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JP2011051929A Method for producing optically active alcohol having aromatic heterocycle 有权
标题翻译：生产具有芳香杂环的光学活性醇的方法
公开(公告)号：JP2011051929A
公开(公告)日：2011-03-17
申请号：JP2009201953
申请日：2009-09-01
申请人： Kanto Chem Co Inc , 関東化学株式会社
发明人： SHIBATA KAZUFUMI , TSUTSUMI KUNIHIKO , KATAYAMA TAKEAKI , MURATA KUNIHIKO , YOSHIDA MASAHIKO
IPC分类号： C07D213/30 , C07B61/00
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently synthesizing an optically active alcohol with high optical purity which has an aromatic hydrocarbon group and a heterocycle in producing an optically active alcohol expected as an intermediate for synthesizing a drug and various intermediates of agricultural chemicals and the like. SOLUTION: The method for producing the optically active alcohol comprises reacting a carbonyl compound having an aromatic hydrocarbon group and a heterocycle with a hydrogen source in the presence of a catalyst including a ruthenium complex having an optically active diphosphine compound having asymmetry on carbon and a certain specific diamine compound as ligands to efficiently synthesize the optically active alcohol having high optical purity. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效合成具有高光学纯度的光学活性醇的方法，其具有芳族烃基和杂环，以制备预期作为合成药物的中间体的光学活性醇和各种中间体农药等。解决方案：制备光学活性醇的方法包括在催化剂存在下使具有芳族烃基和杂环的羰基化合物与氢源反应，所述催化剂包括具有对碳不对称的光学活性二膦化合物的钌络合物和一些特定的二胺化合物作为有效合成具有高光学纯度的光学活性醇的配体。版权所有（C）2011，JPO＆INPIT

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