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1. 发明专利

JP2000070362A BLOOD TREATMENT DEVICE 失效
公开(公告)号：JP2000070362A
公开(公告)日：2000-03-07
申请号：JP24686498
申请日：1998-09-01
申请人： KURARAY CO
发明人： INOUE MASAO , HARADA YOSHIMITSU , HAYASHI NOBUYUKI , NAKAJI SHUHEI
IPC分类号： A61M1/14 , A61M1/34
摘要： PROBLEM TO BE SOLVED: To reduce membrane clog at a membrane module and improve blood treatment performance by a membrane by humidifying and controlling an inlet chamber provided between a pump device and the membrane module, in a device that treats blood with the membrane module and returns it to a human body. SOLUTION: A first pump device 4 is interposed on the way of a blood guide tube 3 having a blood introducing portion 1, and its deliver side is connected with a dialyzing filter 6 containing a membrane module through an inlet chamber 5. By guiding an outlet of the dialyzing filter 6 to a blood delivery portion 2 via a blood delivery tube 8 having a blood return chamber 7, a blood circulation circuit is constituted. The dialyzing filter 6 performs equal amount displacement between dialysis-filtered fluid and dialyzing fluid fed from a second pump device 10 connected with a supply source 11 of the dialyzing fluid through a dialyzing fluid transferring tube 13. By installing the inlet chamber 5 in a heater box and controlling the inside temperature, clogging of the membrane module is prevented.

2. 发明专利

JP2000024474A ENDOTOXIN REMOVING MATERIAL AND ITS PRODUCTION 失效
公开(公告)号：JP2000024474A
公开(公告)日：2000-01-25
申请号：JP19989398
申请日：1998-07-15
申请人： KURARAY CO
发明人： TAKAKURA KOICHI , HAYASHI NOBUYUKI , NAKAJI SHUHEI
IPC分类号： A61M1/36 , B01D69/08 , B01D71/38 , B01D71/82 , D06M13/02 , D06M13/123 , D06M15/61 , D06M101/24
摘要： PROBLEM TO BE SOLVED: To obtain an endotoxin removing material which is an easily producible and inexpensive filter membrane and simultaneously is capable of easily and surely adsorbing away the endotoxin. SOLUTION: The purpose is achieved by the endotoxin removing material consisting of the membrane formed by subjecting a compd. having a functional group contg. basic nitrogen atoms in an aldehyde group-contg. polyvinyl alcohol(PVA) polymer to reaction immobilization. The compd. having the functional group contg. the basic nitrogen atoms is subjected to the reaction immobilization to the membrane consisting of the aldehyde group-contg. PVA polymer.

3. 发明专利

JP2001161807A ION CONCENTRATION REGULATING MATERIAL OF BLOOD FOR BLOOD TRANSFUSION 失效
公开(公告)号：JP2001161807A
公开(公告)日：2001-06-19
申请号：JP35135299
申请日：1999-12-10
申请人： KURARAY CO
发明人： HAYASHI NOBUYUKI , NAKAJI SHUHEI
IPC分类号： A61M1/02 , A61K35/14 , B01J39/05 , B01J39/07 , B01J39/19 , B01J39/20
摘要： PROBLEM TO BE SOLVED: To provide an ion concentration regulating material of blood for blood transfusion capable of easily and certainly adsorbing and removing only potassium ions and excellent in blood compatibility. SOLUTION: An ion concentration regulating material of blood for blood transfusion comprises different metal salt type cation exchange resins.

4. 发明专利

JPH11302973A POLYVINYL ALCOHOL-BASED HOLLOW YARN WITH EXCELLENT BIOCOMPATIBILITY ND ITS PRODUCTION 失效
公开(公告)号：JPH11302973A
公开(公告)日：1999-11-02
申请号：JP11170298
申请日：1998-04-22
申请人： KURARAY CO
发明人： TAKAKURA KOICHI , HAYASHI NOBUYUKI , OKAMOTO TAKEHIKO
IPC分类号： A61L27/00 , D01F6/14 , D06M13/02 , D06M13/325 , D06M13/332 , D06M13/338 , D06M13/402 , D06M13/422 , D06M101/00 , D06M101/16 , D06M101/18
摘要： PROBLEM TO BE SOLVED: To obtain the subject hollow yarn suitable as an inexpensive, safe and chemically modified medical material. SOLUTION: This polyvinyl alcohol-based hollow yarn is obtained by introducing a small amount of an amine into an aldehyde group-bearing polyvinyl alcohol-based polymer through chemical treatment process; wherein the amine is bound to the polyvinyl alcohol-based polymer through covalent bond, and the amine is trimethylammonium acetohydrazide chloride or 2-(diethylamino) ethylamine.

5. 发明专利

JP2001163897A PEPTIDE AND ADSORBENT WITH THE PEPTIDE IMMOBILIZED THEREON 失效
公开(公告)号：JP2001163897A
公开(公告)日：2001-06-19
申请号：JP35288299
申请日：1999-12-13
申请人： KURARAY CO
发明人： OKADA CHIEKO , HAYASHI NOBUYUKI , NAKAJI SHUHEI
IPC分类号： C07K7/06 , C07K7/08 , C07K17/00
摘要： PROBLEM TO BE SOLVED: To obtain a peptide capable of specifically bonding to an endotoxin, and further to provide an inexpensive absorbent capable of selectively adsorbing and removing the endotoxin, minimized in a decrease in the absorbing and removing ability when carrying out a sterilizing treatment or preserving the adsorbent, and having high safety. SOLUTION: This peptide has an amino acid sequence represented by general formulas (I) X-Val-Gln-Gly-X-Trp-Lys-Val-X-Lys, wherein X is Arg, His or Lys or (II) Phe-His-X-Asn-His-X-Ser-Pro-Val-Thr, wherein, X is Arg, His or Lys, and is composed of 10-50 amino acid residues. The adsorbent has the peptide immobilized on a carrier.

6. 发明专利

JP2001300308A ENDOTOXIN ADSORBENT 失效
公开(公告)号：JP2001300308A
公开(公告)日：2001-10-30
申请号：JP2000129635
申请日：2000-04-28
申请人： KURARAY CO
发明人： HAYASHI NOBUYUKI , OKADA CHIEKO , NAKAJI SHUHEI
IPC分类号： A61M1/02 , B01J20/26 , B01J41/04
摘要： PROBLEM TO BE SOLVED: To provide an endotoxin adsorbent capable of easily and surely adsorbing and removing endotoxin and excellent in blood compatibility. SOLUTION: The objective is attained by using the endotoxin adsorbent prepared by coating the carrier with a hydrophilic polymer material.

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