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1. 发明专利

JP2014074044A Soft contact lens composition and adsorption-suppressing method 有权
标题翻译：软接触透镜组合物和吸附抑制方法
公开(公告)号：JP2014074044A
公开(公告)日：2014-04-24
申请号：JP2013252626
申请日：2013-12-06
申请人： Lion Corp , ライオン株式会社
发明人： TABUCHI TERUTO , HATTORI MANABU
IPC分类号： A61K31/135 , A61K9/08 , A61K31/137 , A61K31/196 , A61K31/216 , A61K31/222 , A61K31/245 , A61K31/27 , A61K31/41 , A61K31/4164 , A61K31/4166 , A61K31/4174 , A61K31/4178 , A61K31/435 , A61K31/436 , A61K31/437 , A61K31/4402 , A61K31/444 , A61K31/451 , A61K31/496 , A61K31/522 , A61K31/5377 , A61K31/7036 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/36 , A61K47/44 , A61L27/00 , A61P27/02 , A61P27/14 , G02C13/00
CPC分类号： A61K31/135 , A61K31/137 , A61K31/138 , A61K31/14 , A61K31/216 , A61K31/27 , A61K31/275 , A61K31/41 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/4178 , A61K31/436 , A61K31/4402 , A61K31/4409 , A61K31/4425 , A61K31/4433 , A61K31/47 , A61K31/496 , A61K31/517
摘要： PROBLEM TO BE SOLVED: To provide a soft contact lens composition suppressing adsorption of a basic drug selected from amines having a secondary amino group and/or a tertiary amino group and salts thereof to a soft contact lens and a method for suppressing adsorption of the basic drug to a soft contact lens.SOLUTION: A soft contact lens composition suppressing adsorption of a basic drug to a soft contact lens contains (A) a basic drug selected from amines having a secondary amino group and/or a tertiary amino group and salts thereof and (B) one kind or two or more kinds selected from acidic mucopolysaccharides and salts thereof, and cyclodextrin, and has a pH 3.5 to 4.8. A method is to suppress adsorption of the basic drug to a soft contact lens.
摘要翻译：要解决的问题：提供抑制选自具有仲氨基和/或叔氨基的胺的碱性药物及其盐对软性隐形眼镜的吸附的软性隐形眼镜组合物，以及抑制碱性物质的吸附的方法一种软性隐形眼镜组合物，其抑制碱性药物对软性隐形眼镜的吸附，含有（A）选自具有仲氨基和/或叔氨基的胺的碱性药物及其盐和（B）选自酸性粘多糖及其盐和环糊精中的一种或两种以上，pH为3.5〜4.8。一种方法是抑制碱性药物对软性隐形眼镜的吸附。

2. 发明专利

JP2011093900A Anti-inflammatory agent 有权
标题翻译：抗炎剂
公开(公告)号：JP2011093900A
公开(公告)日：2011-05-12
申请号：JP2010223648
申请日：2010-10-01
申请人： Lion Corp , ライオン株式会社
发明人： TAKIZAWA TAKESHI , HATTORI MANABU , KATAOKA SHINSUKE
IPC分类号： A61K31/133 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide an anti-inflammatory agent having excellent anti-inflammatory effects on inflammation brought on by toxins such as LPS and LTA, and an anti-inflammatory composition containing the same. SOLUTION: This anti-inflammatory agent comprises trometamol. It can be used as an IL-6 expression-level inhibitor, retardant or inactivator of LPS or LTA. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供对毒素如LPS和LTA引起的炎症具有优异的抗炎作用的抗炎剂和含有它们的抗炎组合物。解决方案：该抗炎剂包含氨甲喋呤。它可以用作IL-6表达水平的抑制剂，LPS或LTA的阻滞剂或灭活剂。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2014129325A Composition comprising nanoemulsion particle and production method thereof 有权
标题翻译：包含纳米颗粒的组合物及其生产方法
公开(公告)号：JP2014129325A
公开(公告)日：2014-07-10
申请号：JP2013120622
申请日：2013-06-07
申请人： Lion Corp , ライオン株式会社
发明人： SASAKI HIDENORI , ISHII REIKO , OKUMURA TAKASHI , SASAKI KANA , HATTORI MANABU , ARITA ATSUYA , MIYAKE MIYUKI , KIKUCHI MAIKO
IPC分类号： A61K9/107 , A61K31/23 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/34 , A61K47/44
摘要： PROBLEM TO BE SOLVED: To provide a composition comprising lipid-soluble active ingredient-containing nanoemulsion particles, where the appearance of the composition is transparent, the antiseptic power is enhanced and stimulation is suppressed, as a lipid-soluble active ingredient such as vitamin A is compounded with the composition.SOLUTION: A composition contains (A) 0.0005 to 1.0 W/V% of a lipid-soluble active ingredient, (B-I) 0.5 W/V% or less of polyoxyethylene cured castor oil and/or polyoxyethylene sorbitan fatty acid ester having a mass ratio of 1:0.4 to 25 as presented by (A):(B-I), and (C) 0.5 to 2.0 W/V% of boric acid and/or borax; and comprises nanoemulsion particles which are obtained by adding an oil phase comprising the components (A) and (B-I) to an aqueous phase at 75 to 90°C followed by stirring and contain the components (A) and (B-I) as constructional components.
摘要翻译：要解决的问题：为了提供包含含有脂溶性活性成分的纳米乳剂颗粒的组合物，其中组合物的外观是透明的，作为脂溶性活性成分如维生素A，可以增强抗菌能力并抑制刺激与组合物复合。溶液：组合物含有（A）0.0005〜1.0W / V％的脂溶性活性成分，（BI）0.5W / V％以下的聚氧乙烯固化蓖麻油和/或聚氧乙烯失水山梨糖醇脂肪（A）:( BI）所示的质量比为1:0.4〜25的酸酯，（C）0.5〜2.0W / V的硼酸和/或硼砂; 并且包括通过将包含组分（A）和（B-I）的油相在75-90℃下加入到水相中并随后搅拌并含有组分（A）和（B-I））作为结构组分而获得的纳米乳液颗粒。

4. 发明专利

JP2010031052A Composition for ophthalmic use and antiseptic composition for ophthalmology preparation 审中-公开
标题翻译：用于眼科用途的组合物和用于眼科学准备的抗组合物
公开(公告)号：JP2010031052A
公开(公告)日：2010-02-12
申请号：JP2009257305
申请日：2009-11-10
申请人： Lion Corp , ライオン株式会社
发明人： ODAKA AKITO , UMEZAWA NAOJI , HATTORI MANABU
IPC分类号： A61K31/133 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/18 , A61P27/02 , A61P27/04 , A61P27/14
摘要： PROBLEM TO BE SOLVED: To provide an antiseptic composition for an ophthalmology preparation which is not irritant to eyes and can also safely be applied to the eyes having troubles such as dry eyes, eyestrain, cornea damage, anti-allergies and damage by wearing contact lenses, and also a composition for ophthalmic use excellent in antiseptic force even if an antiseptic agent which provides irritation to eye mucous membranes such as benzalkonium chloride is not contained.
SOLUTION: The composition for ophthalmic use, which is an eye drop agent or an eye washing agent, comprises (A) ≥0.05 mass% and
摘要翻译：要解决的问题：提供一种眼刺激性物品的防腐剂组合物，其对眼睛不刺激，也可以安全地应用于眼睛有干眼症，眼睛疲劳，角膜损伤，抗过敏和损伤等眼睛。佩戴隐形眼镜，并且即使不含有对眼粘膜例如苯扎氯铵的刺激性的防腐剂，也可以使用防腐剂性优异的眼用组合物。＆lt; P＆gt;解决方案：作为滴眼剂或眼睛清洗剂的眼用组合物，含有（A）≥0.05质量％和<0.5质量％的氨基甲酸，和（B）选自组中的一种或多种（A）/（B）= 1/50〜50/1（质量比）的范围内的硼酸，磷酸，乙酸，马来酸，邻苯二甲酸和ε-氨基己酸，（A） /（B）≥3/ 1或（A）/（B）≤3/ 2（均为质量比）; pH为5〜7.5; 刺激性防腐剂如苯扎氯铵的量为0.0005质量％以下，或者不混合刺激性防腐剂。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2008156290A Ophthalmic composition 有权
标题翻译：眼科组合物
公开(公告)号：JP2008156290A
公开(公告)日：2008-07-10
申请号：JP2006347295
申请日：2006-12-25
申请人： Lion Corp , ライオン株式会社
发明人： TABUCHI TERUTO , HATTORI MANABU
IPC分类号： A61K47/04 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/46 , G02C13/00
摘要： PROBLEM TO BE SOLVED: To provide a new ophthalmic composition excellent in preservation effectiveness (preserving power) even without containing a cationic preservative such as benzalkonium chloride, chlorhexidin gluconate, etc., and having a low eye irritation.
SOLUTION: This ophthalmic composition contains a buffering agent, and having 3.5 to 3.9 pH and ≤18 mL Q value expressed by the following formula. Provided that Q=QHCl+QNaOH [wherein, QHCl: the amount of 0.1 mol/L HCl (mL) required for decreasing the pH of the composition of 100 g to pH3.5, QNaOH: the amount of 0.1 mol/L NaOH (mL) required for increasing the pH of the composition of 100 g to pH7.5].
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：即使不含有阳离子防腐剂如苯扎氯铵，氯己定葡萄糖酸盐等，并且具有低眼睛刺激性，提供了具有优异的保存效果（保存力）的新型眼用组合物。解决方案：该眼用组合物含有缓冲剂，并且具有由下式表示的3.5至3.9 pH和≤18mLQ值。假设Q = QHCl + QNaOH [其中，QHCl：将组合物的pH降低至pH3.5所需的0.1mol / L HCl（mL）的量，QNaOH：0.1mol / L NaOH（ mL），将组合物的pH值提高至pH7.5]。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2008009145A Contact lens cleaning composition, and contact lens cleaning method 审中-公开
标题翻译：接触透镜清洁组合物和接触透镜清洗方法
公开(公告)号：JP2008009145A
公开(公告)日：2008-01-17
申请号：JP2006179781
申请日：2006-06-29
申请人： Lion Corp , ライオン株式会社
发明人： HATTORI MANABU , ITO SEIJI
IPC分类号： G02C13/00 , C11D3/06 , C11D3/22 , C11D3/37 , C11D3/48 , C11D17/00
摘要： PROBLEM TO BE SOLVED: To provide a contact lens cleaning composition by which a contact lens is easily scrubbed with less friction at scrubbing, and to prevent the breakage of a soft contact lens due to scrubbing, and to surely scrub all kinds of contact lenses.
SOLUTION: The contact lens cleaning composition contains (A) a polyvinyl-based water-soluble high polymer compound and (B) a compound selected out of mucopolysaccharides, mucopolysaccharide salt, polyphosphoric acid and polyphosphate.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种隐形眼镜清洁组合物，通过该隐形眼镜清洁组合物，可以在擦洗时以较少的摩擦容易地擦洗隐形眼镜，并且防止由于擦洗而导致的软性隐形眼镜的破裂，并且可靠地擦洗各种隐形眼镜。解决方案：隐形眼镜清洁组合物含有（A）聚乙烯基水溶性高分子化合物和（B）选自粘多糖，粘多糖盐，多磷酸和多磷酸盐的化合物。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2007039661A Polymer compound and composition for contact lens 有权
标题翻译：聚合物化合物和接触镜片的组合物
公开(公告)号：JP2007039661A
公开(公告)日：2007-02-15
申请号：JP2006172184
申请日：2006-06-22
申请人： Lion Corp , ライオン株式会社
发明人： SHIMIZU YOSHIO , HARA YUSUKE , TOKI IKUKO , KOMATSU MASANORI , HATTORI MANABU , ITO SEIJI
IPC分类号： C08F226/10 , C08F220/34 , G02C7/04
摘要： PROBLEM TO BE SOLVED: To provide a polymer compound and a composition for contact lenses, holding lens shape, easy for wearing and maintaining comfortable wear feeling. SOLUTION: This polymer compound is obtained by copolymerizing a monomer mixture containing each specific amounts of (A) monomer, (B) monomer, (C) monomer and (D) monomer. (A) A monomer having a tertiary amino group and expressed by general formula (1) [wherein, R 1 is H or methyl; A is O or NH; R 2 , R 3 are each H or an alkyl; R 4 , R 5 are each an alkyl; and (m) is 0, 1 or 2], (B) N-vinyl-2-pyrrolidone, (C) (meth)acrylic acid ester monomer, and (D) a nonionic water-soluble monomer other than the (A) to (C). COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种高分子化合物和隐形眼镜用组合物，保持透镜形状，容易佩戴并保持舒适的穿着感。（A）单体，（B）单体，（C）单体和（D）单体的单体混合物共聚得到该高分子化合物。（A）具有叔氨基并由通式（1）表示的单体[其中，R 1 = H或甲基; A是O或NH; R 2 SP 3，R 3 SP 3各自为H或烷基; R SP 3，R 6，R 6，R 5，和（m）为0,1或2]，（B）N-乙烯基-2-吡咯烷酮，（C）（甲基）丙烯酸酯单体和（D）非（A）至（C）。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2005208628A Precare agent for contact lens and precare method of contact lens 审中-公开
标题翻译：接触透镜的预备剂和接触镜的预处理方法
公开(公告)号：JP2005208628A
公开(公告)日：2005-08-04
申请号：JP2004375457
申请日：2004-12-27
申请人： Lion Corp , ライオン株式会社
发明人： ITO SEIJI , HATTORI MANABU , SHIMOGAKI HISAO , SHIMIZU YOSHIO , HARA YUSUKE
IPC分类号： G02C13/00
摘要： PROBLEM TO BE SOLVED: To provide a precare agent composition for contact lenses which prevents the adhesion of smudge, such as protein, to the lenses arising during wearing of the contact lenses, imparts the feel of dampness to the lenses, and suppresses the degradation in the feel of wearing, such as the dryness of the eyes, and a precare method.
SOLUTION: The precare agent for contact lenses contains (A) a monomer having an amino group and/or a monomer having a quaternary ammonium group, (B) (meth)acrylate monomer, (C) a vinyl lactam monomer, and (D) a polymer compound prepared by copolymerizing one or two or more nonionic hydrophilic monomers exclusive of the aforementioned (A), (B) and (C) at specific ratios.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供一种防止隐形眼镜佩戴期间产生的诸如蛋白质等污迹的隐形眼镜预防剂组合物，赋予镜片湿润感，并抑制穿着感的降低，如眼睛的干燥，以及预防方法。解决方案：隐形眼镜预处理剂含有（A）具有氨基的单体和/或具有季铵基团的单体，（B）（甲基）丙烯酸酯单体，（C）乙烯基内酰胺单体和（D）以特定比例将不同于上述（A），（B）和（C）的一种或两种以上非离子亲水性单体进行共聚制备的高分子化合物。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2004024715A Contact lens detergent composition 审中-公开
公开(公告)号：JP2004024715A
公开(公告)日：2004-01-29
申请号：JP2002188556
申请日：2002-06-27
申请人： Lion Corp , ライオン株式会社
发明人： HATTORI MANABU
IPC分类号： G02C13/00 , A61L2/18 , C11D3/04 , C11D3/20 , C11D3/36 , C11D3/386 , C11D3/39 , C11D17/00
摘要： PROBLEM TO BE SOLVED: To obtain a contact lens detergent composition which has good preservation stability and high cleaning power (especially sterilizing power).
SOLUTION: This contact lens detergent composition contains (a) hydrogen peroxide, (b) a boron compound, and (c) a sugar compound, and has pH at 2 to 7. High cleaning power is obtained by diluting the composition with water. When a contact lens is dipped in the detergent composition and then water is added to dilute it, especially high cleaning power is obtained.
COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2014237686A 眼科用組成物及び白濁・沈殿抑制方法有权
标题翻译：眼睛防治组合物和防止眩晕/降解的方法
公开(公告)号：JP2014237686A
公开(公告)日：2014-12-18
申请号：JP2014157469
申请日：2014-08-01
申请人：ライオン株式会社 , Lion Corp
发明人： TSUTSUI HAZUKI , MIYAKE MIYUKI , ODAKA AKITO , INOUE CHIEKO , TABUCHI TERUTO , HATTORI MANABU
IPC分类号： A61K31/203 , A61K9/08 , A61K31/22 , A61K31/23 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/34 , A61P3/02 , A61P27/02 , A61P27/04
摘要：【解決手段】(A)レチノールパルミチン酸エステル、レチノール酢酸エステル及びレチノイン酸から選ばれるビタミンAと、(B)ポリオキシエチレンポリオキシプロピレングリコールと、(C)トロメタモールと、下記(D)〜(G):(D)グリセリン又はプロピレングリコール、(E)キシリトール、ソルビトール、マンニトール又はトレハロース、(F)リン酸二水素ナトリウム、(G)塩化ナトリウムから選ばれる1種とを含有し、(C)トロメタモールの配合量が、0.001〜5W/V%である眼科用組成物。【効果】本発明によれば、ビタミンAが安定に配合されると共に、凍結融解しても白濁・沈殿が生じない、外観が安定した眼科用組成物及びこの組成物の凍結融解による白濁・沈殿抑制方法を提供することができる。【選択図】なし
摘要翻译：要解决的问题：提供即使在进行冷冻融合并且外观稳定且稳定地与维生素A组合时也不产生混浊/沉淀的眼科组合物，以及通过冻融来防止混浊/沉淀的方法的组合物。解决方案：眼科组合物包含（A）选自棕榈酸视黄醇酯，视黄醇乙酸酯和视黄酸的维生素A，（B）聚氧乙烯聚氧丙烯二醇和（C）氨基甲烷醇; （D） - （G）中的一种：（D）甘油或丙二醇，（E）木糖醇，山梨糖醇，甘露醇或海藻糖，（F）磷酸二氢钠和（G）氯化钠，其中（C）氨基甲烷的加载量为0.001-5W / V％。

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