueous phase at 75 to 90°C followed by stirring and contain the components (A) and (B) as constitutional components.
摘要翻译：要解决的问题：提供组合物的外观透明的粘膜组合物，维生素A的稳定性更优异; 及其制造方法。粘合剂组合物含有（A）0.0005〜0.12W / V％的维生素A，（B）0.007〜0.5W / V％，作为非离子表面活性剂的总量为非离子表面活性剂，聚氧乙烯固化蓖麻油或聚氧乙烯脱水山梨醇脂肪酸酯作为必要成分，其中由（A）:( B）表示的质量比为1:0.4〜14，（C）选自低级醇，糖醇中的一种或多种，糖，马来酸氯苯那敏，盐酸苯海拉明和黄素 - 腺嘌呤二核苷酸钠; 并且包括通过将包含组分（A）和（B）的油相在75至90℃下加入到水相中并随后搅拌并含有组分（A）和（B）作为结构组分而获得的纳米乳液颗粒。

4. 发明专利

JP2014129327A Composition for mucosa and production method thereof 有权
标题翻译： MUCOSA的组合物及其生产方法
公开(公告)号：JP2014129327A
公开(公告)日：2014-07-10
申请号：JP2013120642
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： ISHII REIKO , SASAKI HIDENORI , SASAKI KANA , OKUMURA TAKASHI , HATTORI MANABU , ARITA ATSUYA , MIYAKE MIYUKI , KIKUCHI MAIKO
IPC分类号： A61K31/07 , A61K9/107 , A61K31/05 , A61K31/355 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/44 , A61P27/02 , A61P39/06
摘要： PROBLEM TO BE SOLVED: To provide a composition for mucosa where the appearance of the composition is made transparent, continuous cool feeling is obtained, and stimulation due to combination use of a surfactant and a cooling agent is suppressed; and a production method thereof.SOLUTION: A composition for mucosa contains (A) 0.005 to 0.2 W/V% of a lipid-soluble active ingredient, (B) 0.01 to 0.5 W/V%, as a nonionic surfactant total amount, of a nonionic surfactant having polyoxyethylene cured castor oil or polyoxyethylene sorbitan fatty acid ester as an essential component, where the mass ratio presented by (A):(B) is 1:0.4 to 7.0, and (C) a cooling agent; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B) to an aqueous phase at 75 to 90°C followed by stirring and contain the components (A) and (B) as constructional components.
摘要翻译：要解决的问题：为了提供使组合物的外观透明的粘膜组合物，获得连续的冷感，并且抑制了由于表面活性剂和冷却剂的组合使用引起的刺激; 及其制造方法。粘合剂组合物含有（A）0.005〜0.2W / V％的脂溶性活性成分，（B）0.01〜0.5W / V％，作为非离子表面活性剂总量具有聚氧乙烯固化蓖麻油或聚氧乙烯脱水山梨醇脂肪酸酯作为必要成分的非离子表面活性剂，其中（A）:( B）所示的质量比为1:0.4〜7.0，（C）冷却剂; 并且包括通过将包含组分（A）和（B）的油相在75至90℃下加入到水相中并随后搅拌并含有组分（A）和（B））作为结构组分而获得的纳米乳液颗粒。

5. 发明专利

JP2011207874A Ophthalmic composition for soft contact lens 有权
标题翻译：柔性接触透镜的透明组合物
公开(公告)号：JP2011207874A
公开(公告)日：2011-10-20
申请号：JP2011052353
申请日：2011-03-10
申请人： Lion Corp , ライオン株式会社
发明人： OKUMURA TAKASHI , SUGAFUJI HISAHIRO , SASAKI HIDENORI
IPC分类号： A61K31/135 , A61K9/08 , A61K47/04 , A61K47/08 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/28 , A61K47/34 , A61K47/36 , A61P27/14
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic composition for soft contact lens which controls absorption of an antihistamine selected from diphenhydramine and a salt of the same to the soft contact lens and performs excellent exchange of a lacrimal liquid in attaching the soft contact lens.SOLUTION: The ophthalmic composition for soft contact lens includes (A) diphenhydramine and/or the salt of the same, (B) cromoglycic acid and/or a salt of the same, (C) glycyrrhetinic acid and/or a salt of the same, and (D) chondroitin sulfuric acid and/or a salt of the same.
摘要翻译：要解决的问题：提供一种用于软性隐形眼镜的眼用组合物，其控制从软性隐形眼镜中选择苯海拉明及其盐的抗组胺药物的吸收，并且在粘附软性隐形眼镜时进行泪液的优异交换。：软性隐形眼镜用眼用组合物包括（A）苯海拉明和/或其盐，（B）色甘酸和/或其盐，（C）甘草次酸和/或其盐，和（D）硫酸软骨素和/或其盐。

6. 发明专利

JP2014129325A Composition comprising nanoemulsion particle and production method thereof 有权
标题翻译：包含纳米颗粒的组合物及其生产方法
公开(公告)号：JP2014129325A
公开(公告)日：2014-07-10
申请号：JP2013120622
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： SASAKI HIDENORI , ISHII REIKO , OKUMURA TAKASHI , SASAKI KANA , HATTORI MANABU , ARITA ATSUYA , MIYAKE MIYUKI , KIKUCHI MAIKO
IPC分类号： A61K9/107 , A61K31/23 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/34 , A61K47/44
摘要： PROBLEM TO BE SOLVED: To provide a composition comprising lipid-soluble active ingredient-containing nanoemulsion particles, where the appearance of the composition is transparent, the antiseptic power is enhanced and stimulation is suppressed, as a lipid-soluble active ingredient such as vitamin A is compounded with the composition.SOLUTION: A composition contains (A) 0.0005 to 1.0 W/V% of a lipid-soluble active ingredient, (B-I) 0.5 W/V% or less of polyoxyethylene cured castor oil and/or polyoxyethylene sorbitan fatty acid ester having a mass ratio of 1:0.4 to 25 as presented by (A):(B-I), and (C) 0.5 to 2.0 W/V% of boric acid and/or borax; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B-I) to an aqueous phase at 75 to 90°C followed by stirring and contain the components (A) and (B-I) as constructional components.
摘要翻译：要解决的问题：为了提供包含含有脂溶性活性成分的纳米乳剂颗粒的组合物，其中组合物的外观是透明的，作为脂溶性活性成分如维生素A，可以增强抗菌能力并抑制刺激与组合物复合。溶液：组合物含有（A）0.0005〜1.0W / V％的脂溶性活性成分，（BI）0.5W / V％以下的聚氧乙烯固化蓖麻油和/或聚氧乙烯失水山梨糖醇脂肪（A）:( BI）所示的质量比为1:0.4〜25的酸酯，（C）0.5〜2.0W / V的硼酸和/或硼砂; 并且包括通过将包含组分（A）和（B-I）的油相在75-90℃下加入到水相中并随后搅拌并含有组分（A）和（B-I））作为结构组分而获得的纳米乳液颗粒。

7. 发明专利

JP2014129328A Composition comprising nanoemulsion particle and production method thereof 有权
标题翻译：包含纳米颗粒的组合物及其生产方法
公开(公告)号：JP2014129328A
公开(公告)日：2014-07-10
申请号：JP2013120651
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： SASAKI HIDENORI , ISHII REIKO , OKUMURA TAKASHI , SASAKI KANA , MIYAKE MIYUKI , KIKUCHI MAIKO , HATTORI MANABU , ARITA ATSUYA
IPC分类号： A61K45/00 , A61K9/107 , A61K31/07 , A61K47/34 , A61K47/36
摘要： PROBLEM TO BE SOLVED: To provide a composition comprising lipid-soluble active ingredient-containing nanoemulsion particles where the appearance of the composition is transparent, dryness (dry eye) is improved and stimulation is suppressed, as a lipid-soluble active ingredient such as vitamin A is compounded with the composition.SOLUTION: A composition contains (A) 0.0005 to 1.0 W/V% of a lipid-soluble active ingredient, (B-I) 0.5 W/V% or less of polyoxyethylene cured castor oil and/or polyoxyethylene sorbitan fatty acid ester where the mass ratio presented by (A):(B-I) is 1:0.4 to 10, and (C) a water-soluble polymer compound; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B-I) to an aqueous phase at 75 to 90°C followed by stirring and contains the components (A) and (B-I) as constitutional components.
摘要翻译：要解决的问题：为了提供包含含有脂溶性活性成分的纳米乳液颗粒的组合物，其中组合物的外观是透明的，干性（干眼症）得到改善并且刺激被抑制，作为脂溶性活性成分如维生素 A组合物含有（A）0.0005〜1.0W / V％的脂溶性活性成分，（BI）0.5W / V％以下聚氧乙烯固化蓖麻油和/或聚氧乙烯脱水山梨糖醇脂肪酸酯，其中由（A）:( BI）提供的质量比为1:0.4至10，和（C）水溶性高分子化合物; 并且包括通过将包含组分（A）和（B-I）的油相在75-90℃下加入水相并搅拌并含有组分（A）和（B-I）作为结构成分而获得的纳米乳液颗粒。

8. 发明专利

JP2014129326A Composition comprising nanoemulsion particle and production method thereof 有权
标题翻译：包含纳米颗粒的组合物及其生产方法
公开(公告)号：JP2014129326A
公开(公告)日：2014-07-10
申请号：JP2013120625
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： OKUMURA TAKASHI , SASAKI KANA , ISHII REIKO , SASAKI HIDENORI , HATTORI MANABU , ARITA ATSUYA , MIYAKE MIYUKI , KIKUCHI MAIKO , MATSUKI MAIKO
IPC分类号： A61K9/107 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/34 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide a composition where the appearance of the composition is transparent, adsorption of a lipid-soluble active ingredient into a mucosa such as cornea, conjunctiva, nasal mucous and oral cavity throat for example is enhanced and the effect is more exerted, as a lipid-soluble active ingredient such as vitamin A is compounded with the composition.SOLUTION: A composition contains (A) 0.001 to 1.0 W/V% of a lipid-soluble active ingredient, (B) a nonionic surfactant and (C) one or more kinds selected from inorganic salts, organic acids, organic salts, amino acids, amino acid salts, basic drugs and salts thereof; and comprises nanoemulsion particles, where the (B) component is (B-I) polyoxyethylene cured castor oil and/or polyoxyethylene sorbitan fatty acid ester and the mass ratio presented by (A):(B-I) is 1:0.4 to 10, or where the (B) component is (B-II) a polyoxyethylene polyoxypropylene copolymer and the mass ratio presented by (A):(B-II) is 1:0.8 to 24.
摘要翻译：要解决的问题：为了提供组合物的外观透明的组合物，例如可将脂溶性活性成分吸附到角膜，结膜，鼻粘膜和口腔喉等粘膜中，并且效果更好作为脂溶性活性成分如维生素A与组合物混合。溶液：组合物含有（A）0.001〜1.0W / V％的脂溶性活性成分，（B）非离子表面活性剂和（ C）选自无机盐，有机酸，有机盐，氨基酸，氨基酸盐，碱性药物及其盐中的一种或多种; （B）成分为（BI）聚氧乙烯固化蓖麻油和/或聚氧乙烯脱水山梨醇脂肪酸酯的纳米乳液颗粒，由（A）:( BI）提供的质量比为1:0.4〜10，或者（B）成分为（B-II）聚氧乙烯聚氧丙烯共聚物，（A）:( B-II）所示的质量比为1:0.8〜24。

9. 发明专利

JP2017081850A 造粒物及びこれを含む経口製剤並びに造粒物及び経口製剤の製造方法审中-公开
公开(公告)号：JP2017081850A
公开(公告)日：2017-05-18
申请号：JP2015212031
申请日：2015-10-28
申请人：ライオン株式会社 , Lion Corp
发明人： SASAKI HIDENORI , ONO TSUBASA , IMAI HIROTO
IPC分类号： A61K31/192 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/32 , A61K47/38 , A61K47/40 , A61P29/00
摘要：【課題】イブプロフェンに由来する刺激が抑制され、かつ、イブプロフェンの溶出性に優れた造粒物を提供すること。【解決手段】イブプロフェン(A)と、β−シクロデキストリン(B)と、ポリビニルアルコール及びメチルセルロースからなる群より選ばれる少なくとも1種(C)と、を含有する造粒物。【選択図】なし

10. 发明专利

JP2013181020A Ophthalmic composition 审中-公开
标题翻译：眼科组合物
公开(公告)号：JP2013181020A
公开(公告)日：2013-09-12
申请号：JP2012047575
申请日：2012-03-05
申请人： Lion Corp , ライオン株式会社
发明人： ISHII REIKO , SASAKI KANA , SASAKI HIDENORI
IPC分类号： A61K31/07 , A61K9/08 , A61K31/19 , A61K31/197 , A61K31/215 , A61K31/737 , A61K47/04 , A61K47/18 , A61K47/22
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic composition useful for prevention and amelioration of dry eye symptoms without using any thickening polymer humectant such as hyaluronic acid which may give unsatisfactory usability such as sense of discomfort and unpleasantness when the composition is applied to eyes.SOLUTION: An ophthalmic composition includes: (A) vitamin A; (B) an anti-inflammatory component; (C) cornea protection component; (D) one or more buffers selected from boric acid, borax, and trometamol; and (E) an anti-oxidant. The ophthalmic composition has pH of 5.0-7.5.
摘要翻译：要解决的问题：提供一种可用于预防和改善干眼症状的眼用组合物，而不使用任何增稠聚合物湿润剂如透明质酸，当组合物施用于眼睛时可能会产生不令人满意的可用性，例如不适感和不愉快感。眼用组合物包括：（A）维生素A; （B）抗炎成分; （C）角膜保护部件; （D）一种或多种选自硼酸，硼砂和氨基甲烷的缓冲液; 和（E）抗氧化剂。眼用组合物的pH为5.0-7.5。

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