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1. 发明专利

JP2000044566A PRODUCTION OF PYRIDINE DERIVATIVE 失效
公开(公告)号：JP2000044566A
公开(公告)日：2000-02-15
申请号：JP21994398
申请日：1998-08-04
申请人： KURARAY CO
发明人： KIKUYAMA SHIGEKI , ASANUMA GORO , MATSUDA HIDEKI , SHIONO MANZO
IPC分类号： C07D491/048 , C07D471/04 , C07D495/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for antiviral medicines, etc., in a good yield by reacting a specific pyridine derivative with a specified ester compound in the presence of a base and subjecting the reaction product to a hydrolysis reaction and a decarboxylation reaction. SOLUTION: This method for producing a compound of formula IV (R5 is a group of the formula: -CHR1R2) comprises reacting 1 mole of a pyridine ester derivative of formula I [X is a (substituted) alkoxyl group or the like; A is O, N or a divalent organic group] with 1-3 moles of an ester compound of formula II [R1 and R2 are each H or a (substituted) hydrocarbon; R3 is a (substituted) hydrocarbon] preferably in the presence of 1-3 moles of a base in a solvent preferably in an amount of 0.5-100 pts.wt. based on the compound of formula I preferably at 10-150 deg.C, and subsequently hydrolyzing and decarboxylating the obtained pyridine β-ketoester derivative of formula III [R4 is a (substituted) hydrocarbon]. Water is preferably used in the hydrolysis reaction in an amount of

2. 发明专利

JPH11124353A PRODUCTION OF CYCLOPROPYLACRYLIC ACID DERIVATIVE 失效
公开(公告)号：JPH11124353A
公开(公告)日：1999-05-11
申请号：JP29007097
申请日：1997-10-22
申请人： KURARAY CO
发明人： OSONO SHIGEO , NAKAZAWA MAKOTO , ASANUMA GORO , SHIONO MANZO
IPC分类号： C07C51/353 , C07C57/26
摘要： PROBLEM TO BE SOLVED: To industrially advantageously obtain the subject derivative in high yield and purity by carrying out reaction while removing the produced water out of the reaction system when a specific derivative is reacted with malonic acid in the presence of a base. SOLUTION: (A) A cyclopropanecarbaldehyde derivative of formula I [R to R are each H or a (substituted)alkyl] is reacted with (B) a malonic acid at 0-150 deg.C in the presence of (C) a base (e.g. pyridine) in an amount of preferably 0.1-10 equivalent, more preferably 0.5-2.0 equivalent based on the component B and as necessary, (D) a catalyst and the reaction is carried out while removing the produced water out of the reaction system to provide the objective derivative of formula II. In the reaction, as necessary, a solvent which makes azeotrope with water and has low mutual solubility to water can be used. It normally takes about 1-5 hr to complete the reaction. A derivative of formula II can be converted to cyclopropylacetylene useful as a medicine intermediate.

3. 发明专利

JPH10139760A PRODUCTION OF HALOGENOPYRIDINE DERIVATIVE 失效
公开(公告)号：JPH10139760A
公开(公告)日：1998-05-26
申请号：JP24396597
申请日：1997-09-09
申请人： KURARAY CO
发明人： KUWAYAMA TOMOYA , INOUE SHINICHI , ASANUMA GORO , SHIONO MANZO
IPC分类号： C07D213/61 , C07D213/83
摘要： PROBLEM TO BE SOLVED: To simply and inexpensively obtain the subject compound that is useful as a synthetic intermediate of lazabemide, a therapeutic agent for Parkinson's disease, in a high yield by the reaction of a specific halogeno-2- sulfonylpyridine derivative with a halogenating agent. SOLUTION: The reaction of a compound of formula I [X is a halogen; R is a (cyclo)alkyl, a (substituted) aryl, a (substituted) aralkyl] with a halogenating agent, for example, chlorine, sulfuryl chloride, bromine, or dibromohydantoin affords the compound of formula II (Y is a halogen). The compound of formula I as a raw material is prepared by reaction of a compound of formula III (R is an acyl) with a compound of the formula: R SO2 CN.

4. 发明专利

JPH1087626A 5-CYANO-2-SULFONYLPYRIDINE AND ITS PRODUCTION 失效
公开(公告)号：JPH1087626A
公开(公告)日：1998-04-07
申请号：JP23895896
申请日：1996-09-10
申请人： KURARAY CO
发明人： HAMAZAKI TAKASHI , KUWAYAMA TOMOYA , ASANUMA GORO , SHIONO MANZO
IPC分类号： C07D213/12 , C07D213/85
摘要： PROBLEM TO BE SOLVED: To obtain 5-cyano-2-sulfonylpyridine useful as a synthetic intermediate of a pyridine compound as a starting material of a medicine or an agrochemical. SOLUTION: This 5-cyano-2-sulfonylpyridine is expressed by the formula I [R is an alkyl, a cycloalkyl, a (substituted) aryl, etc.]. The compound of the formula I is obtained by producing 2-alkaliformyl-3-butene nitrile by reacting 3-butene nitrile with a formate in the presence of an alkali metal alcoholate of the formula: R OM (R is an alkyl; M,is an alkali metal), producing a diene compound of the formula II (R is an acyl, an alkyl, etc.) by reacting with an alkylating agent, etc., and reacting a sulfonyl cyanide of the formula: N≡C-SO2 R with the resultant diene compound.

5. 发明专利

JP2525085B2 失效
公开(公告)号：JP2525085B2
公开(公告)日：1996-08-14
申请号：JP4601191
申请日：1991-02-19
申请人： KURARAY CO
发明人： ASANUMA GORO , TAMAI HIRONOBU
IPC分类号： B01J27/06 , C07B61/00 , C07C45/61 , C07C403/14 , C07C403/16

6. 发明专利

JPH05186452A PRODUCTION OF L-AMBROX 失效
公开(公告)号：JPH05186452A
公开(公告)日：1993-07-27
申请号：JP35877891
申请日：1991-12-29
申请人： KURARAY CO
发明人： ASANUMA GORO , TAMAI HIRONOBU
IPC分类号： C07D307/92 , C11B9/00
摘要： PURPOSE:To obtain L-ambrox useful as a perfumery substance having excellent amber fragrance in high optical purity at a low cost by lactonizing (-)-2,5,5,8a- tetramethyl-1-(carboxymethyl)-2-hydroxydecalin and subjecting the product to reduction and dehydrative cyclization. CONSTITUTION:(-)-2,5,5,8a-Tetramethyl-1-(carboxymethyl)-2-hydroxydecalin of formula I is lactonized by dehydration reaction to obtain decahydro-3a,6,6,9a- tetramethyl-(3aalpha; 5abeta, 9aalpha, 9bbeta)-(+)-naphtho[2,1-b]furan-2(1H)-one of formula II. The product is reduced with a metal hydride and the obtained (-)-2,5,5,8a- tetramethyl-1-(hydroxyethyl)-2-hydroxydecalin of formula III is subjected to dehydrative cyclization to obtain the objective (-)-3a,6,6,9a-tetramethyl- dodecahydronaphtho[2,1-b]furan of formula IV.

7. 发明专利

JPH0158169B2 失效
公开(公告)号：JPH0158169B2
公开(公告)日：1989-12-11
申请号：JP12342484
申请日：1984-06-14
申请人： KURARAY CO
发明人： FUJITA YOSHIJI , SHIONO MANZO , YAMAMOTO FUMITO , ASANUMA GORO , FUJII HIROSHI
IPC分类号： C07C29/40 , C07C27/00 , C07C31/20 , C07C33/02 , C07C33/04 , C07C67/00

8. 发明专利

JP2011213620A Method for producing primary alkyl bromide 审中-公开
标题翻译：生产丙烯酰胺的方法
公开(公告)号：JP2011213620A
公开(公告)日：2011-10-27
申请号：JP2010081475
申请日：2010-03-31
申请人： Kuraray Co Ltd , 株式会社クラレ
发明人： MIYOSHI KEI , ASANUMA GORO
IPC分类号： C07C17/16 , C07C19/075
摘要： PROBLEM TO BE SOLVED: To provide a means for industrially producing a primary alkyl bromide by an inexpensive and simple procedure.SOLUTION: The method for producing a primary alkyl bromide comprises causing a primary alcohol to react with hydrogen bromide in an organic solvent, where the reaction is carried out while removing water in the reaction system.
摘要翻译：要解决的问题：提供一种通过便宜且简单的方法工业生产伯烷基溴的方法。解决方案：制备伯烷基溴的方法包括使伯醇与有机溶剂中的溴化氢反应，其中在反应体系中除去水的同时进行反应。

9. 发明专利

JP2000143660A PRODUCTION OF 2-{[(2-PYRIDYL)METHYL]THIO}-1HBENZIMIDAZOLE DERIVATIVE 失效
公开(公告)号：JP2000143660A
公开(公告)日：2000-05-26
申请号：JP32365498
申请日：1998-11-13
申请人： KURARAY CO
发明人： SUGIOKA TAKASHI , KUWAYAMA TOMOYA , ASANUMA GORO
IPC分类号： C07D213/71 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful for an intermediate of an omeprazole-related compound useful as antiulcer agent in one process at a high yield by using an available and handleable raw material. SOLUTION: This compound of formula II is obtained by reacting a compound of formula I (X is H, a halogen, an alkyl or the like; R1 is H, an alkyl or an aryl; R2 is H, a halogen, an alkyl or an aryl; R3 is a halogen; R4 is H, a halogen, an alkoxyl, an alkylthio or the like) with a metal alkoxide of the formula: R6OM [R6 is an alkyl; M is an alkaline (earth) metal]. The compound of formula I is obtained by reacting a compound of formula III with a compound of formula IV (R5 is an alkyl, a cycloalkyl, an aryl or the like), or the compound of formula I may be reacted with a metal alkoxide without isolating. By the method, the objective compound is provided in a short process at a high yield.

10. 发明专利

JP2000034281A PRODUCTION OF 2-ARALKYLOXYPYRIDINE DERIVATIVE 失效
公开(公告)号：JP2000034281A
公开(公告)日：2000-02-02
申请号：JP35117498
申请日：1998-12-10
申请人： KURARAY CO
发明人： KUWAYAMA TOMOYA , ASANUMA GORO
IPC分类号： C07D213/64 , B01J23/04 , C07B61/00 , C07D213/71
摘要： PROBLEM TO BE SOLVED: To obtain a 2-aralkyloxypyridine derivative that can be derived to hydroxypyridine useful as a synthetic intermediate for medicines and agrochemicals by hydrogenolysis with industrial advantage by reacting a specific sulfonyl-pyridine derivative with an aralkyl alcohol in the presence of a base. SOLUTION: 2-Sulfonylpyridine derivative represented by formula I [R1 is H, a (substituted) alkyl or the like; R2 and R3 are each H, a halogen or the like; R4 is H, an alkoxy group; R5 is a (substituted) alkyl or the like] is reacted with an aralkyl alcohol, preferably in an amount of 1-10 moles per mole of the pyridine derivative (for example, benzyl alcohol) in the presence of a base (preferably an alkali metal hydroxide or the like), in a preferred embodiment, in a solvent (for example, pentane or the like) in an amount of >=10-fold weight of the base, preferably at a temp. of 80-120 deg.C to give the objective compound of formula II [R6 is a (substituted) aralkyl]. A phase transfer catalyst may be added to the reaction system in an amount of 0.01-10 wt.% based on the base.

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