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1. 发明专利

JP2003055401A Glycosaminoglycan/polycation composite crosslinked by multifunctional crosslinker and process for preparation thereof 有权
标题翻译：通过多功能交联剂交联的谷氨酰胺聚糖/聚合复合物及其制备方法
公开(公告)号：JP2003055401A
公开(公告)日：2003-02-26
申请号：JP2001250856
申请日：2001-08-21
申请人： Japan Science & Technology Corp , National Institute For Materials Science , Nitta Gelatin Inc , Seikagaku Kogyo Co Ltd , 新田ゼラチン株式会社 , 独立行政法人物質・材料研究機構 , 生化学工業株式会社 , 科学技術振興事業団
发明人： TANAKA JUNZO , TAGUCHI TETSUSHI , MIYAZAKI KIYOUSUKE , SAKURA YOSHIYUKI , OTSUKA TATSURO , BANDAI YOSHINOBU
IPC分类号： A61L27/00 , A61K31/785 , A61L27/20 , A61L27/26 , A61L27/38 , A61L27/44 , A61L27/48 , A61L27/50 , A61P19/02 , C08B37/00 , C08B37/08 , C08G63/91 , C08G65/322 , C08G65/329 , C08G65/333 , C08H1/06
CPC分类号： A61L27/3852 , A61L27/20 , A61L27/26 , A61L27/44 , A61L27/48 , A61L27/50 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08G65/322 , C08G65/329 , C08G65/33337 , C08H1/06 , C08L2203/02 , C08L5/00
摘要： PROBLEM TO BE SOLVED: To solve such problems that the conventional preparation process for a glycosaminoglycan/polycation composite of a material for a regenerating matrix for organs such as cartilage or the like comprises a crosslinking reaction carried out in an alcohol or water and consequently the resultant injectable crosslinked biological material composition is considered to have a bad influence on cells and organs (cell death) and also the resultant polyion complex (ununiform deposit) is formed.
SOLUTION: The glycosaminoglycan/polycation composite is synthesized by carrying out a formation of the crosslinks of a glycosaminoglycan with a polycation under a physiological condition, using a multifunctional crosslinker having two or more electrophilic leaving groups (for example, a succinimidlyl group or a derivative thereof) at the carboxyl ends of a polyethylene glycol and also a crosslinker concentration of 0.3-3 mM. Since the synthetic reaction can be carried out under a physiological condition, cells can previously be mixed and subjected to a crosslinking reaction.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：为了解决用于诸如软骨等器官的再生基质材料的糖胺聚糖/聚阳离子复合材料的常规制备方法包括在醇或水中进行的交联反应，因此得到的可注射交联的生物材料组合物被认为对细胞和器官具有不良影响（细胞死亡），并且还形成所得的聚离子复合物（不均匀沉积物）。解决方案：通过使用具有两个或多个亲电离去基团的多官能交联剂（例如，琥珀酰亚胺基或其衍生物）在生理条件下进行糖胺聚糖与聚阳离子交联的形成来合成糖胺聚糖/聚阳离子复合物）和聚乙二醇的羧基末端，交联剂浓度为0.3-3mM。由于合成反应可以在生理条件下进行，所以可预先将细胞混合并进行交联反应。

2. 发明专利

JP2003335686A Ossification agent and agent for treatment of osteoporosis 有权
标题翻译： OSSIFICATION代理和治疗OSTEOPOSOSIS的代理
公开(公告)号：JP2003335686A
公开(公告)日：2003-11-25
申请号：JP2002138989
申请日：2002-05-14
申请人： Japan Science & Technology Corp , National Institute For Materials Science , Nitta Gelatin Inc , 新田ゼラチン株式会社 , 独立行政法人物質・材料研究機構 , 科学技術振興事業団
发明人： KIKUCHI MASANORI , TANAKA JUNZO , ITO NORIKAZU , BANDAI YOSHINOBU , MATSUMOTO HIROKO , KOYAMA TOMIHISA , TAKAKUDA KAZUO
IPC分类号： A61K38/17 , A61K33/06 , A61K33/42 , A61K38/39 , A61L27/46 , A61L27/58 , A61P19/00 , A61P19/10
CPC分类号： A61L27/58 , A61K33/06 , A61K33/42 , A61K38/39 , A61L27/46 , A61K2300/00 , C08L89/06
摘要： PROBLEM TO BE SOLVED: To obtain an ossification agent and an agent for the treatment of osteoporosis exhibiting effective ossification action at a desired part in the body.
SOLUTION: The ossification agent for implantation is composed of a composite material containing hydroxyapatite and collagen. The agent for the treatment of osteoporosis is composed of the ossification agent.
COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：获得骨化剂和用于治疗在体内所需部位出现有效骨化作用的骨质疏松症的药剂。解决方案：用于植入的骨化剂由含有羟基磷灰石和胶原的复合材料组成。骨质疏松症治疗药物由骨化剂组成。版权所有（C）2004，JPO

3. 发明专利

JP2011184351A Anti-obesity agent 审中-公开
标题翻译：抗生素代谢物
公开(公告)号：JP2011184351A
公开(公告)日：2011-09-22
申请号：JP2010050720
申请日：2010-03-08
申请人： Nitta Gelatin Inc , Osaka City Univ , 公立大学法人大阪市立大学 , 新田ゼラチン株式会社
发明人： SOEDA MAIKO , BANDAI YOSHINOBU , YUASA ISAO , KOJIMA AKIKO
IPC分类号： A61K36/18 , A23L1/30 , A61P3/04
摘要： PROBLEM TO BE SOLVED: To provide an anti-obesity agent, containing a component excellent in anti-obesity activity and also having high safety as an active ingredient. SOLUTION: This anti-obesity agent is provided by using an extract of the seeds of a mango (e.g. Mangifera indica) as the active ingredient. The mangoes are plants classified to the plants belonging to the genus Mangifera of family Anacardiaceae, and approximately 200 kinds are present in the world. For example, as apple mangoes produced in Mexico, the kinds of oro, tommy-atkins, hayden, kent, kate, etc., are known, and also a kensington kind from Australia, and a namdokmai kind from Thailand are known, but as the raw material for the anti-obesity agent, they are not especially limited, and any of them can be used. The anti-obesity agent can be suitably utilized e.g. as a medicine, quasi drug, health food, etc. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供含有抗肥胖症活性优异，安全性高的成分的抗肥胖剂作为活性成分。解决方案：通过使用芒果的种子提取物（例如芒果（Mangifera indica））作为活性成分提供该抗肥胖剂。芒果是属于属于槐科的芒果属植物的植物，世界上约有200种。例如，作为在墨西哥生产的苹果芒果，已知的是oro，tommy-atkins，hayden，kent，kate等的种类，也是来自澳大利亚的kensington型和来自泰国的namdokmai类，但是抗肥胖剂的原料没有特别限制，可以使用任何一种。抗肥胖剂可以适当地利用，例如，作为药物，准药物，保健食品等。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2009173678A Method for removing endotoxin from collagen protein 审中-公开
标题翻译：从胶原蛋白中去除内毒素的方法
公开(公告)号：JP2009173678A
公开(公告)日：2009-08-06
申请号：JP2009111346
申请日：2009-04-30
申请人： Nitta Gelatin Inc , 新田ゼラチン株式会社
发明人： NAGATOMI KOJI , HIRAOKA YOSUKE , YOSHIOKA KAZUO , BANDAI YOSHINOBU
IPC分类号： C07K14/78 , C07K1/14
摘要： PROBLEM TO BE SOLVED: To provide a method of removing endotoxin from an endotoxin-containing collagen protein, sufficiently decomposing the endotoxin while suppressing denaturing and decomposition of the collagen protein itself with further enabling the endotoxin-removed collagen protein to be separated and recovered with ease after the decomposition treatment; and to provide the collagen protein removed of the endotoxin in quantities. SOLUTION: After decomposing the endotoxin in the state of fiberizing and dispersing the endotoxin-containing collagen protein in a basic alcohol and/or acetone solution, the resultant collagen protein is separated and recovered. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决问题的方法：提供一种从含有内毒素的胶原蛋白中去除内毒素的方法，足以分解内毒素同时抑制胶原蛋白本身的变性和分解，进一步使得除去内毒素的胶原蛋白分离，经分解处理后容易回收; 并提供大量去除内毒素的胶原蛋白。解决方案：在将含内毒素的胶原蛋白纤维化并分散在碱性醇和/或丙酮溶液中的状态下分解内毒素后，分离回收所得胶原蛋白。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2006075235A Manufacturing method for fibrous material used for reinforcing scaffold material of cell 有权
标题翻译：用于增强细胞材料的纤维材料的制造方法
公开(公告)号：JP2006075235A
公开(公告)日：2006-03-23
申请号：JP2004260111
申请日：2004-09-07
申请人： Medgel Corp , Nitta Gelatin Inc , 新田ゼラチン株式会社 , 株式会社メドジェル
发明人： TABATA YASUHIKO , HIRAOKA YOSUKE , BANDAI YOSHINOBU
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a manufacturing method for a fibrous material capable of expressing a high dynamic intensity without increasing the amount of biodegradable and absorbable synthetic polymers used besides fibers in the fibrous material used for reinforcing a scaffold material of a cell. SOLUTION: This manufacturing method for the fibrous material forms bonding points between the fibers by coating the fiber composed of first biodegradable and absorbable synthetic polymers with second biodegradable and absorbable synthetic polymers using solution formed by dissolving the second biodegradable and absorbable synthetic polymers in solvent whose 95 wt.% or more is composed of dioxane and/or ethyl acetate. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够表现高动态强度的纤维材料的制造方法，而不增加用于增强细胞支架材料的纤维材料中除了纤维以外使用的生物可降解和可吸收的合成聚合物的量。解决方案：这种纤维材料的制造方法通过将由第一可生物降解和可吸收的合成聚合物组成的纤维用第二可生物降解和可吸收的合成聚合物涂覆在纤维之间形成结合点，所述溶液通过将第二可生物降解和可吸收的合成聚合物溶解在 95重量％以上的二恶烷和/或乙酸乙酯的溶剂。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2003327599A Collagen derived from fish, method for producing the same and application thereof 审中-公开
标题翻译：从鱼获得的胶原蛋白，其生产方法及其应用
公开(公告)号：JP2003327599A
公开(公告)日：2003-11-19
申请号：JP2002197840
申请日：2002-07-05
申请人： Nitta Gelatin Inc , 新田ゼラチン株式会社
发明人： BANDAI YOSHINOBU , SAEKI KOJI , NAGATOMI KOJI , TANISAKA KEIZO , HIZUKA MASAHIRO
IPC分类号： A23J3/04 , A61K8/00 , A61K8/02 , A61K8/65 , A61K8/96 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/00 , A61Q19/10 , C07K14/78 , C12P21/06 , A61K7/00 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/48 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To provide a colorless, transparent and odorless collagen derived from a fish, a method suitable for industrial production for producing the collagen derived from the fish in a high yield, and a cosmetic composition sufficiently exhibiting the effects of the collagen derived from the fish. SOLUTION: The collagen derived from the fish is obtained by extracting the collagen from a scale as a raw material by an enzymatic treatment, and has ≥85% transmission at 400 nm wave length. The method for producing the collagen derived from the fish by extracting the collagen from the scale as the raw material by the enzymatic treatment involves mechanically crushing the scale as an essential step, and the enzymatic treatment is carried out by dividing the treatment into several steps. The cosmetic composition contains the collagen derived from the fish. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：为了提供衍生自鱼的无色，透明和无味的胶原蛋白，适合于以高产率生产来自鱼的胶原的工业生产方法，以及足以显示出效果的化妆品组合物来自鱼的胶原蛋白。解决方案：通过酶处理从原料中提取胶原蛋白，得到来自鱼的胶原，并且在400nm波长下具有≥85％的透射率。通过酶处理从原料中提取作为原料的鳞片状的胶原蛋白来生产来自鱼的胶原的方法包括机械破碎鳞片作为必要步骤，酶处理通过将处理分为几个步骤进行。化妆品组合物含有源自鱼的胶原蛋白。版权所有（C）2004，JPO

7. 发明专利

JP2005229871A Scaffold material 有权
标题翻译： SCAFFOLD材料
公开(公告)号：JP2005229871A
公开(公告)日：2005-09-02
申请号：JP2004041916
申请日：2004-02-18
申请人： Medgel Corp , Nitta Gelatin Inc , 新田ゼラチン株式会社 , 株式会社メドジェル
发明人： TABATA YASUHIKO , HIRAOKA YOSUKE , BANDAI YOSHINOBU
IPC分类号： C12N5/07 , C12N5/071 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a scaffold material that has high mechanical strengths, excellent cellular adhesiveness, cell growth and cytodifferentiation inducibility and efficiently carries out cell growth/differentiation in vitro. SOLUTION: This scaffold material is useful for cell culture in-vitro and comprises a nonbiodegradable absorbable synthetic polymer existing in a fibrous form in sponge composed of collagen. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供具有高机械强度，优异的细胞粘附性，细胞生长和细胞分化诱导性并在体外有效进行细胞生长/分化的支架材料。解决方案：该支架材料可用于体外细胞培养，并且包括以胶原蛋白形成的海绵中以纤维形式存在的不可生物降解的可吸收合成聚合物。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004300077A Method for removing endotoxin from collagen protein 有权
标题翻译：从胶原蛋白中去除内毒素的方法
公开(公告)号：JP2004300077A
公开(公告)日：2004-10-28
申请号：JP2003095768
申请日：2003-03-31
申请人： Nitta Gelatin Inc , 新田ゼラチン株式会社
发明人： NAGATOMI KOJI , HIRAOKA YOSUKE , YOSHIOKA KAZUO , BANDAI YOSHINOBU
IPC分类号： A61L27/00 , C07K14/78
摘要： PROBLEM TO BE SOLVED: To provide a method for removing endotoxin from endotoxin-containing collagen protein, capable of sufficiently decomposing the endotoxin while suppressing the denaturation or decomposition of the collagen protein itself, thus enabling the resultant collagen protein to be easily isolated and recovered, and to provide such collagen protein markedly freed of endotoxin. SOLUTION: The method for removing endotoxin comprises subjecting the endotoxin to decomposition treatment in such a condition that the endotoxin-containing collagen protein is brought to fibrillated dispersion in a basic alcohol and/or acetone solution and then isolating and recovering the resultant collagen protein. COPYRIGHT: (C)2005,JPO&NCIPI

9. 发明专利

JP2002080501A GLYCOSAMINOGLYCAN-POLYCATION COMPLEX FOR MATRIX OF ANAGENESIS AND METHOD FOR PRODUCING THE SAME 失效
公开(公告)号：JP2002080501A
公开(公告)日：2002-03-19
申请号：JP2000273187
申请日：2000-09-08
申请人： JAPAN SCIENCE & TECH CORP , NAT INST FOR MATERIALS SCIENCE , SEIKAGAKU KOGYO CO LTD , NITTA GELATIN KK , TANAKA JUNZO
发明人： TANAKA JUNZO , TAGUCHI TETSUSHI , MIYAZAKI KIYOUSUKE , SAKURA YOSHIYUKI , OTSUKA TATSURO , BANDAI YOSHINOBU
IPC分类号： A61L27/00 , C08B37/08
摘要： PROBLEM TO BE SOLVED: To develop a material for anagenesis which is useful as a matrix of various anageneses of cartilage, liver, blood vessel, nerve, or the like, and which exhibits physical properties extremely similar to each tissue and has an excellent biological function in a system capable of putting the material in a mold and molding the material. SOLUTION: This glycosaminoglycan-polycation complex for a matrix of anagenesis is crosslinked by a condensation reaction between glycosaminoglycan and a polycation. The glycosaminoglycan-polycation complex is produced by crosslinking the glycosaminoglycan and the polycation in a salt concentration not to form a polyion complex by a condensation reaction using water-soluble carbodiimide as a condensation agent.

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