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1. 发明专利

JP2006168033A Anti-fogging laminate and its manufacturing method 有权
标题翻译：防雾层压板及其制造方法
公开(公告)号：JP2006168033A
公开(公告)日：2006-06-29
申请号：JP2004361221
申请日：2004-12-14
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , HARAGUCHI KAZUTOSHI
IPC分类号： B32B27/18 , C09D4/02 , C09K3/18
摘要： PROBLEM TO BE SOLVED: To provide an anti-fogging laminate having the excellent adhesion with a base material, enhanced in dynamic physical properties and heat resistance, and excellent in transparency, and its manufacturing method capable of forming a homogeneous coating film in an extremely short time.
SOLUTION: The anti-fogging laminate is constituted by providing a transparent dried gel layer, which is constituted by forming three dimensional meshes from a water-soluble organic polymer and a water-swellable clay mineral and has a thickness of 1-500 μm, on the surface of the base material. A manufacturing method of an organic and inorganic composite hydrogel is constituted by irradiating a water-soluble acrylic monomer with an energy beam in the coexistence of the water-swellable clay mineral in a solution prepared by dispersing a water-insoluble polymerization initiator in an aqueous medium to react the same.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决的问题：提供一种具有优异的基材粘合性，增强动力学物理性能和耐热性，透明度优异的防雾层压体及其制造方法，其能够形成均匀的涂膜极短的时间。防雾层压板由透明干燥凝胶层构成，该透明干燥凝胶层由水溶性有机聚合物和水溶胀性粘土矿物形成三维网状构成，厚度为1-500 在基材的表面上。有机和无机复合水凝胶的制造方法通过在将水溶性聚合引发剂分散在水性介质中而制备的溶液中，将水溶性丙烯酸类单体与水溶胀性粘土矿物共存，反应一样。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2005224110A Method for detecting polynucleotide or oligonucleotide and micro fluid device 审中-公开
标题翻译：检测多核苷酸或寡核苷酸和微流体装置的方法
公开(公告)号：JP2005224110A
公开(公告)日：2005-08-25
申请号：JP2004033301
申请日：2004-02-10
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , ANAZAWA TAKANORI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method for rapidly detecting the presence or absence or amount of a polynucleotide or an oligonucleotide having a target base sequence in a specimen solution with good accuracy, especially a method for detecting SNP (single nucleotide polymorphism) or single nucleotide mutation. SOLUTION: The method for detecting the polynucleotide or oligonucleotide comprises bringing the specimen solution containing the polynucleotide or oligonucleotide which is the object of detection into contact with each probe-immobilizing part of a micro fluid device having a porous layer where a probe is immobilized on the surface in each capillary-like channel, then washing the probe-immobilizing part, removing components of the specimen solution unbound to the probe and subsequently measuring the fluorescence intensity of the probe-immobilizing part. In the method, the transmittance of light at 670 nm wavelength in a site for measuring the fluorescence intensity of the porous layer where the probe is immobilized is 10-60% and the measurement of the fluorescence intensity is made at ≥650 nm wavelength. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种用于以高精度快速检测样品溶液中具有靶碱基序列的多核苷酸或寡核苷酸的存在或量的方法，特别是检测SNP（单核苷酸多态性）或单核苷酸突变。检测多核苷酸或寡核苷酸的方法包括使含有检测对象的多核苷酸或寡核苷酸的检测体溶液与具有探针的多孔层的微流体装置的每个探针固定部分接触固定在每个毛细管样通道的表面上，然后洗涤探针固定部分，除去未结合到探针的样品溶液的组分，随后测量探针固定部分的荧光强度。在该方法中，在测定固定有探针的多孔层的荧光强度的部位的670nm波长的光的透射率为10〜60％，荧光强度的测定为≥650nm以上。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004313840A Temperature conducting device and temperature conducting method 审中-公开
公开(公告)号：JP2004313840A
公开(公告)日：2004-11-11
申请号：JP2003107865
申请日：2003-04-11
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： ANAZAWA TAKANORI , TERAMAE ATSUSHI , TAKADA TETSUO
IPC分类号： G01N37/00 , B01J19/00 , H05B3/10
摘要： PROBLEM TO BE SOLVED: To provide a temperature conducting device constituted so as to precisely form a temperature distribution having a steep temperature gradient provided with a predetermined temperature difference to the minute distance range of a material having to receive the conduction of a temperature, for example, like a micro-fluid element, to miniaturize a heater or a radiator and to eliminate the waste of energy, and a method for forming the steep temperature gradient provided with the predetermined temperature difference to the material having to receive the conduction of a temperature.
SOLUTION: In a black main body 1, heat conductivity in the direction parallel to the surface of the block main body 1 is 0.3-10 w×m
-1 ×K
-1 lower than the heat conductivity in the direction vertical to the surface. Further, the block main body 1 is constituted by alternately arranging at least two first heat conductive members low in heat conductivity and at least two second heat conductive members of which the heat conductivity is higher than that of the first heat conductive members in the direction parallal to the surface in a laminar state.
COPYRIGHT: (C)2005,JPO&NCIPI

4. 发明专利

JP2004225788A Check valve, and micro-fluid element 审中-公开
公开(公告)号：JP2004225788A
公开(公告)日：2004-08-12
申请号：JP2003013519
申请日：2003-01-22
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： ANAZAWA TAKANORI , TERAMAE ATSUSHI , TAKADA TETSUO
IPC分类号： B81B5/00 , F04B43/02 , F15C4/00 , F16K13/00 , F16K15/14
摘要： PROBLEM TO BE SOLVED: To provide a micro-check valve of simple structure that can be manufactured without requiring a fine and expensive laminating device.
SOLUTION: This device comprises a valve chamber 4 having an inflow port 6 and an outflow port 7. A valve element 5 formed of gel is disposed in the valve chamber 4.
COPYRIGHT: (C)2004,JPO&NCIPI

5. 发明专利

JP2004097209A Method for analyzing polynucleotide 审中-公开
公开(公告)号：JP2004097209A
公开(公告)日：2004-04-02
申请号：JP2003194233
申请日：2003-07-09
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： ANAZAWA TAKANORI , TAKADA TETSUO , TERAMAE ATSUSHI
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a method for rapidly and accurately detecting a polynucleotide having a base sequence in which one base is different from another base sequence referred to as a standard, even when a very small amount thereof is used as a sample. SOLUTION: In this method, examined polynucleotides are combined with probes in a short time under such a condition that a polynucleotide (A) having the base sequence referred to as the standard and the polynucleotide (B) having the base sequence in which the one base is different from the base sequence referred to as the standard are nonselectively combined with a probe compound, and then detachment amounts of the examined nucleotides are measured when they are separated, so that one-base polymorphism or one-base mutation is rapidly and accurately detected. Further, the examined nucleotides are analyzed by only contacting the polynucleotides with a very small area to which the probe compound is fastened, so that an amount of the sample required for analysis is very small. Therefore, another amount of the samples required for conducting many measurements at the same time is small. COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2003066033A Microplate and producing method thereof 审中-公开
标题翻译：麦芽糖及其制备方法
公开(公告)号：JP2003066033A
公开(公告)日：2003-03-05
申请号：JP2001252781
申请日：2001-08-23
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , TERAMAE ATSUSHI , ANAZAWA TAKANORI
IPC分类号： G01N33/48 , C08J7/04 , G01N1/00
摘要： PROBLEM TO BE SOLVED: To provide a microplate having various physical properties such as a microplate capable of easily making a well fine and suppressing the adsorption of an organism component low by making the well surface hydrophilic, a microplate having a surface capable of adsorbing or covalent-bonding a target protein such as antigen, or a microplate hardly causing the leakage of an aqueous solution having a hydrophilic well bottom part and a hydrophobic well wall part to the outside; and an easy producing method thereof.
SOLUTION: This microplate comprises a number of wells as sample housing recessed parts aligned on a base material, at least one of the wall part and bottom part of the well being formed of the hardened matter of an active energy ray-hardenable resin composition A.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供具有各种物理性质的微孔板，例如微孔板，其能够容易地制备出良好的微细孔，并通过使孔表面亲水性来抑制生物体组分的吸附，使微孔板具有能够吸附或共价的表面使目标蛋白如抗原或微孔板难以将具有亲水性井底部分和疏水性井壁部分的水溶液泄漏到外部; 及其易于制备的方法。解决方案：该微孔板包括许多孔，作为样品容器，凹入部分对准在基材上，孔的壁部分和底部中的至少一个由活性能量射线可硬化树脂组合物A的硬化物形成。

7. 发明专利

JP2011072297A Cell culture substrate 审中-公开
标题翻译：细胞培养基质
公开(公告)号：JP2011072297A
公开(公告)日：2011-04-14
申请号：JP2009230454
申请日：2009-10-02
申请人： Asahi Glass Co Ltd , Kawamura Inst Of Chem Res , 旭硝子株式会社 , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , HARAGUCHI KAZUTOSHI , ITO TORU , KONNO KOICHI
IPC分类号： C12M1/00 , C12M1/22
CPC分类号： C12M23/20 , C12M25/00
摘要： PROBLEM TO BE SOLVED: To provide a cell culture substrate having an uncrosslinked polymer contained in the substrate and having a lower limit critical solution temperature, further, which cell culture substrate is rapid in change from hydrophobic one to hydrophilic one relative to the environmental temperature and especially can separate and recover from the culture substrate the macrophage cells differentiated from human peripheral blood monocyte cells, without damaging surface antigen of the cells and at a high yield.
SOLUTION: The culture substrate for peripheral blood monocyte cells and macrophage cells, contains polymethoxyethylacrylate (A), poly(N-isopropylacrylamide) (B), and a water swelling clay mineral (C).
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有底物中含有的未交联聚合物并且具有下限临界溶解温度的细胞培养基质，此外，相对于环境温度，特别是可以从培养基质中分离和回收巨噬细胞与人外周血单核细胞分化，而不破坏细胞的表面抗原并以高产率。解决方案：外周血单核细胞和巨噬细胞的培养基质含有聚甲氧基乙基丙烯酸酯（A），聚（N-异丙基丙烯酰胺）（B）和水溶性粘土矿物（C）。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2007014854A Filtration filter, manufacturing method of filtration filter, and hemofiltration method 审中-公开
标题翻译：过滤器，过滤器的制造方法和HEMOFILTRATION方法
公开(公告)号：JP2007014854A
公开(公告)日：2007-01-25
申请号：JP2005197434
申请日：2005-07-06
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： TAKADA TETSUO , ANAZAWA TAKANORI , KATO SHINJI
IPC分类号： B01D39/16 , B01D39/18 , B01D61/14 , B01D67/00 , B01D69/10 , B01D71/10 , B01D71/40 , G01N1/10 , G01N1/28 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a filtration filter which has a characteristic that a practical filtration velocity is presented by a little pressure difference in filtering a sampling target component from an adhesive material-containing liquid and viscous fluid by an all filtration system, and wherein a sampling yield of a filtrate component with respect to a sample amount is high, and a sufficient sample amount can be obtained up to clogging, and a manufacturing method of the filtration filter.
SOLUTION: The filtration filter is formed by a step that a porous filtration film made by curing a composition for forming film containing an active energy ray curing compound and porogen, and a fibrous filtration film are adhered by the curing of the composition for forming film.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种过滤器，其特征在于，通过全过滤系统从含粘合剂材料的液体和粘性流体过滤采样目标成分时通过一点压力差来呈现实际的过滤速度，并且其中滤液组分相对于样品量的取样产率高，并且可以获得充足的样品量直到堵塞，以及过滤过滤器的制造方法。解决方案：过滤器通过以下步骤形成：通过固化用于形成含有活性能量射线固化化合物和致孔剂的膜的组合物和纤维过滤膜而制备的多孔过滤膜通过固化用于成膜。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2005163585A Micro fluid device pump and fluid transfer method 审中-公开
标题翻译：微流体装置泵和流体传递方法
公开(公告)号：JP2005163585A
公开(公告)日：2005-06-23
申请号：JP2003401503
申请日：2003-12-01
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： ANAZAWA TAKANORI , TAKADA TETSUO
IPC分类号： B81B3/00 , F04B43/12
摘要： PROBLEM TO BE SOLVED: To provide a fluid transfer method in which a pump mechanism which is small and simple in structure can be used, and a complicated control is eliminated, and a micro fluid device pump equipped with the pump mechanism which is simple in structure, can be easily manufactured, is excellent in quantitative determination, and can be also applied to gas transfer. SOLUTION: In the fluid transfer method, there is used the micro fluid device pump comprising a valve which opens by producing a pressure difference with fluid compression midway along a capillary tube passage, a first compression part in which a passage cross section is deformed with compression from outside in the passage, and a second compression part which is deformed with pressure from outside between the valve and the first compression part. (1) After the first compression part is compressed to deform the passage cross section, (2) while the first compression part is kept to compress, the second compression part is compressed from outside to deform the passage cross section, the pressure difference is produced in the valve by fluid compression to open the valve, the fluid is transferred from the first compression part into the valve by passing through the valve, and (3) the compression at the first compression part and the second compression part is released. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种流体传递方法，其中可以使用结构简单且结构简单的泵机构，并且消除了复杂的控制，以及配备有泵机构的微流体装置泵结构简单，可轻松制造，定量测定性能优异，也可应用于气体输送。解决方案：在流体转移方法中，使用微流体装置泵，该微流体装置泵包括通过沿着毛细管通道在中途产生压力差而打开的阀，第一压缩部分，其中通道横截面为在通道内从外部压缩变形，以及第二压缩部，其在阀和第一压缩部之间从外部受压而变形。（1）在第一压缩部被压缩以使通道横截面变形后，（2）当第一压缩部保持压缩时，第二压缩部从外部被压缩以使通道横截面变形，产生压差在通过流体压缩的阀门中打开阀门，流体通过阀门从第一压缩部件转移到阀门中，（3）第一压缩部件和第二压缩部件处的压缩被释放。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2005005434A Temperature conduction device, manufacturing method for block body therefor and temperature conduction method 审中-公开
标题翻译：温度传导装置及其制造方法及其温度传导方法
公开(公告)号：JP2005005434A
公开(公告)日：2005-01-06
申请号：JP2003166334
申请日：2003-06-11
申请人： Kawamura Inst Of Chem Res , 財団法人川村理化学研究所
发明人： ANAZAWA TAKANORI , TERAMAE ATSUSHI , TAKADA TETSUO
IPC分类号： H05K7/20
摘要： PROBLEM TO BE SOLVED: To provide a temperature conduction device by which a temperature distribution having a steep temperature gradient, in which a specified temperature difference is set within the minute distance range of a temperature conductive material such as a micro-fluid element, can be formed accurately, a heater and a radiator can be miniaturized and the waste of energy is prevented, and a method for forming the steep temperature gradient in which the specified temperature difference is set to the temperature conductive material.
SOLUTION: The temperature conduction device has a block body and a temperature control unit, the temperature gradient can be generated on the certain surface of the block body, and the temperature of the certain surface is conducted to the temperature conductive material, a thermal conductivity running parallel with the certain surface and being directed in the direction that the temperature gradient can be generated is lower than that in the vertical direction to the certain surface and is kept within a range of 0.3 to 10 W m
-1 K
-1 in the block body. In the conduction device, the inside of a matrix composed of a member (1) is filled with a member (2) having the thermal conductivity different from the member (1) with an anisotropy in the block body.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种温度传导装置，通过该温度传导装置具有陡峭的温度梯度的温度分布，其中将特定的温度差设定在诸如微流体元件的温度导电材料的微小距离范围内可以精确地形成，加热器和散热器可以小型化，并且可以防止能量的浪费，以及形成其中对温度导电材料设定了规定温度差的陡峭温度梯度的方法。
解决方案：温度传导装置具有块体和温度控制单元，可以在块体的某个表面上产生温度梯度，并且将某一表面的温度传导到导热材料的温度，与特定表面平行且沿着可产生温度梯度的方向导向的热导率低于在某一表面的垂直方向上的导热率，并且保持在0.3至10Wm -1的范围内 K -1 。在导电装置中，由构件（1）构成的基体的内部填充有具有不同于构件（1）的导热性的构件（2），并且在块体中具有各向异性。版权所有（C）2005，JPO＆NCIPI

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