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1. 发明专利

JP2006262875A Gene construct for expressing protein in poultry fallopian tube, and method for producing protein using the gene construct 审中-公开
标题翻译：用于在POULTRY FALLOPIAN管中表达蛋白质的基因构建体，以及使用基因构建体产生蛋白质的方法
公开(公告)号：JP2006262875A
公开(公告)日：2006-10-05
申请号：JP2005089885
申请日：2005-03-25
申请人： Hiroshima Industrial Promotion Organization , Hiroshima Univ , 国立大学法人広島大学 , 財団法人ひろしま産業振興機構
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , OGAWA MARI
IPC分类号： C12N15/09 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a gene construct for expressing a desired protein in the fallopian tube of poultry including chicken without using any virus vector system for realizing a safe protein production system using transgenic poultry(chicken), and to provide a method for producing the protein using the gene product. SOLUTION: The gene construct contains the genomic sequence of a chicken-derived ovoalbumin gene, wherein an exogenous gene is transferred in the translation initiation site of the ovoalbumin gene. By transferring the exogenous gene into a chicken's gene using this gene construct, the protein encoded by the exogenous gene can be specifically expressed in chicken fallopian tube. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供用于在包括鸡的家禽的输卵管中表达所需蛋白质的基因构建体，而不使用任何病毒载体系统来实现使用转基因家禽（鸡）的安全蛋白质生产系统，并提供一种使用该基因产物生产蛋白质的方法。解决方案：基因构建体含有来自卵的卵清蛋白基因的基因组序列，其中外源基因被转移到卵清蛋白基因的翻译起始位点。通过使用该基因构建体将外源基因转移到鸡的基因中，由外源基因编码的蛋白质可以在鸡输卵管中特异性表达。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2008031043A Chicken lif (leukemia inhibitory factor) protein and its use 审中-公开
标题翻译：鸡肉LIF（LEUKEMIA抑制因子）蛋白及其使用
公开(公告)号：JP2008031043A
公开(公告)日：2008-02-14
申请号：JP2004336747
申请日：2004-11-19
申请人： Hiroshima Industrial Promotion Organization , Hiroshima Univ , 国立大学法人広島大学 , 財団法人ひろしま産業振興機構
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , OGAWA MARI
IPC分类号： C07K14/52 , A01K67/02 , C07K16/24 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02
CPC分类号： C07K14/465 , A01K2217/05 , A01K2227/30 , C07K16/24
摘要： PROBLEM TO BE SOLVED: To supply a differentiation inhibitory factor for chicken embryonic stem cells or embryonic germ cells which are essentially required to create transgenic chickens. SOLUTION: A cell line which can stably express chicken LIF protein is acquired, and the protein is smoothly isolated, purified and subsequently mass-produced. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为鸡胚胎干细胞或胚胎生殖细胞提供分化抑制因子，这些细胞基本上是产生转基因鸡所必需的。解决方案：获得能够稳定表达鸡LIF蛋白的细胞系，并且蛋白质被顺利分离，纯化并随后批量生产。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2007167013A Vector for producing objective protein in egg yolk of birds and use thereof 审中-公开
标题翻译：用于生产目标蛋白质的产品用途及其用途
公开(公告)号：JP2007167013A
公开(公告)日：2007-07-05
申请号：JP2005371195
申请日：2005-12-23
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , HORIUCHI HIROYUKI , SATO MASAHARU , FURUSAWA SHUICHI , KAWASHIMA TAKESHI
IPC分类号： C12N15/09 , C12P21/02 , C12P21/06
摘要： PROBLEM TO BE SOLVED: To obtain a vector for producing an objective protein in an egg (especially egg yolk) of a bird including a chicken, to provide a method for producing an objective protein using the vector and a kit containing the vector. SOLUTION: The vector (one example) comprises a promoter and a polynucleotide having a gene encoding a cathepsin D recognition domain, bonded to the 3' terminal side of a gene encoding a domain containing at least a signal sequence and an SE fragment in a chicken-derived vitellogenin protein in which the polynucleotide is controllably bonded to the promoter. The vector has a polynucleotide having a gene encoding a histidine tag, bonded to the 3' terminal side of a gene encoding a cathepsin D recognition domain. The vector contains a poly A addition signal. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了获得用于在包括鸡的鸟的卵（特别是蛋黄）中产生目标蛋白质的载体，以提供使用载体生产目标蛋白的方法和含有载体的试剂盒。解决方案：载体（一个实例）包含启动子和具有编码组织蛋白酶D识别结构域的基因的多核苷酸，该多核苷酸与编码至少含有信号序列的结构域和SE片段的基因的3'末端相连接在其中多核苷酸可控地结合到启动子的鸡源性卵黄蛋白原蛋白中。载体具有编码组氨酸标签的基因的多核苷酸，其键合到编码组织蛋白酶D识别结构域的基因的3'末端侧。向量包含poly A加法信号。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2005278633A Method for producing chicken type monoclonal antibody, and chicken type monoclonal antibody produced by the production method 有权
标题翻译：生产鸡型单克隆抗体的方法和生产方法生产的鸡型单克隆抗体
公开(公告)号：JP2005278633A
公开(公告)日：2005-10-13
申请号：JP2004325658
申请日：2004-11-09
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , NISHIBORI NAOKO , SHIMAMOTO SATOSHI
IPC分类号： C12N15/09 , A61K39/395 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To establish a method for efficiently producing a chicken type monoclonal antibody and a structure-modified chicken type monoclonal antibody, to provide a chicken type monoclonal antibody produced by the production method, to provide an expression vector used for the production method, to provide a transformed cell into which the expression vector is transduced, and to provide a primer set. SOLUTION: By the method for producing the chicken type monoclonal antibody, a perfect length chicken type monoclonal antibody (Full antibody), a structure-modified chicken type monoclonal antibody in which seven amino acids are deleted from the C-terminal side of the H chain (Δ7aa antibody), a structure-modified chicken type monoclonal antibody in which fifty five amino acid residues are deleted, while leaving the cysteine residue of CH2 domain, (ΔCH2 antibody), or a structure-modified chicken type monoclonal antibody in which both CH3 domain and CH4 domain are deleted (ΔFc antibody), can be produced. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了建立一种有效生产鸡型单克隆抗体和结构修饰的鸡型单克隆抗体的方法，以提供通过制备方法生产的鸡型单克隆抗体，以提供用于制备方法，以提供其中转导表达载体的转化细胞，并提供引物组。解决方案：通过生产鸡型单克隆抗体的方法，将完全长度的鸡型单克隆抗体（全抗体），结构修饰的鸡型单克隆抗体，其中7个氨基酸从C末端侧缺失 H链（Δ7aa抗体），其中缺少五十五个氨基酸残基，同时保留CH2结构域的半胱氨酸残基（ΔCH2抗体）或结构修饰的鸡型单克隆抗体的结构修饰的鸡型单克隆抗体可以制备CH3结构域和CH4结构域的缺失（ΔFc抗体）。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2006241026A Antibody and use of the same 有权
标题翻译：抗体及其使用
公开(公告)号：JP2006241026A
公开(公告)日：2006-09-14
申请号：JP2005056665
申请日：2005-03-01
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , NISHIBORI NAOKO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI
IPC分类号： C07K16/46 , A61K39/395 , A61P43/00 , C12N15/09 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide an antibody reactive to antigen of mammalian animals and having a reduced immunogenicity.
SOLUTION: The invention relates to the antibody comprising a constant region originating from human and a variable region comprising a complementary determining region originating from fowl and a frame work region originating from human and the antibody includes the complementary determining region originating from fowl which is not close to human in systematology and has a wide antigen-recognizing activity to antigen of human and mammalian animals excluding human and has a small immunogenicity to human. The antibody can be properly applied as pharmaceuticals.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供对哺乳动物的抗原具有反应性并具有降低的免疫原性的抗体。解决方案：本发明涉及包含源自人的恒定区的抗体和包含源自家禽的互补决定区和源自人的框架工作区的可变区，抗体包括起源于家禽的互补决定区，在系统学上不接近人类，并且对人类和哺乳动物的人类和哺乳动物的抗原具有广泛的抗原识别活性，并且对人的免疫原性小。该抗体可以适当地用作药物。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2004283111A Nucleic acid, monoclonal antibody derived from chicken containing the same nucleic acid and method for detecting prion protein by using the same 有权
公开(公告)号：JP2004283111A
公开(公告)日：2004-10-14
申请号：JP2003080553
申请日：2003-03-24
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , NAKAMURA NAOTO
IPC分类号： G01N33/53 , C07K16/18 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a monoclonal antibody derived from chicken suitable for mass production by a genetic recombination method. SOLUTION: The nucleic acid consists of the following (a) or (b). (a) A nucleic acid composed of a specific base sequence. (b) A nucleic acid, in which a part of the specific base sequence is lost, substituted or added, having 80% homology with the base sequence. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JP2007071645A Protein measurement method 有权
标题翻译：蛋白质测量方法
公开(公告)号：JP2007071645A
公开(公告)日：2007-03-22
申请号：JP2005257938
申请日：2005-09-06
申请人： Hiroshima Univ , Sharp Corp , Teikyo Univ , シャープ株式会社 , 国立大学法人広島大学 , 学校法人帝京大学
发明人： TAKAHASHI KATSUYOSHI , SHIMURA KIYOHITO , MATSUDA HARUO , AOZASA MASAYOSHI
IPC分类号： G01N33/53 , C07K1/12 , C12M1/34 , C12P21/06 , C12Q1/37 , G01N27/327 , G01N27/447 , G01N33/561
CPC分类号： C12Q1/37
摘要： PROBLEM TO BE SOLVED: To provide a measurement method and a measurement instrument for measuring protein with high accuracy whether it is soluble or insoluble. SOLUTION: As to a method for measuring specific protein in a sample, a method is provided which is characterized by including a first process for decomposing the specific protein in the sample into peptide fragments and a second process for measuring the existence of a specific peptide fragment by using an affinity/bonding substance having affinity for and bondability to the specific peptide fragment which is soluble and derived from the specific protein. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种测量方法和用于高精度测量蛋白质的测量仪器，无论其是可溶性还是不溶性的。解决方案：关于样品中特定蛋白质的测定方法，提供了一种方法，其特征在于包括将样品中的特定蛋白质分解为肽片段的第一种方法和用于测量样品中存在的第二种方法通过使用对特异性蛋白质可溶性和衍生的特异性肽片段具有亲和性和结合能力的亲和力/结合物质来制备特异性肽片段。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2006282521A Avian chimera antibody and its utilization 有权
标题翻译： AVIAN CHIMERA抗体及其应用
公开(公告)号：JP2006282521A
公开(公告)日：2006-10-19
申请号：JP2005101296
申请日：2005-03-31
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , NISHIBORI NAOKO , SHIMAMOTO SATOSHI
IPC分类号： C07K16/46 , C12N15/09 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide a divalent avian type monoclonal antibody having a small mol.wt., and to provide its representative utilization technique.
SOLUTION: This avian chimera antibody is obtained by adding a hinge region derived from a mammal, preferably a human, instead of a region corresponding to the hinge region of an avian antibody. Thereby, the divalent antibody having a small mol.wt. can be obtained, and the divalent antibody can be realized in a prokaryote such as Escherichia coli. In addition, the flexibility of the antibody can more be improved because of having the hinge portion derived from the mammal.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有小摩尔重量的二价禽类型单克隆抗体，并提供其代表性的利用技术。解决方案：通过添加源自哺乳动物，优选人的铰链区，而不是与禽抗体的铰链区相对应的区域来获得该禽类嵌合体抗体。因此，具有小摩尔重量％可以在原核生物如大肠杆菌中实现二价抗体。此外，由于具有衍生自哺乳动物的铰链部分，抗体的灵活性可以更多地改善。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2005245337A Vector for manifesting poultry-human chimera antibody, method for producing poultry-human chimera antibody by using the vector and use thereof 有权
标题翻译：用于生产人类CHIMERA抗体的载体，使用载体生产人类CHIMERA抗体的方法及其用途
公开(公告)号：JP2005245337A
公开(公告)日：2005-09-15
申请号：JP2004061453
申请日：2004-03-04
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI , NISHIBORI NAOKO , SHIMAMOTO SATOSHI
IPC分类号： C12N15/00 , A61K39/395 , A61P19/02 , A61P29/00 , A61P35/00 , C07K16/46 , C12P21/08
摘要： PROBLEM TO BE SOLVED: To provide the technology for easily producing poultry-human chimera antibody of high practical value, but not an antibody fragment, and provide a typical application method. SOLUTION: The vector for manifesting poultry-human chimera antibody comprises at least CMV promoter, the integration site for integrating poultry variable region gene (H, A or B), the reader sequence for poultry immunoglobulin (V L ), human immunoglobulin constant region gene (Cκ, Cγ1 or Cγ4). An arbitrary poultry variable region gene is integrated into the integrating site, and introduced into mammalian cells whereby a poultry-human chimera antibody having the poultry-originating variable area and the human-originating constant area can be produced. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供易于生产具有高实用价值但不是抗体片段的家禽 - 人嵌合体抗体的技术，并提供典型的施用方法。解决方案：用于展示家禽 - 人类嵌合体抗体的载体至少包含CMV启动子，用于整合家禽可变区基因（H，A或B）的整合位点，家禽免疫球蛋白的阅读器序列（V L < / SB>），人免疫球蛋白恒定区基因（Cκ，Cγ1或Cγ4）。将一个任意的家禽可变区基因整合到整合位点，并引入到哺乳动物细胞中，从而可以生产具有家禽可变面积和人源恒定面积的家禽 - 人嵌合体抗体。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2010004895A Method for preparation of humanized chicken antibody 审中-公开
标题翻译：人源化抗体制备方法
公开(公告)号：JP2010004895A
公开(公告)日：2010-01-14
申请号：JP2009236484
申请日：2009-10-13
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： MATSUDA HARUO , NISHIBORI NAOKO , FURUSAWA SHUICHI , HORIUCHI HIROYUKI
IPC分类号： C12P21/02 , A61K39/395 , C07K16/46 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an antibody reactive to an antigen of a mammalian animal and having a reduced immunogenicity.
SOLUTION: The antibody characterized by including a constant region originating from human and a variable region including a complementary determining region originating from chicken and a frame work region originating from human, has a wide antigen-recognizing activity to antigen of human and mammalian animals excluding human and has a small immunogenicity to human since the antibody includes the complementary determining region originating from chicken which is not close to human in systematology. The antibody can be properly applied as pharmaceuticals.
COPYRIGHT: (C)2010,JPO&INPIT

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