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1. 发明专利

JP2005110687A Tool and method for collecting nucleic acid 有权
标题翻译：用于收集核酸的工具和方法
公开(公告)号：JP2005110687A
公开(公告)日：2005-04-28
申请号：JP2004337944
申请日：2004-11-22
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SAKURAI TOMOYA , YOKOBAYASHI TOSHIAKI
IPC分类号： C12N15/09 , B01J20/281 , B01J20/283 , B01L3/02 , C12M1/00 , C12M1/26 , C12Q1/68 , G01N30/08 , G01N30/26 , G01N30/88 , G01N33/50 , G01N35/00 , G01N35/02 , G01N35/10 , G01N30/48
CPC分类号： G01N35/109 , B01F2215/0037 , B01L3/0275 , B01L2200/0631 , G01N35/0099 , G01N35/028 , G01N35/1004 , G01N2035/00237 , G01N2035/103 , G01N2035/1058 , Y10T436/255
摘要： PROBLEM TO BE SOLVED: To provide a tool and method for conveniently collecting nucleic acids from biological samples containing nucleic acids. SOLUTION: A chip for catching nucleic acids has a built-in silica-containing solid phase so as to contact with a liquid, wherein the solid phase has a water passage portion and an average gap between the solid phases in the water passage portion is not more than 25 μm. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供用于从含有核酸的生物样品中方便地收集核酸的工具和方法。解决方案：用于捕获核酸的芯片具有内置的含二氧化硅的固相以与液体接触，其中固相具有水通道部分和水通道中固相之间的平均间隙部分不超过25μm。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2001083050A NUCLEIC ACID RECOVERING METHOD AND REAGENT KIT 失效
公开(公告)号：JP2001083050A
公开(公告)日：2001-03-30
申请号：JP26320399
申请日：1999-09-17
申请人： HITACHI LTD
发明人： SAKURAI TOMOYA , YOKOBAYASHI TOSHIAKI , YASUDA KENJI , FUKUZONO SHINICHI
IPC分类号： C12Q1/68 , G01N1/10 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To speedily and simply provide a method for recovering nucleic acids of high degree of purification from uncleic acid containing materials without lowering yields, a method suitable for an automatic device for a recovering nucleic acid component present in an organic sample, and a method suitable for an automated device for recovering plasmid DNA from E. coli. SOLUTION: This method is provided with a first process to accelerate the freeing of uncleic acids from uncleic acid containing materials, a second process to mix the freed uncleic acids with a substance which accelerates bonding of uncleic acids to a solid phase, a third process to bring the mixed liquid into contact with a uncleic acid bonding solid phase under an acid condition, a fourth process to separate the solid phase from the liquid, a fifth process to clean the solid phase bonded with the uncleic acids by a salt containing acid solution, and a sixth process to elute the uncleic acids from the solid phase under an alkali condition. With this constitution, it is possible to obtain uncleic acids of degree of purity suitable for gene inspection and gene analysis speedily and simply, without using substances which may be hazardous.

3. 发明专利

JPH06186469A METHOD AND DEVICE FOR AUTOMATICALLY DETECTING FOCUS FOR MICROSCOPE DEVICE 失效
公开(公告)号：JPH06186469A
公开(公告)日：1994-07-08
申请号：JP40681590
申请日：1990-12-26
申请人： HITACHI LTD
发明人： OWADA HAKUO , YABE RIYOUHEI , YOKOBAYASHI TOSHIAKI , ABE TADASHI
IPC分类号： G02B7/28 , G02B21/26
摘要： PURPOSE:To improve noise resistance and to precisely and automatically detect a focus by increasing the moving amount of one step in a moving area distant from a focusing point position and decreasing it in a moving area near the focusing point position. CONSTITUTION:A photoelectric converter 7 and a television camera 8 are fitted to a microscope main body 1. The microscopic image of a sample 4 obtained by an objective lens 2 is inputted to the converter 7 and the camera 8. An electric signal related to the microscopic image outputted from the converter 7 is inputted to a focusing position detection device 9 and a cell detection device 10. Then, a focus signal is outputted from the detection device 9. In such a case, as for the moving amount of one step of the lens 2, it is increased in the moving area distant from the focusing point position and decreased in the moving area near it based on a discrimination signal outputted by a moving area discrimination means which is provided in an arithmetic controller 11 and which discriminates the moving area of the lens 2.

4. 发明专利

JPS62238466A AUTOMATIC ANALYZER 失效
公开(公告)号：JPS62238466A
公开(公告)日：1987-10-19
申请号：JP8016686
申请日：1986-04-09
申请人： HITACHI LTD
发明人： HASHIMOTO HIROSHI , NAKAMURA NORIKAZU , YOKOBAYASHI TOSHIAKI
IPC分类号： G01N35/00 , G01M99/00 , G01R31/30
摘要： PURPOSE:To discover the abnormal operation of each part at an early stage, by supplying voltage from a voltage converting means to each part by slightly increasing and decreasing the voltage of a power source by the voltage converting means when each part is operated during maintenance to discover trouble by a maintenance diagnostic system. CONSTITUTION:An operating power is supplied to the analytical part 13, computer system 1, a mechanical interface 7, keyboard 11, printer 9, display 10 and logarithmic amplifier 14 of an automatic analyzer from a power source apparatus 30. This apparatus 30 is separated into a DC power source (a) and an AC power source (b) and AD voltage is converted to DC one by the rectifier 31 and smoothing circuit 32 of the DC power source (a) to be inputted to IC33 for controlling the power source. The contacts A-C of an electromagnetic relay 34 are changed over on the basis of the control voltage ER of IC33 by the control signal of an interface 7 to supply different voltage to each part of load 35. At the time the AC power source (b) is used, the voltage from the different tap of a transformer 36 is applied to an electromagnetic relay 37 to supply different voltage to each part of load 38.

5. 发明专利

JPS61126806A Input protecting method of semiconductor amplifier circuit 失效
标题翻译：半导体放大器电路的输入保护方法
公开(公告)号：JPS61126806A
公开(公告)日：1986-06-14
申请号：JP24801384
申请日：1984-11-26
申请人： Hitachi Ltd
发明人： YOKOBAYASHI TOSHIAKI , SASAKI KEIZO
IPC分类号： H03F1/52 , H03F1/42
摘要： PURPOSE: To protect an input section of an amplifier circuit from an overvoltage such as static electricity without using a special circuit component by utilizing discharge between patterns on a printed board so as to absorb an overvoltage energy.
CONSTITUTION: A current limit resistor 2 is inserted to the input section of a voltage follower type voltage amplification circuit 12 comprising a JFET type operational amplifier 1. A discharge part 5 where a pattern on the printed board is close to a ground pattern is provided between the current limit resistor 2 and an input connector 6. An input resistance of 10
10 Ω is ensured sufficiently by less region of opposed approaching parts and resist processing of the board. The discharge energy to be absorbed is not limited by the ground line 6 but similar effect is obtained with a low impedance line such as a power line or a chassis.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：通过利用印刷电路板上的图案之间的放电来保护放大器电路的输入部分免受诸如静电之类的过电压而不使用特殊的电路部件，从而吸收过电压能量。构成：将电流限制电阻2插入到包括JFET型运算放大器1的电压跟随器型电压放大电路12的输入部分。印刷电路板上的图形接近接地图案的放电部分5设置在电流限制电阻2和输入连接器6.通过相对接近的部件的较小区域充分确保10 10欧姆的输入电阻，并抵抗电路板的加工。待吸收的放电能量不受接地线6的限制，但是通过诸如电力线或底盘的低阻抗线获得相似的效果。

6. 发明专利

JPH11271316A Sample-rack transfer apparatus and its control method 失效
标题翻译：样品架传送装置及其控制方法
公开(公告)号：JPH11271316A
公开(公告)日：1999-10-08
申请号：JP7370198
申请日：1998-03-23
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SHOJI YOSHIYUKI , KURIMURA MASAAKI , ODAKURA MASAAKI , YOKOBAYASHI TOSHIAKI
IPC分类号： G01N35/04
摘要： PROBLEM TO BE SOLVED: To obtain a sample-rack transfer apparatus which prevents a wasteful waiting time and an empty place between sample racks from being generated when they are transferred and which can transfer the sample racks efficiently.
SOLUTION: A sample-rack transfer apparatus which executes predetermined treatments sequentially is provided with a means by which a first sample-rack transfer passage to a third sample-rack transfer passage are skipped by using a fourth sample-rack transfer passage. That is to say, a sample rack 8 which is carried into the apparatus and which is judged to be passed is not carried into a sample-rack feed side so as to be transferred to a sample-rack passage side. The generation of a wasteful waiting time and an empty place between sample racks is prevented by sensors 101 to 106 and by a control part, and the sample racks can be transferred efficiently.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：获得样品架传送装置，其防止在传送样品架之间产生浪费的等待时间和空间，并且可以有效地传送样品架。解决方案：依次执行预定处理的样架传送装置设置有通过使用第四样架传送通道跳过到第三样架传送通道的第一样架传送通道的装置。也就是说，携带到装置中并被判断通过的样架8不被携带到样架供给侧，以便被传送到样架通道侧。通过传感器101〜106和控制部防止样品架之间产生浪费的等待时间和空白处，可有效地传送样品架。

7. 发明专利

JPH11271315A Automatic urine analyzing device 失效
标题翻译：自动尿液分析装置
公开(公告)号：JPH11271315A
公开(公告)日：1999-10-08
申请号：JP7697098
申请日：1998-03-25
申请人： Hitachi Ltd , Hitachi Sci Syst Ltd , 株式会社日立サイエンスシステムズ , 株式会社日立製作所
发明人： NISHIGORI TETSUO , OGASAWARA TAKAO , YOKOBAYASHI TOSHIAKI
IPC分类号： G01N33/493 , G01N35/02 , G01N35/04
摘要： PROBLEM TO BE SOLVED: To eliminate the possibility of running out of test papers during measurement, using an expired test paper, and obtaining anomalous data, by providing a storage medium for a test paper storage cartridge and writing information used in a device.
SOLUTION: When conditions necessary for measurement are inputted from an input/output device 12. and a start key is pressed, a CPU 10 stores the information in memory 11, and a storage medium write/read device 8 reads information such as stored number, expiration date from a storage medium 13 glued to a cartridge 1 and passes to the CPU 10. A test paper 7 is extracted from the cartridge 1 to a transferring line 2 and is immersed in a sample-filled test tube 6 by a dipping arm 4 for a predetermined period of time. Then the test paper 7 is returned to the transferring line 2 again and is moved to a location of a photometer 3 to measure reflectance, etc. The measured results are stored in the memory 11 and are displayed on the input/output device 12 at the same time. If an expired cartridge 1 is set, the CPU 10 reads the information and displays a message to further its exchange on the input/output device 12.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：为了消除在测量期间耗尽测试纸的可能性，使用过期的试纸，并通过提供用于测试纸存储盒的存储介质和写入设备中使用的信息来获得异常数据。解决方案：当从输入/输出设备12输入测量所需的条件并按下开始键时，CPU10将信息存储在存储器11中，并且存储介质写/读设备8读取诸如存储号码，从存储介质13粘贴到盒1的过期日期并传送到CPU 10.将试纸7从盒1中提取到传送线2，并通过浸渍臂4浸入样品填充的试管6中在预定的时间段内。然后再次将测试纸7返回到传输线2，并移动到光度计3的位置以测量反射率等。测量结果存储在存储器11中，并且在输入/输出设备12上显示在同时。如果设置过期的墨盒1，则CPU 10读取信息并在输入/输出设备12上显示消息以进一步进行其交换。

8. 发明专利

JPH11223595A SORTING METHOD FOR PARTICLE IMAGE OF ORGANISM 失效
公开(公告)号：JPH11223595A
公开(公告)日：1999-08-17
申请号：JP2567598
申请日：1998-02-06
申请人： HITACHI LTD
发明人： KOJIMA YASUAKI , TAKI MIKI , OWADA HAKUO , YOKOBAYASHI TOSHIAKI , SANO KAZUTAKA , KINOU KAORI , MACHIDA KAZUHISA , KAWASAKI YOSHIFUMI
IPC分类号： G01N33/483 , G01N15/02 , G01N15/14 , G01N33/49 , G01N33/493 , G06F17/30 , G06T1/00 , G06T7/00 , G06T11/80
摘要： PROBLEM TO BE SOLVED: To obtain a sorting method in which measured results of a plurality of treated specimens can be processed preferentially according to a prescribed condition by a method wherein the specimen inside a specimen list are rearranged under a preferential processing condition and the next specimen is read out according to a rearranged sequence. SOLUTION: Specimens inside a specimen list are rearranged under a preferential processing condition, and a processing sequence is decided on the basis of a rearranged specimen list. That is to say, when a specimen list botton is clicked by a mouse from the inside of a tool bar 305 in a standard screen 300 on a display, a specimen list screen is displayed. Among from a plurality of specimens in the displayed specimen list screen, the specimen to be treated, e.g. the specimen whose particles are to be sorted, is selected. Then, when the specimen list screen is closed, data on the specimen is displayed in a specimen data part 302, a qualitative-data display part 303 and a sorted-result display part 304, and an automatically sorted particle image is displayed in a working area 308. Then, the next specimen is selected on the basis of the degree of priority, and its particle image is accessed.

9. 发明专利

JPH0572213A MEASURING METHOD OF AUTOMATIC ANALYTICAL APPARATUS 失效
公开(公告)号：JPH0572213A
公开(公告)日：1993-03-23
申请号：JP709291
申请日：1991-01-24
申请人： HITACHI LTD
发明人： YOKOBAYASHI TOSHIAKI , MIMAKI HIROSHI , TAKAHASHI KATSUAKI
IPC分类号： G01N35/02
摘要： PURPOSE:To prevent lowering of measuring precision due to a difference in the state of leakage of reaction vessels by a method wherein a liquid put in the reaction vessel is held till the time just before a sample is injected into the reaction vessel. CONSTITUTION:A prescribed sample is distributed by a necessary amount into a reaction vessel 2 by using a nozzle 8 of a sample pipetting mechanism 7 and on the basis of the operation of a sample distributing mechanism 21. A reagent for a blood sugar analysis, for instance, is selected out of reagents arranged in a sample disk mechanism 9 and is distributed by a reagent distributing mechanism 19 by using nozzles of reagent pipetting mechanisms 10A and 10B. Thereafter the sample and the reagent are agitated and mixed by an agitating mechanism 11. The sample in the vessel 2 is kept at a constant temperature by circulation water supplied from a thermostat 4 and made to react for a prescribed time. Absorbance is measured by using two wavelengths set in a multi-wavelength photometer 12. The absorbance is taken in a microcomputer 15 via a multiplexer, a Log converter 17, etc., corrected by a cell blank correction value measured in a pretreatment and then converted into concentration.

10. 发明专利

JPS62135767A CELL ANALYZING INSTRUMENT 失效
公开(公告)号：JPS62135767A
公开(公告)日：1987-06-18
申请号：JP27771985
申请日：1985-12-10
申请人： HITACHI LTD
发明人： MATSUSHITA HAJIME , YABE RIYOUHEI , KURIMURA MASAAKI , YOKOBAYASHI TOSHIAKI
IPC分类号： G01N33/48 , G01N15/14 , G01N35/00 , G06K9/00
摘要： PURPOSE:To lessen the manpower for an inspection and to improve the reliability thereof by identifying normal and abnormal cells from the image signal of the sample of a dyed cell specimen, again subjecting only the abnormal cells to a precision inspection and extracting the specimen requiring a visual inspection. CONSTITUTION:The sample 2 of the dyed blood specimen is set in a cassette 1 of a sample cassette loader 3. The sample 2 is fed to a microscope 8 to inspect and is made into the image signal by a television camera 11. The image signal is inputted into a circuit 12 for taking-in an image signal and extracting characteristics. The measurement data thereof is put into a calculator 16 through a computer controller 13 and is collated with the analysis data stored in a memory 14, by which the primary analysis to identify the normal cells and the abnormal cells is made. The secondary analysis to compare the characteristic parameter of the cell image with the known data under the precision conditions of only the abnormal cells is again made to extract the specimen requiring the visual inspection. Since the specimen requiring the visual inspection is efficiently extracted by a cell classifying device in the above-mentioned manner, the automatic analysis is efficiently made by increasing the number of the specimens.

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