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1. 发明专利

JP2005294201A Processing method and device of spray tip of electro spray ionizing method 审中-公开
标题翻译：电喷雾离子喷涂方法的喷涂方法和装置的处理方法
公开(公告)号：JP2005294201A
公开(公告)日：2005-10-20
申请号：JP2004111038
申请日：2004-04-05
申请人： Hitachi High-Technologies Corp , Hitachi Sci Syst Ltd , 株式会社日立サイエンスシステムズ , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , KUROSAWA KOICHI , YOSHIE MASAKI , YAMAMOTO MITSUNOBU
IPC分类号： G01N27/62 , H01J37/317 , H01J49/10
摘要： PROBLEM TO BE SOLVED: To realize a processing method of a spray tip having an inner diameter of an opening of several μm to several tens μm.
SOLUTION: A gas for protection membrane 18 is discharged from a gas gun for protection membrane on a surface of a tip cross-section of a capillary tube 5 having inner diameter 0.10 mm or less fixed on a sample table. When the surface of the capillary tube 5 cross-section is scanned by beams as shown in the arrow mark 2, gas 18 is accumulated on the surface of the scanning region, and a surface protection membrane 19 is formed. When the protection membrane is formed, firstly the ion beam 7 is scanned by a diameter larger than the inner diameter 21 of the capillary tube 5, and after the protection membrane 19 is formed, the scanning inner diameter is gradually made small. Thereby, an ion beam gas-assisted deposition membrane 19 is formed on the capillary column 5 cross-section, and the spray tip having a target opening diameter 20 can be worked.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：实现具有几μm至几十μm的开口内径的喷嘴的处理方法。解决方案：用于保护膜18的气体在固定在样品台上的内径为0.10mm以下的毛细管5的前端横截面的表面上从用于保护膜的气枪排出。如箭头2所示，当毛细管5的横截面由光束扫描时，气体18积聚在扫描区域的表面上，形成表面保护膜19。当形成保护膜时，首先以大于毛细管5的内径21的直径扫描离子束7，在保护膜19形成之后，扫描内径逐渐变小。由此，在毛细管柱5的截面上形成离子束气体辅助沉积膜19，并且可以加工具有目标开口直径20的喷嘴。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006092980A Mass spectroscope 有权
标题翻译：质谱仪
公开(公告)号：JP2006092980A
公开(公告)日：2006-04-06
申请号：JP2004278670
申请日：2004-09-27
申请人： Hitachi High-Technologies Corp , Hitachi Sci Syst Ltd , 株式会社日立サイエンスシステムズ , 株式会社日立ハイテクノロジーズ
发明人： YOSHIE MASAKI , YOSHIOKA SHINJI , KODA MASAYOSHI , SHISHIKA TSUKASA
IPC分类号： H01J49/02 , G01N27/62 , H01J49/26
摘要： PROBLEM TO BE SOLVED: To provide a mass spectroscope capable of obtaining detailed structural information on components as an object for analysis, while realizing restraint of jumboizing of a device and shortening of measurement time.
SOLUTION: A 3DQ part is formed with an end-cap electrode 2, a ring electrode 3, and an insulator 4, and a gas lead-in port 8 is formed at the insulator 4. A gas lead-in path 7 branched into a plurality of tubes is connected to the gas lead-in port 8. Each branched tube is connected to a collision gas generating device 5 through a mass-flow meter 6. Each collision gas generating device 5 has different kinds of collision gas sealed, a mixed-gas flow volume is set by the mass-flow meter 6, the gas is mixed in the path 7, and then led into the 3DQ. First, xenon is picked up as the gas, and an MS/MS measurement is started. Since a molecular volume of the object for analysis is diminished with the lapse of time, helium is mixed in the led-in gas and a gas-kind ratio is graded. With one time of the MS/MS method using a single collision cell, polymers down to low-molecule components are efficiently cleft, and a structural information of each molecule can be obtained.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够获得作为分析对象的组件的详细结构信息的质谱仪，同时实现装置的巨大的限制和缩短测量时间。解决方案：3DQ部分形成有端盖电极2，环形电极3和绝缘体4，并且在绝缘体4处形成气体导入口8.气体导入路径7 分支成多个管的部分与气体导入口8连接。各分支管通过质量流量计6连接于碰撞气体发生装置5.每个碰撞气体发生装置5具有不同种类的碰撞气密封通过质量流量计6设定混合气体流量，在路径7中混合气体，然后导入3DQ。首先，将氙气作为天然气，MS / MS测量开始。由于分析对象的分子体积随着时间的推移而减少，所以氦气在引入气体中混合，并且气体比率被分级。使用一次MS / MS方法使用单个碰撞池，低分子成分的聚合物有效地裂开，可获得每个分子的结构信息。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2003022779A Ion trap mas spectrometer 有权
标题翻译：离子捕捉MAS光谱仪
公开(公告)号：JP2003022779A
公开(公告)日：2003-01-24
申请号：JP2001206679
申请日：2001-07-06
申请人： Hitachi Ltd , Hitachi Sci Syst Ltd , 株式会社日立サイエンスシステムズ , 株式会社日立製作所
发明人： YOSHIOKA SHINJI , SHIZUKUISHI KENICHI , MOCHIZUKI KOHEI
IPC分类号： G01N27/62 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide an ion trap maws spectrometer wherein the temperature of an end cap electrode and a ring electrode, which form ion trap space, can be fully equalized. SOLUTION: By using a heating block 4 of an approximately cylinder type, which is made from a material that has electric insulation and comparatively rich thermal conductivity, end cap electrodes 1 and 2 and a ring electrode 3 for forming the ion trap space TS are stored in this heating block. By heating the heating block 4 with two or more heaters 5, the end cap electrodes 1 and 2 and the ring electrode 3 are made so that they may be heated and maintained at a uniform temperature. At this point, by installing temperature sensors 7 to each the end cap electrodes 1 and 2 and the ring electrode 3, respectively, the current supplied to the heaters 5 are made to be controlled by the detection result of the temperature by the sensors. Since each the electrodes are uniformly heated with sufficient accuracy, analysis accuracy improves greatly.
摘要翻译：要解决的问题：提供一种离子阱仪器，其中形成离子阱空间的端帽电极和环形电极的温度可以完全相等。解决方案：通过使用由具有电绝缘性和相当丰富的导热性的材料制成的大致圆柱型的加热块4，端盖电极1和2以及用于形成离子阱空间TS的环形电极3被储存在这个加热块。通过用两个以上的加热器5加热加热块4，制成端盖电极1和2以及环形电极3，使得它们可被加热并保持在均匀的温度。此时，通过分别向端盖电极1和2以及环形电极3分别安装温度传感器7，通过传感器对温度的检测结果来控制供给到加热器5的电流。由于每个电极均以足够的精度均匀加热，所以分析精度大大提高。

4. 发明专利

JP2011192519A Mass spectrometry apparatus and method using ion-molecule reaction ionization 有权
标题翻译：大分子光谱仪器和使用离子分子反应离子化的方法
公开(公告)号：JP2011192519A
公开(公告)日：2011-09-29
申请号：JP2010057249
申请日：2010-03-15
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , MOCHIZUKI KOHEI , YOSHIE MASAKI
IPC分类号： H01J49/10 , G01N27/62
CPC分类号： H01J49/107 , H01J49/145 , H01J49/168
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometry apparatus using ion-molecule reaction ionization, capable of correct qualitative and quantitative analysis in a short time regarding a sample having multicomponents without accompanying large sizing of it. SOLUTION: The ionization mass spectrometry apparatus has a plurality of ion sources 3-1 to 3-4 mutually connected in series, and a control/analysis part 6 controls to which of the ion sources 3-1 to 3-4 a voltage is supplied from a high voltage source 7 by a discharge needle 8. When a plurality of ion sources are operated, the ion source near the sample introduction part 1 becomes an ordinary APCI, and the formed ions are discharged to the outside of the ion source by an exclusion electrode 9. The remaining neutral molecules which are not ionized are sent to the ion source on the mass spectrometry apparatus side by an extraction electrode 10. Thereby, by combination of each stages of the ion sources 3-1 to 3-4, the component which is hard to detect by only one stage can be detected. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供使用离子分子反应电离的质谱装置，能够在短时间内对具有多组分的样品进行正确的定性和定量分析，而不伴随其大尺寸。解决方案：电离质谱仪具有串联相互连接的多个离子源3-1至3-4，并且控制/分析部分6控制哪个离子源3-1至3-4a 电压由高电压源7通过放电针8供给。当操作多个离子源时，样品导入部1附近的离子源成为普通的APCI，形成的离子被排出到离子的外部通过排除电极9将未离子化的剩余中性分子通过提取电极10送入质谱装置侧的离子源。由此，通过离子源3-1〜3- 如图4所示，可以检测到仅通过一个阶段难以检测的部件。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2015015118A 試料導入装置有权
标题翻译：样品介绍设备
公开(公告)号：JP2015015118A
公开(公告)日：2015-01-22
申请号：JP2013140274
申请日：2013-07-04
申请人：株式会社日立ハイテクノロジーズ , Hitachi High-Technologies Corp
发明人： YAMASHITA ERI , ITO SHINYA , YOSHIOKA SHINJI , YOSHIE MASAKI
IPC分类号： H01J49/04 , G01N27/62 , H01J49/10
摘要：【課題】本発明の目的は、生体試料を処理した試料液を大気圧イオン化法を用いた質量分析計にて測定する際に、簡単な構成で測定の時間効率を下げることなくイオン化部詰まりの発生を抑制することができる試料導入装置を提供することである【解決手段】溶媒を用いて試料を質量分析計へと導入する試料導入装置であり、溶媒収容部と、溶媒を送液する溶媒送液部と、流路上に試料を導入する試料導入手段と、流路を切り替える第1流路切り替えバルブと、第1流路切り替えバルブに接続されたサンプルループと、洗浄液収容部と、洗浄液を送液する洗浄液送液部と、を備え、第1流路切り替えバルブは、溶媒がサンプルループを介さずに質量分析計側へ送液され、かつ、試料がサンプルループへ送液される第1流路と、溶媒がサンプルループを介して質量分析計側へ送液される第2流路とを切り替えるバルブであり、洗浄液送液部は、第1流路切り替えバルブが、第1流路を形成する時に、洗浄液を質量分析計側へ送液する。【選択図】図1
摘要翻译：要解决的问题：提供一种能够以简单的结构抑制电离部分堵塞的发生的样品引入装置，而不会通过使用大气压的质谱仪在测量生物样品的样品液体的测量中降低测量的时间效率电离方法。解决方案：提供了一种通过使用溶剂将样品引入质谱仪的样品引入装置，该装置包括：溶剂容器部分; 供给溶剂的溶剂供给部; 用于将样品引入流路的样品引入装置; 切换流路的第一流路切换阀; 连接到第一流道切换阀的样品回路; 清洗液容纳部; 以及供给清洗液的清洗液供给部。第一流道切换阀是在第一流动通道之间切换的第一流动通道，通过该第一流动通道将溶剂供给到质谱仪侧，而不通过样品回路，并且样品被供给到样品回路;以及第二流动通道，溶剂通过样品回路供给到质谱仪侧，当第一流路切换阀形成第一流路时，清洗液供给部将清洗液供给到质谱仪侧。

6. 发明专利

JP2014021083A Mass spectrometric method and mass spectrometric system 审中-公开
标题翻译：质谱法和质谱系统
公开(公告)号：JP2014021083A
公开(公告)日：2014-02-03
申请号：JP2012163220
申请日：2012-07-24
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： BABA NORIKO , YOSHIOKA SHINJI , YASUDA HIROYUKI
IPC分类号： G01N27/62
CPC分类号： G01N30/7233 , G01N30/72 , G01N30/8634 , H01J49/0027 , H01J49/025
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometric method free from the reduction of quantitative accuracy.SOLUTION: The mass spectrometric system uses an analysis system including a mass spectrometer and a sub-detector connected to the preceding stage of the mass spectrometer to display intensities of sample components and detection times as chromatogram data and includes: a) analyzing a sample by an analyzer having the sub-detector after injection of the sample and injecting the sample which has passed the sub-detector, to the mass spectrometer; b) acquiring data by both the sub-detector and the mass spectrometer; c) determining which of detection peaks detected by the sub-detector and the mass spectrometer should be analyzed, on the basis of whether overlapping peaks exist or not and whether the same peak exists between the sub-detector and the mass spectrometer or not.
摘要翻译：要解决的问题：提供不降低定量精度的质谱方法。解决方案：质谱系统使用包括质谱仪和亚质量检测器的分析系统，连接到质谱仪的前一阶段以显示强度的样品组分和检测时间作为色谱图数据，包括：a）在注射样品并将已经通过子检测器的样品注入质谱仪之后，通过具有子检测器的分析仪对样品进行分析; b）通过子检测器和质谱仪获取数据; c）基于是否存在重叠峰以及在子检测器和质谱仪之间是否存在相同的峰，确定应该分析由亚检测器和质谱仪检测到的哪个检测峰。

7. 发明专利

JP2013149554A Tandem mass spectroscope and its mass spectroscopic method 有权
标题翻译： TANDEM MASS SPECTROSCOPE及其质谱方法
公开(公告)号：JP2013149554A
公开(公告)日：2013-08-01
申请号：JP2012010805
申请日：2012-01-23
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： TERUI YASUSHI , YOSHIOKA SHINJI , YASUDA HIROYUKI , HIYAMA TOSHIYUKI
IPC分类号： H01J49/42 , G01N27/62
摘要： PROBLEM TO BE SOLVED: To make it easy for a user to input measurement sample characteristics as a setting condition of an MSMS voltage set for each measurement sample before measurement when examining the MSMS voltage setting as a device condition for taking respective MSMS analyses of a variety of measurement samples such as in-vivo polymers and medicine dynamic states before the measurement and making settings for each measurement sample.SOLUTION: A user makes the MSMS voltage settings by specifying at least one of molecule species to be measured and a bond state of a molecule to be measured.
摘要翻译：要解决的问题：为了使用户能够将测量样本特性输入作为在测量之前为每个测量样本设置的MSMS电压的设置条件，当检查MSMS电压设置作为用于进行各种MSMS分析的设备条件时的测量样品，例如在测量之前的体内聚合物和药物动态，并且对每个测量样品进行设置。解决方案：用户通过指定待测量的分子种类和至少一种待测量的分子种类来进行MSMS电压设置待测量的分子。

8. 发明专利

JP2013007639A Liquid chromatography mass spectrometer device 审中-公开
标题翻译：液相色谱质谱仪
公开(公告)号：JP2013007639A
公开(公告)日：2013-01-10
申请号：JP2011140134
申请日：2011-06-24
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , YASUDA HIROYUKI
IPC分类号： G01N27/62 , G01N30/72
CPC分类号： H01J49/10 , G01N30/7266 , H01J49/044 , H01J49/049
摘要： PROBLEM TO BE SOLVED: To provide a mass spectrometer device with high detection sensitivity, achieved by efficiently vaporizing a sprayed sample solution to generate charged microdroplets to improve ionization efficiency of sample, and reducing large droplets with high ionic strength.SOLUTION: A liquid chromatography mass spectrometer device comprises: liquid chromatographic separation means which separates a sample solution into the respective components thereof; a sample spraying unit which sprays, as droplets, the sample solution separated and eluted by the liquid chromatographic separation means; ion generation means which generates ions by charging the droplets (charged droplet ); a mass spectrometer unit which introduces the ions to perform mass separation; and a desolvation unit which removes the solvent contained in the charged droplets. The desolvation unit of the present invention comprises: a desolvation flow chamber through which the charged droplets flow; heating means which heats the desolvation flow chamber; and a helical droplet conduit provided in the desolvation flow chamber.
摘要翻译：要解决的问题：提供具有高检测灵敏度的质谱仪装置，其通过有效地蒸发喷射的样品溶液以产生带电微滴来提高样品的离子化效率，并且以高离子强度减少大液滴来实现。解决方案：液相色谱质谱仪装置包括：将样品溶液分离成其相应组分的液相色谱分离装置; 样品喷射单元，其以液滴的形式喷射由液相色谱分离装置分离和洗脱的样品溶液; 离子产生装置，其通过对液滴（带电液滴）进行充电而产生离子; 引入离子进行质量分离的质谱仪单元; 以及除去含有液滴中的溶剂的去溶剂化单元。本发明的去溶剂化单元包括：去溶剂化流室，带电液滴通过该去溶剂流室流动; 加热去溶剂流室的加热装置; 以及设置在去溶剂化流动室中的螺旋液滴导管。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2007127562A Liquid feed pump 有权
标题翻译：液体进料泵
公开(公告)号：JP2007127562A
公开(公告)日：2007-05-24
申请号：JP2005321692
申请日：2005-11-07
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： OGATA IZUMI , ITO SHINYA , YOSHIOKA SHINJI , YOSHIE MASAKI , YAMASHITA ERI
IPC分类号： G01N30/32 , G01N27/62 , G01N30/26 , G01N30/72 , G01N30/86
摘要： PROBLEM TO BE SOLVED: To provide a liquid feed pump capable of executing a peak parking operation by a single pump, while using splitless type one of high flow rate accuracy.
SOLUTION: A pressurizing plunger 1 is connected to a stable liquid feeding plunger 2 by a switching valve 3, the plunger 1 is separated from the plunger 2, after pressurized to a fixed flow rate, and a liquid is stably fed by the plunger 2 together with a solvent from the pump 8, to a mass spectrometer 14, via a valve 11, a sample injection injector 12 and a separation column 13. Pressure detected by a sensor 17 is stored when the mass spectrometer 14 detects a target component, and the plunger 1 is connected to the plunger 2. The plunger 1 is separated from the plunger 2, after driving the plunger 1 to bring peak parking target pressure, and the plunger 2 feeds the liquid at a peak parking flow rate. The plunger 1 is connected to the plunger 2, after finishing the peak parking, and the plunger 1 is separated from the plunger 2, after driving the plunger 1 to bring a stored pressure value, and the plunger 2 starts the liquid feed again.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够通过单个泵执行峰值停车操作的液体供给泵，同时使用高流量精度的不分流式。解决方案：加压柱塞1通过切换阀3连接到稳定的液体供给柱塞2，柱塞1在加压到固定流量之后与柱塞2分离，并且液体被稳定地供给柱塞2与来自泵8的溶剂，以及通过阀11，样品注入器12和分离塔13的质谱仪14一起。当质谱仪14检测到目标成分时，存储由传感器17检测到的压力柱塞1连接到柱塞2.柱塞1在驱动柱塞1之后与柱塞2分离以产生最高停车目标压力，并且柱塞2以最高驻车流量进给液体。在完成峰值停车之后柱塞1连接到柱塞2，并且在驱动柱塞1以产生储存的压力值之后柱塞1与柱塞2分离，并且柱塞2再次启动液体进料。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2006292542A Liquid chromatograph mass spectrometer 审中-公开
标题翻译：液相色谱质谱仪
公开(公告)号：JP2006292542A
公开(公告)日：2006-10-26
申请号：JP2005113487
申请日：2005-04-11
申请人： Hitachi High-Technologies Corp , 株式会社日立ハイテクノロジーズ
发明人： YOSHIOKA SHINJI , MOCHIZUKI KOHEI , KODA MASAYOSHI , SHISHIKA TSUKASA
IPC分类号： G01N30/34 , G01N27/62 , G01N30/72
摘要： PROBLEM TO BE SOLVED: To provide a liquid chromatograph mass spectrometer, constituted so as to use a water-organic solvent mixture type eluate to change the composition of the eluant with the lapse of time, capable of optimizing spray ionizing conditions, while ensuring proper separation and capable of stabilizing spray ionization to high-accuracy analysis.
SOLUTION: An inverse gradient pump 6 for sending an addition liquid, of which the mixture ratio is inverse to the eluate sent from a gradient pump 1, is installed in the liquid chromatograph mass spectrometer. In the additive liquid joint 7 provided in between a column 3 and an emitter 4, the additive liquid from the inverse gradient pump 6 is mixed with the eluant, containing the sample components that have eluted from the column 3 and the mixture liquid is held to a constant mixture ratio. Since the mixture liquid has a constant mixture ratio, ionization efficiency can be made substantially constant.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种液相色谱质谱仪，其构造为使用水 - 有机溶剂混合型洗脱液以随时间改变洗脱剂的组成，能够优化喷雾电离条件，同时确保适当的分离，并能够将喷雾电离稳定到高精度分析。解决方案：用于发送与梯度泵1发送的洗脱液相反的混合比的反相梯度泵6安装在液相色谱质谱仪中。在设置在塔3和发射体4之间的添加液体接头7中，将来自反向梯度泵6的添加剂液与含有从塔3洗脱的样品成分和混合液保持的洗脱液混合恒定混合比。由于混合液具有恒定的混合比，电离效率可以基本上恒定。版权所有（C）2007，JPO＆INPIT

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