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1. 发明专利

JP2010252785A Device for concentrating and separating cell 审中-公开
标题翻译：用于浓缩和分离细胞的装置
公开(公告)号：JP2010252785A
公开(公告)日：2010-11-11
申请号：JP2010039371
申请日：2010-02-24
申请人： Kanagawa Acad Of Sci & Technol , On-Chip Cellomics Consortium Co Ltd , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 株式会社オンチップ・セロミクス・コンソーシアム , 財団法人神奈川科学技術アカデミー
发明人： YASUDA KENJI , HAYASHI MASATO , HATTORI AKIHIRO
IPC分类号： C12M1/00 , C12M1/34 , G01N33/48
CPC分类号： C12M47/04 , B01D21/283 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0415 , B01L2400/0424 , B01L2400/0439
摘要： PROBLEM TO BE SOLVED: To provide a device for concentrating, separating and purifying a small amount of cells in a continuous manner without pre-treating them.
SOLUTION: The device for concentrating and separating cells has: the function of continuously concentrating cells; the function for then continuously arranging the concentrated cells in predetermined regions of a flow path; the function for simultaneously identifying the shape and fluorescent emission in single-cell units on the basis of cell concentration and purification images, which serve to continuously separate and purify cells that have different properties in that they are either attracted to or repelled by an induction electrophoresis force of a predetermined frequency and the function for identifying cells on the basis of this shape and fluorescent emission information, thereby separating and purifying the cells.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于浓缩，分离和纯化少量细胞的装置，而不进行预处理。
解决方案：细胞浓缩分离装置具有连续浓缩细胞功能; 然后将浓缩的细胞连续地排列在流路的预定区域中的功能; 基于细胞浓度和纯化图像同时鉴定单细胞单元形状和荧光发射的功能，其用于连续分离和纯化具有不同性质的细胞，因为它们被吸引或被感应电泳排斥基于该形状和荧光发射信息识别单元的功能，从而分离和净化单元。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011257241A Cell analyzer 有权
标题翻译：细胞分析仪
公开(公告)号：JP2011257241A
公开(公告)日：2011-12-22
申请号：JP2010131384
申请日：2010-06-08
申请人： Kanagawa Acad Of Sci & Technol , Kanagawa Prefectural Hospital Organization , On-Chip Cellomics Consortium Co Ltd , Tokyo Medical And Dental Univ , 国立大学法人東京医科歯科大学 , 地方独立行政法人神奈川県立病院機構 , 株式会社オンチップ・セロミクス・コンソーシアム , 財団法人神奈川科学技術アカデミー
发明人： YASUDA KENJI , TERAZONO HIDEYUKI , KIN HYON-CHOL , HAYASHI MASATO , HATTORI AKIHIRO , MIYAGI YOHEI , OTSU TAKASHI
IPC分类号： G01N33/49 , G01N21/64 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a cell purification device which selectively collects grouped or agglomerated cells.SOLUTION: The present invention provides a cell concentration and purification device including: a function to continuously arrange cells in a specific region of a microchannel; a function to simultaneously recognize whether a cell is in a group state or not and emission of fluorescence, on an image basis and in one cell unit; and a function to selectively separate and purify a cell group or a cell mass by recognition based on information of its shape and the emission of fluorescence.
摘要翻译：要解决的问题：提供选择性收集分组或聚集的细胞的细胞纯化装置。解决方案：本发明提供了一种细胞浓缩和净化装置，包括：在微通道的特定区域中连续排列细胞的功能; 同时识别细胞是否处于组状态的功能，以及基于图像和一个细胞单位的荧光发射的功能; 以及通过基于其形状和荧光发射的信息的识别来选择性地分离和纯化细胞群或细胞团的功能。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2014183854A Cell analyzer 审中-公开
标题翻译：细胞分析仪
公开(公告)号：JP2014183854A
公开(公告)日：2014-10-02
申请号：JP2014141864
申请日：2014-07-10
申请人： Kanagawa Academy Of Science And Technology , 公益財団法人神奈川科学技術アカデミー , Tokyo Medical And Dental Univ , 国立大学法人東京医科歯科大学 , On-Chip Cellomics Consortium Co Ltd , 株式会社オンチップ・セロミクス・コンソーシアム , Kanagawa Prefectural Hospital Organization , 地方独立行政法人神奈川県立病院機構
发明人： YASUDA KENJI , TERAZONO HIDEYUKI , KIN HYON-CHOL , HAYASHI MASATO , HATTORI AKIHIRO , MIYAGI YOHEI , OTSU TAKASHI
IPC分类号： C12M1/34 , C12M1/00 , C12M1/26 , C12Q1/04
摘要： PROBLEM TO BE SOLVED: To provide a cell purification device which selectively collects grouped or agglomerated cells.SOLUTION: The present invention provides a cell concentration and purification device including: a function to continuously arrange cells in a specific region of a microchannel; a function to simultaneously recognize whether a cell is in a group state or not and emission of fluorescence, on an image basis and in one cell unit; and a function to selectively separate and purify a cell group or a cell mass by recognition based on information of its shape and the emission of fluorescence.
摘要翻译：要解决的问题：提供一种选择性收集分组或凝聚细胞的细胞纯化装置。解决方案：本发明提供一种细胞浓缩和净化装置，其包括：连续排列微通道特定区域中的细胞的功能; 同时识别细胞是否处于组状态的功能，以及基于图像和一个细胞单位的荧光发射的功能; 以及通过基于其形状和荧光发射的信息的识别来选择性地分离和纯化细胞群或细胞团的功能。

4. 发明专利

JP2012196197A Selection method for nucleic acid specifically bonding to target molecule of target cell surface 审中-公开
标题翻译：核酸特异性结合靶向细胞表面目标分子的选择方法
公开(公告)号：JP2012196197A
公开(公告)日：2012-10-18
申请号：JP2011108571
申请日：2011-05-13
申请人： Kanagawa Acad Of Sci & Technol , On-Chip Cellomics Consortium , Tokyo Medical & Dental Univ , 一般社団法人オンチップ・セロミクス・コンソーシアム , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： YASUDA KENJI , TERAZONO HIDEYUKI , KIN KENTETSU , HAYASHI MASAHITO , HATTORI AKIHIRO
IPC分类号： C12N15/09 , C12M3/00 , C12N5/0784 , C12N5/0786 , C12N15/115 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for easily obtaining a nucleic acid chain specifically bonding to target protein on the surface of a cell characteristic of the specific cell.SOLUTION: Membrane protein is decomposed by making a proteolytic enzyme such as a protease decomposing the membrane surface protein or the like act after bonding a nucleic acid chain candidate to the protein or the like on the cell surface so as to purify and collect the nucleic acid chain candidate specifically bonding to the target protein on the specific cell surface, so that the nucleic acid chain can be collected.
摘要翻译：待解决的问题：提供容易获得特定细胞特征性细胞表面特异性结合靶蛋白的核酸链的方法。解决方案：通过在蛋白质等上将核酸链候选物与细胞表面结合之后，通过使蛋白水解酶如分解膜表面蛋白等的蛋白酶分解来分解膜蛋白，从而净化和收集核酸链候选物特异性结合特定细胞表面上的靶蛋白，从而可以收集核酸链。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2012055267A Cell observation apparatus and cell observation method 有权
标题翻译：细胞观察装置和细胞观察方法
公开(公告)号：JP2012055267A
公开(公告)日：2012-03-22
申请号：JP2010203503
申请日：2010-09-10
申请人： Kanagawa Acad Of Sci & Technol , On-Chip Cellomics Consortium , Tokyo Medical & Dental Univ , 一般社団法人オンチップ・セロミクス・コンソーシアム , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： YASUDA KENJI , TERAZONO HIDEYUKI , KIN KENTETSU , HAYASHI MASATO , HATTORI AKIHIRO
IPC分类号： C12M1/34 , C12Q1/02
CPC分类号： C12M41/36
摘要： PROBLEM TO BE SOLVED: To provide a cell observation apparatus capable of observing an image of each cell in a tissue as an image dependent on wavelength of light.SOLUTION: The cell observation apparatus includes: a combination of light sources capable of generating a plurality of monochromatic lights; an optical system for introducing the light of these light sources to a microscope; a microscopic system for performing microscopical observation of the cell; an optical camera for measuring the image output from the microscopic system; an imaging frame of the obtained image of the optical camera; a means for recording only an optical image from a monochromatic light source in the single imaging frame by synchronizing with the monochromatic pulse light; and an instrument for selectively reproducing the graphic image in the desired monochromatic light by recording the numer of the imaging frame according to the color of the emitted monochromatic light.
摘要翻译：要解决的问题：提供一种能够观察组织中每个细胞的图像作为取决于光的波长的图像的细胞观察装置。解决方案：细胞观察装置包括：能够产生多个单色光的光源的组合; 用于将这些光源的光引入显微镜的光学系统; 用于进行细胞的微观观察的微观系统; 用于测量从微观系统输出的图像的光学相机; 所获得的光学摄像机图像的成像框架; 通过与单色脉冲光同步，仅在单个成像帧中记录来自单色光源的光学图像的装置; 以及用于通过根据发射的单色光的颜色记录成像帧的数目来选择性地再现所需单色光中的图形图像的仪器。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2011158331A Identification method of film-like element 有权
标题翻译：电影元素的识别方法
公开(公告)号：JP2011158331A
公开(公告)日：2011-08-18
申请号：JP2010019366
申请日：2010-01-29
申请人： Kanagawa Acad Of Sci & Technol , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： KIN KENTETSU , TAKEI HIROYUKI , YASUDA KENJI
IPC分类号： G01N23/20 , G01N23/225
摘要： PROBLEM TO BE SOLVED: To provide an observation method for identifying a fine particle set to which a heterogeneous element has been added using: a method of determining observation conditions of SEM reflection electron measurement capable of giving a maximum luminance contrast and performing measurement with high reproducibility with respect to the kind and thickness of a film-like element; and a method of predicting a combination of element kinds that can be identified by SEM reflection electron measurement.
SOLUTION: The invention provides a fine particle label in which different regions of the surface of a carrier are film-coated with three or more kinds of elements. Different regions of the surface of the carrier are film-coated using a combination of three or more kinds of elements such that, when the elements are arranged in ascending or descending order based on the value of total reflectivity coefficient η of each element, a difference between total reflectivity coefficient η of adjacent elements is 0.02 or more.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于鉴别添加有异质元素的微粒组的观察方法：一种确定能够给出最大亮度对比度并进行测量的SEM反射电子测量的观察条件的方法相对于膜状元件的种类和厚度具有高的再现性; 以及通过SEM反射电子测定可以识别的元素种类的组合的预测方法。解决方案：本发明提供了一种细颗粒标签，其中载体表面的不同区域被三种或更多种元素膜涂覆。载体表面的不同区域使用三种或更多种元素的组合进行薄膜包覆，使得当基于每个元件的总反射率系数η的值按升序或降序排列元素时，差异在相邻元件的总反射系数η之间为0.02以上。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2010054336A Discrimination method of microbody having element thin film existing on surface 有权
标题翻译：具有表面光滑薄膜的微观识别方法
公开(公告)号：JP2010054336A
公开(公告)日：2010-03-11
申请号：JP2008219481
申请日：2008-08-28
申请人： Kanagawa Acad Of Sci & Technol , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： KIN KENTETSU , TAKEI HIROYUKI , YASUDA KENJI
IPC分类号： G01N23/225 , G01N23/203 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To discriminate the kind of a microbody whose surface is covered with two or more layers of thin films by measuring the amount of reflected electrons in electron beam inspection. SOLUTION: The microbody surface is covered with two or more layers of thin films of various materials. In this case, the thin films are constituted of a reference layer used for immobilization of biomolecules using a common material and a variable layer used for discrimination using a different material. When constituting the thin films, the this films are manufactured, while strictly controlling the film thickness by using a resistance heating type deposition device or the like. The manufactured microbody is irradiated with an electron beam. A proper incident electron acceleration voltage is selected so that incident electrons reach the variable layer. The kind of the material of the microbody variable layer is discriminated from a difference of brightness of a reflected electron image acquired from the microbody by electron beam irradiation. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：通过测量电子束检查中反射电子的量来鉴别表面被两层或多层薄膜覆盖的微体的种类。解决方案：微体表面被两层或多层各种材料薄膜覆盖。在这种情况下，薄膜由用于使用普通材料固定生物分子的参考层和用于使用不同材料进行鉴别的可变层构成。当构成薄膜时，制造这种薄膜，同时通过使用电阻加热型沉积装置等严格控制薄膜厚度。用电子束照射制造的微体。选择适当的入射电子加速电压，使得入射电子到达可变层。通过电子束照射，从微体取得的反射电子图像的亮度差来区分微体可变层的材料种类。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2013110999A Liquid-refluxing type high speed gene amplification device 有权
标题翻译：液相反应型高速基因扩增装置
公开(公告)号：JP2013110999A
公开(公告)日：2013-06-10
申请号：JP2011259210
申请日：2011-11-28
申请人： Kanagawa Acad Of Sci & Technol , 財団法人神奈川科学技術アカデミー , On-Chip Cellomics Consortium , 一般社団法人オンチップ・セロミクス・コンソーシアム , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学
发明人： YASUDA KENJI , TERAZONO HIDEYUKI , HATTORI AKIHIRO
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/64 , G01N37/00
CPC分类号： C12M41/18 , B01L3/50851 , B01L3/50855 , B01L7/02 , B01L7/52 , B01L2200/025 , B01L2200/147 , B01L2300/0816 , B01L2300/0829 , B01L2300/1838 , B01L2300/185 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , C12Q1/6806 , C12Q1/6846 , G01N21/6452 , C12Q2565/629
摘要： PROBLEM TO BE SOLVED: To provide a device for controlling a reaction, capable of performing accurate temperature control, temperature measurement, and rapid rise and fall of the temperature.SOLUTION: This liquid-refluxing type device for controlling the reaction is provided by comprising an additional mechanism enabling more stable temperature control, a pretreating mechanism including the introduction of a reverse transcription reaction process enabling RNA detection before a PCR reaction, a melting curve analyzing function, a chip technology optimum for holding liquid droplet and optical measurement, an optical measurement function for the PCR reaction and a temperature gradient-controlling mechanism by a quantitative infrared light irradiation/absorption-controlling means.
摘要翻译：要解决的问题：提供一种控制反应的装置，能够进行精确的温度控制，温度测量和温度的快速上升和下降。解决方案：用于控制反应的该液体回流型装置通过包括能够进行更稳定的温度控制的附加机理来提供，包括引入可逆PCR反应之前的RNA检测的逆转录反应方法的预处理机理，熔解曲线分析功能，用于保持液滴和光学测量的最佳的芯片技术，用于PCR反应的光学测量功能和通过定量红外光照射/吸收控制装置的温度梯度控制机制。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2011101941A Hollow microbody and method for producing the same 有权
标题翻译：中空微生物及其生产方法
公开(公告)号：JP2011101941A
公开(公告)日：2011-05-26
申请号：JP2010130512
申请日：2010-06-07
申请人： Kanagawa Acad Of Sci & Technol , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： KIN KENTETSU , TAKEI HIROYUKI , YASUDA KENJI
IPC分类号： B82B1/00 , B82B3/00 , C09K11/00 , G01N33/53 , G01N33/543 , G01N33/552 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide a microbody composed of only the aimed element components and a method for producing the microbody.
SOLUTION: In the method for producing the microbody, a microstructure composed of an organic material is arranged as a template, on a substrate, the aimed elements are deposited on the surface of the organic structure by a vacuum vapor deposition method or the like, and then the organic structure as the template is decomposed and removed by a UV-ozone treatment method or the like to obtain a microbody composed of only the aimed element components.
COPYRIGHT: (C)2011,JPO&INPIT

10. 发明专利

JP2012010664A Device for analyzing cell 有权
标题翻译：用于分析细胞的装置
公开(公告)号：JP2012010664A
公开(公告)日：2012-01-19
申请号：JP2010152412
申请日：2010-07-02
申请人： Kanagawa Acad Of Sci & Technol , On-Chip Cellomics Consortium , Tokyo Medical & Dental Univ , 一般社団法人オンチップ・セロミクス・コンソーシアム , 国立大学法人東京医科歯科大学 , 財団法人神奈川科学技術アカデミー
发明人： YASUDA KENJI , HATTORI AKIHIRO
IPC分类号： C12M1/34 , C12Q1/06 , G01N21/27 , G01N27/02 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a device for analyzing a cell that measures a cellar secretion using a time and spatial resolution.SOLUTION: There is provided the device for analyzing the cell includes: a function continuously measuring the change in impedance of ion flow in a thin tube, wherein the ion flow is generated as a result of a combining of a target molecular to a capture region having a function to combine with the specific target molecular; and the device for releasing the target molecular combined to the capture region in a fixed period.

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